The Experts below are selected from a list of 7188 Experts worldwide ranked by ideXlab platform
Suman Wason - One of the best experts on this subject based on the ideXlab platform.
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Addition of ibuprofen to Pseudoephedrine and chlorpheniramine in the treatment of seasonal allergic rhinitis
Annals of Allergy Asthma & Immunology, 2004Co-Authors: Eli O. Meltzer, Gary D. Berman, Geraldine Doyle, Joel Waksman, Paul Butkerait, Stephen A. Cooper, Roger G. Berlin, Andrew Pedinoff, Jonathan Corren, Suman WasonAbstract:Background Patients with seasonal allergic rhinitis experience many nasal and concomitant nonnasal symptoms. Many patients also experience headaches and facial pain, pressure, or discomfort. Standard over-the-counter therapy with antihistamines and nasal decongestants often does not completely relieve all symptoms associated with allergic rhinitis. Objective To establish the contribution of ibuprofen when used with Pseudoephedrine and chlorpheniramine, a standard over-the-counter regimen, to relieve the symptoms of seasonal allergic rhinitis. Methods In this 7-day, multicenter, randomized, placebo-controlled, double-blind, double-dummy, parallel-group trial, qualified subjects were randomly assigned to 1 of 4 treatment groups that received combined ibuprofen/Pseudoephedrine/chlorpheniramine (200/30/2 mg or 400/60/4 mg), combined Pseudoephedrine/chlorpheniramine (30/2 mg), or placebo. Therapy began when the subject experienced a minimum of moderate allergy-associated pain, and it continued 3 times a day for 7 consecutive days. Results Mean pain intensity reduction in both ibuprofen/Pseudoephedrine/chlorpheniramine treatment groups was 40% greater than in the placebo group and 33% greater than in the Pseudoephedrine/chlorpheniramine treatment group ( P P P Conclusions In both doses of the triple combination, ibuprofen added to the effects of chlorpheniramine and Pseudoephedrine, resulting in superior relief of pain and all nonpain allergy symptoms compared with Pseudoephedrine/chlorpheniramine treatment. Furthermore, the superior efficacy of the lower dose of the triple combination allowed for a decrease in the incidence of adverse effects.
Jonathan Corren - One of the best experts on this subject based on the ideXlab platform.
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Addition of ibuprofen to Pseudoephedrine and chlorpheniramine in the treatment of seasonal allergic rhinitis
Annals of Allergy Asthma & Immunology, 2004Co-Authors: Eli O. Meltzer, Gary D. Berman, Geraldine Doyle, Joel Waksman, Paul Butkerait, Stephen A. Cooper, Roger G. Berlin, Andrew Pedinoff, Jonathan Corren, Suman WasonAbstract:Background Patients with seasonal allergic rhinitis experience many nasal and concomitant nonnasal symptoms. Many patients also experience headaches and facial pain, pressure, or discomfort. Standard over-the-counter therapy with antihistamines and nasal decongestants often does not completely relieve all symptoms associated with allergic rhinitis. Objective To establish the contribution of ibuprofen when used with Pseudoephedrine and chlorpheniramine, a standard over-the-counter regimen, to relieve the symptoms of seasonal allergic rhinitis. Methods In this 7-day, multicenter, randomized, placebo-controlled, double-blind, double-dummy, parallel-group trial, qualified subjects were randomly assigned to 1 of 4 treatment groups that received combined ibuprofen/Pseudoephedrine/chlorpheniramine (200/30/2 mg or 400/60/4 mg), combined Pseudoephedrine/chlorpheniramine (30/2 mg), or placebo. Therapy began when the subject experienced a minimum of moderate allergy-associated pain, and it continued 3 times a day for 7 consecutive days. Results Mean pain intensity reduction in both ibuprofen/Pseudoephedrine/chlorpheniramine treatment groups was 40% greater than in the placebo group and 33% greater than in the Pseudoephedrine/chlorpheniramine treatment group ( P P P Conclusions In both doses of the triple combination, ibuprofen added to the effects of chlorpheniramine and Pseudoephedrine, resulting in superior relief of pain and all nonpain allergy symptoms compared with Pseudoephedrine/chlorpheniramine treatment. Furthermore, the superior efficacy of the lower dose of the triple combination allowed for a decrease in the incidence of adverse effects.
