The Experts below are selected from a list of 90 Experts worldwide ranked by ideXlab platform
Antonella Tosti - One of the best experts on this subject based on the ideXlab platform.
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Proximal Subungual Onychomycosis
2017Co-Authors: George D Glinos, Antonella TostiAbstract:PSO can be caused by dermatophytes, non-dermatophytic molds, and Candida spp. PSO due to dermatophytes is rare. Most often seen in immunocompromised patients (e.g., AIDS, diabetes, transplant recipients). T. rubrum is the most common cause of infection. Infection starts at the Proximal nail and progresses distally.
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Treatment of Onychomycosis with oral antifungal agents
Expert Opinion on Drug Delivery, 2005Co-Authors: Matilde Iorizzo, Bianca Maria Piraccini, Giulia Rech, Antonella TostiAbstract:Onychomycosis is the most common nail disease and describes the invasion of the nail by fungi. Different clinical patterns of infection depend on the way and the extent by which fungi colonise the nail: distal Subungual Onychomycosis, Proximal Subungual Onychomycosis, white superficial Onychomycosis, endonyx Onychomycosis and total dystropic Onychomycosis. The type of nail invasion depends on both the fungus responsible and on host susceptibility. Treatment of Onychomycosis depends on the clinical type of the Onychomycosis, the number of affected nails and the severity of nail involvement. The goals for antifungal therapy are mycological cure and a normal looking nail. In this paper the treatment of Onychomycosis with oral antifungal agents will be reviewed.
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Proximal Subungual Onychomycosis due to microsporum canis
British Journal of Dermatology, 1996Co-Authors: Bianca Maria Piraccini, R Morelli, Caterina Stinchi, Antonella TostiAbstract:Summary A case of Proximal Subungual Onychomycosis due to Microsporum canis in a 36-year-old woman is presented. The Onychomycosis involved the left thumb and the little fingernails, with thinning of the nail plate and crumbling of the nail plate surface. A milky-white discoloration of the Proximal portion of the left thumbnail was also evident. A 2-mm longitudinal nail biopsy showed a large number of fungal elements in the whole length of the nail plate. Fungal hyphae were more numerous in the ventral nail plate and produced detachment of the superficial nail plate. The nail bed was not invaded by fungal elements and was devoid of inflammatory changes. Proximal Subungual Onychomycosis is uncommon in immunocompetent individuals but has frequently been described in patients with AIDS. In our patient, in whom the Proximal Subungual Onychomycosis was due to M. canis, there were no clinical or biochemical signs of immunodeficiency. Oral treatment with terbinafine, 250 mg/daily for 2 months, produced clinical and mycological cure.
Bianca Maria Piraccini - One of the best experts on this subject based on the ideXlab platform.
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Treatment of Onychomycosis with oral antifungal agents
Expert Opinion on Drug Delivery, 2005Co-Authors: Matilde Iorizzo, Bianca Maria Piraccini, Giulia Rech, Antonella TostiAbstract:Onychomycosis is the most common nail disease and describes the invasion of the nail by fungi. Different clinical patterns of infection depend on the way and the extent by which fungi colonise the nail: distal Subungual Onychomycosis, Proximal Subungual Onychomycosis, white superficial Onychomycosis, endonyx Onychomycosis and total dystropic Onychomycosis. The type of nail invasion depends on both the fungus responsible and on host susceptibility. Treatment of Onychomycosis depends on the clinical type of the Onychomycosis, the number of affected nails and the severity of nail involvement. The goals for antifungal therapy are mycological cure and a normal looking nail. In this paper the treatment of Onychomycosis with oral antifungal agents will be reviewed.
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Proximal Subungual Onychomycosis due to microsporum canis
British Journal of Dermatology, 1996Co-Authors: Bianca Maria Piraccini, R Morelli, Caterina Stinchi, Antonella TostiAbstract:Summary A case of Proximal Subungual Onychomycosis due to Microsporum canis in a 36-year-old woman is presented. The Onychomycosis involved the left thumb and the little fingernails, with thinning of the nail plate and crumbling of the nail plate surface. A milky-white discoloration of the Proximal portion of the left thumbnail was also evident. A 2-mm longitudinal nail biopsy showed a large number of fungal elements in the whole length of the nail plate. Fungal hyphae were more numerous in the ventral nail plate and produced detachment of the superficial nail plate. The nail bed was not invaded by fungal elements and was devoid of inflammatory changes. Proximal Subungual Onychomycosis is uncommon in immunocompetent individuals but has frequently been described in patients with AIDS. In our patient, in whom the Proximal Subungual Onychomycosis was due to M. canis, there were no clinical or biochemical signs of immunodeficiency. Oral treatment with terbinafine, 250 mg/daily for 2 months, produced clinical and mycological cure.
