The Experts below are selected from a list of 236922 Experts worldwide ranked by ideXlab platform
Adalberto Merighi - One of the best experts on this subject based on the ideXlab platform.
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practical mechanical threshold estimation in rodents using von frey hairs semmes weinstein monofilaments towards a rational method
Journal of Neuroscience Methods, 2015Co-Authors: Matthew J.g. Bradman, Chiara Salio, Francesco Ferrini, Adalberto MerighiAbstract:Abstract Here, we reconsider the status quo in testing mechanical sensitivity with von Frey's hairs. The aim is to improve paw withdrawal estimates by integrating current psychometric theory, and to maximise the clinical relevance and statistical power of mechanosensory models. A wealth of research into human tactile stimulus perception may be extended to the quantification of laboratory animal behaviour. We start by reviewing each step of the test, from its design and application through to data analysis. Filament range is assessed as a whole; possible test designs are compared; techniques of filament application to mice and rats are considered; curve fitting software is introduced; possibilities for data pooling and curve fitting are evaluated. A rational update of classical methods in line with recent advances in Psychometrics and supported by open source software is expected to improve data homogeneity, and Reduce and Refine animal use in accord with the ‘3R’ principles.
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Practical mechanical threshold estimation in rodents using von Frey hairs/Semmes-Weinstein monofilaments: Towards a rational method
Journal of Neuroscience Methods, 2015Co-Authors: Matthew J.g. Bradman, Chiara Salio, Francesco Ferrini, Adalberto MerighiAbstract:Here, we reconsider the status quo in testing mechanical sensitivity with von Frey's hairs. The aim is to improve paw withdrawal estimates by integrating current psychometric theory, and to maximise the clinical relevance and statistical power of mechanosensory models. A wealth of research into human tactile stimulus perception may be extended to the quantification of laboratory animal behaviour. We start by reviewing each step of the test, from its design and application through to data analysis. Filament range is assessed as a whole possible test designs are compared; techniques of filament application to mice and rats are considered; curve fitting software is introduced; possibilities for data pooling and curve fitting are evaluated. A rational update of classical methods in line with recent advances in Psychometrics and supported by open source software is expected to improve data homogeneity, and Reduce and Refine animal use in accord with the '3R' principles.
Matthew J.g. Bradman - One of the best experts on this subject based on the ideXlab platform.
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practical mechanical threshold estimation in rodents using von frey hairs semmes weinstein monofilaments towards a rational method
Journal of Neuroscience Methods, 2015Co-Authors: Matthew J.g. Bradman, Chiara Salio, Francesco Ferrini, Adalberto MerighiAbstract:Abstract Here, we reconsider the status quo in testing mechanical sensitivity with von Frey's hairs. The aim is to improve paw withdrawal estimates by integrating current psychometric theory, and to maximise the clinical relevance and statistical power of mechanosensory models. A wealth of research into human tactile stimulus perception may be extended to the quantification of laboratory animal behaviour. We start by reviewing each step of the test, from its design and application through to data analysis. Filament range is assessed as a whole; possible test designs are compared; techniques of filament application to mice and rats are considered; curve fitting software is introduced; possibilities for data pooling and curve fitting are evaluated. A rational update of classical methods in line with recent advances in Psychometrics and supported by open source software is expected to improve data homogeneity, and Reduce and Refine animal use in accord with the ‘3R’ principles.
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Practical mechanical threshold estimation in rodents using von Frey hairs/Semmes-Weinstein monofilaments: Towards a rational method
Journal of Neuroscience Methods, 2015Co-Authors: Matthew J.g. Bradman, Chiara Salio, Francesco Ferrini, Adalberto MerighiAbstract:Here, we reconsider the status quo in testing mechanical sensitivity with von Frey's hairs. The aim is to improve paw withdrawal estimates by integrating current psychometric theory, and to maximise the clinical relevance and statistical power of mechanosensory models. A wealth of research into human tactile stimulus perception may be extended to the quantification of laboratory animal behaviour. We start by reviewing each step of the test, from its design and application through to data analysis. Filament range is assessed as a whole possible test designs are compared; techniques of filament application to mice and rats are considered; curve fitting software is introduced; possibilities for data pooling and curve fitting are evaluated. A rational update of classical methods in line with recent advances in Psychometrics and supported by open source software is expected to improve data homogeneity, and Reduce and Refine animal use in accord with the '3R' principles.
Chiara Salio - One of the best experts on this subject based on the ideXlab platform.
