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Janey L Wiggs - One of the best experts on this subject based on the ideXlab platform.
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lack of association of polymorphisms in elastin with Pseudoexfoliation syndrome and glaucoma
Journal of Glaucoma, 2010Co-Authors: Bao Jian Fan, Cynthia L Grosskreutz, Jonathan L Haines, Louis R Pasquale, Douglas J Rhee, Dayse Figuieredo R Sena, Teresa C Chen, E Delbono, Janey L WiggsAbstract:PurposeTo evaluate the elastin gene (ELN) as a secondary risk factor for Pseudoexfoliation syndrome (PXFS) and the associated glaucoma Pseudoexfoliation glaucoma (PXFG).MethodsOne hundred seventy-eight unrelated patients with PXFS, including 132 patients with PXFG, and 113 unrelated controls were re
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DNA sequence variants in the LOXL1 gene are associated with Pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity
BMC Medical Genetics, 2008Co-Authors: Louis Pasquale, Cynthia L Grosskreutz, Douglas Rhee, Teresa Chen, Margaret M Deangelis, Elizabeth Del Bono, Joan W Miller, Tiansen Li, Jonathan L Haines, Janey L WiggsAbstract:Background Pseudoexfoliation syndrome is a major risk factor for glaucoma in many populations throughout the world. Using a U.S. clinic-based case control sample with broad ethnic diversity, we show that three common SNPs in LOXL1 previously associated with Pseudoexfoliation in Nordic populations are significantly associated with Pseudoexfoliation syndrome and Pseudoexfoliation glaucoma. Methods Three LOXL1 SNPs were genotyped in a patient sample (206 Pseudoexfoliation, 331 primary open angle glaucoma, and 88 controls) from the Glaucoma Consultation Service at the Massachusetts Eye and Ear Infirmary. The SNPs were evaluation for association with pseudeoexfoliation syndrome, Pseudoexfoliation glaucoma, and primary open angle glaucoma. Results The strongest association was found for the G allele of marker rs3825942 (G153D) with a frequency of 99% in Pseudoexfoliation patients (with and without glaucoma) compared with 79% in controls (p = 1.6 × 10^-15; OR = 20.93, 95%CI: 8.06, 54.39). The homozygous GG genotype is also associated with Pseudoexfoliation when compared to controls (p = 1.2 × 10^-12; OR = 23.57, 95%CI: 7.95, 69.85). None of the SNPs were significantly associated with primary open angle glaucoma. Conclusion The Pseudoexfoliation syndrome is a common cause of glaucoma. These results indicate that the G153D LOXL1 variant is significantly associated with an increased risk of Pseudoexfoliation and Pseudoexfoliation glaucoma in an ethnically diverse patient population from the Northeastern United States. Given the high prevalence of pseudooexfoliation in this geographic region, these results also indicate that the G153D LOXL1 variant is a significant risk factor for adult-onset glaucoma in this clinic based population.
Jonathan L Haines - One of the best experts on this subject based on the ideXlab platform.
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lack of association of polymorphisms in elastin with Pseudoexfoliation syndrome and glaucoma
Journal of Glaucoma, 2010Co-Authors: Bao Jian Fan, Cynthia L Grosskreutz, Jonathan L Haines, Louis R Pasquale, Douglas J Rhee, Dayse Figuieredo R Sena, Teresa C Chen, E Delbono, Janey L WiggsAbstract:PurposeTo evaluate the elastin gene (ELN) as a secondary risk factor for Pseudoexfoliation syndrome (PXFS) and the associated glaucoma Pseudoexfoliation glaucoma (PXFG).MethodsOne hundred seventy-eight unrelated patients with PXFS, including 132 patients with PXFG, and 113 unrelated controls were re
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DNA sequence variants in the LOXL1 gene are associated with Pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity
BMC Medical Genetics, 2008Co-Authors: Louis Pasquale, Cynthia L Grosskreutz, Douglas Rhee, Teresa Chen, Margaret M Deangelis, Elizabeth Del Bono, Joan W Miller, Tiansen Li, Jonathan L Haines, Janey L WiggsAbstract:Background Pseudoexfoliation syndrome is a major risk factor for glaucoma in many populations throughout the world. Using a U.S. clinic-based case control sample with broad ethnic diversity, we show that three common SNPs in LOXL1 previously associated with Pseudoexfoliation in Nordic populations are significantly associated with Pseudoexfoliation syndrome and Pseudoexfoliation glaucoma. Methods Three LOXL1 SNPs were genotyped in a patient sample (206 Pseudoexfoliation, 331 primary open angle glaucoma, and 88 controls) from the Glaucoma Consultation Service at the Massachusetts Eye and Ear Infirmary. The SNPs were evaluation for association with pseudeoexfoliation syndrome, Pseudoexfoliation glaucoma, and primary open angle glaucoma. Results The strongest association was found for the G allele of marker rs3825942 (G153D) with a frequency of 99% in Pseudoexfoliation patients (with and without glaucoma) compared with 79% in controls (p = 1.6 × 10^-15; OR = 20.93, 95%CI: 8.06, 54.39). The homozygous GG genotype is also associated with Pseudoexfoliation when compared to controls (p = 1.2 × 10^-12; OR = 23.57, 95%CI: 7.95, 69.85). None of the SNPs were significantly associated with primary open angle glaucoma. Conclusion The Pseudoexfoliation syndrome is a common cause of glaucoma. These results indicate that the G153D LOXL1 variant is significantly associated with an increased risk of Pseudoexfoliation and Pseudoexfoliation glaucoma in an ethnically diverse patient population from the Northeastern United States. Given the high prevalence of pseudooexfoliation in this geographic region, these results also indicate that the G153D LOXL1 variant is a significant risk factor for adult-onset glaucoma in this clinic based population.