Abdullah M S Alhatmi - One of the best experts on this subject based on the ideXlab platform.
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Proximal Subungual Onychomycosis caused by fusarium falciforme successfully cured with posaconazole
British Journal of Dermatology, 2015Co-Authors: Abdullah M S Alhatmi, Alexandro Bonifaz, L Calderon, Ilse Curfsbreuker, Jacques F Meis, A D Van Diepeningen, G S De HoogAbstract:Proximal Subungual Onychomycosis (PSO) is a fungal infection on the inner layer of the nail plate which starts from the eponychium and nail matrix.(1) Onychomycosis can be caused by a variety of dermatophytes, yeasts and non-dermatophyte molds (NDMs) including species of Aspergillus, Acremonium, Scopulariopsis, Chaetomium, and Fusarium.(2) Fusarium and Acremonium species require special attention, because of their intrinsically low susceptibility to most common antifungal agents and their ability to disseminate in severely compromised hosts, using the nail as a potential source of infection.(3,4) This article is protected by copyright. All rights reserved.
Richard C. Summerbell - One of the best experts on this subject based on the ideXlab platform.
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Combined distal and lateral Subungual and white superficial Onychomycosis in the toenails.
Journal of The American Academy of Dermatology, 1999Co-Authors: Aditya K. Gupta, Richard C. SummerbellAbstract:Abstract Background: The 5 main types of Onychomycosis are distal and lateral Subungual Onychomycosis (DLSO), white superficial Onychomycosis (WSO), Proximal Subungual Onychomycosis (PSO), Candida Onychomycosis, and total dystrophic Onychomycosis (TDO) (primary or secondary type). In the literature there is infrequent discussion about 2 types of Onychomycosis present in the toenails of the same individual. Objective: We attempted to determine the prevalence and etiologic organisms of DLSO and WSO occurring in the same individual. Methods: We surveyed 4411 subjects presenting to dermatology offices for causes other than the management of Onychomycosis. In each patient the toenails were examined. If they appeared abnormal, nail material was obtained for mycologic evaluation; partitioned sampling was performed when more than one type of Onychomycosis was present. Results: In our series, 39 (0.9%) of 4411 patients had the combination DLSO and WSO, compared with 417 (9.4%) and 111 (2.5%) who had DLSO and WSO, respectively. After controlling for age and sex in the general population, the projected prevalence rates of DLSO, WSO, and combined DLSO and WSO in the province of Ontario, Canada were 7.1%, 1.5%, and 0.5%, respectively. The combination of DLSO and WSO in the toenails of an individual occurred more frequently than that predicted by chance alone ( P Trichophyton mentagrophytes . In the remaining 16 subjects other organisms cultured were T rubrum , Acremonium spp, Aspergillus spp, Fusarium oxysporum , and Onychocola canadensis . In 33 (84.6%) of 39 subjects with the combination of DLSO and WSO on the toenails, the same fungal organism was associated with both the DLSO and WSO. Conclusion: When both DLSO and WSO are concurrently present in the toenails of an individual, partitioned sampling (ie, sampling for each of the two types of Onychomycosis) may provide us with a better understanding of the different organisms associated with the Onychomycosis and the relationship between the two types of Onychomycosis. (J Am Acad Dermatol 1999;41:938-44.)
G S De Hoog - One of the best experts on this subject based on the ideXlab platform.
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Proximal Subungual Onychomycosis caused by fusarium falciforme successfully cured with posaconazole
British Journal of Dermatology, 2015Co-Authors: Abdullah M S Alhatmi, Alexandro Bonifaz, L Calderon, Ilse Curfsbreuker, Jacques F Meis, A D Van Diepeningen, G S De HoogAbstract:Proximal Subungual Onychomycosis (PSO) is a fungal infection on the inner layer of the nail plate which starts from the eponychium and nail matrix.(1) Onychomycosis can be caused by a variety of dermatophytes, yeasts and non-dermatophyte molds (NDMs) including species of Aspergillus, Acremonium, Scopulariopsis, Chaetomium, and Fusarium.(2) Fusarium and Acremonium species require special attention, because of their intrinsically low susceptibility to most common antifungal agents and their ability to disseminate in severely compromised hosts, using the nail as a potential source of infection.(3,4) This article is protected by copyright. All rights reserved.
