The Experts below are selected from a list of 180 Experts worldwide ranked by ideXlab platform
Raimundas Lunevicius - One of the best experts on this subject based on the ideXlab platform.
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Long-term results of single intradermal 1 % methylene blue injection for intractable idiopathic Pruritus Ani: a prospective study
Techniques in Coloproctology, 2012Co-Authors: Narimantas Evaldas Samalavicius, Tomas Poskus, Rakesh Kumar Gupta, Raimundas LuneviciusAbstract:Background The aim of this study was to assess the effectiveness and side effects of methylene blue injection into the perianal skin of patients with chronic refractory idiopathic Pruritus Ani (IPA). Methods Patients with IPA who failed to respond to standard perianal skin care advice and treatment of associated pathologies were included. One per cent methylene blue solution was injected intradermally into the itching perianal area up to the level of the dentate line, with a 10-ml syringe with a 22-gauge needle, using a total of 15 ml. A patient symptom score from 1 to 5 was used (1 = worst). The study was designed as a single-centre, prospective, non-randomized trial. Results Between September 2004 and November 2008, 10 patients with IPA were included in the study. Symptoms resolved within 4 weeks in all cases. Numbness of the perianal area and tattooing disappeared within the period of 3−4 weeks. There was no skin necrosis or anaphylaxis. The median follow-up was 47 months, range 29–60 months. Anal itching recurred in 8 patients. Four of those 8 patients noted that anal itching was less severe when it recurred, and it was unchanged in the other 4 patients. Six out of 10 patients felt much better or reported the resolution of Pruritus Ani. Conclusions An intradermal application of 1 % methylene blue solution is associated with a positive effect on IPA with mild side effects related to sensory cutaneous innervation in all patients within the first 4 weeks following the procedure and a 20 % success rate within 60 months.
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long term results of single intradermal 1 methylene blue injection for intractable idiopathic Pruritus Ani a prospective study
Techniques in Coloproctology, 2012Co-Authors: Narimantas Evaldas Samalavicius, Tomas Poskus, Rakesh Kumar Gupta, Raimundas LuneviciusAbstract:Background The aim of this study was to assess the effectiveness and side effects of methylene blue injection into the perianal skin of patients with chronic refractory idiopathic Pruritus Ani (IPA).
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Long-term results of single intradermal 1 % methylene blue injection for intractable idiopathic Pruritus Ani: a prospective study
Techniques in Coloproctology, 2012Co-Authors: Narimantas Evaldas Samalavicius, Tomas Poskus, Rakesh Kumar Gupta, Raimundas LuneviciusAbstract:Background The aim of this study was to assess the effectiveness and side effects of methylene blue injection into the perianal skin of patients with chronic refractory idiopathic Pruritus Ani (IPA).
M. Oguz - One of the best experts on this subject based on the ideXlab platform.
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Intradermal methylene blue injection for the treatment of intractable idiopathic Pruritus Ani: results of 30 cases
Techniques in Coloproctology, 2004Co-Authors: B. B. Mentes, M. Akin, S. Leventoglu, F. A. Gultekin, M. OguzAbstract:Some cases of idiopathic Pruritus anu may be refractory to treatment with dietary and hygienic instructions and short-term topical medications. In this study, we documented our technique and results with methylene blue injection in a large series of patients with intractable idiopathic Pruritus Ani. The results of 30 adult patients with well-documented intractable idiopathic Pruritus Ani who were treated with intradermal methylene blue injection are reported. No antibiotic prophylaxis, anesthesia or sedation was used. A total of 15 ml of a 1% methylene blue solution was injected intracutaneously and subcutaneously in the affected perianal area. A second injection (rescue treatment) was offered one month later to patients who declared partial response, and follow-up was restarted. One month after injection, 24 patients (80%) were symptom-free, 5 declared partial remissions, and one patient still had the same degree of Pruritus Ani. Five patients with partial remission underwent a second methylene blue injection, which provided complete relief in four. Therefore, the early response rate was 80% with single injection and 93.3% (28 of 30) with the rescue treatment. At six months, three recurrences were noted, indicating to a success rate of 83.3% (25 of 30). At 12 months after treatment, 23 patients (76.7%) were symptom free. This study has shown that intradermal methylene blue injection is a safe, simple, fast and efficient method of treating intractable idiopathic Pruritus Ani.