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dna sequence variants in the loxl1 gene are associated with Pseudoexfoliation glaucoma in a u s clinic based population with broad ethnic diversity
BMC Medical Genetics, 2008Co-Authors: Bao Jian Fan, Cynthia L Grosskreutz, Margaret M Deangelis, Joan W Miller, Louis R Pasquale, Douglas J Rhee, T C Chen, Ivana K Kim, Elizabeth Del Bono, Jonathan L HainesAbstract:Background Pseudoexfoliation syndrome is a major risk factor for glaucoma in many populations throughout the world. Using a U.S. clinic-based case control sample with broad ethnic diversity, we show that three common SNPs in LOXL1 previously associated with Pseudoexfoliation in Nordic populations are significantly associated with Pseudoexfoliation syndrome and Pseudoexfoliation glaucoma.
Liv Drolsum - One of the best experts on this subject based on the ideXlab platform.
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posterior capsular opacification in patients with Pseudoexfoliation syndrome a long term perspective
Acta Ophthalmologica, 2013Co-Authors: Atle Einar Ostern, Liv Drolsum, Marit Saethre, Gunhild Falleth Sandvik, Marianne RaenAbstract:. Purpose: To compare posterior capsular opacification in patients with and without Pseudoexfoliation syndrome 6–7 years following surgery. Methods: Forty-four eyes of 44 patients with Pseudoexfoliation syndrome who underwent cataract surgery with phacoemulsification in 2001 and 2002 were available for follow-up in 2008. These patients were compared to 86 age- and gender-matched patients (86 eyes) without Pseudoexfoliation syndrome who had surgery during the same time period. Posterior capsule opacification was assessed using digital retroillumination photography. The images were analysed with a software program (POCOman) to determine the extent and severity of the capsular opacification. Results: Percentage and severity of posterior capsular opacification within the central 4.0 and 1.3 mm of the optical zone were compared in eyes with and without Pseudoexfoliation syndrome. Neither of these results were statistically significant. Before the re-examination in 2008, neodymium:yttrium-aluminium-garnet laser posterior capsulotomy had been conducted in 16% (n = 7) of eyes with Pseudoexfoliation syndrome, as well as in 16% (n = 14) of eyes without Pseudoexfoliation syndrome. Conclusion: Our study indicates that, with phacoemulsification, development of long-term posterior capsular opacification is not increased in patients with Pseudoexfoliation syndrome after uncomplicated cataract surgery.
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Pseudoexfoliation syndrome and extracapsular cataract extraction
Acta Ophthalmologica, 2009Co-Authors: Liv Drolsum, Erling Haaskjold, Martin DavangerAbstract:. Extracapsular cataract extraction (ECCE) in 139 eyes with Pseudoexfoliation syndrome was compared to 762 eyes without Pseudoexfoliation syndrome in a consecutive study. Preoperative findings, operative procedure and problems were registered, stored and analyzed in a computer program package. Of the patients with Pseudoexfoliation syndrome 88.5% were 70 years or older, compared to 67.2% of the patients without Pseudoexfoliation syndrome (p < 0.001). Glaucoma occurred in 48.9% of eyes with Pseudoexfoliation syndrome and in 6.8% of eyes without Pseudoexfoliation syndrome, respectively. Poorly dilated pupil was demonstrated in 46.8% and in 5.8% of eyes with and without Pseudoexfoliation syndrome, respectively. Capsule/zonulae tears (without vitreous loss) occurred in 4.3% of the Pseudoexfoliation syndrome eyes, compared to 1.3% in eyes without Pseudoexfoliation syndrome (p < 0.05). The incidence of vitreous loss was similar in both groups. We found no correlation between the pupil size and capsule/zonulae tears or vitreous loss in either group. In conclusion, when appropriate care is undertaken, ECCE with posterior chamber IOL implantation is a safe procedure in Pseudoexfoliation syndrome eyes.
