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Kristiina Moilanen - One of the best experts on this subject based on the ideXlab platform.
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a comparison of the cumulative incidence and early risk factors for psychotic disorder in young adults in the northern finland birth cohorts 1966 and 1986
Epidemiology and Psychiatric Sciences, 2017Co-Authors: Svetlana Filatova, Riikka Marttila, Heli Koivumaahonkanen, Tanja Nordstrom, Juha Veijola, Pirjo Maki, Gulam Khandaker, Matti Isohanni, Erika Jaaskelainen, Kristiina MoilanenAbstract:Aims. Few studies have compared time trends for the incidence of psychosis. To date, the results have been inconsistent, showing a decline, an increase or no significant change. As far as we know, no studies explored changes in prevalence of early risk factors. The aim of this study was to investigate differences in early risk factors and cumulative incidences of psychosis by type of psychosis in two comparable birth cohorts. Methods. The Northern Finland Birth cohorts (NFBCs) 1966 (N = 12 058) and 1986 (N = 9432) are prospective general population-based cohorts with the children followed since mother's mid-pregnancy. The data for Psychoses, i.e. schizophrenia (narrow, spectrum), bipolar disorder with psychotic features, major depressive episode with psychotic features, brief psychosis and other Psychoses (ICD 8–10) were collected from nationwide registers including both inpatients and outpatients. The data on early risk factors including sex and place of birth of the offspring, parental age and psychosis, maternal education at birth were prospectively collected from the population registers. The follow-up reached until the age of 27 years. Results. An increase in the cumulative incidence of all Psychoses was seen (1.01% in NFBC 1966 v. 1.90% in NFBC 1986; p < 0.001), which was due to an increase in diagnosed affective and other Psychoses. Earlier onset of cases and relatively more Psychoses in women were observed in the NFBC 1986. Changes in prevalence of potential early risk factors were identified, but only parental psychosis was a significant predictor in both cohorts (hazard ratios ≥3.0; 95% CI 1.86–4.88). The difference in psychosis incidence was not dependent on changes in prevalence of studied early risk factors. Conclusions. Surprisingly, increase in the cumulative incidence of psychosis and also changes in the types of Psychoses were found between two birth cohorts 20 years apart. The observed differences could be due to real changes in incidence or they can be attributable to changes in diagnostic practices, or to early psychosis detection and treatment.
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a comparison of the cumulative incidence and early risk factors for psychotic disorder in young adults in the northern finland birth cohorts 1966 and 1986
Epidemiology and Psychiatric Sciences, 2017Co-Authors: Svetlana Filatova, Riikka Marttila, Heli Koivumaahonkanen, Tanja Nordstrom, Juha Veijola, Pirjo Maki, Gulam Khandaker, Matti Isohanni, Erika Jaaskelainen, Kristiina MoilanenAbstract:Aims. Few studies have compared time trends for the incidence of psychosis. To date, the results have been inconsistent, showing a decline, an increase or no significant change. As far as we know, no studies explored changes in prevalence of early risk factors. The aim of this study was to investigate differences in early risk factors and cumulative incidences of psychosis by type of psychosis in two comparable birth cohorts. Methods. The Northern Finland Birth cohorts (NFBCs) 1966 ( N = 12 058) and 1986 ( N = 9432) are prospective general population-based cohorts with the children followed since mother's mid-pregnancy. The data for Psychoses, i.e. schizophrenia (narrow, spectrum), bipolar disorder with psychotic features, major depressive episode with psychotic features, brief psychosis and other Psychoses (ICD 8–10) were collected from nationwide registers including both inpatients and outpatients. The data on early risk factors including sex and place of birth of the offspring, parental age and psychosis, maternal education at birth were prospectively collected from the population registers. The follow-up reached until the age of 27 years. Results. An increase in the cumulative incidence of all Psychoses was seen (1.01% in NFBC 1966 v . 1.90% in NFBC 1986; p Conclusions. Surprisingly, increase in the cumulative incidence of psychosis and also changes in the types of Psychoses were found between two birth cohorts 20 years apart. The observed differences could be due to real changes in incidence or they can be attributable to changes in diagnostic practices, or to early psychosis detection and treatment.
