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Hans Mørch Jensen - One of the best experts on this subject based on the ideXlab platform.
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Case Report Persistent Genital Arousal Disorder: Confluent Patient History of Agitated Depression, Paroxetine Cessation, and a Tarlov Cyst
2016Co-Authors: Simone Eibye, Hans Mørch JensenAbstract:License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We report a case of a woman suffering from persistent genital arousal disorder (PGAD) after paroxetine cessation. She was admitted to a Psychiatric Department and diagnosed with agitated depression. Physical investigation showed no gynaecological or neurological explanation; however, a pelvic MRI scan revealed a Tarlov cyst. Size and placement of the cyst could not explain the patient’s symptoms; thus neurosurgical approach would not be helpful. Her depression was treated with antidepressant with little effect. Electroconvulsive therapy improved the patient’s symptoms though they did not fully resolve. More awareness of PGAD and thorough interdisciplinary conferences are necessary to insure an unequivocal treatment strategy. 1. Background Persistent genital arousal disorder (PGAD) is a rare disease. Only a few case reports have been published [1–4] and no prevalence has been reported yet. It is often women who suffer from the symptoms of PGAD; however, the diagnosis is not gender-specific.The symptoms of PGAD are as follows [5]
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Persistent genital arousal disorder: confluent patient history of agitated depression, paroxetine cessation, and a tarlov cyst.
Case reports in psychiatry, 2014Co-Authors: Simone Eibye, Hans Mørch JensenAbstract:We report a case of a woman suffering from persistent genital arousal disorder (PGAD) after paroxetine cessation. She was admitted to a Psychiatric Department and diagnosed with agitated depression. Physical investigation showed no gynaecological or neurological explanation; however, a pelvic MRI scan revealed a Tarlov cyst. Size and placement of the cyst could not explain the patient's symptoms; thus neurosurgical approach would not be helpful. Her depression was treated with antidepressant with little effect. Electroconvulsive therapy improved the patient's symptoms though they did not fully resolve. More awareness of PGAD and thorough interdisciplinary conferences are necessary to insure an unequivocal treatment strategy.
Stefan K Bohlander - One of the best experts on this subject based on the ideXlab platform.
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association of jacobsen syndrome and bipolar affective disorder in a patient with a de novo 11q terminal deletion
American Journal of Medical Genetics Part A, 2006Co-Authors: Detlef Bohm, K Hoffmann, Franco Laccone, Bernd Wilken, Peter Dechent, Jens Frahm, I Bartels, Stefan K BohlanderAbstract:We report on a young woman with Jacobsen syndrome (JBS) who was admitted to our Psychiatric Department because of a bipolar affective disorder (BPAD). Chromosome analysis was performed due to the fact that she had mental retardation, short stature, and subtle facial anomalies. A deletion of the distal long arm of chromosome 11 was found. A detailed mapping of the deletion breakpoint by quantitative real time PCR revealed a true terminal 11q deletion of approximately 8 Mb corresponding to the karyotype 46,XX,del(11)(q24.2). Polymorphic DNA marker analysis showed that the deletion is located on the paternal chromosome. Additionally, laboratory investigations revealed a low platelet count and magnetic resonance imaging of the brain showed white matter T2 hyperintensities in frontotemporal regions, which are unlikely to result from a demyelinating process as indicated by localized proton magnetic resonance spectroscopy. To our knowledge, this is the first report describing a BPAD in a case with JBS.
Simone Eibye - One of the best experts on this subject based on the ideXlab platform.
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Case Report Persistent Genital Arousal Disorder: Confluent Patient History of Agitated Depression, Paroxetine Cessation, and a Tarlov Cyst
2016Co-Authors: Simone Eibye, Hans Mørch JensenAbstract:License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We report a case of a woman suffering from persistent genital arousal disorder (PGAD) after paroxetine cessation. She was admitted to a Psychiatric Department and diagnosed with agitated depression. Physical investigation showed no gynaecological or neurological explanation; however, a pelvic MRI scan revealed a Tarlov cyst. Size and placement of the cyst could not explain the patient’s symptoms; thus neurosurgical approach would not be helpful. Her depression was treated with antidepressant with little effect. Electroconvulsive therapy improved the patient’s symptoms though they did not fully resolve. More awareness of PGAD and thorough interdisciplinary conferences are necessary to insure an unequivocal treatment strategy. 1. Background Persistent genital arousal disorder (PGAD) is a rare disease. Only a few case reports have been published [1–4] and no prevalence has been reported yet. It is often women who suffer from the symptoms of PGAD; however, the diagnosis is not gender-specific.The symptoms of PGAD are as follows [5]
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Persistent genital arousal disorder: confluent patient history of agitated depression, paroxetine cessation, and a tarlov cyst.