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results and complications after extracapsular cataract extraction in eyes with Pseudoexfoliation syndrome
Acta Ophthalmologica, 2009Co-Authors: Liv Drolsum, Erling Haaskjold, Martin DavangerAbstract:. Postoperative results and complications in 136 eyes with Pseudoexfoliation syndrome were compared to 744 eyes without Pseudoexfoliation syndrome in a consecutive study. The patients were followed for 4 months postoperatively. Excluding cases with glaucoma, 81.4% of the Pseudoexfoliation eyes and 83.0% of the eyes without Pseudoexfoliation achieved a corrected visual acuity of 5/8.5 or better. IOL malposition was rare in both groups (1.5% in the Pseudoexfoliation group and 1.6% in the group without Pseudoexfoliation). IOP elevation the first day postoperatively occurred most often in the Pseudoexfoliation eyes. In the Pseudoexfoliation eyes, postoperative iritis and cellular precipitates were demonstrated in 16.2% and 11.0%, respectively, compared to 3.8% and 3.2% in the eyes without Pseudoexfoliation (p < 0.001). The frequency of an inflammatory reaction was highly correlated to small pupil size during operation in both groups.
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Phacoemulsification in eyes with Pseudoexfoliation
Journal of cataract and refractive surgery, 1998Co-Authors: Liv Drolsum, Erling Haaskjold, Kjell U. SandvigAbstract:Abstract Purpose: To compare intraoperative and postoperative complications in eyes with and without Pseudoexfoliation having cataract surgery by phacoemulsification. Setting: Department of Ophthalmology, National Hospital, Oslo, Norway. Methods: Of 1152 consecutive phacoemulsification procedures, 164 cases with Pseudoexfoliation (Group 1) and 916 cases without (Group 2) were followed for 4 months after cataract surgery in a prospective study. Of all cataract operations performed during that time, 96.2% were phacoemulsification procedures: 90.4 and 97.4% in eyes with and without Pseudoexfoliation, respectively ( P Results: The frequency of capsular/zonular tear or vitreous loss was 9.6 and 3.7% in Groups 1 and 2, respectively ( P = .0002). A visual acuity of 0.5 or better was achieved in 86.5% of eyes in Group 1 and 92.4% in Group 2 ( P = .02). There were no statistically significant between-group differences in the frequency of a postoperative inflammatory response 1 day (6.7 versus 4.4%), 1 week (2.4 versus 1.6%), or 4 months (1.8 versus 0.9%) postoperatively. Conclusion: Phacoemulsification was safe in most eyes with Pseudoexfoliation even though significantly more complications occurred intraoperatively in these eyes. The low frequency of an inflammatory response indicates that the presence of Pseudoexfoliation does not significantly increase the risk of inflammation.
Yusuf Çağlar - One of the best experts on this subject based on the ideXlab platform.
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HOMOCYSTEINE LEVELS IN PLASMA AND SENSORINEURAL HEARING LOSS IN PATIENTS WITH Pseudoexfoliation SYNDROME
European journal of ophthalmology, 2006Co-Authors: B. Aydogan Ozkan, Nurşen Yüksel, G. Keskin, Özgül Altıntaş, Vl Karabas, Yusuf Çağlar, A. AlmacAbstract:PURPOSE. To determine the incidence and severity of hearing loss in different frequencies in patients with Pseudoexfoliation. Furthermore, possible links between homocysteine and Pseudoexfoliation were evaluated. METHODS. Seventy-five consecutive patients with Pseudoexfoliation and 75 sex- and age-matched subjects without Pseudoexfoliation as control group were included in this prospective case-control study. Pure-tone audiometry was obtained in all subjects in both groups. Blood samples were obtained from 70 patients with Pseudoexfoliation after overnight fasting for levels of homocysteine and analyzed by routine laboratory measurements. RESULTS. Fifty-two (69%) patients with Pseudoexfoliation and 39 (52%) controls had sensorineural hearing loss in speech frequencies. The difference between Pseudoexfoliation and control group with regard to the frequency of sensorineural hearing loss in speech frequencies was statistically significant (p=0.03). No relationship was found between the degree of glaucomatous damage and hearing threshold variables in the patients with Pseudoexfoliation glaucoma. Plasma homocysteine levels showed no significant difference when patients with Pseudoexfoliation and hearing loss were compared with patients with Pseudoexfoliation and normal hearing threshold (p=0.5). Hyperhomocysteinemia was found in 58% (29/50) of Pseudoexfoliation patients with hearing loss, and 55 % (11/20) of Pseudoexfoliation patients with normal hearing threshold (p=0.8). No statistically significant correlation was found between plasma homocysteine and hearing loss in patients with Pseudoexfoliation. CONCLUSIONS. These findings suggest an association between sensorineural hearing loss and Pseudoexfoliation in patients with Pseudoexfoliation and glaucoma. The severity of hearing loss was not correlated with the degree of glaucomatous damage. There is no association between increased homocysteine levels and hearing loss in patients with Pseudoexfoliation.
