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D J Clarke - One of the best experts on this subject based on the ideXlab platform.
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the phenomenology and diagnosis of Psychiatric Illness in people with prader willi syndrome
Psychological Medicine, 2008Co-Authors: S Soni, H Boer, Joyce Whittington, Anthony J Holland, T Webb, Esther N Maina, D J ClarkeAbstract:Background. Psychotic Illness is strongly associated with the maternal uniparental disomy (mUPD) genetic subtype of Prader-Willi syndrome (PWS), but not the deletion subtype (delPWS). This study investigates the clinical features of Psychiatric Illness associated with PWS. We consider possible genetic and other mechanisms that may be responsible for the development of psychotic Illness, predominantly in those with mUPD. Method. The study sample comprised 119 individuals with genetically confirmed PWS, of whom 46 had a history of Psychiatric Illness. A detailed clinical and family Psychiatric history was obtained from these 46 using the PAS-ADD, OPCRIT, Family History and Life Events Questionnaires. Results. Individuals with mUPD had a higher rate of Psychiatric Illness than those with delPWS (22/34 v. 24/85, p<0.001). The profile of Psychiatric Illness in both genetic subtypes resembled an atypical affective disorder with or without psychotic symptoms. Those with delPWS were more likely to have developed a non-psychotic depressive Illness (p=0.005) and those with mUPD a bipolar disorder with psychotic symptoms (p=0.00005). Individuals with delPWS and psychotic Illness had an increased family history of affective disorder. This was confined exclusively to their mothers. Conclusions. Psychiatric Illness in PWS is predominately affective with atypical features. The prevalence and possibly the severity of Illness are greater in those with mUPD. We present a 'two-hit' hypothesis, involving imprinted genes on chromosome 15, for the development of affective psychosis in people with PWS, regardless of genetic subtype.
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The phenomenology and diagnosis of Psychiatric Illness in people with Prader-Willi syndrome.
Psychological medicine, 2008Co-Authors: S Soni, H Boer, Joyce Whittington, Anthony J Holland, T Webb, Esther N Maina, D J ClarkeAbstract:Background. Psychotic Illness is strongly associated with the maternal uniparental disomy (mUPD) genetic subtype of Prader-Willi syndrome (PWS), but not the deletion subtype (delPWS). This study investigates the clinical features of Psychiatric Illness associated with PWS. We consider possible genetic and other mechanisms that may be responsible for the development of psychotic Illness, predominantly in those with mUPD. Method. The study sample comprised 119 individuals with genetically confirmed PWS, of whom 46 had a history of Psychiatric Illness. A detailed clinical and family Psychiatric history was obtained from these 46 using the PAS-ADD, OPCRIT, Family History and Life Events Questionnaires. Results. Individuals with mUPD had a higher rate of Psychiatric Illness than those with delPWS (22/34 v. 24/85, p
H Boer - One of the best experts on this subject based on the ideXlab platform.
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Psychiatric Illness in a cohort of adults with Prader-Willi syndrome
Research in developmental disabilities, 2011Co-Authors: Margje Sinnema, H Boer, Philippe Collin, Marian A. Maaskant, Kees E. P. Van Roozendaal, Constance T.r.m. Schrander-stumpel, Leopold M.g. CurfsAbstract:Previous studies have suggested an association between PWS and comorbid Psychiatric Illness. Data on prevalence rates of psychopathology is still scarce. This paper describes a large-scale, systematic study investigating the prevalence of Psychiatric Illness in a Dutch adult PWS cohort. One hundred and two individuals were screened for Psychiatric Illness. Case vignettes were written by the first author on 63 individuals with a positive screening on psychopathology according to the interviews, medical history, medication use and behavioural questionnaires. These case vignettes were rated by two psychiatrists specializing in intellectual disability (ID). Psychopathology was divided into four diagnostic categories: bipolar disorder with psychotic symptoms, psychotic Illness, depressive Illness with psychotic symptoms and depressive Illness without psychotic symptoms. Nine out of 53 persons (17%) with a 15q11-13 deletion and 28 out of 44 (64%) persons with maternal uniparental disomy (mUPD) were diagnosed with a current or previous Psychiatric Illness. Depressive Illness with psychotic symptoms was the cause of Psychiatric problems in the majority of persons with PWS due to deletion (56%). In the case of mUPD, almost all individuals with histories of psychopathology suffered from psychotic symptoms (85%) with or without affective component. Psychiatric examination should be part of general management of adults with PWS, especially when caused by mUPD. More attention should be paid to the presence of precursor symptoms, indicating a developing Psychiatric episode. Longitudinal studies are needed to gain more insight into the natural history of Psychiatric Illness in adults with PWS.
