Prothrombin Time

14,000,000 Leading Edge Experts on the ideXlab platform

Scan Science and Technology

Contact Leading Edge Experts & Companies

Scan Science and Technology

Contact Leading Edge Experts & Companies

The Experts below are selected from a list of 18930 Experts worldwide ranked by ideXlab platform

Ya-ting Chang - One of the best experts on this subject based on the ideXlab platform.

  • Characteristics of scrub typhus, murine typhus, and Q fever among elderly patients: Prolonged Prothrombin Time as a predictor for severity
    Elsevier, 2019
    Co-Authors: Ko Chang, Nan-yao Lee, Wei-ru Lin, Yen-hsu Chen, Jih-jin Tsai, Tun-chieh Chen, Chun-yu Lin, Ya-ting Chang
    Abstract:

    Background/purpose: The clinical manifestations of scrub typhus, murine typhus and acute Q fever in the elderly are not clear. Methods: We conducted a retrospective study to identify the characteristics of the elderly aged ≥65 years with a comparison group aged 18–64 years among patients with scrub typhus, murine typhus, or acute Q fever who were serologically confirmed at three hospitals in Taiwan during 2002–2011. Results: Among 441 cases, including 187 cases of scrub typhus, 166 acute Q fever, and 88 murine typhus, 68 (15.4%) cases were elderly patients. The elderly had a higher severe complication rate (10.3% vs. 3.5%, p = 0.022), but did not have a significantly higher mortality rate (1.47% vs. 0.54%, p = 0.396). Compared with those without severe complications, we found the elderly (p = 0.022), dyspnea (p = 0.006), less relative bradycardia (p = 0.004), less febrile illness (p = 0.004), prolonged Prothrombin Time (PT) (p = 0.002), higher levels of initial C-reactive protein (p = 0.039), blood leukocyte counts (p = 0.01), and lower platelet counts (p = 0.012) are significantly associated with severe complications. Only prolonged Prothrombin Time was associated with severe complications in multivariate analysis (p = 0.018, CI 95% 0.01–0.66). Among clinical symptoms and laboratory data, multivariate analysis revealed chills was less frequently occurred in the elderly (p = 0.012, 95% confidence interval [CI]: 1.33–9.99). Conclusion: The elderly cases with scrub typhus, murine typhus, or acute Q fever would be more likely to have severe complications, for which Prothrombin Time prolongation is an important predictor for severe complications. Keywords: Elderly, Scrub typhus, Acute Q fever, Murine typhus, Complication

  • characteristics of scrub typhus murine typhus and q fever among elderly patients prolonged Prothrombin Time as a predictor for severity
    Journal of Microbiology Immunology and Infection, 2017
    Co-Authors: Ko Chang, Nan-yao Lee, Wei-ru Lin, Yen-hsu Chen, Jih-jin Tsai, Tun-chieh Chen, Chun-yu Lin, Ya-ting Chang
    Abstract:

    Abstract Background/purpose The clinical manifestations of scrub typhus, murine typhus and acute Q fever in the elderly are not clear. Methods We conducted a retrospective study to identify the characteristics of the elderly aged ≥65 years with a comparison group aged 18–64 years among patients with scrub typhus, murine typhus, or acute Q fever who were serologically confirmed at three hospitals in Taiwan during 2002–2011. Results Among 441 cases, including 187 cases of scrub typhus, 166 acute Q fever, and 88 murine typhus, 68 (15.4%) cases were elderly patients. The elderly had a higher severe complication rate (10.3% vs. 3.5%, p  = 0.022), but did not have a significantly higher mortality rate (1.47% vs. 0.54%, p  = 0.396). Compared with those without severe complications, we found the elderly ( p  = 0.022), dyspnea ( p  = 0.006), less relative bradycardia ( p  = 0.004), less febrile illness ( p  = 0.004), prolonged Prothrombin Time (PT) ( p  = 0.002), higher levels of initial C-reactive protein ( p  = 0.039), blood leukocyte counts ( p  = 0.01), and lower platelet counts ( p  = 0.012) are significantly associated with severe complications. Only prolonged Prothrombin Time was associated with severe complications in multivariate analysis ( p  = 0.018, CI 95% 0.01–0.66). Among clinical symptoms and laboratory data, multivariate analysis revealed chills was less frequently occurred in the elderly ( p  = 0.012, 95% confidence interval [CI]: 1.33–9.99). Conclusion The elderly cases with scrub typhus, murine typhus, or acute Q fever would be more likely to have severe complications, for which Prothrombin Time prolongation is an important predictor for severe complications.