Pirjo Maki - One of the best experts on this subject based on the ideXlab platform.
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School success in childhood and subsequent prodromal symptoms and Psychoses in the Northern Finland Birth Cohort 1986.
Psychological medicine, 2019Co-Authors: M. Lassila, Tanja Nordstrom, Pirjo Maki, Erika Jaaskelainen, Tuula Hurtig, E. Oinas, Jouko MiettunenAbstract:BACKGROUND Low IQ is a risk factor for psychosis, but the effect of high IQ is more controversial. The aim was to explore the association of childhood school success with prodromal symptoms in adolescence and Psychoses in adulthood. METHODS In the general population-based Northern Finland Birth Cohort 1986 (n = 8 229), we studied the relationship between teacher-assessed learning deficits, special talents and general school success at age 8 years and both prodromal symptoms (PROD-screen) at age 15-16 years and the occurrence of Psychoses by age 30 years. RESULTS More prodromal symptoms were experienced by those talented in oral presentation [boys: adjusted odds ratio (OR) 1.49; 95% confidence interval 1.14-1.96; girls: 1.23; 1.00-1.52] or drawing (boys: 1.44; 1.10-1.87). Conversely, being talented in athletics decreased the probability of psychotic-like symptoms (boys: OR 0.72; 0.58-0.90). School success below average predicted less prodromal symptoms with boys (OR 0.68; 0.48-0.97), whereas above-average success predicted more prodromal symptoms with girls (OR 1.22; 1.03-1.44). The occurrence of Psychoses was not affected. Learning deficits did not associate with prodromal symptoms or Psychoses. CONCLUSIONS Learning deficits in childhood did not increase the risk of prodromal symptoms in adolescence or later psychosis in this large birth cohort. Learning deficits are not always associated with increased risk of psychosis, which might be due to, e.g. special support given in schools. The higher prevalence of prodromal symptoms in talented children may reflect a different kind of relationship of school success with prodromal symptoms compared to full Psychoses.
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a comparison of the cumulative incidence and early risk factors for psychotic disorder in young adults in the northern finland birth cohorts 1966 and 1986
Epidemiology and Psychiatric Sciences, 2017Co-Authors: Svetlana Filatova, Riikka Marttila, Heli Koivumaahonkanen, Tanja Nordstrom, Juha Veijola, Pirjo Maki, Gulam Khandaker, Matti Isohanni, Erika Jaaskelainen, Kristiina MoilanenAbstract:Aims. Few studies have compared time trends for the incidence of psychosis. To date, the results have been inconsistent, showing a decline, an increase or no significant change. As far as we know, no studies explored changes in prevalence of early risk factors. The aim of this study was to investigate differences in early risk factors and cumulative incidences of psychosis by type of psychosis in two comparable birth cohorts. Methods. The Northern Finland Birth cohorts (NFBCs) 1966 (N = 12 058) and 1986 (N = 9432) are prospective general population-based cohorts with the children followed since mother's mid-pregnancy. The data for Psychoses, i.e. schizophrenia (narrow, spectrum), bipolar disorder with psychotic features, major depressive episode with psychotic features, brief psychosis and other Psychoses (ICD 8–10) were collected from nationwide registers including both inpatients and outpatients. The data on early risk factors including sex and place of birth of the offspring, parental age and psychosis, maternal education at birth were prospectively collected from the population registers. The follow-up reached until the age of 27 years. Results. An increase in the cumulative incidence of all Psychoses was seen (1.01% in NFBC 1966 v. 1.90% in NFBC 1986; p < 0.001), which was due to an increase in diagnosed affective and other Psychoses. Earlier onset of cases and relatively more Psychoses in women were observed in the NFBC 1986. Changes in prevalence of potential early risk factors were identified, but only parental psychosis was a significant predictor in both cohorts (hazard ratios ≥3.0; 95% CI 1.86–4.88). The difference in psychosis incidence was not dependent on changes in prevalence of studied early risk factors. Conclusions. Surprisingly, increase in the cumulative incidence of psychosis and also changes in the types of Psychoses were found between two birth cohorts 20 years apart. The observed differences could be due to real changes in incidence or they can be attributable to changes in diagnostic practices, or to early psychosis detection and treatment.
