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K W Chan - One of the best experts on this subject based on the ideXlab platform.
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acquired Pseudocholinesterase Deficiency after high dose cyclophosphamide
Bone Marrow Transplantation, 1999Co-Authors: V Koseoglu, J Chiang, K W ChanAbstract:Succinylcholine, a depolarizing neuromuscular blocking agent used in anesthesia is hydrolyzed in the plasma by the enzyme Pseudocholinesterase (PSC). Conditions associated with reduced PSC activity lead to sustained action of succinylcholine and result in prolonged apnea. Cyclophosphamide is an inhibitor of PSC and its suppressive effect may be dose-dependent. We report a case of severe PSC Deficiency after high-dose cyclophosphamide at 7 g/m2. The patient received succinylcholine during anesthesia 9 h after chemotherapy and developed prolonged apnea. This case highlights the potential risk of drug-induced PSC Deficiency and cautions the use of depolarizing muscular relaxants soon after high-dose cyclophosphamide.
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case report acquired Pseudocholinesterase Deficiency after high dose cyclophosphamide
1999Co-Authors: V Koseoglu, J Chiang, K W ChanAbstract:Summary:Succinylcholine, a depolarizing neuromuscular blockingagent used in anesthesia is hydrolyzed in the plasmaby the enzyme Pseudocholinesterase (PSC). Conditionsassociated with reduced PSC activity lead to sustainedaction of succinylcholine and result in prolonged apnea.Cyclophosphamide is an inhibitor of PSC and its sup-pressive effect may be dose-dependent. We report a caseof severe PSC deficiency after high-dose cyclophos-phamide at 7 g/m 2 . The patient received succinylcholineduring anesthesia 9 h after chemotherapy anddeveloped prolonged apnea. This case highlights thepotential risk of drug-induced PSC deficiency and cau-tions the use of depolarizing muscular relaxants soonafter high-dose cyclophosphamide.Keywords: cyclophosphamide; prolonged apnea; pseudo-cholinesterase; succinylcholineSuccinylcholine is a depolarizing muscle relaxant com-monly used during general anesthesia. After intravenousinjection it is hydrolyzed and inactivated within a fewminutes by the enzyme Pseudocholinesterase (PSC).Reduced PSC activity allows the accumulation of suc-cinylcholine in the synapses and neuromuscular junction,interfering with the regular sequences of nerve impulseconduction.
V Koseoglu - One of the best experts on this subject based on the ideXlab platform.
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acquired Pseudocholinesterase Deficiency after high dose cyclophosphamide
Bone Marrow Transplantation, 1999Co-Authors: V Koseoglu, J Chiang, K W ChanAbstract:Succinylcholine, a depolarizing neuromuscular blocking agent used in anesthesia is hydrolyzed in the plasma by the enzyme Pseudocholinesterase (PSC). Conditions associated with reduced PSC activity lead to sustained action of succinylcholine and result in prolonged apnea. Cyclophosphamide is an inhibitor of PSC and its suppressive effect may be dose-dependent. We report a case of severe PSC Deficiency after high-dose cyclophosphamide at 7 g/m2. The patient received succinylcholine during anesthesia 9 h after chemotherapy and developed prolonged apnea. This case highlights the potential risk of drug-induced PSC Deficiency and cautions the use of depolarizing muscular relaxants soon after high-dose cyclophosphamide.