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Efficacy of once-daily desloratadine/Pseudoephedrine for relief of nasal congestion.
Allergy and Asthma Proceedings, 2002Co-Authors: Eric J. Schenkel, Jonathan Corren, John J. MurrayAbstract:The majority of patients with seasonal allergic rhinitis (SAR) suffer from nasal congestion. Desloratadine, a nonsedating H 1 -receptor antagonist, has given decongestant relief to patients with mild-to-moderate nasal congestion associated with SAR. The following study was undertaken to show that a once-daily formulation of desloratadine/Pseudoephedrine would provide greater decongestant relief to patients experiencing moderate-to-severe nasal congestion compared with component monotherapy. A total of 1018 patients were assigned randomly to receive desloratadine/ Pseudoephedrine (5 mg/240 mg), desloratadine (5 mg), or Pseudoephedrine (240 mg) daily for 15 days. Over the 15-day study period, patients receiving desloratadine/Pseudoephedrine combination tablets had a significant reduction in mean A.M./P.M. reflective nasal congestion scores compared with patients receiving desloratadine or Pseudoephedrine (p < 0.01); this reduction reached significance by day 2. Desloratadine/Pseudoephedrine combination tablets also produced a greater reduction in A.M. instantaneous nasal congestion scores compared with component monotherapy (p < 0.01), indicating not only superior efficacy but also a full 24-hour effect. Desloratadine monotherapy reduced all mean nasal congestion scores to a similar degree as compared with Pseudoephedrine monotherapy (p = NS). No unusual or unexpected adverse events were reported in any group. It was concluded that desloratadine/Pseudoephedrine offers additional benefit to patients with moderate-to-severe SAR-associated nasal congestion compared with Pseudoephedrine therapy alone.
Prashanth Komarneni - One of the best experts on this subject based on the ideXlab platform.
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simultaneous quantification of fexofenadine and Pseudoephedrine in human plasma by liquid chromatography tandem mass spectrometry with electrospray ionization method development validation and application to a clinical study
Rapid Communications in Mass Spectrometry, 2006Co-Authors: Ramakrishna Nirogi, Vishwottam Kandikere, Manoj Kumar Shukla, Koteshwara Mudigonda, Santosh Maurya, Prashanth KomarneniAbstract:To support the pharmacokinetic and bioavailability study of a once-daily fexofenadine/Pseudoephedrine combination, a high-performance liquid chromatography/positive ion electrospray tandem mass spectrometry (HPLC/ESI-MS/MS) method for the simultaneous quantification of fexofenadine and Pseudoephedrine was developed and validated with 500 µL human plasma using mosapride as an internal standard (IS). Following solid-phase extraction, the analytes were separated using an isocratic mobile phase on a reversed-phase column and analyzed by MS/MS in the multiple reaction monitoring mode using the respective [M+H]+ ions, m/z 502/466 for fexofenadine, m/z 166/148 for pseuoephedrine and m/z 422/198 for the IS. The method exhibited linear dynamic ranges of 1–500 ng/mL and 2–1000 ng/mL for fexofenadine and Pseudoephedrine, respectively, in human plasma. The lower limits of quantification were 1 and 2 ng/mL with a relative standard deviation of less than 10% for fexofenadine and Pseudoephedrine, respectively. Acceptable precision and accuracy were obtained for concentrations over the standard curve range. The total chromatographic run time was 2 min and more than 400 human plasma samples could be analyzed in one day by running the system overnight. The method is precise and sensitive enough for its intended purpose. Copyright © 2006 John Wiley & Sons, Ltd.
James L Gleason - One of the best experts on this subject based on the ideXlab platform.