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a comparison of the cumulative incidence and early risk factors for psychotic disorder in young adults in the northern finland birth cohorts 1966 and 1986
Epidemiology and Psychiatric Sciences, 2017Co-Authors: Svetlana Filatova, Riikka Marttila, Heli Koivumaahonkanen, Tanja Nordstrom, Juha Veijola, Pirjo Maki, Gulam Khandaker, Matti Isohanni, Erika Jaaskelainen, Kristiina MoilanenAbstract:Aims. Few studies have compared time trends for the incidence of psychosis. To date, the results have been inconsistent, showing a decline, an increase or no significant change. As far as we know, no studies explored changes in prevalence of early risk factors. The aim of this study was to investigate differences in early risk factors and cumulative incidences of psychosis by type of psychosis in two comparable birth cohorts. Methods. The Northern Finland Birth cohorts (NFBCs) 1966 ( N = 12 058) and 1986 ( N = 9432) are prospective general population-based cohorts with the children followed since mother's mid-pregnancy. The data for Psychoses, i.e. schizophrenia (narrow, spectrum), bipolar disorder with psychotic features, major depressive episode with psychotic features, brief psychosis and other Psychoses (ICD 8–10) were collected from nationwide registers including both inpatients and outpatients. The data on early risk factors including sex and place of birth of the offspring, parental age and psychosis, maternal education at birth were prospectively collected from the population registers. The follow-up reached until the age of 27 years. Results. An increase in the cumulative incidence of all Psychoses was seen (1.01% in NFBC 1966 v . 1.90% in NFBC 1986; p Conclusions. Surprisingly, increase in the cumulative incidence of psychosis and also changes in the types of Psychoses were found between two birth cohorts 20 years apart. The observed differences could be due to real changes in incidence or they can be attributable to changes in diagnostic practices, or to early psychosis detection and treatment.
Tanja Nordstrom - One of the best experts on this subject based on the ideXlab platform.
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School success in childhood and subsequent prodromal symptoms and Psychoses in the Northern Finland Birth Cohort 1986.
Psychological medicine, 2019Co-Authors: M. Lassila, Tanja Nordstrom, Pirjo Maki, Erika Jaaskelainen, Tuula Hurtig, E. Oinas, Jouko MiettunenAbstract:BACKGROUND Low IQ is a risk factor for psychosis, but the effect of high IQ is more controversial. The aim was to explore the association of childhood school success with prodromal symptoms in adolescence and Psychoses in adulthood. METHODS In the general population-based Northern Finland Birth Cohort 1986 (n = 8 229), we studied the relationship between teacher-assessed learning deficits, special talents and general school success at age 8 years and both prodromal symptoms (PROD-screen) at age 15-16 years and the occurrence of Psychoses by age 30 years. RESULTS More prodromal symptoms were experienced by those talented in oral presentation [boys: adjusted odds ratio (OR) 1.49; 95% confidence interval 1.14-1.96; girls: 1.23; 1.00-1.52] or drawing (boys: 1.44; 1.10-1.87). Conversely, being talented in athletics decreased the probability of psychotic-like symptoms (boys: OR 0.72; 0.58-0.90). School success below average predicted less prodromal symptoms with boys (OR 0.68; 0.48-0.97), whereas above-average success predicted more prodromal symptoms with girls (OR 1.22; 1.03-1.44). The occurrence of Psychoses was not affected. Learning deficits did not associate with prodromal symptoms or Psychoses. CONCLUSIONS Learning deficits in childhood did not increase the risk of prodromal symptoms in adolescence or later psychosis in this large birth cohort. Learning deficits are not always associated with increased risk of psychosis, which might be due to, e.g. special support given in schools. The higher prevalence of prodromal symptoms in talented children may reflect a different kind of relationship of school success with prodromal symptoms compared to full Psychoses.
