The Experts below are selected from a list of 4029 Experts worldwide ranked by ideXlab platform
Joshua A Gordon - One of the best experts on this subject based on the ideXlab platform.
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Once upon a spine: setting striatal dopamine
Nature Neuroscience, 2015Co-Authors: Christoph Kellendonk, Joshua A GordonAbstract:The prefrontal cortex is known to influence dopamine release in the striatum–but how? New data in mice suggest that cortical spine density affects striatal dopamine release via monosynaptic control of dopamine neurons, tracing a chain of events from spine loss to antipsychotic-responsive Psychomotor Agitation.
Christoph Kellendonk - One of the best experts on this subject based on the ideXlab platform.
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Once upon a spine: setting striatal dopamine
Nature Neuroscience, 2015Co-Authors: Christoph Kellendonk, Joshua A GordonAbstract:The prefrontal cortex is known to influence dopamine release in the striatum–but how? New data in mice suggest that cortical spine density affects striatal dopamine release via monosynaptic control of dopamine neurons, tracing a chain of events from spine loss to antipsychotic-responsive Psychomotor Agitation.
M Cristina D Colombo - One of the best experts on this subject based on the ideXlab platform.
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retrospective analysis of Psychomotor Agitation hypomanic symptoms and suicidal ideation in unipolar depression
Depression and Anxiety, 2006Co-Authors: M Paolo D Olgiati, M Alessandro D Serretti, M Cristina D ColomboAbstract:In bipolar depression, Psychomotor Agitation is relatively common and often is associated with other noneuphoric hypomanic symptoms and suicidal ideation. Our goal in this retrospective study was to ascertain the co-occurrence of Agitation, bipolar features, and suicidal ideation in unipolar disorder. We retrospectively evaluated 314 inpatients with DSM-IV major depressive disorder (MDD) and no other Axis I diagnosis with the National Institutes of Mental Health (NIMH) Life Chart Method and the Operational Criteria for Psychotic Illness (OPCRIT) checklist to ascertain their symptom profiles across all episodes. Univariate and multivariate comparisons were performed between the subgroups with and without Psychomotor Agitation (OPCRIT item 23> or =1). Agitated depression (AD, a major depressive episode with Psychomotor Agitation) was present in 19% of the sample. Compared to nonagitated counterparts, patients with AD were older and had lower educational levels and more dysphoria, insomnia, positive thought disorder, and psychotic manifestations. Hypomanic symptoms other than Agitation were relatively uncommon (<10%) and more represented in subjects with AD. No significant differences emerged between AD and control groups with respect to most bipolar validators (gender, familiarity, recurrence). Patients with AD had higher levels of suicidal ideation than non-AD controls; however, such a difference was no longer significant after controlling for psychotic features. Excessive self-reproach, early awakening, diurnal changes, poor appetite, and hypomanic symptoms were independently associated with suicidal thoughts in nonpsychotic MDD. Incomplete information on drug treatment, exclusion of patients with Axis I comorbidity, and tertiary care setting were the most important limitations of the study. Although we failed to support the bipolar nature of MDD-AD by common validators, probably because we used a more heterogeneous definition of Agitation compared to similar studies, our data confirm the association of Agitation with hypomanic symptoms and suicidal thoughts in major depression, and emphasize the complex phenomenology of AD in an inpatient setting.
Giovambattista De Sarro - One of the best experts on this subject based on the ideXlab platform.
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venlafaxine propafenone interaction resulting in hallucinations and Psychomotor Agitation
Annals of Pharmacotherapy, 2008Co-Authors: Pietro Gareri, Pasquale De Fazio, Luca Gallelli, Salvatore De Fazio, Alessandro Davoli, Giuseppe Seminara, Antonino Maria Cotroneo, Giovambattista De SarroAbstract:Objective:To report a case of visual hallucinations and Psychomotor Agitation probably induced by an interaction between venlafaxine and propafenone.Case Summary:An 85-year-old woman was admitted for evaluation of a mood disorder on March 20, 2006. Her general practitioner had prescribed sertraline for treatment, which had started about 6 months earlier. The patient's medical history included hypertension, supraventricular tachycardia, chronic bronchitis, and arthritis, for which she received ramipril, ticlopidine, torsemide, theophylline, acetaminophen, and triazolam. The patient had also received propafenone 150 mg every 12 hours for 3 years. Results of biochemical tests were normal; however, a computed tomography (CT) scan of the brain showed signs of cortical atrophy. Sertraline was discontinued after a few days because of its reduced effectiveness and was replaced with extended-re lease venlafaxine 75 mg/day. No other changes to the patient's drug therapy were made. Four weeks later, because of the p...
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Venlafaxine—Propafenone Interaction Resulting in Hallucinations and Psychomotor Agitation
Annals of Pharmacotherapy, 2008Co-Authors: Pietro Gareri, Pasquale De Fazio, Luca Gallelli, Salvatore De Fazio, Alessandro Davoli, Giuseppe Seminara, Antonino Maria Cotroneo, Giovambattista De SarroAbstract:Objective:To report a case of visual hallucinations and Psychomotor Agitation probably induced by an interaction between venlafaxine and propafenone.Case Summary:An 85-year-old woman was admitted for evaluation of a mood disorder on March 20, 2006. Her general practitioner had prescribed sertraline for treatment, which had started about 6 months earlier. The patient's medical history included hypertension, supraventricular tachycardia, chronic bronchitis, and arthritis, for which she received ramipril, ticlopidine, torsemide, theophylline, acetaminophen, and triazolam. The patient had also received propafenone 150 mg every 12 hours for 3 years. Results of biochemical tests were normal; however, a computed tomography (CT) scan of the brain showed signs of cortical atrophy. Sertraline was discontinued after a few days because of its reduced effectiveness and was replaced with extended-re lease venlafaxine 75 mg/day. No other changes to the patient's drug therapy were made. Four weeks later, because of the p...
Andrea Fagiolini - One of the best experts on this subject based on the ideXlab platform.
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Unmet Needs in the Assessment and Treatment of Psychomotor Agitation
New Directions in Psychiatry, 2020Co-Authors: Alessandro Cuomo, Simone Bolognesi, Arianna Goracci, D. Koukouna, Pier Francesco Laurenzi, Andrea FagioliniAbstract:Agitation is described as a state of excessive Psychomotor activity accompanied by increased tension and irritability. Agitation may be associated with psychiatric conditions, drug or alcohol withdrawal or intoxication, or several other medical conditions such as dementia, trauma, delirium, endocrine abnormalities, sepsis or infection, stroke, and many other illnesses, which need to be ruled out.
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p 1 k 034 Psychomotor Agitation in emergency medicine settings
European Neuropsychopharmacology, 2015Co-Authors: F Taranto, Simone Bolognesi, Arianna Goracci, V Zanobini, Andrea FagioliniAbstract:the SIGMA assessments (6.4%) would have triggered alerts and 44 raters (40%) would have seen at least one alert. Conclusion: The PANSS and the MADRS are significantly different instruments in terms of number of items and construct overlap, but the scoring accuracy of both may improve if incompatible item scores are flagged in real time. These and many other such interventions can reduce scoring errors that contribute to poor interrater reliability, which can compromise the ability to detect a positive signal. Neuropsychological test publishers have begun to utilize tablet PC platforms for test administration and scoring, enabling the inclusion of additional clinical guidance during administration as well as automated scoring. The adaptation of this technology to clinical trials has the potential to improve the quality of rater administration of subjective semi-structured scales such as the PANSS and the MADRS.