The Experts below are selected from a list of 555 Experts worldwide ranked by ideXlab platform
Rick W Wright - One of the best experts on this subject based on the ideXlab platform.
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calcium pyrophosphate dihydrate deposition disease Pseudogout after total knee arthroplasty
Journal of Arthroplasty, 2007Co-Authors: Christopher B Hirose, Rick W WrightAbstract:The authors report a case of calcium pyrophosphate dihydrate deposition disease (Pseudogout) presenting in the early period after primary total knee arthroplasty. The patient's symptoms resolved with conservative management including colchicine and indomethacin. The presentation of Pseudogout resembles septic arthritis and should be included in the differential diagnosis to prevent unnecessary surgery in these patients.
Peter G Bullough - One of the best experts on this subject based on the ideXlab platform.
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tophaceous Pseudogout tumoral calcium pyrophosphate dihydrate crystal deposition disease
Human Pathology, 1995Co-Authors: Tsuyoshi Ishida, Howard D Dorfman, Peter G BulloughAbstract:Most cases of calcium deposition seen radiologically in soft tissues are caused by calcium hydroxyapatite and occur either as a complication of trauma with associated necrosis (eg, fat necrosis), generalized connective tissue diseases (eg, scleroderma), metabolic disturbances (eg, hyperparathyroidism, familial hyperphosphatemia), sarcoidosis, myeloma, or metastases. Hydroxyapatite deposits are seen at many soft tissue sites, including joint capsules, ligaments, blood vessels, dermis, etc. On the other hand, deposits of calcium pyrophosphate are seen typically in the meniscus, articular cartilage, ligamentum flavum, and intervertebral disc. They usually are punctate or linear in distribution within the meniscus or parallel to the subchondral bone end plate. We report seven cases of massive focal calcium pyrophosphate dihydrate (CPPD) crystal deposition disease (tophaceous Pseudogout) that occurred in atypical locations for CPPD. The ages of the patients ranged from 31 to 86 years (average, 60.7 years). One patient was male and six were female. The temporomandibular joint was involved in three patients and the metatarsophalangeal joint of the great toe was involved in two patients. The hip joint and cervical spine were involved in one patient each. A mass or swelling with or without pain was a common symptom. None of the patients in our series had clinical or radiographic evidence of CPPD crystal deposition disease in any other joints. Roentgenograms showed calcified lesions with a granular or fluffy pattern. Histologically, the lesions showed small or large deposits of intensely basophilic calcified material containing needle shaped and rhomboid crystals with weakly positive birefringence characteristic of CPPD. Foreign body granulomatous reaction to the CPPD deposition was constantly found. Chondroid metaplasia around and in the areas of CPPD deposition was observed commonly. Some of the chondroid areas showed cellular atypia in chondrocytes suggestive of a malignant cartilage tumor. It is important to recognize this rare form of CPPD crystal deposition disease and to identify the CPPD crystals in the calcified deposits, thus avoiding the misdiagnosis of benign or malignant cartilaginous lesions.
Christopher B Hirose - One of the best experts on this subject based on the ideXlab platform.
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calcium pyrophosphate dihydrate deposition disease Pseudogout after total knee arthroplasty
Journal of Arthroplasty, 2007Co-Authors: Christopher B Hirose, Rick W WrightAbstract:The authors report a case of calcium pyrophosphate dihydrate deposition disease (Pseudogout) presenting in the early period after primary total knee arthroplasty. The patient's symptoms resolved with conservative management including colchicine and indomethacin. The presentation of Pseudogout resembles septic arthritis and should be included in the differential diagnosis to prevent unnecessary surgery in these patients.
Michael Salcman - One of the best experts on this subject based on the ideXlab platform.
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calcium pyrophosphate arthropathy of the spine case report and review of the literature
Neurosurgery, 1994Co-Authors: Michael Salcman, Agha Khan, Daniel A. SymondsAbstract:Calcium pyrophosphate deposition disease is a relatively uncommon arthropathy characterized by the clinical features of Pseudogout, the radiographic manifestations of chondrocalcinosis, and the pathological deposition of calcium pyrophosphate crystals in both hyaline and fibrocartilage. Symptomatic involvement of the spine by calcium pyrophosphate deposition disease is rare except by nodular deposition in the ligamentum flavum and atlanto-occipital ligament. We report a 50-year-old woman who presented with an acute herniated disc syndrome secondary to an intraspinal inflammatory calcium pyrophosphate deposition disease mass at the level of the L4-L5 interspace. The magnetic resonance image and histopathological features of the case are also discussed.
Cem Gabay - One of the best experts on this subject based on the ideXlab platform.
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anakinra is a possible alternative in the treatment and prevention of acute attacks of Pseudogout in end stage renal failure
Joint Bone Spine, 2009Co-Authors: Nadia Announ, Gaby Palmer, Pierreandre Guerne, Cem GabayAbstract:Abstract We describe the case of a 71-year-old man with recurrent Pseudogout attacks affecting multiple joints. He had end-stage renal failure that contra-indicated the use of non-steroidal anti-inflammatory drugs and was resistant to therapy with glucocorticoids. Based on the recent findings that interleukin (IL)-1β is involved in crystal-induced inflammation, the patient received anakinra, a specific IL-1 inhibitor, in order to treat an acute attack of Pseudogout. In addition, anakinra was administered as preventive therapy 3 days per week after each hemodialysis session. Under this treatment, he did not present any severe episode of arthritis after a follow-up of 8 months. This observation suggests that anakinra is efficacious and safe for the prevention of crystal-induced arthritis in patients with severe renal failure.