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a comparison of the cumulative incidence and early risk factors for psychotic disorder in young adults in the northern finland birth cohorts 1966 and 1986
Epidemiology and Psychiatric Sciences, 2017Co-Authors: Svetlana Filatova, Riikka Marttila, Heli Koivumaahonkanen, Tanja Nordstrom, Juha Veijola, Pirjo Maki, Gulam Khandaker, Matti Isohanni, Erika Jaaskelainen, Kristiina MoilanenAbstract:Aims. Few studies have compared time trends for the incidence of psychosis. To date, the results have been inconsistent, showing a decline, an increase or no significant change. As far as we know, no studies explored changes in prevalence of early risk factors. The aim of this study was to investigate differences in early risk factors and cumulative incidences of psychosis by type of psychosis in two comparable birth cohorts. Methods. The Northern Finland Birth cohorts (NFBCs) 1966 (N = 12 058) and 1986 (N = 9432) are prospective general population-based cohorts with the children followed since mother's mid-pregnancy. The data for Psychoses, i.e. schizophrenia (narrow, spectrum), bipolar disorder with psychotic features, major depressive episode with psychotic features, brief psychosis and other Psychoses (ICD 8–10) were collected from nationwide registers including both inpatients and outpatients. The data on early risk factors including sex and place of birth of the offspring, parental age and psychosis, maternal education at birth were prospectively collected from the population registers. The follow-up reached until the age of 27 years. Results. An increase in the cumulative incidence of all Psychoses was seen (1.01% in NFBC 1966 v. 1.90% in NFBC 1986; p < 0.001), which was due to an increase in diagnosed affective and other Psychoses. Earlier onset of cases and relatively more Psychoses in women were observed in the NFBC 1986. Changes in prevalence of potential early risk factors were identified, but only parental psychosis was a significant predictor in both cohorts (hazard ratios ≥3.0; 95% CI 1.86–4.88). The difference in psychosis incidence was not dependent on changes in prevalence of studied early risk factors. Conclusions. Surprisingly, increase in the cumulative incidence of psychosis and also changes in the types of Psychoses were found between two birth cohorts 20 years apart. The observed differences could be due to real changes in incidence or they can be attributable to changes in diagnostic practices, or to early psychosis detection and treatment.
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a comparison of the cumulative incidence and early risk factors for psychotic disorder in young adults in the northern finland birth cohorts 1966 and 1986
Epidemiology and Psychiatric Sciences, 2017Co-Authors: Svetlana Filatova, Riikka Marttila, Heli Koivumaahonkanen, Tanja Nordstrom, Juha Veijola, Pirjo Maki, Gulam Khandaker, Matti Isohanni, Erika Jaaskelainen, Kristiina MoilanenAbstract:Aims. Few studies have compared time trends for the incidence of psychosis. To date, the results have been inconsistent, showing a decline, an increase or no significant change. As far as we know, no studies explored changes in prevalence of early risk factors. The aim of this study was to investigate differences in early risk factors and cumulative incidences of psychosis by type of psychosis in two comparable birth cohorts. Methods. The Northern Finland Birth cohorts (NFBCs) 1966 ( N = 12 058) and 1986 ( N = 9432) are prospective general population-based cohorts with the children followed since mother's mid-pregnancy. The data for Psychoses, i.e. schizophrenia (narrow, spectrum), bipolar disorder with psychotic features, major depressive episode with psychotic features, brief psychosis and other Psychoses (ICD 8–10) were collected from nationwide registers including both inpatients and outpatients. The data on early risk factors including sex and place of birth of the offspring, parental age and psychosis, maternal education at birth were prospectively collected from the population registers. The follow-up reached until the age of 27 years. Results. An increase in the cumulative incidence of all Psychoses was seen (1.01% in NFBC 1966 v . 1.90% in NFBC 1986; p Conclusions. Surprisingly, increase in the cumulative incidence of psychosis and also changes in the types of Psychoses were found between two birth cohorts 20 years apart. The observed differences could be due to real changes in incidence or they can be attributable to changes in diagnostic practices, or to early psychosis detection and treatment.
