The Experts below are selected from a list of 2631 Experts worldwide ranked by ideXlab platform
Katsuko Komatsu - One of the best experts on this subject based on the ideXlab platform.
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Metabolite 1 of Protopanaxadiol-Type Saponins, an Axonal Regenerative Factor, Stimulates Teneurin-2 Linked by PI3-Kinase Cascade
Neuropsychopharmacology, 2005Co-Authors: Chihiro Tohda, Itsuki Hashimoto, Tomoharu Kuboyama, Katsuko KomatsuAbstract:Metabolite 1 of Protopanaxadiol-Type Saponins, an Axonal Regenerative Factor, Stimulates Teneurin-2 Linked by PI3-Kinase Cascade
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aβ 25 35 induced memory impairment axonal atrophy and synaptic loss are ameliorated by m1 a metabolite of Protopanaxadiol type saponins
Neuropsychopharmacology, 2004Co-Authors: Chihiro Tohda, Noriaki Matsumoto, Meselhy R Meselhy, Katsuko KomatsuAbstract:A β (25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins
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Aβ(25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins
Neuropsychopharmacology, 2004Co-Authors: Chihiro Tohda, Noriaki Matsumoto, Meselhy R Meselhy, Katsuko KomatsuAbstract:We previously screened neurite outgrowth activities of several Ginseng drugs in human neuroblastoma, and demonstrated that Protopanaxadiol (ppd)-type saponins were active constituents. Since ppd-type saponins are known to be completely metabolized to 20- O - β - D -glucopyranosyl-20( S )-Protopanaxadiol (M1) by intestinal bacteria when taken orally, M1 and ginsenoside Rb_1, as a representative of ppd-type saponins, were examined for cognitive disorder. In a mouse model of Alzheimer's disease (AD) by A β (25–35) i.c.v. injection, impaired spatial memory was recovered by p.o. administration of ginsenoside Rb_1 or M1. Although the expression levels of phosphorylated NF-H and synaptophysin were reduced in the cerebral cortex and the hippocampus of A β (25–35)-injected mice, their levels in ginsenoside Rb_1- and M1-treated mice were almost completely recovered up to control levels. Potencies of the effects were not different between ginsenoside Rb_1 and M1 when given orally, suggesting that most of the ginsenoside Rb_1 may be metabolized to M1, and M1 is an active principal of ppd-type saponins for the memory improvement. In cultured rat cortical neurons, M1 showed extension activity of axons, but not dendrites. The axon-specific outgrowth was seen even when neuritic atrophy had already progressed in response to administration of A β (25–35) as well as in the normal condition. These results suggest that M1 has axonal extension activity in degenerated neurons, and improve memory disorder and synaptic loss induced by A β (25–35). M1 was shown to be effective in vitro and in vivo , indicating that Ginseng drugs containing ppd-type saponins may reactivate neuronal function in AD by p.o. administration.
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Aβ(25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins
Neuropsychopharmacology, 2003Co-Authors: Chihiro Tohda, Noriaki Matsumoto, Meselhy R Meselhy, Katsuko KomatsuAbstract:A β (25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins
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axonal and dendritic extension by Protopanaxadiol type saponins from ginseng drugs in sk n sh cells
Japanese Journal of Pharmacology, 2002Co-Authors: Chihiro Tohda, Noriaki Matsumoto, Meselhy R Meselhy, Katsuko KomatsuAbstract:Extension of axons and dendrites in neurons may compensate for and repair damaged neuronal networks in the dementia brain. To find out drugs capable of regenerating the neuronal network, we focused on several herbal drugs belonging to the genus Panax, kinds of Ginseng, and investigated neurite outgrowth activity of their extracts and compounds. We found that the methanol extracts of Ginseng (root of P. ginseng), Notoginseng (root of P. notoginseng) and Ye-Sanchi in Chinese (rhizome of a relative to P. vietnamensis) increased neurite outgrowth in SK-N-SH cells. The Protopanaxadiol-type saponins, ginsenosides Rb1 and Rb3, and notoginsenosides R4 and Fa isolated from Ye-Sanchi extract extended neurites, while protopanaxatriol-, ocotillol- and oleanane-type saponins had no effect on the neurite outgrowth. The percentage of cells with multipolar neurites and number of varicosities were intensely high in cells treated with the methanol extract of Ye-Sanchi as well as ginsenosides Rb1 and Rb3, and notoginsenosides R4 and Fa. Both phosphorylated NF-H-expressing neurites and MAP2-expressing ones were extended by treatment with those saponins and the extract. Especially, longer neurites were mainly positive for phosphorylated NF-H. These results suggest that Protopanaxadiol-type saponins enhance axonal and dendritic formation activity.