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the phenomenology and diagnosis of Psychiatric Illness in people with prader willi syndrome
Psychological Medicine, 2008Co-Authors: S Soni, H Boer, Joyce Whittington, Anthony J Holland, T Webb, Esther N Maina, D J ClarkeAbstract:Background. Psychotic Illness is strongly associated with the maternal uniparental disomy (mUPD) genetic subtype of Prader-Willi syndrome (PWS), but not the deletion subtype (delPWS). This study investigates the clinical features of Psychiatric Illness associated with PWS. We consider possible genetic and other mechanisms that may be responsible for the development of psychotic Illness, predominantly in those with mUPD. Method. The study sample comprised 119 individuals with genetically confirmed PWS, of whom 46 had a history of Psychiatric Illness. A detailed clinical and family Psychiatric history was obtained from these 46 using the PAS-ADD, OPCRIT, Family History and Life Events Questionnaires. Results. Individuals with mUPD had a higher rate of Psychiatric Illness than those with delPWS (22/34 v. 24/85, p<0.001). The profile of Psychiatric Illness in both genetic subtypes resembled an atypical affective disorder with or without psychotic symptoms. Those with delPWS were more likely to have developed a non-psychotic depressive Illness (p=0.005) and those with mUPD a bipolar disorder with psychotic symptoms (p=0.00005). Individuals with delPWS and psychotic Illness had an increased family history of affective disorder. This was confined exclusively to their mothers. Conclusions. Psychiatric Illness in PWS is predominately affective with atypical features. The prevalence and possibly the severity of Illness are greater in those with mUPD. We present a 'two-hit' hypothesis, involving imprinted genes on chromosome 15, for the development of affective psychosis in people with PWS, regardless of genetic subtype.
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The phenomenology and diagnosis of Psychiatric Illness in people with Prader-Willi syndrome.
Psychological medicine, 2008Co-Authors: S Soni, H Boer, Joyce Whittington, Anthony J Holland, T Webb, Esther N Maina, D J ClarkeAbstract:Background. Psychotic Illness is strongly associated with the maternal uniparental disomy (mUPD) genetic subtype of Prader-Willi syndrome (PWS), but not the deletion subtype (delPWS). This study investigates the clinical features of Psychiatric Illness associated with PWS. We consider possible genetic and other mechanisms that may be responsible for the development of psychotic Illness, predominantly in those with mUPD. Method. The study sample comprised 119 individuals with genetically confirmed PWS, of whom 46 had a history of Psychiatric Illness. A detailed clinical and family Psychiatric history was obtained from these 46 using the PAS-ADD, OPCRIT, Family History and Life Events Questionnaires. Results. Individuals with mUPD had a higher rate of Psychiatric Illness than those with delPWS (22/34 v. 24/85, p
S Soni - One of the best experts on this subject based on the ideXlab platform.
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the phenomenology and diagnosis of Psychiatric Illness in people with prader willi syndrome
Psychological Medicine, 2008Co-Authors: S Soni, H Boer, Joyce Whittington, Anthony J Holland, T Webb, Esther N Maina, D J ClarkeAbstract:Background. Psychotic Illness is strongly associated with the maternal uniparental disomy (mUPD) genetic subtype of Prader-Willi syndrome (PWS), but not the deletion subtype (delPWS). This study investigates the clinical features of Psychiatric Illness associated with PWS. We consider possible genetic and other mechanisms that may be responsible for the development of psychotic Illness, predominantly in those with mUPD. Method. The study sample comprised 119 individuals with genetically confirmed PWS, of whom 46 had a history of Psychiatric Illness. A detailed clinical and family Psychiatric history was obtained from these 46 using the PAS-ADD, OPCRIT, Family History and Life Events Questionnaires. Results. Individuals with mUPD had a higher rate of Psychiatric Illness than those with delPWS (22/34 v. 24/85, p<0.001). The profile of Psychiatric Illness in both genetic subtypes resembled an atypical affective disorder with or without psychotic symptoms. Those with delPWS were more likely to have developed a non-psychotic depressive Illness (p=0.005) and those with mUPD a bipolar disorder with psychotic symptoms (p=0.00005). Individuals with delPWS and psychotic Illness had an increased family history of affective disorder. This was confined exclusively to their mothers. Conclusions. Psychiatric Illness in PWS is predominately affective with atypical features. The prevalence and possibly the severity of Illness are greater in those with mUPD. We present a 'two-hit' hypothesis, involving imprinted genes on chromosome 15, for the development of affective psychosis in people with PWS, regardless of genetic subtype.