Erika Jaaskelainen - One of the best experts on this subject based on the ideXlab platform.
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School success in childhood and subsequent prodromal symptoms and Psychoses in the Northern Finland Birth Cohort 1986.
Psychological medicine, 2019Co-Authors: M. Lassila, Tanja Nordstrom, Pirjo Maki, Erika Jaaskelainen, Tuula Hurtig, E. Oinas, Jouko MiettunenAbstract:BACKGROUND Low IQ is a risk factor for psychosis, but the effect of high IQ is more controversial. The aim was to explore the association of childhood school success with prodromal symptoms in adolescence and Psychoses in adulthood. METHODS In the general population-based Northern Finland Birth Cohort 1986 (n = 8 229), we studied the relationship between teacher-assessed learning deficits, special talents and general school success at age 8 years and both prodromal symptoms (PROD-screen) at age 15-16 years and the occurrence of Psychoses by age 30 years. RESULTS More prodromal symptoms were experienced by those talented in oral presentation [boys: adjusted odds ratio (OR) 1.49; 95% confidence interval 1.14-1.96; girls: 1.23; 1.00-1.52] or drawing (boys: 1.44; 1.10-1.87). Conversely, being talented in athletics decreased the probability of psychotic-like symptoms (boys: OR 0.72; 0.58-0.90). School success below average predicted less prodromal symptoms with boys (OR 0.68; 0.48-0.97), whereas above-average success predicted more prodromal symptoms with girls (OR 1.22; 1.03-1.44). The occurrence of Psychoses was not affected. Learning deficits did not associate with prodromal symptoms or Psychoses. CONCLUSIONS Learning deficits in childhood did not increase the risk of prodromal symptoms in adolescence or later psychosis in this large birth cohort. Learning deficits are not always associated with increased risk of psychosis, which might be due to, e.g. special support given in schools. The higher prevalence of prodromal symptoms in talented children may reflect a different kind of relationship of school success with prodromal symptoms compared to full Psychoses.
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a comparison of the cumulative incidence and early risk factors for psychotic disorder in young adults in the northern finland birth cohorts 1966 and 1986
Epidemiology and Psychiatric Sciences, 2017Co-Authors: Svetlana Filatova, Riikka Marttila, Heli Koivumaahonkanen, Tanja Nordstrom, Juha Veijola, Pirjo Maki, Gulam Khandaker, Matti Isohanni, Erika Jaaskelainen, Kristiina MoilanenAbstract:Aims. Few studies have compared time trends for the incidence of psychosis. To date, the results have been inconsistent, showing a decline, an increase or no significant change. As far as we know, no studies explored changes in prevalence of early risk factors. The aim of this study was to investigate differences in early risk factors and cumulative incidences of psychosis by type of psychosis in two comparable birth cohorts. Methods. The Northern Finland Birth cohorts (NFBCs) 1966 (N = 12 058) and 1986 (N = 9432) are prospective general population-based cohorts with the children followed since mother's mid-pregnancy. The data for Psychoses, i.e. schizophrenia (narrow, spectrum), bipolar disorder with psychotic features, major depressive episode with psychotic features, brief psychosis and other Psychoses (ICD 8–10) were collected from nationwide registers including both inpatients and outpatients. The data on early risk factors including sex and place of birth of the offspring, parental age and psychosis, maternal education at birth were prospectively collected from the population registers. The follow-up reached until the age of 27 years. Results. An increase in the cumulative incidence of all Psychoses was seen (1.01% in NFBC 1966 v. 1.90% in NFBC 1986; p < 0.001), which was due to an increase in diagnosed affective and other Psychoses. Earlier onset of cases and relatively more Psychoses in women were observed in the NFBC 1986. Changes in prevalence of potential early risk factors were identified, but only parental psychosis was a significant predictor in both cohorts (hazard ratios ≥3.0; 95% CI 1.86–4.88). The difference in psychosis incidence was not dependent on changes in prevalence of studied early risk factors. Conclusions. Surprisingly, increase in the cumulative incidence of psychosis and also changes in the types of Psychoses were found between two birth cohorts 20 years apart. The observed differences could be due to real changes in incidence or they can be attributable to changes in diagnostic practices, or to early psychosis detection and treatment.
