The Experts below are selected from a list of 228 Experts worldwide ranked by ideXlab platform
Benjamin Levi - One of the best experts on this subject based on the ideXlab platform.
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Computed Tomography Evidence of Psoas Muscle Atrophy Without Concomitant Tendon Wasting in Early Sepsis.
The Journal of surgical research, 2018Co-Authors: Carrie A. Kubiak, Kavitha Ranganathan, Stewart C Wang, Niki Matusko, Jon A. Jacobson, Pauline K. Park, Benjamin LeviAbstract:Morphomic studies have demonstrated a correlation between sarcopenia and clinical outcomes in septic patients. However, tendon morphomics has not yet been studied in this context. The purpose of the present study was to evaluate tendon morphology in septic patients through analytic morphomics. We hypothesized that morphomic analyses would reveal concomitant muscle and tendon wasting in sepsis patients. The results of this study may help to implement different rehabilitation modalities for critically ill patients. The volume and fat content of bilateral Psoas Muscles and tendons were measured on abdominal computed tomography scans of 25 ICU septic and 25 control trauma patients admitted to the University of Michigan between 2011 and 2012. Univariate and multivariate analyses were performed to determine the relationship between Psoas muscle and tendon morphometric data, and the association with clinical variables such as smoking and comorbidities. Average Psoas muscle volume was 12.21 ± 5.6 cm3 for control patients and 9.318 ± 3.3 cm3 in septic patients (P = 0.0023). The average Psoas muscle/fat ratio for septic patients was 0.0288 ± 0.071 cm3, compared with 0.0107 ± 0.008 cm3 in the control group (P = 0.075). Average tendon volume in the septic population (0.508 ± 0.191 cm3) was not different than the control cohort (0.493 ± 0.182 cm3) (P = 0.692). Our results demonstrate significantly smaller Psoas muscle volume in septic patients than in age-, gender-, and BMI-matched trauma patients but no demonstrable change in tendon morphology between patient groups. These findings begin to define the boundaries of clinical application within the field of morphomics. Copyright © 2018 Elsevier Inc. All rights reserved.
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temporalis muscle morphomics the Psoas of the craniofacial skeleton
Journal of Surgical Research, 2014Co-Authors: Kavitha Ranganathan, Michael N Terjimanian, Jeffrey Lisiecki, Jacob Rinkinen, Anudeep Mukkamala, Cameron Brownley, Stewart C Wang, Steven R. Buchman, Benjamin LeviAbstract:Abstract Background The Psoas muscle has been shown to predict patient outcomes based on the quantification of muscle area using computed tomography (CT) scans. The accuracy of morphomic analysis on other Muscles has not been clearly delineated. In this study, we determine the correlation between temporalis muscle mass, Psoas muscle area, age, body mass index (BMI), and gender. Methods Temporalis and Psoas muscle dimensions were determined on all trauma patients who had both abdominal and maxillofacial CT scans at the University of Michigan between 2004 and 2011. Age, BMI, and gender were obtained through chart review. Univariate and multivariate analyses were performed to determine the relative relationship between morphomic data of the temporalis and Psoas Muscles and the ability of such information to correspond with clinical variables, such as BMI, age, and gender. Results A total of 646 patients were included in the present study. Among the 249 (38.5%) women and 397 (61.5%) men, the average age was 49.2 y. Average BMI was 27.9 kg/m². Total Psoas muscle area directly correlated with mean temporalis muscle thickness ( r = 0.57, P r = −0.52, P r = −0.36, P r = 0.18, P r = 0.14, P = 0.002), although stronger correlations were found in a more “frail,” subgroup as defined by a BMI of r = 0.59, P = 0.002). Conclusions We demonstrate that dimensions of the temporalis muscle can be quantified and may serve as a proxy for age. Going forward, we aim to assess the utility of temporalis and Psoas morphomics in predicting complication rates among trauma patients admitted to the hospital to predict outcomes in the future.
Guy Molenaers - One of the best experts on this subject based on the ideXlab platform.
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Botulinum toxin type A injections in the Psoas muscle of children with cerebral palsy: muscle atrophy after motor end plate-targeted injections.