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intradermal methylene blue injection for the treatment of intractable idiopathic Pruritus Ani results of 30 cases
Techniques in Coloproctology, 2004Co-Authors: B. B. Mentes, M. Akin, S. Leventoglu, F. A. Gultekin, M. OguzAbstract:Some cases of idiopathic Pruritus anu may be refractory to treatment with dietary and hygienic instructions and short-term topical medications. In this study, we documented our technique and results with methylene blue injection in a large series of patients with intractable idiopathic Pruritus Ani. The results of 30 adult patients with well-documented intractable idiopathic Pruritus Ani who were treated with intradermal methylene blue injection are reported. No antibiotic prophylaxis, anesthesia or sedation was used. A total of 15 ml of a 1% methylene blue solution was injected intracutaneously and subcutaneously in the affected perianal area. A second injection (rescue treatment) was offered one month later to patients who declared partial response, and follow-up was restarted. One month after injection, 24 patients (80%) were symptom-free, 5 declared partial remissions, and one patient still had the same degree of Pruritus Ani. Five patients with partial remission underwent a second methylene blue injection, which provided complete relief in four. Therefore, the early response rate was 80% with single injection and 93.3% (28 of 30) with the rescue treatment. At six months, three recurrences were noted, indicating to a success rate of 83.3% (25 of 30). At 12 months after treatment, 23 patients (76.7%) were symptom free. This study has shown that intradermal methylene blue injection is a safe, simple, fast and efficient method of treating intractable idiopathic Pruritus Ani.
Narimantas Evaldas Samalavicius - One of the best experts on this subject based on the ideXlab platform.
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Long-term results of single intradermal 1 % methylene blue injection for intractable idiopathic Pruritus Ani: a prospective study
Techniques in Coloproctology, 2012Co-Authors: Narimantas Evaldas Samalavicius, Tomas Poskus, Rakesh Kumar Gupta, Raimundas LuneviciusAbstract:Background The aim of this study was to assess the effectiveness and side effects of methylene blue injection into the perianal skin of patients with chronic refractory idiopathic Pruritus Ani (IPA). Methods Patients with IPA who failed to respond to standard perianal skin care advice and treatment of associated pathologies were included. One per cent methylene blue solution was injected intradermally into the itching perianal area up to the level of the dentate line, with a 10-ml syringe with a 22-gauge needle, using a total of 15 ml. A patient symptom score from 1 to 5 was used (1 = worst). The study was designed as a single-centre, prospective, non-randomized trial. Results Between September 2004 and November 2008, 10 patients with IPA were included in the study. Symptoms resolved within 4 weeks in all cases. Numbness of the perianal area and tattooing disappeared within the period of 3−4 weeks. There was no skin necrosis or anaphylaxis. The median follow-up was 47 months, range 29–60 months. Anal itching recurred in 8 patients. Four of those 8 patients noted that anal itching was less severe when it recurred, and it was unchanged in the other 4 patients. Six out of 10 patients felt much better or reported the resolution of Pruritus Ani. Conclusions An intradermal application of 1 % methylene blue solution is associated with a positive effect on IPA with mild side effects related to sensory cutaneous innervation in all patients within the first 4 weeks following the procedure and a 20 % success rate within 60 months.
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long term results of single intradermal 1 methylene blue injection for intractable idiopathic Pruritus Ani a prospective study
Techniques in Coloproctology, 2012Co-Authors: Narimantas Evaldas Samalavicius, Tomas Poskus, Rakesh Kumar Gupta, Raimundas LuneviciusAbstract:Background The aim of this study was to assess the effectiveness and side effects of methylene blue injection into the perianal skin of patients with chronic refractory idiopathic Pruritus Ani (IPA).
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Long-term results of single intradermal 1 % methylene blue injection for intractable idiopathic Pruritus Ani: a prospective study
Techniques in Coloproctology, 2012Co-Authors: Narimantas Evaldas Samalavicius, Tomas Poskus, Rakesh Kumar Gupta, Raimundas LuneviciusAbstract:Background The aim of this study was to assess the effectiveness and side effects of methylene blue injection into the perianal skin of patients with chronic refractory idiopathic Pruritus Ani (IPA).
