The Experts below are selected from a list of 31872 Experts worldwide ranked by ideXlab platform
Parviz K Amid - One of the best experts on this subject based on the ideXlab platform.
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causes prevention and surgical treatment of postherniorrhaphy neuropathic inguinodynia triple neurectomy with Proximal End implantation
Hernia, 2004Co-Authors: Parviz K AmidAbstract:The recommEnded surgical treatment for chronic neuropathic pain after herniorrhaphy has been a two-stage operation including: (a) ilioinguinal and iliohypogastric neurectomies through an inguinal approach and (b) genital nerve neurectomy through a flank approach. Two hundred twenty-five patients underwent triple neurectomies with Proximal End implantation to treat chronic postherniorrhaphy neuralgia. Four patients reported no improvement. Eighty percent of patients recovered completely, and 15% had transient insignificant pain with no functional impairment. These results are comparable to the results of the two-stage operation. Simultaneous neurectomy of the ilioinguinal, iliohypogastric, and genital nerves without mobilization of the spermatic cord is an effective one-stage procedure to treat postherniorrhaphy neuralgia. It can be performed under local anesthesia and avoids testicular complications. Proximal End implantation of the nerves prevents adherence of the cut Ends to the aponeurotic structures of the groin, which can result in recurrence of the pain. A one-stage surgical procedure resecting all three nerves from an anterior approach avoids a second operation through the flank and successfully treats chronic neuralgia.
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a 1 stage surgical treatment for postherniorrhaphy neuropathic pain triple neurectomy and Proximal End implantation without mobilization of the cord
Archives of Surgery, 2002Co-Authors: Parviz K AmidAbstract:Background The recommEnded surgical treatment for chronic neuropathic pain after herniorrhaphy has been a 2-stage operation including: (1) ilioinguinal and iliohypogastric neurectomies through an inguinal approach and (2) genital nerve neurectomy through a flank approach. Hypothesis A 1-stage surgical procedure resecting all 3 nerves from an anterior approach avoids a second operation through the flank and successfully treats chronic neuralgia. Setting A private practice dedicated to abdominal wall hernia surgery in general community hospitals. Patients Between 1995 and 2001, 49 patients underwent triple neurectomies with Proximal End implantation to treat chronic postherniorrhaphy neuralgia. Intervention Triple neurectomy of the ilioinguinal, iliohypogastric, and genital nerves performed under local anesthesia with implantation of their Proximal Ends and without mobilization of the spermatic cord. Results Two patients (4%) reported no improvement. Eighty percent of patients recovered completely, and 16% had transient insignificant pain with no functional impairment. These results are comparable to the results of the 2-stage operation. Conclusions Simultaneous neurectomy of the ilioinguinal, iliohypogastric, and genital nerves without mobilization of the spermatic cord is an effective 1-stage procedure to treat postherniorrhaphy neuralgia. It is performed under local anesthesia and avoids testicular complications. Proximal End implantation of the nerves prevents adherence of the cut Ends to the aponeurotic structure of the groin, which can result in recurrence of the pain.
Arieh Riskin - One of the best experts on this subject based on the ideXlab platform.
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A novel method of distal End-tidal CO2 capnography in intubated infants: comparison with arterial CO2 and with Proximal mainstream End-tidal CO2.
Pediatrics, 2008Co-Authors: Amir Kugelman, Dana Zeiger-aginsky, David Bader, Irit Shoris, Arieh RiskinAbstract:OBJECTIVE. The objective of this study was to evaluate a novel method of distal End-tidal CO2 capnography by comparison with Paco2 and with the more standard method that measures mainstream Proximal End-tidal CO2 in intubated infants. METHODS. Included in the study were all infants who were ventilated with conventional mechanical ventilation and intubated with a double-lumen Endotracheal tube in our NICU during the study period. Data were collected prospectively from 2 capnographs simultaneously and compared with Paco2. Sidestream distal End-tidal CO2 was measured by a Microstream capnograph via the extra port of a double-lumen Endotracheal tube. Mainstream Proximal End-tidal CO2 was measured via capnograph connected to the Endotracheal tube. RESULTS. Twenty-seven infants (median [range] birth-weight: 1835 [490–4790] g; gestational age: 32.5 [24.8–40.8] weeks) participated in the study. We used for analysis 222 and 212 measurements of distal End-tidal CO2 and Proximal End-tidal CO2, respectively. Distal compared with Proximal End-tidal CO2 had a better correlation with Paco2 and a better agreement with Paco2. The accuracy of distal End-tidal CO2 decreased, but it remained a useful measure of Paco2 in the high range of Paco2 (≥60 mmHg) or in conditions of severe lung disease. A subanalysis for infants who weighed CONCLUSIONS. Distal End-tidal CO2 measured via a double-lumen Endotracheal tube was found to have good correlation and agreement with Paco2, remained reliable in conditions of severe lung disease, and was more accurate than the standard mainstream Proximal End-tidal CO2.