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The phenomenology and diagnosis of Psychiatric Illness in people with Prader-Willi syndrome.
Psychological medicine, 2008Co-Authors: S Soni, H Boer, Joyce Whittington, Anthony J Holland, T Webb, Esther N Maina, D J ClarkeAbstract:Background. Psychotic Illness is strongly associated with the maternal uniparental disomy (mUPD) genetic subtype of Prader-Willi syndrome (PWS), but not the deletion subtype (delPWS). This study investigates the clinical features of Psychiatric Illness associated with PWS. We consider possible genetic and other mechanisms that may be responsible for the development of psychotic Illness, predominantly in those with mUPD. Method. The study sample comprised 119 individuals with genetically confirmed PWS, of whom 46 had a history of Psychiatric Illness. A detailed clinical and family Psychiatric history was obtained from these 46 using the PAS-ADD, OPCRIT, Family History and Life Events Questionnaires. Results. Individuals with mUPD had a higher rate of Psychiatric Illness than those with delPWS (22/34 v. 24/85, p
Shoumitro Deb - One of the best experts on this subject based on the ideXlab platform.
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Psychiatric Illness and mental retardation
Current Opinion in Psychiatry, 2000Co-Authors: Shoumitro Deb, Sian Nerys WestonAbstract:Psychiatric Illness in people with mental retardation has attracted increasing clinical and research interest over the past year. In recognition of this trend, the Journal of Intellectual Disability Research recently published special issues on mental health and intellectual disability. A number of
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rate of Psychiatric Illness 1 year after traumatic brain injury
American Journal of Psychiatry, 1999Co-Authors: Shoumitro Deb, Ita Lyons, Charis Koutzoukis, Imad Ali, G MccarthyAbstract:OBJECTIVE: Neurobehavioral symptoms are not uncommon after a traumatic brain injury. However, Psychiatric syndromes per se have rarely been studied in patients with such an injury. The purpose of this study was to evaluate the type and extent of Psychiatric syndromes in patients with traumatic brain injury. METHOD: One hundred ninety-six hospitalized adults were studied 1 year after a traumatic brain injury with the use of a two-stage Psychiatric diagnostic procedure. Psychiatric diagnoses were made according to ICD-10 criteria on the basis of data from the Schedules for Clinical Assessment in Neuropsychiatry interview. RESULTS: Of 164 patients interviewed, 30 (18.3%) had an ICD-10 diagnosis of a Psychiatric Illness. Among the 120 patients who were 18–64 years old, 21.7% had a Psychiatric Illness, compared with 16.4% in a study of the general population. A depressive Illness was present in 13.9% of the traumatic brain injury patients, compared with 2.1% of the general population, and panic disorder was pr...
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Psychopathology of people with mental handicap and epilepsy. II: Psychiatric Illness.
The British journal of psychiatry : the journal of mental science, 1991Co-Authors: Shoumitro Deb, David HunterAbstract:The prevalence of Psychiatric Illness was studied in 150 epileptic mentally handicapped people (both hospital in-patients and living in the community) and a matched group of 150 non-epileptic controls. The Profile of Abilities and Adjustment (PAA) scale was used for the initial screening of Psychiatric Illness. Mildly to moderately handicapped individuals who had good communication skills and scored positively on the PAA schedule for Psychiatric Illness were interviewed using the PSE interview schedule. Severely mentally handicapped individuals who scored positively on the PAA's Psychiatric Illness subscale were observed and information was gathered from their medical notes and carers. A Psychiatric diagnosis was made using DSM-III-R criteria. The non-epileptic group showed significantly more Psychiatric Illness than the epileptic group. Psychiatric Illness was diagnosed in 25% of the cohort.