B. B. Mentes - One of the best experts on this subject based on the ideXlab platform.
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Intradermal methylene blue injection for the treatment of intractable idiopathic Pruritus Ani: results of 30 cases
Techniques in Coloproctology, 2004Co-Authors: B. B. Mentes, M. Akin, S. Leventoglu, F. A. Gultekin, M. OguzAbstract:Some cases of idiopathic Pruritus anu may be refractory to treatment with dietary and hygienic instructions and short-term topical medications. In this study, we documented our technique and results with methylene blue injection in a large series of patients with intractable idiopathic Pruritus Ani. The results of 30 adult patients with well-documented intractable idiopathic Pruritus Ani who were treated with intradermal methylene blue injection are reported. No antibiotic prophylaxis, anesthesia or sedation was used. A total of 15 ml of a 1% methylene blue solution was injected intracutaneously and subcutaneously in the affected perianal area. A second injection (rescue treatment) was offered one month later to patients who declared partial response, and follow-up was restarted. One month after injection, 24 patients (80%) were symptom-free, 5 declared partial remissions, and one patient still had the same degree of Pruritus Ani. Five patients with partial remission underwent a second methylene blue injection, which provided complete relief in four. Therefore, the early response rate was 80% with single injection and 93.3% (28 of 30) with the rescue treatment. At six months, three recurrences were noted, indicating to a success rate of 83.3% (25 of 30). At 12 months after treatment, 23 patients (76.7%) were symptom free. This study has shown that intradermal methylene blue injection is a safe, simple, fast and efficient method of treating intractable idiopathic Pruritus Ani.
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intradermal methylene blue injection for the treatment of intractable idiopathic Pruritus Ani results of 30 cases
Techniques in Coloproctology, 2004Co-Authors: B. B. Mentes, M. Akin, S. Leventoglu, F. A. Gultekin, M. OguzAbstract:Some cases of idiopathic Pruritus anu may be refractory to treatment with dietary and hygienic instructions and short-term topical medications. In this study, we documented our technique and results with methylene blue injection in a large series of patients with intractable idiopathic Pruritus Ani. The results of 30 adult patients with well-documented intractable idiopathic Pruritus Ani who were treated with intradermal methylene blue injection are reported. No antibiotic prophylaxis, anesthesia or sedation was used. A total of 15 ml of a 1% methylene blue solution was injected intracutaneously and subcutaneously in the affected perianal area. A second injection (rescue treatment) was offered one month later to patients who declared partial response, and follow-up was restarted. One month after injection, 24 patients (80%) were symptom-free, 5 declared partial remissions, and one patient still had the same degree of Pruritus Ani. Five patients with partial remission underwent a second methylene blue injection, which provided complete relief in four. Therefore, the early response rate was 80% with single injection and 93.3% (28 of 30) with the rescue treatment. At six months, three recurrences were noted, indicating to a success rate of 83.3% (25 of 30). At 12 months after treatment, 23 patients (76.7%) were symptom free. This study has shown that intradermal methylene blue injection is a safe, simple, fast and efficient method of treating intractable idiopathic Pruritus Ani.
P M Sagar - One of the best experts on this subject based on the ideXlab platform.
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intra dermal methylene blue hydrocortisone and lignocaine for chronic intractable Pruritus Ani
Colorectal Disease, 2002Co-Authors: I D Botterill, P M SagarAbstract:Objective To assess the use of intradermal methylene blue, lignocaine and hydrocortisone in cases of chronic Pruritus Ani refractory to standard primary, dermatological and colorectal care. Methods Five ml 1% methylene blue, 100 mg hydrocortisone and 15 ml 1% lignocaine were injected into the peri-anal skin of 25 patients with chronic Pruritus Ani which had proved refractory to standard care. Clinical and telephone follow-up was undertaken. Results After one injection of the above solution, 16 (64%) of patients were rendered symptom free. Repeat injection in those initial nonresponders ultimately rendered 22 (88%) symptom free overall. Morbidity was 4%. Treatment failure occurred in three patients (12%). Conclusions Methylene blue used in solution with hydrocortisone and lignocaine can achieve effective control of Pruritus Ani in 88% of patients who have failed to respond to standard dermatological, hygiene and surgical treatments.
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Intra‐dermal methylene blue, hydrocortisone and lignocaine for chronic, intractable Pruritus Ani
Colorectal Disease, 2002Co-Authors: I D Botterill, P M SagarAbstract:Objective To assess the use of intradermal methylene blue, lignocaine and hydrocortisone in cases of chronic Pruritus Ani refractory to standard primary, dermatological and colorectal care. Methods Five ml 1% methylene blue, 100 mg hydrocortisone and 15 ml 1% lignocaine were injected into the peri-anal skin of 25 patients with chronic Pruritus Ani which had proved refractory to standard care. Clinical and telephone follow-up was undertaken. Results After one injection of the above solution, 16 (64%) of patients were rendered symptom free. Repeat injection in those initial nonresponders ultimately rendered 22 (88%) symptom free overall. Morbidity was 4%. Treatment failure occurred in three patients (12%). Conclusions Methylene blue used in solution with hydrocortisone and lignocaine can achieve effective control of Pruritus Ani in 88% of patients who have failed to respond to standard dermatological, hygiene and surgical treatments.