David X. Liu - One of the best experts on this subject based on the ideXlab platform.
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ATF5 Connects the Pericentriolar Materials to the Proximal End of the Mother Centriole
Cell, 2015Co-Authors: Bhanupriya Madarampalli, Kathleen Lengel, Yidi Xu, Yunsheng Yuan, Guangfu Li, Jinming Yang, Zhimin Lu, Dan Liu, Xinyuan Liu, David X. LiuAbstract:Although it is known that the centrioles play instructive roles in pericentriolar material (PCM) assembly and that the PCM is essential for proper centriole formation, the mechanism that governs centriole-PCM interaction is poorly understood. Here, we show that ATF5 forms a characteristic 9-fold symmetrical ring structure in the inner layer of the PCM outfitting the Proximal End of the mother centriole. ATF5 controls the centriole-PCM interaction in a cell-cycle- and centriole-age-depEndent manner. Interaction of ATF5 with polyglutamylated tubulin (PGT) on the mother centriole and with PCNT in the PCM rEnders ATF5 as a required molecule in mother centriole-directed PCM accumulation and in PCM-depEndent centriole formation. ATF5 depletion blocks PCM accumulation at the centrosome and causes fragmentation of centrioles, leading to the formation of multi-polar mitotic spindles and genomic instability. These data show that ATF5 is an essential structural protein that is required for the interaction between the mother centriole and the PCM.
Brian Oliver - One of the best experts on this subject based on the ideXlab platform.
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Sperm Head-Tail Linkage Requires Restriction of Pericentriolar Material to the Proximal Centriole End.
Developmental Cell, 2020Co-Authors: Brian J. Galletta, Jacob M. Ortega, Samantha L. Smith, Carey J. Fagerstrom, Justin M. Fear, Sharvani Mahadevaraju, Brian OliverAbstract:The centriole, or basal body, is the center of attachment between the sperm head and tail. While the distal End of the centriole templates the cilia, the Proximal End associates with the nucleus. Using Drosophila, we identify a centriole-centric mechanism that ensures proper Proximal End docking to the nucleus. This mechanism relies on the restriction of pericentrin-like protein (PLP) and the pericentriolar material (PCM) to the Proximal End of the centriole. PLP is restricted Proximally by limiting its mRNA and protein to the earliest stages of centriole elongation. Ectopic positioning of PLP to more distal portions of the centriole is sufficient to redistribute PCM and microtubules along the entire centriole length. This results in erroneous, lateral centriole docking to the nucleus, leading to spermatid decapitation as a result of a failure to form a stable head-tail linkage.
Amir Kugelman - One of the best experts on this subject based on the ideXlab platform.
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A novel method of distal End-tidal CO2 capnography in intubated infants: comparison with arterial CO2 and with Proximal mainstream End-tidal CO2.
Pediatrics, 2008Co-Authors: Amir Kugelman, Dana Zeiger-aginsky, David Bader, Irit Shoris, Arieh RiskinAbstract:OBJECTIVE. The objective of this study was to evaluate a novel method of distal End-tidal CO2 capnography by comparison with Paco2 and with the more standard method that measures mainstream Proximal End-tidal CO2 in intubated infants. METHODS. Included in the study were all infants who were ventilated with conventional mechanical ventilation and intubated with a double-lumen Endotracheal tube in our NICU during the study period. Data were collected prospectively from 2 capnographs simultaneously and compared with Paco2. Sidestream distal End-tidal CO2 was measured by a Microstream capnograph via the extra port of a double-lumen Endotracheal tube. Mainstream Proximal End-tidal CO2 was measured via capnograph connected to the Endotracheal tube. RESULTS. Twenty-seven infants (median [range] birth-weight: 1835 [490–4790] g; gestational age: 32.5 [24.8–40.8] weeks) participated in the study. We used for analysis 222 and 212 measurements of distal End-tidal CO2 and Proximal End-tidal CO2, respectively. Distal compared with Proximal End-tidal CO2 had a better correlation with Paco2 and a better agreement with Paco2. The accuracy of distal End-tidal CO2 decreased, but it remained a useful measure of Paco2 in the high range of Paco2 (≥60 mmHg) or in conditions of severe lung disease. A subanalysis for infants who weighed CONCLUSIONS. Distal End-tidal CO2 measured via a double-lumen Endotracheal tube was found to have good correlation and agreement with Paco2, remained reliable in conditions of severe lung disease, and was more accurate than the standard mainstream Proximal End-tidal CO2.