Robert S Thompson - One of the best experts on this subject based on the ideXlab platform.
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Psychiatric Illness following traumatic brain injury in an adult health maintenance organization population
Archives of General Psychiatry, 2004Co-Authors: Jesse R Fann, Wayne Katon, Bart E Burington, Alexandra Leonetti, Kenneth M Jaffe, Robert S ThompsonAbstract:Background Psychiatric Illness after traumatic brain injury (TBI) has been shown to be prevalent in hospitalized and tertiary care patient populations. Objective To determine the risk of Psychiatric Illness after TBI in an adult health maintenance organization population. Design Prospective cohort study. Setting Large staff-model health maintenance organization. Participants Nine hundred thirty-nine health plan members diagnosed as having TBI in 1993 and enrolled in the prior year, during which no TBI was ascertained. Three health plan members per TBI-exposed subject were randomly selected as unexposed comparisons, matched for age, sex, and reference date. Main Outcome Measure Psychiatric Illness in the 3 years after the TBI reference date, determined using computerized records of Psychiatric diagnoses according to the International Classification of Diseases, Ninth Revision, Clinical Modification , prescriptions, and service utilization. Results Prevalence of any Psychiatric Illness in the first year was 49% following moderate to severe TBI, 34% following mild TBI, and 18% in the comparison group. Among subjects without Psychiatric Illness in the prior year, the adjusted relative risk for any Psychiatric Illness in the 6 months following moderate to severe TBI was 4.0 (95% confidence interval [CI], 2.4-6.8) and following mild TBI was 2.8 (95% CI, 2.1-3.7; P P = .005). Prior Psychiatric Illness significantly modified the relationship between TBI and subsequent Psychiatric Illness ( P = .04) and was a significant predictor ( P Conclusions Both moderate to severe and mild TBI are associated with an increased risk of subsequent Psychiatric Illness. Whereas moderate to severe TBI is associated with a higher initial risk, mild TBI may be associated with persistent Psychiatric Illness.
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Psychiatric Illness After Mild Traumatic Brain Injury in Children
Archives of physical medicine and rehabilitation, 2004Co-Authors: Teresa L. Massagli, Wayne Katon, Jesse R Fann, Bart E Burington, Kenneth M Jaffe, Robert S ThompsonAbstract:Abstract Massagli TL, Fann JR, Burington BE, Jaffe KM, Katon WJ, Thompson RS. Psychiatric Illness after mild traumatic brain injury in children. Arch Phys Med Rehabil 2004;85:1428–34. Objective To determine the incidence of Psychiatric Illness 3 years after mild traumatic brain injury (TBI) in children. Design Prospective cohort study with 3-year follow-up. Setting Emergency department, hospital, and outpatient clinics in a large health maintenance organization. Participants Children, 14 years old or less (n=490), who sustained a mild TBI in 1993. Three TBI unexposed subjects per TBI exposed patient were matched by sex, age, and enrollment at the time of injury (n=1470). Interventions Not applicable. Main outcome measures Computerized records were examined to identify Psychiatric diagnoses, Psychiatric medication prescription, and utilization of Psychiatric services for the year before TBI and 3 years after. Adjusted relative risks for incidence of Psychiatric Illness were estimated for those with and without a premorbid Psychiatric disorder. Results The cumulative incidence estimates for any Psychiatric Illness in the 3 years after mild TBI were 30% in children exposed to mild TBI and 20% in unexposed children ( P =.0001). Cumulative incidence estimates were particularly high in both TBI exposed (55%) and unexposed children (63%) who had Psychiatric Illness in the year before the index TBI (Psychiatric history). The exposed and unexposed children with Psychiatric history did not have significantly different estimates of incidence during follow-up for any of the studied indicators of Psychiatric Illness. In those with no Psychiatric history, 26% of exposed and 16% of unexposed children ( P Conclusions In the 3 years after mild TBI, children with no evidence of prior-year Psychiatric history were at significantly increased risk for Psychiatric Illness, particularly hyperactivity in the first year after injury. Prior-year Psychiatric history conferred a significant independent risk for subsequent Psychiatric Illness. There was no evidence for an additional increase in risk in the 3-year follow-up that is attributable to mild TBI in children with prior Psychiatric history.