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a comparison of the cumulative incidence and early risk factors for psychotic disorder in young adults in the northern finland birth cohorts 1966 and 1986
Epidemiology and Psychiatric Sciences, 2017Co-Authors: Svetlana Filatova, Riikka Marttila, Heli Koivumaahonkanen, Tanja Nordstrom, Juha Veijola, Pirjo Maki, Gulam Khandaker, Matti Isohanni, Erika Jaaskelainen, Kristiina MoilanenAbstract:Aims. Few studies have compared time trends for the incidence of psychosis. To date, the results have been inconsistent, showing a decline, an increase or no significant change. As far as we know, no studies explored changes in prevalence of early risk factors. The aim of this study was to investigate differences in early risk factors and cumulative incidences of psychosis by type of psychosis in two comparable birth cohorts. Methods. The Northern Finland Birth cohorts (NFBCs) 1966 ( N = 12 058) and 1986 ( N = 9432) are prospective general population-based cohorts with the children followed since mother's mid-pregnancy. The data for Psychoses, i.e. schizophrenia (narrow, spectrum), bipolar disorder with psychotic features, major depressive episode with psychotic features, brief psychosis and other Psychoses (ICD 8–10) were collected from nationwide registers including both inpatients and outpatients. The data on early risk factors including sex and place of birth of the offspring, parental age and psychosis, maternal education at birth were prospectively collected from the population registers. The follow-up reached until the age of 27 years. Results. An increase in the cumulative incidence of all Psychoses was seen (1.01% in NFBC 1966 v . 1.90% in NFBC 1986; p Conclusions. Surprisingly, increase in the cumulative incidence of psychosis and also changes in the types of Psychoses were found between two birth cohorts 20 years apart. The observed differences could be due to real changes in incidence or they can be attributable to changes in diagnostic practices, or to early psychosis detection and treatment.
Juha Veijola - One of the best experts on this subject based on the ideXlab platform.
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a comparison of the cumulative incidence and early risk factors for psychotic disorder in young adults in the northern finland birth cohorts 1966 and 1986
Epidemiology and Psychiatric Sciences, 2017Co-Authors: Svetlana Filatova, Riikka Marttila, Heli Koivumaahonkanen, Tanja Nordstrom, Juha Veijola, Pirjo Maki, Gulam Khandaker, Matti Isohanni, Erika Jaaskelainen, Kristiina MoilanenAbstract:Aims. Few studies have compared time trends for the incidence of psychosis. To date, the results have been inconsistent, showing a decline, an increase or no significant change. As far as we know, no studies explored changes in prevalence of early risk factors. The aim of this study was to investigate differences in early risk factors and cumulative incidences of psychosis by type of psychosis in two comparable birth cohorts. Methods. The Northern Finland Birth cohorts (NFBCs) 1966 (N = 12 058) and 1986 (N = 9432) are prospective general population-based cohorts with the children followed since mother's mid-pregnancy. The data for Psychoses, i.e. schizophrenia (narrow, spectrum), bipolar disorder with psychotic features, major depressive episode with psychotic features, brief psychosis and other Psychoses (ICD 8–10) were collected from nationwide registers including both inpatients and outpatients. The data on early risk factors including sex and place of birth of the offspring, parental age and psychosis, maternal education at birth were prospectively collected from the population registers. The follow-up reached until the age of 27 years. Results. An increase in the cumulative incidence of all Psychoses was seen (1.01% in NFBC 1966 v. 1.90% in NFBC 1986; p < 0.001), which was due to an increase in diagnosed affective and other Psychoses. Earlier onset of cases and relatively more Psychoses in women were observed in the NFBC 1986. Changes in prevalence of potential early risk factors were identified, but only parental psychosis was a significant predictor in both cohorts (hazard ratios ≥3.0; 95% CI 1.86–4.88). The difference in psychosis incidence was not dependent on changes in prevalence of studied early risk factors. Conclusions. Surprisingly, increase in the cumulative incidence of psychosis and also changes in the types of Psychoses were found between two birth cohorts 20 years apart. The observed differences could be due to real changes in incidence or they can be attributable to changes in diagnostic practices, or to early psychosis detection and treatment.