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case report acquired Pseudocholinesterase Deficiency after high dose cyclophosphamide
1999Co-Authors: V Koseoglu, J Chiang, K W ChanAbstract:Summary:Succinylcholine, a depolarizing neuromuscular blockingagent used in anesthesia is hydrolyzed in the plasmaby the enzyme Pseudocholinesterase (PSC). Conditionsassociated with reduced PSC activity lead to sustainedaction of succinylcholine and result in prolonged apnea.Cyclophosphamide is an inhibitor of PSC and its sup-pressive effect may be dose-dependent. We report a caseof severe PSC deficiency after high-dose cyclophos-phamide at 7 g/m 2 . The patient received succinylcholineduring anesthesia 9 h after chemotherapy anddeveloped prolonged apnea. This case highlights thepotential risk of drug-induced PSC deficiency and cau-tions the use of depolarizing muscular relaxants soonafter high-dose cyclophosphamide.Keywords: cyclophosphamide; prolonged apnea; pseudo-cholinesterase; succinylcholineSuccinylcholine is a depolarizing muscle relaxant com-monly used during general anesthesia. After intravenousinjection it is hydrolyzed and inactivated within a fewminutes by the enzyme Pseudocholinesterase (PSC).Reduced PSC activity allows the accumulation of suc-cinylcholine in the synapses and neuromuscular junction,interfering with the regular sequences of nerve impulseconduction.
J Chiang - One of the best experts on this subject based on the ideXlab platform.
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acquired Pseudocholinesterase Deficiency after high dose cyclophosphamide
Bone Marrow Transplantation, 1999Co-Authors: V Koseoglu, J Chiang, K W ChanAbstract:Succinylcholine, a depolarizing neuromuscular blocking agent used in anesthesia is hydrolyzed in the plasma by the enzyme Pseudocholinesterase (PSC). Conditions associated with reduced PSC activity lead to sustained action of succinylcholine and result in prolonged apnea. Cyclophosphamide is an inhibitor of PSC and its suppressive effect may be dose-dependent. We report a case of severe PSC Deficiency after high-dose cyclophosphamide at 7 g/m2. The patient received succinylcholine during anesthesia 9 h after chemotherapy and developed prolonged apnea. This case highlights the potential risk of drug-induced PSC Deficiency and cautions the use of depolarizing muscular relaxants soon after high-dose cyclophosphamide.
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case report acquired Pseudocholinesterase Deficiency after high dose cyclophosphamide
1999Co-Authors: V Koseoglu, J Chiang, K W ChanAbstract:Summary:Succinylcholine, a depolarizing neuromuscular blockingagent used in anesthesia is hydrolyzed in the plasmaby the enzyme Pseudocholinesterase (PSC). Conditionsassociated with reduced PSC activity lead to sustainedaction of succinylcholine and result in prolonged apnea.Cyclophosphamide is an inhibitor of PSC and its sup-pressive effect may be dose-dependent. We report a caseof severe PSC deficiency after high-dose cyclophos-phamide at 7 g/m 2 . The patient received succinylcholineduring anesthesia 9 h after chemotherapy anddeveloped prolonged apnea. This case highlights thepotential risk of drug-induced PSC deficiency and cau-tions the use of depolarizing muscular relaxants soonafter high-dose cyclophosphamide.Keywords: cyclophosphamide; prolonged apnea; pseudo-cholinesterase; succinylcholineSuccinylcholine is a depolarizing muscle relaxant com-monly used during general anesthesia. After intravenousinjection it is hydrolyzed and inactivated within a fewminutes by the enzyme Pseudocholinesterase (PSC).Reduced PSC activity allows the accumulation of suc-cinylcholine in the synapses and neuromuscular junction,interfering with the regular sequences of nerve impulseconduction.
Ozge Canbek - One of the best experts on this subject based on the ideXlab platform.
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severe Pseudocholinesterase Deficiency and ect a case report
Düşünen Adam: The Journal of Psychiatry and Neurological Sciences, 2018Co-Authors: Eren Yildizhan, Nesrin Tomruk, Hafize Miray Aytac, Hakan Yildirim, Ozge CanbekAbstract:Pseudocholinesterase (PCE) Deficiency is an inherited condition in which recovery from anesthetic agents like succinylcholine and mivacurium is slow and is complicated with prolonged paralysis of respiratory muscles in susceptible patients. We present a very rare case that we encountered in our practice; the patient is a 29-year-old woman with a 15-year history of schizophrenia with Pseudocholinesterase Deficiency. Since the detection of PCE levels of all patients eligible for ECT is part of our pre-ECT assessment procedure, we could detect the Deficiency before the ECT procedure. We performed modified ECT with propophol and rocuronium instead of succinylcholine as usual. Sugammadex was used for fastening the recovery. Response to treatment which is measured with Positive and Negative Symptom Scale was good and we completed 9 ECT sessions without complication. We suggest further investigation of this topic because screening for PCE levels in pre-ECT assessment may reduce complications of modified ECT with anesthesia.