Research in developmental disabilities, 2013Co-Authors: Anja Van Campenhout, Ann Verhaegen, Steven Pans, Guy MolenaersAbstract:MEP targeting during BoNT-A injections has been demonstrated to improve outcome. Two injection techniques of the Psoas muscle - proximal MEP targeting versus a widely used more distal injection technique - are compared using muscle volume assessment by digital MRI segmentation as outcome measure. 7 spastic diplegic children received injections in both Psoas Muscles: two different injection techniques randomly in 5 patients, in 2 patients bilateral MEP targeting. MRI images of the Psoas were taken before, after 2 months and in 3 patients after 6 months. Average post injection volume (in relation to pre-injection volume) for the MEP targeted Muscles (9) is 79.5% versus 107.8% in the 5 distal injected Psoas Muscles (p=0.0033). In all 5 asymmetric injected patients the MEP targeted Psoas had a larger volume reduction than the more distal injected Psoas muscle. This atrophy remains even 6 months after the injection. This is the first study were a longitudinal follow-up by MRI demonstrates muscle atrophy after BoNT-A in children with CP. Injections in the MEP zone of the muscle, which is the more proximal part of the Psoas muscle, cause atrophy in contrary to more distal injections were this atrophy is not observed. Copyright © 2012 Elsevier Ltd. All rights reserved.
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Localization of motor nerve branches of the human Psoas muscle
Muscle & nerve, 2010Co-Authors: Anja Van Campenhout, Guy Hubens, Katrien Fagard, Guy MolenaersAbstract:Endplate-targeted botulinum toxin injections can achieve optimal neuromuscular blockade. The goal of this study was to identify the motor endplate (MEP) zone in the human Psoas muscle through dissection. In 24 human cadaver Psoas Muscles the nerve branches and their intramuscular course were followed by stereoscopic microscopic dissection as far as their terminal ramifications. From the lumbar plexus, an average of 3.7 (range 2-7) nerve branches enter the Psoas muscle. The proximal and distal limit of the MEP-zone are situated at about 30% and 70%, respectively, of the distance between the twelfth thoracic vertebra (Th12) and the passing of the Psoas under the inguinal ligament. In reference to the sacral promontory (P), these limits are respectively from 50% of the Th12-P distance to 20% of the P-pubis distance. This study of the MEP zone of the human Psoas muscle can allow the clinician to inject BTX-A close to its site of action.
Francisco Cervantes - One of the best experts on this subject based on the ideXlab platform.
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successful treatment by selective arterial embolization of severe retroperitoneal hemorrhage secondary to bone marrow biopsy in post polycythemic myelofibrosis
Annals of Hematology, 2004Co-Authors: Eduardo Arellanorodrigo, M I Real, Ana Muntanola, M Burrel, Maria Rozman, G V Fraire, Francisco CervantesAbstract:Severe retroperitoneal hemorrhage represents an infrequent and serious complication of bone marrow biopsy. A 53-year-old man, diagnosed with polycythemia vera 12 years earlier, was submitted to a bone marrow biopsy due to the appearance of anemia with clinical and hematological features suggesting myelofibrotic transformation, a diagnosis that was confirmed by the marrow study. At 2 h of a right anterior iliac bone marrow trephine biopsy, the patient suddenly developed severe pain in the area of the biopsy, with antialgic flexion of the right leg. Computed tomographic (CT) scan of the abdomen showed a 5 x 9.5 cm hematoma in the right iliac and Psoas Muscles. The patient was initially managed with analgesics and transfusional support, but the pain persisted and a continuous fall in the hematocrit was observed in the following days. Angiographic examination of the right external iliac artery showed contrast extravasation arising from the circumflex iliac branch, which was embolized using polivinyl alcohol particles and one coil. Following such procedure, the patient recovered uneventfully and was discharged in good condition a few days later. This case illustrates the effectiveness of an endovascular approach in providing a fast and minimally invasive treatment for this life-threatening complication of bone marrow trephine biopsy.
Anja Van Campenhout - One of the best experts on this subject based on the ideXlab platform.
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Botulinum toxin type A injections in the Psoas muscle of children with cerebral palsy: muscle atrophy after motor end plate-targeted injections.
Research in developmental disabilities, 2013Co-Authors: Anja Van Campenhout, Ann Verhaegen, Steven Pans, Guy MolenaersAbstract:MEP targeting during BoNT-A injections has been demonstrated to improve outcome. Two injection techniques of the Psoas muscle - proximal MEP targeting versus a widely used more distal injection technique - are compared using muscle volume assessment by digital MRI segmentation as outcome measure. 7 spastic diplegic children received injections in both Psoas Muscles: two different injection techniques randomly in 5 patients, in 2 patients bilateral MEP targeting. MRI images of the Psoas were taken before, after 2 months and in 3 patients after 6 months. Average post injection volume (in relation to pre-injection volume) for the MEP targeted Muscles (9) is 79.5% versus 107.8% in the 5 distal injected Psoas Muscles (p=0.0033). In all 5 asymmetric injected patients the MEP targeted Psoas had a larger volume reduction than the more distal injected Psoas muscle. This atrophy remains even 6 months after the injection. This is the first study were a longitudinal follow-up by MRI demonstrates muscle atrophy after BoNT-A in children with CP. Injections in the MEP zone of the muscle, which is the more proximal part of the Psoas muscle, cause atrophy in contrary to more distal injections were this atrophy is not observed. Copyright © 2012 Elsevier Ltd. All rights reserved.