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a comparison of the cumulative incidence and early risk factors for psychotic disorder in young adults in the northern finland birth cohorts 1966 and 1986
Epidemiology and Psychiatric Sciences, 2017Co-Authors: Svetlana Filatova, Riikka Marttila, Heli Koivumaahonkanen, Tanja Nordstrom, Juha Veijola, Pirjo Maki, Gulam Khandaker, Matti Isohanni, Erika Jaaskelainen, Kristiina MoilanenAbstract:Aims. Few studies have compared time trends for the incidence of psychosis. To date, the results have been inconsistent, showing a decline, an increase or no significant change. As far as we know, no studies explored changes in prevalence of early risk factors. The aim of this study was to investigate differences in early risk factors and cumulative incidences of psychosis by type of psychosis in two comparable birth cohorts. Methods. The Northern Finland Birth cohorts (NFBCs) 1966 ( N = 12 058) and 1986 ( N = 9432) are prospective general population-based cohorts with the children followed since mother's mid-pregnancy. The data for Psychoses, i.e. schizophrenia (narrow, spectrum), bipolar disorder with psychotic features, major depressive episode with psychotic features, brief psychosis and other Psychoses (ICD 8–10) were collected from nationwide registers including both inpatients and outpatients. The data on early risk factors including sex and place of birth of the offspring, parental age and psychosis, maternal education at birth were prospectively collected from the population registers. The follow-up reached until the age of 27 years. Results. An increase in the cumulative incidence of all Psychoses was seen (1.01% in NFBC 1966 v . 1.90% in NFBC 1986; p Conclusions. Surprisingly, increase in the cumulative incidence of psychosis and also changes in the types of Psychoses were found between two birth cohorts 20 years apart. The observed differences could be due to real changes in incidence or they can be attributable to changes in diagnostic practices, or to early psychosis detection and treatment.
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disc1 conditioned gwas for psychosis proneness in a large finnish birth cohort
PLOS ONE, 2012Co-Authors: Juha Veijola, Liisa Tomppo, Jesper Ekelund, Dirk Lichtermann, Marjoriitta Jarvelin, William HennahAbstract:Background Genetic evidence implicates the DISC1 gene in the etiology of a number of mental illnesses. Previously, we have reported association between DISC1 and measures of psychosis proneness, the Revised Social Anhedonia Scale (RSAS) and Revised Physical Anhedonia Scale (RPAS), in the Northern Finland Birth Cohort 1966 (NFBC66). As part of the studies of this Finnish birth cohort genome-wide association analysis has recently been performed. Methodology In the present study, we re-analyzed the genome-wide association data with regard to these two measures of psychosis proneness, conditioning on our previous DISC1 observation. From the original NFBC66 sample (N = 12 058), 4 561 individuals provided phenotype and genotype data. No markers were significant at the genome-wide level. However, several genes with biological relevance to mental illnesses were highlighted through loci displaying suggestive evidence for association (≥3 SNP with P Conclusions By conditioning a previous genome-wide association study on DISC1, we have been able to identify eight genes as associating to psychosis proneness. Further, these molecules predominantly link to the DISC1 pathway, strengthening the evidence for the role of this gene network in the etiology of mental illness. The use of quantitative measures of psychosis proneness in a large population cohort will make these findings, once verified; more generalized to a broad selection of disorders related to Psychoses and psychosis proneness.