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Homocysteine and nitric oxide levels in plasma of patients with Pseudoexfoliation syndrome, Pseudoexfoliation glaucoma, and primary open-angle glaucoma
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2005Co-Authors: Özgül Altıntaş, Nurşen Yüksel, Vl Karabas, H Maral, M O Dillioglugil, Yusuf ÇağlarAbstract:Purpose To evaluate plasma total homocysteine (tHcy) and nitric oxide (NO) marker levels in patients with Pseudoexfoliation syndrome (PXS), Pseudoexfoliation glaucoma (PXG), primary open-angle glaucoma (POAG), and normal controls.
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Ocular hemodynamics in Pseudoexfoliation syndrome and Pseudoexfoliation glaucoma
Ophthalmology, 2001Co-Authors: Nurşen Yüksel, V. Levent Karabaş, Arzu Arslan, Ali Demirci, Yusuf ÇağlarAbstract:Abstract Objective To evaluate orbital blood flow velocities by using color Doppler imaging in patients with Pseudoexfoliation syndrome and Pseudoexfoliation glaucoma. Design Prospective, comparative case series. Participants Twenty-eight patients with Pseudoexfoliation syndrome (n = 14) or Pseudoexfoliation glaucoma (n = 14) and 14 healthy control participants were included. Intervention Color Doppler imaging was used with a 7.5-MHz probe. Evaluation of the ophthalmic, central retinal, short posterior nasal, and temporal ciliary arteries was performed, and peak systolic and end diastolic flow velocities were measured. Resistive indices were calculated. Results When compared with the control participants, patients with Pseudoexfoliation syndrome showed statistically significant decreases in the mean peak systolic velocity of the central retinal artery (11.21 ± 2.19 cm/second; P P P P P P P P P P Conclusions The findings suggest that hemodynamic parameters in the retrobulbar vessels were altered in patients with Pseudoexfoliation syndrome and Pseudoexfoliation glaucoma; however, these alterations were more prominent in the latter group.
Ali Reza Faghihi - One of the best experts on this subject based on the ideXlab platform.
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Sensorineural hearing loss in Pseudoexfoliation syndrome.
Ophthalmology, 2008Co-Authors: Shahin Yazdani, Adib Tousi, Mohammad Pakravan, Ali Reza FaghihiAbstract:Purpose To determine hearing thresholds at sound frequencies important for speech comprehension in subjects with ocular Pseudoexfoliation and to compare them with that of age- and sex-matched controls without Pseudoexfoliation. Design Case–control study. Participants Eighty-three subjects with ocular Pseudoexfoliation and 83 age- and gender-matched controls without Pseudoexfoliation. Methods Pure tone audiometry (air and bone conduction) was performed at 1, 2, and 3 kilohertzes in all subjects. Hearing thresholds were compared with an age- and gender-stratified standard (ISO7029) and between study groups. Main Outcome Measures Individual hearing thresholds at 1, 2, and 3 kilohertz and hearing loss, defined as the sum of tested thresholds lower than the ISO7029 standard median. Results A total of 166 eligible subjects were evaluated. Equal numbers of male and female subjects were allocated into each of the study groups (60 male and 23 female subjects in either group). Mean ages of male and female participants did not significantly differ in cases versus controls ( P = 0.88 and P = 0.83). Below average hearing thresholds were present in 88.4% of examined ears in the case group, versus 53.6% in the control group ( P P Conclusions Hearing thresholds at frequencies that are important for speech comprehension are significantly worse in individuals with ocular Pseudoexfoliation than in matched controls. This finding may support the multiorgan nature of Pseudoexfoliation syndrome.