Chihiro Tohda - One of the best experts on this subject based on the ideXlab platform.
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Metabolite 1 of Protopanaxadiol-Type Saponins, an Axonal Regenerative Factor, Stimulates Teneurin-2 Linked by PI3-Kinase Cascade
Neuropsychopharmacology, 2005Co-Authors: Chihiro Tohda, Itsuki Hashimoto, Tomoharu Kuboyama, Katsuko KomatsuAbstract:Metabolite 1 of Protopanaxadiol-Type Saponins, an Axonal Regenerative Factor, Stimulates Teneurin-2 Linked by PI3-Kinase Cascade
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aβ 25 35 induced memory impairment axonal atrophy and synaptic loss are ameliorated by m1 a metabolite of Protopanaxadiol type saponins
Neuropsychopharmacology, 2004Co-Authors: Chihiro Tohda, Noriaki Matsumoto, Meselhy R Meselhy, Katsuko KomatsuAbstract:A β (25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins
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Aβ(25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins
Neuropsychopharmacology, 2004Co-Authors: Chihiro Tohda, Noriaki Matsumoto, Meselhy R Meselhy, Katsuko KomatsuAbstract:We previously screened neurite outgrowth activities of several Ginseng drugs in human neuroblastoma, and demonstrated that Protopanaxadiol (ppd)-type saponins were active constituents. Since ppd-type saponins are known to be completely metabolized to 20- O - β - D -glucopyranosyl-20( S )-Protopanaxadiol (M1) by intestinal bacteria when taken orally, M1 and ginsenoside Rb_1, as a representative of ppd-type saponins, were examined for cognitive disorder. In a mouse model of Alzheimer's disease (AD) by A β (25–35) i.c.v. injection, impaired spatial memory was recovered by p.o. administration of ginsenoside Rb_1 or M1. Although the expression levels of phosphorylated NF-H and synaptophysin were reduced in the cerebral cortex and the hippocampus of A β (25–35)-injected mice, their levels in ginsenoside Rb_1- and M1-treated mice were almost completely recovered up to control levels. Potencies of the effects were not different between ginsenoside Rb_1 and M1 when given orally, suggesting that most of the ginsenoside Rb_1 may be metabolized to M1, and M1 is an active principal of ppd-type saponins for the memory improvement. In cultured rat cortical neurons, M1 showed extension activity of axons, but not dendrites. The axon-specific outgrowth was seen even when neuritic atrophy had already progressed in response to administration of A β (25–35) as well as in the normal condition. These results suggest that M1 has axonal extension activity in degenerated neurons, and improve memory disorder and synaptic loss induced by A β (25–35). M1 was shown to be effective in vitro and in vivo , indicating that Ginseng drugs containing ppd-type saponins may reactivate neuronal function in AD by p.o. administration.