Peter Reinstrup - One of the best experts on this subject based on the ideXlab platform.

Yu Chen Barrett - One of the best experts on this subject based on the ideXlab platform.

  • a novel Prothrombin Time assay for assessing the anticoagulant activity of oral factor xa inhibitors
    Clinical and Applied Thrombosis-Hemostasis, 2013
    Co-Authors: Yu Chen Barrett, Zhaoqing Wang, Robert M Knabb
    Abstract:

    Conventional Prothrombin Time (PT) assays have limited sensitivity and dynamic range in monitoring the anticoagulant activity of direct factor Xa inhibitors. Hence, new assays are needed. We modifi...

  • clinical laboratory measurement of direct factor xa inhibitors anti xa assay is preferable to Prothrombin Time assay
    Thrombosis and Haemostasis, 2010
    Co-Authors: Yu Chen Barrett, Zhaoqing Wang, Charles Frost, Andrew Shenker
    Abstract:

    Apixaban and other factor Xa (FXa) inhibitors are in late-stage clinical development for prevention and treatment of thromboembolic diseases. Although routine monitoring will not be required, in certain situations assessment of drug level may be helpful. This study evaluated the suitability of commercially available Prothrombin Time/international normalised ratio (PT/INR) and anti-FXa activity assays to measure FXa inhibitors in plasma. Twelve PT (ISI 0.89-1.88) and three anti-Xa assays were evaluated in vitro using human plasma spiked with four FXa inhibitors (0-2,000 ng/ml). Assay variability and correlation with drug plasma exposure were evaluated in patients with venous thromboembolism (VTE) treated with apixaban. All FXa inhibitors prolonged PT; however, assay sensitivity was dependent on thromboplastin reagents used and FXa inhibitors tested. To achieve a doubling of PT, the concentration of each FXa inhibitor varied 2.6- to 8-fold between thromboplastin reagents. The rank order of a FXa inhibitor’s effect on PT ratio varied across thromboplastin reagents. Conversion to INR increased variability. Different anti-Xa assays showed different dynamic ranges for each FXa inhibitor; however, their rank order was consistent. For apixaban, the dynamic range of <7.8–240 ng/ml, and inter- and intra-assay precision of <6% coefficient of variation by Rotachrom assay appeared suitable for the anticipated apixaban plasma concentrations with 2.5 and 5 mg bid clinical doses. The stronger correlation between apixaban plasma concentration and anti-Xa activity (r2 = 0.88–0.89) compared with PT/INR (r2 = 0.36) in patients undergoing VTE treatment suggested that anti-Xa activity was the better indicator of apixaban plasma concentrations.

Chikako Kamisato - One of the best experts on this subject based on the ideXlab platform.

  • laboratory measurements of the oral direct factor xa inhibitor edoxaban comparison of Prothrombin Time activated partial thromboplastin Time and thrombin generation assay
    American Journal of Clinical Pathology, 2015
    Co-Authors: Yoshiyuki Morishima, Chikako Kamisato
    Abstract:

    Objectives: Edoxaban, an oral direct factor Xa inhibitor, does not require routine monitoring. However, assessment of the anticoagulant effects may be required in certain situations. Methods: We investigated the effects of edoxaban on Prothrombin Time (PT), activated partial thromboplastin Time (aPTT), and thrombin generation using human platelet-poor plasma (PPP) or platelet-rich plasma (PRP). Results: Edoxaban concentration-dependently prolonged PT and aPTT. There was a considerable variation in the magnitude of PT prolongation among the reagents used. The variability in aPTT prolongation among the reagents was smaller than that of PT. Edoxaban concentration-dependently inhibited thrombin generation, with a more potent effect seen in PPP than in PRP. Thrombin generation assay was three Times more sensitive to edoxaban than PT and aPTT. Conclusions: PT had disadvantages of a large variability among different PT reagents. aPTT could be used as a conventional and convenient test with a smaller variation among reagents. Thrombin generation was the most sensitive assay.

A Tripodi - One of the best experts on this subject based on the ideXlab platform.

Related terms

Prothrombin Time - 15 days free trial to Access Experts & Abstracts