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practical mechanical threshold estimation in rodents using von frey hairs semmes weinstein monofilaments towards a rational method
Journal of Neuroscience Methods, 2015Co-Authors: Matthew J.g. Bradman, Chiara Salio, Francesco Ferrini, Adalberto MerighiAbstract:Abstract Here, we reconsider the status quo in testing mechanical sensitivity with von Frey's hairs. The aim is to improve paw withdrawal estimates by integrating current psychometric theory, and to maximise the clinical relevance and statistical power of mechanosensory models. A wealth of research into human tactile stimulus perception may be extended to the quantification of laboratory animal behaviour. We start by reviewing each step of the test, from its design and application through to data analysis. Filament range is assessed as a whole; possible test designs are compared; techniques of filament application to mice and rats are considered; curve fitting software is introduced; possibilities for data pooling and curve fitting are evaluated. A rational update of classical methods in line with recent advances in Psychometrics and supported by open source software is expected to improve data homogeneity, and Reduce and Refine animal use in accord with the ‘3R’ principles.
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Practical mechanical threshold estimation in rodents using von Frey hairs/Semmes-Weinstein monofilaments: Towards a rational method
Journal of Neuroscience Methods, 2015Co-Authors: Matthew J.g. Bradman, Chiara Salio, Francesco Ferrini, Adalberto MerighiAbstract:Here, we reconsider the status quo in testing mechanical sensitivity with von Frey's hairs. The aim is to improve paw withdrawal estimates by integrating current psychometric theory, and to maximise the clinical relevance and statistical power of mechanosensory models. A wealth of research into human tactile stimulus perception may be extended to the quantification of laboratory animal behaviour. We start by reviewing each step of the test, from its design and application through to data analysis. Filament range is assessed as a whole possible test designs are compared; techniques of filament application to mice and rats are considered; curve fitting software is introduced; possibilities for data pooling and curve fitting are evaluated. A rational update of classical methods in line with recent advances in Psychometrics and supported by open source software is expected to improve data homogeneity, and Reduce and Refine animal use in accord with the '3R' principles.
Francesco Ferrini - One of the best experts on this subject based on the ideXlab platform.
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practical mechanical threshold estimation in rodents using von frey hairs semmes weinstein monofilaments towards a rational method
Journal of Neuroscience Methods, 2015Co-Authors: Matthew J.g. Bradman, Chiara Salio, Francesco Ferrini, Adalberto MerighiAbstract:Abstract Here, we reconsider the status quo in testing mechanical sensitivity with von Frey's hairs. The aim is to improve paw withdrawal estimates by integrating current psychometric theory, and to maximise the clinical relevance and statistical power of mechanosensory models. A wealth of research into human tactile stimulus perception may be extended to the quantification of laboratory animal behaviour. We start by reviewing each step of the test, from its design and application through to data analysis. Filament range is assessed as a whole; possible test designs are compared; techniques of filament application to mice and rats are considered; curve fitting software is introduced; possibilities for data pooling and curve fitting are evaluated. A rational update of classical methods in line with recent advances in Psychometrics and supported by open source software is expected to improve data homogeneity, and Reduce and Refine animal use in accord with the ‘3R’ principles.
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Practical mechanical threshold estimation in rodents using von Frey hairs/Semmes-Weinstein monofilaments: Towards a rational method
Journal of Neuroscience Methods, 2015Co-Authors: Matthew J.g. Bradman, Chiara Salio, Francesco Ferrini, Adalberto MerighiAbstract:Here, we reconsider the status quo in testing mechanical sensitivity with von Frey's hairs. The aim is to improve paw withdrawal estimates by integrating current psychometric theory, and to maximise the clinical relevance and statistical power of mechanosensory models. A wealth of research into human tactile stimulus perception may be extended to the quantification of laboratory animal behaviour. We start by reviewing each step of the test, from its design and application through to data analysis. Filament range is assessed as a whole possible test designs are compared; techniques of filament application to mice and rats are considered; curve fitting software is introduced; possibilities for data pooling and curve fitting are evaluated. A rational update of classical methods in line with recent advances in Psychometrics and supported by open source software is expected to improve data homogeneity, and Reduce and Refine animal use in accord with the '3R' principles.
Alan J. Budney - One of the best experts on this subject based on the ideXlab platform.
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The Cannabis Withdrawal Scale development: Patterns and predictors of cannabis withdrawal and distress
Drug and Alcohol Dependence, 2011Co-Authors: David J. Allsop, Melissa M. Norberg, Shanlin Fu, Jan Copeland, Alan J. BudneyAbstract:Background: Rates of treatment seeking for cannabis are increasing, and relapse is common. Management of cannabis withdrawal is an important intervention point. No psychometrically sound measure for cannabis withdrawal exists, and as a result treatment developments cannot be optimally targeted. The aim is to develop and test the Psychometrics of the Cannabis Withdrawal Scale and use it to explore predictors of cannabis withdrawal. Methods: A volunteer sample of 49 dependent cannabis users provided daily scores on the Cannabis Withdrawal Scale during a baseline week and 2 weeks of abstinence. Results: Internal reliability (Cronbach's alpha=0.91), test-retest stability (average intra-class correlation=0.95) and content validity analysis show that the Cannabis Withdrawal Scale has excellent psychometric properties. Nightmares and/or strange dreams was the most valid item (Wald χ2=105.6, P