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Aβ(25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins
Neuropsychopharmacology, 2003Co-Authors: Chihiro Tohda, Noriaki Matsumoto, Meselhy R Meselhy, Katsuko KomatsuAbstract:A β (25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins
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axonal and dendritic extension by Protopanaxadiol type saponins from ginseng drugs in sk n sh cells
Japanese Journal of Pharmacology, 2002Co-Authors: Chihiro Tohda, Noriaki Matsumoto, Meselhy R Meselhy, Katsuko KomatsuAbstract:Extension of axons and dendrites in neurons may compensate for and repair damaged neuronal networks in the dementia brain. To find out drugs capable of regenerating the neuronal network, we focused on several herbal drugs belonging to the genus Panax, kinds of Ginseng, and investigated neurite outgrowth activity of their extracts and compounds. We found that the methanol extracts of Ginseng (root of P. ginseng), Notoginseng (root of P. notoginseng) and Ye-Sanchi in Chinese (rhizome of a relative to P. vietnamensis) increased neurite outgrowth in SK-N-SH cells. The Protopanaxadiol-type saponins, ginsenosides Rb1 and Rb3, and notoginsenosides R4 and Fa isolated from Ye-Sanchi extract extended neurites, while protopanaxatriol-, ocotillol- and oleanane-type saponins had no effect on the neurite outgrowth. The percentage of cells with multipolar neurites and number of varicosities were intensely high in cells treated with the methanol extract of Ye-Sanchi as well as ginsenosides Rb1 and Rb3, and notoginsenosides R4 and Fa. Both phosphorylated NF-H-expressing neurites and MAP2-expressing ones were extended by treatment with those saponins and the extract. Especially, longer neurites were mainly positive for phosphorylated NF-H. These results suggest that Protopanaxadiol-type saponins enhance axonal and dendritic formation activity.
Young Kyoung Rhee - One of the best experts on this subject based on the ideXlab platform.
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the ginsenoside derivative 20 s Protopanaxadiol inhibits solar ultraviolet light induced matrix metalloproteinase 1 expression
Journal of Cellular Biochemistry, 2017Co-Authors: Hee Yang, Deokkun Oh, Jung Han Yoon Park, Young Kyoung RheeAbstract:Ginsenosides are major pharmacologically active compounds present in ginseng (Panax ginseng). Among the ginsenosides, 20-O-β-D-glucopyranosyl-20(S)-Protopanaxadiol (GPPD) and ginsenoside Rb1 (Rb1) have previously been reported to exhibit anti-wrinkle effects. In this study, 20(S)-Protopanaxadiol (20(S)-PPD), an aglycone derivative of the Rb1 metabolite was investigated for its anti-wrinkle benefit and compared to GPPD and Rb1. The anti-wrinkle effect of 20(S)-PPD during solar UV light was investigated using a human skin equivalent model and human keratinocytes. 20(S)-PPD attenuated solar UV-induced matrix metalloproteinase (MMP)-1 expression to a greater extent than GPPD and Rb1. 20(S)-PPD treatment modulated MMP-1 mRNA expression and the transcriptional activity of activator protein (AP)-1, a major transcription factor of MMP-1. Two upstream signaling pathways for AP-1, the MEK1/2-ERK1/2-p90RSK and MEK3/6-p38 pathways, were also suppressed. Taken together, these findings highlight the potential of 20(S)-PPD for further development as a preventative agent for sunlight-induced skin wrinkle. J. Cell. Biochem. 118: 3756–3764, 2017. © 2017 Wiley Periodicals, Inc.
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The Ginsenoside Derivative 20(S)‐Protopanaxadiol Inhibits Solar Ultraviolet Light‐Induced Matrix Metalloproteinase‐1 Expression
Journal of Cellular Biochemistry, 2017Co-Authors: Hee Yang, Deokkun Oh, Jung Han Yoon Park, Young Kyoung RheeAbstract:Ginsenosides are major pharmacologically active compounds present in ginseng (Panax ginseng). Among the ginsenosides, 20-O-β-D-glucopyranosyl-20(S)-Protopanaxadiol (GPPD) and ginsenoside Rb1 (Rb1) have previously been reported to exhibit anti-wrinkle effects. In this study, 20(S)-Protopanaxadiol (20(S)-PPD), an aglycone derivative of the Rb1 metabolite was investigated for its anti-wrinkle benefit and compared to GPPD and Rb1. The anti-wrinkle effect of 20(S)-PPD during solar UV light was investigated using a human skin equivalent model and human keratinocytes. 20(S)-PPD attenuated solar UV-induced matrix metalloproteinase (MMP)-1 expression to a greater extent than GPPD and Rb1. 20(S)-PPD treatment modulated MMP-1 mRNA expression and the transcriptional activity of activator protein (AP)-1, a major transcription factor of MMP-1. Two upstream signaling pathways for AP-1, the MEK1/2-ERK1/2-p90RSK and MEK3/6-p38 pathways, were also suppressed. Taken together, these findings highlight the potential of 20(S)-PPD for further development as a preventative agent for sunlight-induced skin wrinkle. J. Cell. Biochem. 118: 3756–3764, 2017. © 2017 Wiley Periodicals, Inc.