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Pseudoephedrine as a practical chiral auxiliary for the synthesis of highly enantiomerically enriched carboxylic acids alcohols aldehydes and ketones
Journal of the American Chemical Society, 1997Co-Authors: Andrew G. Myers, Bryant H. Yang, Hou Chen, Lydia Mckinstry, And David J Kopecky, James L GleasonAbstract:The use of Pseudoephedrine as a practical chiral auxiliary for asymmetric synthesis is described in full. Both enantiomers of Pseudoephedrine are inexpensive commodity chemicals and can be N-acylated in high yields to form tertiary amides. In the presence of lithium chloride, the enolates of the corresponding Pseudoephedrine amides undergo highly diastereoselective alkylations with a wide range of alkyl halides to afford α-substituted products in high yields. These products can then be transformed in a single operation into highly enantiomerically enriched carboxylic acids, alcohols, aldehydes, and ketones.
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a one step synthesis of Pseudoephedrine glycinamide a versatile precursor for the synthesis of α amino acids
Tetrahedron Letters, 1995Co-Authors: Andrew G. Myers, T Yoon, James L GleasonAbstract:Abstract Both enantiomers of Pseudoephedrine glycinamide [(+)- or (−)- 1 ] were synthesized by either of two procedures: (1) a standard two-step coupling of N -Boc-Gly with Pseudoephedrine followed by deprotection, or (2) a more economical one-step coupling reaction of Gly-OMe with Pseudoephedrine mediated by LiCl and base.
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Use of Pseudoephedrine as a Practical Chiral Auxiliary for Asymmetric Synthesis
Journal of the American Chemical Society, 1994Co-Authors: Andrew G. Myers, Bryant H. Yang, Hou Chen, James L GleasonAbstract:The use of Pseudoephedrine as a practical chiral auxiliary for asymmetric synthesis is describe. Both enantiomers of Pseudoephedrine are inexpensive commodity chemicals and can be N-acylated in high yields to form tertiary amides. In the presence of lithium chloride, the enolates of the corresponding Pseudoephedrine amides undergo highly diastereoselective a1kylations with a wide range of alkyl halides to afford α-substituted products in high yields. These products can then be transformed in a single operation into highly enantiomerically enriched carboxylic acids, alcohols, and aldehydes. Lithium amidotrihydroborate (LAB) is shown to be a powerful reductant for the selective reduction of tertiary amides in general and Pseudoephedrine amides in particular to form primary alcohols.
Eli O. Meltzer - One of the best experts on this subject based on the ideXlab platform.
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Addition of ibuprofen to Pseudoephedrine and chlorpheniramine in the treatment of seasonal allergic rhinitis
Annals of Allergy Asthma & Immunology, 2004Co-Authors: Eli O. Meltzer, Gary D. Berman, Geraldine Doyle, Joel Waksman, Paul Butkerait, Stephen A. Cooper, Roger G. Berlin, Andrew Pedinoff, Jonathan Corren, Suman WasonAbstract:Background Patients with seasonal allergic rhinitis experience many nasal and concomitant nonnasal symptoms. Many patients also experience headaches and facial pain, pressure, or discomfort. Standard over-the-counter therapy with antihistamines and nasal decongestants often does not completely relieve all symptoms associated with allergic rhinitis. Objective To establish the contribution of ibuprofen when used with Pseudoephedrine and chlorpheniramine, a standard over-the-counter regimen, to relieve the symptoms of seasonal allergic rhinitis. Methods In this 7-day, multicenter, randomized, placebo-controlled, double-blind, double-dummy, parallel-group trial, qualified subjects were randomly assigned to 1 of 4 treatment groups that received combined ibuprofen/Pseudoephedrine/chlorpheniramine (200/30/2 mg or 400/60/4 mg), combined Pseudoephedrine/chlorpheniramine (30/2 mg), or placebo. Therapy began when the subject experienced a minimum of moderate allergy-associated pain, and it continued 3 times a day for 7 consecutive days. Results Mean pain intensity reduction in both ibuprofen/Pseudoephedrine/chlorpheniramine treatment groups was 40% greater than in the placebo group and 33% greater than in the Pseudoephedrine/chlorpheniramine treatment group ( P P P Conclusions In both doses of the triple combination, ibuprofen added to the effects of chlorpheniramine and Pseudoephedrine, resulting in superior relief of pain and all nonpain allergy symptoms compared with Pseudoephedrine/chlorpheniramine treatment. Furthermore, the superior efficacy of the lower dose of the triple combination allowed for a decrease in the incidence of adverse effects.