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Localization of motor nerve branches of the human Psoas muscle
Muscle & nerve, 2010Co-Authors: Anja Van Campenhout, Guy Hubens, Katrien Fagard, Guy MolenaersAbstract:Endplate-targeted botulinum toxin injections can achieve optimal neuromuscular blockade. The goal of this study was to identify the motor endplate (MEP) zone in the human Psoas muscle through dissection. In 24 human cadaver Psoas Muscles the nerve branches and their intramuscular course were followed by stereoscopic microscopic dissection as far as their terminal ramifications. From the lumbar plexus, an average of 3.7 (range 2-7) nerve branches enter the Psoas muscle. The proximal and distal limit of the MEP-zone are situated at about 30% and 70%, respectively, of the distance between the twelfth thoracic vertebra (Th12) and the passing of the Psoas under the inguinal ligament. In reference to the sacral promontory (P), these limits are respectively from 50% of the Th12-P distance to 20% of the P-pubis distance. This study of the MEP zone of the human Psoas muscle can allow the clinician to inject BTX-A close to its site of action.
Egon Burian - One of the best experts on this subject based on the ideXlab platform.
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Regional Variation in Paraspinal Muscle Composition Using Chemical Shift Encoding-Based Water-Fat MRI
Quantitative imaging in medicine and surgery, 2020Co-Authors: Nico Sollmann, Agnes Zoffl, Daniela Franz, Jan Syväri, Michael Dieckmeyer, Egon Burian, Elisabeth Klupp, Dennis M. Hedderich, Christina Holzapfel, Theresa DrabschAbstract:Background: Paraspinal musculature forms one of the largest muscle compartments of the human body, but evidence for regional variation of its composition and dependency on gender or body mass index (BMI) is scarce. Methods: This study applied six-echo chemical shift encoding-based water-fat magnetic resonance imaging (MRI) at 3 Tesla in 76 subjects (24 males and 52 females, age: 40.0±13.7 years, BMI: 25.4±5.6 kg/m2) to evaluate the proton density fat fraction (PDFF) of Psoas Muscles and erector spinae Muscles, with the latter being divided into three segments in relation to levels of spine anatomy (L3-L5, T12-L2, and T9-T11). Results: For the Psoas Muscles and the erector spinae Muscles (L3-L5), gender differences in PDFF values were observed (PDFF Psoas Muscles: males: 5.1%±3.4% vs. females: 6.0%±2.2%, P=0.006; PDFF erector spinae Muscles L3-L5: males: 10.7%±7.6% vs. females: 18.2%±6.8%, P
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Lumbar muscle and vertebral bodies segmentation of chemical shift encoding-based water-fat MRI: the reference database MyoSegmenTUM spine
BMC, 2019Co-Authors: Egon Burian, Jan Syväri, Michael Dieckmeyer, Elisabeth Klupp, Alexander Rohrmeier, Sarah Schlaeger, Maximilian N. Diefenbach, Dominik Weidlich, Claus Zimmer, Ernst J. RummenyAbstract:Abstract Background Magnetic resonance imaging (MRI) is the modality of choice for diagnosing and monitoring muscular tissue pathologies and bone marrow alterations in the context of lower back pain, neuromuscular diseases and osteoporosis. Chemical shift encoding-based water-fat MRI allows for reliable determination of proton density fat fraction (PDFF) of the muscle and bone marrow. Prior to quantitative data extraction, segmentation of the examined structures is needed. Performed manually, the segmentation process is time consuming and therefore limiting the clinical applicability. Thus, the development of automated segmentation algorithms is an ongoing research focus. Construction and content This database provides ground truth data which may help to develop and test automatic lumbar muscle and vertebra segmentation algorithms. Lumbar muscle groups and vertebral bodies (L1 to L5) were manually segmented in chemical shift encoding-based water-fat MRI and made publically available in the database MyoSegmenTUM. The database consists of water, fat and PDFF images with corresponding segmentation masks for lumbar muscle groups (right/left erector spinae and Psoas Muscles, respectively) and lumbar vertebral bodies 1–5 of 54 healthy Caucasian subjects. The database is freely accessible online at https://osf.io/3j54b/?view_only=f5089274d4a449cda2fef1d2df0ecc56. Conclusion A development and testing of segmentation algorithms based on this database may allow the use of quantitative MRI in clinical routine