Meselhy R Meselhy - One of the best experts on this subject based on the ideXlab platform.
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aβ 25 35 induced memory impairment axonal atrophy and synaptic loss are ameliorated by m1 a metabolite of Protopanaxadiol type saponins
Neuropsychopharmacology, 2004Co-Authors: Chihiro Tohda, Noriaki Matsumoto, Meselhy R Meselhy, Katsuko KomatsuAbstract:A β (25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins
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Aβ(25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins
Neuropsychopharmacology, 2004Co-Authors: Chihiro Tohda, Noriaki Matsumoto, Meselhy R Meselhy, Katsuko KomatsuAbstract:We previously screened neurite outgrowth activities of several Ginseng drugs in human neuroblastoma, and demonstrated that Protopanaxadiol (ppd)-type saponins were active constituents. Since ppd-type saponins are known to be completely metabolized to 20- O - β - D -glucopyranosyl-20( S )-Protopanaxadiol (M1) by intestinal bacteria when taken orally, M1 and ginsenoside Rb_1, as a representative of ppd-type saponins, were examined for cognitive disorder. In a mouse model of Alzheimer's disease (AD) by A β (25–35) i.c.v. injection, impaired spatial memory was recovered by p.o. administration of ginsenoside Rb_1 or M1. Although the expression levels of phosphorylated NF-H and synaptophysin were reduced in the cerebral cortex and the hippocampus of A β (25–35)-injected mice, their levels in ginsenoside Rb_1- and M1-treated mice were almost completely recovered up to control levels. Potencies of the effects were not different between ginsenoside Rb_1 and M1 when given orally, suggesting that most of the ginsenoside Rb_1 may be metabolized to M1, and M1 is an active principal of ppd-type saponins for the memory improvement. In cultured rat cortical neurons, M1 showed extension activity of axons, but not dendrites. The axon-specific outgrowth was seen even when neuritic atrophy had already progressed in response to administration of A β (25–35) as well as in the normal condition. These results suggest that M1 has axonal extension activity in degenerated neurons, and improve memory disorder and synaptic loss induced by A β (25–35). M1 was shown to be effective in vitro and in vivo , indicating that Ginseng drugs containing ppd-type saponins may reactivate neuronal function in AD by p.o. administration.
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Aβ(25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins
Neuropsychopharmacology, 2003Co-Authors: Chihiro Tohda, Noriaki Matsumoto, Meselhy R Meselhy, Katsuko KomatsuAbstract:A β (25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins
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axonal and dendritic extension by Protopanaxadiol type saponins from ginseng drugs in sk n sh cells
Japanese Journal of Pharmacology, 2002Co-Authors: Chihiro Tohda, Noriaki Matsumoto, Meselhy R Meselhy, Katsuko KomatsuAbstract:Extension of axons and dendrites in neurons may compensate for and repair damaged neuronal networks in the dementia brain. To find out drugs capable of regenerating the neuronal network, we focused on several herbal drugs belonging to the genus Panax, kinds of Ginseng, and investigated neurite outgrowth activity of their extracts and compounds. We found that the methanol extracts of Ginseng (root of P. ginseng), Notoginseng (root of P. notoginseng) and Ye-Sanchi in Chinese (rhizome of a relative to P. vietnamensis) increased neurite outgrowth in SK-N-SH cells. The Protopanaxadiol-type saponins, ginsenosides Rb1 and Rb3, and notoginsenosides R4 and Fa isolated from Ye-Sanchi extract extended neurites, while protopanaxatriol-, ocotillol- and oleanane-type saponins had no effect on the neurite outgrowth. The percentage of cells with multipolar neurites and number of varicosities were intensely high in cells treated with the methanol extract of Ye-Sanchi as well as ginsenosides Rb1 and Rb3, and notoginsenosides R4 and Fa. Both phosphorylated NF-H-expressing neurites and MAP2-expressing ones were extended by treatment with those saponins and the extract. Especially, longer neurites were mainly positive for phosphorylated NF-H. These results suggest that Protopanaxadiol-type saponins enhance axonal and dendritic formation activity.