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modified electroconvulsive therapy in Pseudocholinesterase Deficiency a case report
European Psychiatry, 2017Co-Authors: Eren Yildizhan, Nesrin Tomruk, Hakan Yildirim, M Dereli, Armagan Ozdemir, Ozge CanbekAbstract:Introduction Pseudocholinesterase (PCHE) Deficiency is an inherited condition, in which recovery from anesthetic agents like succinylcholine and mivacurium is slow and complicated with prolonged paralysis of respiratory muscles in susceptible patients. Succinylcholine is used very frequently as a muscle relaxant during the procedure. Objectives In Bakirkoy research and training hospital for psychiatric and neurological diseases, 24.310 patients were hospitalized for acute conditions and 3490 of these patients were treated with electroconvulsive therapy (ECT) in 3 years. We present a very rare case that we encountered in our practice; a severe PCHE Deficiency case that could have complicated the modified ECT procedure unless necessary precautions were taken. Aims Detection of PCHE levels of all patients eligible for ECT is part of our pre-ECT assessments procedure, and the case presented here shows the benefits of this method. Methods The patient is a 29-year-old woman, with a 15 year history of schizophrenia. She was hospitalized for homicidal risk and refusal of treatment. Inadequate clinical response with pharmacological interventions and continuous aggressive excitations directed us to consider ECT. Results After the detection of PCHE Deficiency (PCHE level: 126 U/L), we performed the modified ECT with propophol and rocuronium instead of succinylcholine as usual. Sugammadex 100 mg was used for fastening the recovery. Response to treatment, which is recorded with positive and negative syndrome scale, was good and we completed 9 ECT sessions without complication. Conclusions Screening for PCHE levels in the pre-ECT assessments is efficacious in order to decrease the complications of the ECT procedure.
Halil Ibrahim Eken - One of the best experts on this subject based on the ideXlab platform.
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İKİ YAŞINDAKİ BİR ÇOCUKTA KONJENİTAL PSÖDOKOLİNESTERAZ ENZİM EKSİKLİĞİNE BAĞLI UZAMIŞ APNE
Mustafa Kemal University, 2015Co-Authors: Mustafa Ozgur, Muge Cakirca, Halil Ibrahim EkenAbstract:Mivacurium nondepolarizing neuromusculer blocking agent hydrolyzed by plasmacholinesterase, especially used for endotracheal intubation for short time surgeries. In this article a case of prolonged apnea after mivacurium administration Pseudocholinesterase Deficiency (serum level of Pseudocholinesterase was 1658 IU/L, normal: 4000-11.000 IU/L) was reporte
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iki yasindaki bir cocukta konjenital psodokolinesteraz enzim eksikliğine bağli uzamis apne prolonged apnea due to kongenital Pseudocholinesterase Deficiency in a two years old child
2013Co-Authors: Mustafa Ozgur, Muge Cakirca, Halil Ibrahim EkenAbstract:SUMMARY Mivacurium is a short-acting nondepolarizing neuromusculer blocking agent hydrolyzed by plasmacholinesterase, especially used for endotracheal intubation for short time surgeries. In this article a case of prolonged apnea after mivacurium administration and kongenital Pseudocholinesterase Deficiency (serum level of Pseudocholinesterase was 1658 IU/L, normal: 4000-11.000 IU/L) was reported.