Case reports in psychiatry, 2014Co-Authors: Simone Eibye, Hans Mørch JensenAbstract:We report a case of a woman suffering from persistent genital arousal disorder (PGAD) after paroxetine cessation. She was admitted to a Psychiatric Department and diagnosed with agitated depression. Physical investigation showed no gynaecological or neurological explanation; however, a pelvic MRI scan revealed a Tarlov cyst. Size and placement of the cyst could not explain the patient's symptoms; thus neurosurgical approach would not be helpful. Her depression was treated with antidepressant with little effect. Electroconvulsive therapy improved the patient's symptoms though they did not fully resolve. More awareness of PGAD and thorough interdisciplinary conferences are necessary to insure an unequivocal treatment strategy.
Kim Juul Larsen - One of the best experts on this subject based on the ideXlab platform.
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young people s risk of suicide attempts after contact with a Psychiatric Department a nested case control design using danish register data
Journal of Child Psychology and Psychiatry, 2012Co-Authors: Erik Christiansen, Kim Juul LarsenAbstract:Background: There seems to be an increased risk of children and adolescents committing or attempting suicide after contact with a Psychiatric Department. Children and adolescents living in families with low socio-economic status (SES) might have an especially increased suicide attempt risk. Methods: A complete extraction of Danish register data for every individual born in the period 1983–1989 was made. Of these 403,431 individuals, 3,465 had attempted suicide. In order to control for confounder effects from gender, age and calendar-time, a nested case–control study was designed. A total population of 72,765 individuals was used to analyze the risk of suicide attempts after contact with a Psychiatric Department. The case–control data were analyzed using conditional logistic regression. Results: This study shows that a child/adolescent’s risk of suicide attempt peaks immediately after discharge from last contact with a Psychiatric Department. The risk of suicide attempt is highest for children and adolescents suffering from personality disorders, depression and substance use disorders. Children and adolescents with previous contact with a Psychiatric Department and parental income in the lowest third have a significantly higher risk of suicide attempt. Suicide attempters were more likely to have been given several different diagnoses and several different psychopharmacological drugs prior to their attempted suicide. Conclusions: The findings in this study highlight the need for psychopathology assessment in every case of attempted suicide. This study also shows that well-known risk factors such as contact with a Psychiatric Department do not affect all individuals in the same way. Individuals from families with low SES had the highest risk. This suggests that the presence of factors influencing both vulnerability and resiliency, e.g., family level of SES, needs to be included in the assessment.
Peter Lange - One of the best experts on this subject based on the ideXlab platform.
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clinical course of illness in women with early onset puerperal psychosis a 12 year follow up study
The Journal of Clinical Psychiatry, 2014Co-Authors: Hanspeter Kapfhammer, Eva Z Reininghaus, Werner Fitz, Peter LangeAbstract:Objective To complete a follow-up analysis at a mean of 12 years after patients had presented with an early onset puerperal psychotic index episode. Method A retrospective design was used. Patients with puerperal psychosis and onset within 4 weeks after childbirth who had been referred to the Psychiatric Department of the Ludwig Maximilian University of Munich, Munich, Germany, between 1975 and 1995 (maximum: 24 years, minimum: 7 years) were followed up after a mean of 12 years post index episode. Ninety patients were included in the study. Before the index episode, 35 of the patients had previous nonpuerperal psychoses, while 55 patients presented their index episode as the first manifestation of a psychotic illness. Diagnostic evaluation at follow-up was performed by the Structured Clinical Interview for DSM-IV Axis I Disorders according to DSM-IV-TR. Differential rates of risk of psychotic relapse were calculated. Data on some gynecologic variables (postpartum blues, premenstrual tension, Psychiatric symptoms triggered perimenstrually, mood symptoms while taking oral contraceptives) were collected. Clinical and psychosocial outcomes were measured by the Global Assessment Scale and Disability Assessment Scale. Results Patients who presented with major depression and bipolar affective disorder with psychotic features at the initial index episode showed overall diagnostic stability. Many patients with initial brief psychosis (cycloid psychosis) shifted to a clear bipolar affective disorder. The general risk of a psychotic relapse was high (previous psychosis = 0.77 vs first psychotic manifestation = 0.56; not significant). The risk after further pregnancies was 0.57 versus 0.48, respectively (not significant), and the risk regarding at least 1 other psychotic nonindex episode was 0.71 versus 0.44, respectively (P = .015). Gynecologic variables did not significantly discriminate between the groups. In some patients, a possible link to a hormonal susceptibility was discussed. Patients who remained without any further psychotic relapse (n = 24) had a favorable outcome. Conclusions Puerperal psychosis of an early onset seemed to be of a prevailing affective nature. Brief psychosis (cycloid psychosis) during a puerperal index episode showed a strong link to bipolar affective disorder in the further course of illness. Outcome was excellent in patients without a further psychotic relapse.