Noriaki Matsumoto - One of the best experts on this subject based on the ideXlab platform.
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aβ 25 35 induced memory impairment axonal atrophy and synaptic loss are ameliorated by m1 a metabolite of Protopanaxadiol type saponins
Neuropsychopharmacology, 2004Co-Authors: Chihiro Tohda, Noriaki Matsumoto, Meselhy R Meselhy, Katsuko KomatsuAbstract:A β (25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins
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Aβ(25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins
Neuropsychopharmacology, 2004Co-Authors: Chihiro Tohda, Noriaki Matsumoto, Meselhy R Meselhy, Katsuko KomatsuAbstract:We previously screened neurite outgrowth activities of several Ginseng drugs in human neuroblastoma, and demonstrated that Protopanaxadiol (ppd)-type saponins were active constituents. Since ppd-type saponins are known to be completely metabolized to 20- O - β - D -glucopyranosyl-20( S )-Protopanaxadiol (M1) by intestinal bacteria when taken orally, M1 and ginsenoside Rb_1, as a representative of ppd-type saponins, were examined for cognitive disorder. In a mouse model of Alzheimer's disease (AD) by A β (25–35) i.c.v. injection, impaired spatial memory was recovered by p.o. administration of ginsenoside Rb_1 or M1. Although the expression levels of phosphorylated NF-H and synaptophysin were reduced in the cerebral cortex and the hippocampus of A β (25–35)-injected mice, their levels in ginsenoside Rb_1- and M1-treated mice were almost completely recovered up to control levels. Potencies of the effects were not different between ginsenoside Rb_1 and M1 when given orally, suggesting that most of the ginsenoside Rb_1 may be metabolized to M1, and M1 is an active principal of ppd-type saponins for the memory improvement. In cultured rat cortical neurons, M1 showed extension activity of axons, but not dendrites. The axon-specific outgrowth was seen even when neuritic atrophy had already progressed in response to administration of A β (25–35) as well as in the normal condition. These results suggest that M1 has axonal extension activity in degenerated neurons, and improve memory disorder and synaptic loss induced by A β (25–35). M1 was shown to be effective in vitro and in vivo , indicating that Ginseng drugs containing ppd-type saponins may reactivate neuronal function in AD by p.o. administration.
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Aβ(25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins
Neuropsychopharmacology, 2003Co-Authors: Chihiro Tohda, Noriaki Matsumoto, Meselhy R Meselhy, Katsuko KomatsuAbstract:A β (25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins
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axonal and dendritic extension by Protopanaxadiol type saponins from ginseng drugs in sk n sh cells
Japanese Journal of Pharmacology, 2002Co-Authors: Chihiro Tohda, Noriaki Matsumoto, Meselhy R Meselhy, Katsuko KomatsuAbstract:Extension of axons and dendrites in neurons may compensate for and repair damaged neuronal networks in the dementia brain. To find out drugs capable of regenerating the neuronal network, we focused on several herbal drugs belonging to the genus Panax, kinds of Ginseng, and investigated neurite outgrowth activity of their extracts and compounds. We found that the methanol extracts of Ginseng (root of P. ginseng), Notoginseng (root of P. notoginseng) and Ye-Sanchi in Chinese (rhizome of a relative to P. vietnamensis) increased neurite outgrowth in SK-N-SH cells. The Protopanaxadiol-type saponins, ginsenosides Rb1 and Rb3, and notoginsenosides R4 and Fa isolated from Ye-Sanchi extract extended neurites, while protopanaxatriol-, ocotillol- and oleanane-type saponins had no effect on the neurite outgrowth. The percentage of cells with multipolar neurites and number of varicosities were intensely high in cells treated with the methanol extract of Ye-Sanchi as well as ginsenosides Rb1 and Rb3, and notoginsenosides R4 and Fa. Both phosphorylated NF-H-expressing neurites and MAP2-expressing ones were extended by treatment with those saponins and the extract. Especially, longer neurites were mainly positive for phosphorylated NF-H. These results suggest that Protopanaxadiol-type saponins enhance axonal and dendritic formation activity.
