The Experts below are selected from a list of 90 Experts worldwide ranked by ideXlab platform

Gert Holstege - One of the best experts on this subject based on the ideXlab platform.

  • Premature Ejaculation, Selective Serotonin Reuptake Inhibitor (ssri) Induced Delayed Ejaculation In The Framework Of The Emotional Motor System
    1998
    Co-Authors: Marcel D. Waldinger, Hemmie H.g. Berendsen, Bertil F.m. Blok, Berend Olivier, Gert Holstege
    Abstract:

    Premature ejaculation has generally been considered a Psychosexual Disorder with psychogenic aetiology. Although still mainly treated by behavioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic anti depressants (SSRIs) in delaying ejaculation. We describe here the europhysiology and the peripheral neuroanatomy of ejaculation and provide a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections. A hypothesis of the role of 5-HT1A and 5-HT2C receptors in premature ejaculation is postulated.

  • Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system
    Behavioural brain research, 1998
    Co-Authors: Marcel D. Waldinger, Hemmie H.g. Berendsen, Bertil F.m. Blok, Berend Olivier, Gert Holstege
    Abstract:

    Premature ejaculation has generally been considered a Psychosexual Disorder with psychogenic aetiology. Although still mainly treated by behavioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic antidepressants (SSRIs) in delaying ejaculation. We describe here the neurophysiology and the peripheral neuroanatomy of ejaculation and provide a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections. A hypothesis of the role of 5-HT1A and 5-HT2C receptors in premature ejaculation is postulated.

Marcel D. Waldinger - One of the best experts on this subject based on the ideXlab platform.

  • Animal models of ejaculatory behavior.
    Current pharmaceutical design, 2005
    Co-Authors: Tommy Pattij, Berend Olivier, Marcel D. Waldinger
    Abstract:

    Premature ejaculation is generally regarded the most frequent male ejaculatory complaint and has been considered a Psychosexual Disorder with psychogenic aetiology. The efficacy of various antidepressants, however, to delay ejaculation in men and to pharmacologically treat premature ejaculation suggests a strong neurobiological involvement. Most of our current understanding of the neurobiology and neuroanatomy of sexual behavior and ejaculatory function has been derived from preclinical studies using several laboratory species. In the present paper we will review the various animal models that have been developed to further study ejaculatory function in the laboratory rat. In addition, we will briefly review the effects of serotonergic antidepressants and serotonergic compounds on sexual and ejaculatory behavior. Together, these preclinical studies may contribute to a better understanding of the neurobiology of ejaculation and help the development of novel drug targets to treat ejaculatory Disorders such as premature ejaculation.

  • Premature Ejaculation, Selective Serotonin Reuptake Inhibitor (ssri) Induced Delayed Ejaculation In The Framework Of The Emotional Motor System
    1998
    Co-Authors: Marcel D. Waldinger, Hemmie H.g. Berendsen, Bertil F.m. Blok, Berend Olivier, Gert Holstege
    Abstract:

    Premature ejaculation has generally been considered a Psychosexual Disorder with psychogenic aetiology. Although still mainly treated by behavioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic anti depressants (SSRIs) in delaying ejaculation. We describe here the europhysiology and the peripheral neuroanatomy of ejaculation and provide a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections. A hypothesis of the role of 5-HT1A and 5-HT2C receptors in premature ejaculation is postulated.

  • Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system
    Behavioural brain research, 1998
    Co-Authors: Marcel D. Waldinger, Hemmie H.g. Berendsen, Bertil F.m. Blok, Berend Olivier, Gert Holstege
    Abstract:

    Premature ejaculation has generally been considered a Psychosexual Disorder with psychogenic aetiology. Although still mainly treated by behavioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic antidepressants (SSRIs) in delaying ejaculation. We describe here the neurophysiology and the peripheral neuroanatomy of ejaculation and provide a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections. A hypothesis of the role of 5-HT1A and 5-HT2C receptors in premature ejaculation is postulated.

Berend Olivier - One of the best experts on this subject based on the ideXlab platform.

  • Animal models of ejaculatory behavior.
    Current pharmaceutical design, 2005
    Co-Authors: Tommy Pattij, Berend Olivier, Marcel D. Waldinger
    Abstract:

    Premature ejaculation is generally regarded the most frequent male ejaculatory complaint and has been considered a Psychosexual Disorder with psychogenic aetiology. The efficacy of various antidepressants, however, to delay ejaculation in men and to pharmacologically treat premature ejaculation suggests a strong neurobiological involvement. Most of our current understanding of the neurobiology and neuroanatomy of sexual behavior and ejaculatory function has been derived from preclinical studies using several laboratory species. In the present paper we will review the various animal models that have been developed to further study ejaculatory function in the laboratory rat. In addition, we will briefly review the effects of serotonergic antidepressants and serotonergic compounds on sexual and ejaculatory behavior. Together, these preclinical studies may contribute to a better understanding of the neurobiology of ejaculation and help the development of novel drug targets to treat ejaculatory Disorders such as premature ejaculation.

  • Premature Ejaculation, Selective Serotonin Reuptake Inhibitor (ssri) Induced Delayed Ejaculation In The Framework Of The Emotional Motor System
    1998
    Co-Authors: Marcel D. Waldinger, Hemmie H.g. Berendsen, Bertil F.m. Blok, Berend Olivier, Gert Holstege
    Abstract:

    Premature ejaculation has generally been considered a Psychosexual Disorder with psychogenic aetiology. Although still mainly treated by behavioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic anti depressants (SSRIs) in delaying ejaculation. We describe here the europhysiology and the peripheral neuroanatomy of ejaculation and provide a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections. A hypothesis of the role of 5-HT1A and 5-HT2C receptors in premature ejaculation is postulated.

  • Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system
    Behavioural brain research, 1998
    Co-Authors: Marcel D. Waldinger, Hemmie H.g. Berendsen, Bertil F.m. Blok, Berend Olivier, Gert Holstege
    Abstract:

    Premature ejaculation has generally been considered a Psychosexual Disorder with psychogenic aetiology. Although still mainly treated by behavioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic antidepressants (SSRIs) in delaying ejaculation. We describe here the neurophysiology and the peripheral neuroanatomy of ejaculation and provide a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections. A hypothesis of the role of 5-HT1A and 5-HT2C receptors in premature ejaculation is postulated.

Hemmie H.g. Berendsen - One of the best experts on this subject based on the ideXlab platform.

  • Premature Ejaculation, Selective Serotonin Reuptake Inhibitor (ssri) Induced Delayed Ejaculation In The Framework Of The Emotional Motor System
    1998
    Co-Authors: Marcel D. Waldinger, Hemmie H.g. Berendsen, Bertil F.m. Blok, Berend Olivier, Gert Holstege
    Abstract:

    Premature ejaculation has generally been considered a Psychosexual Disorder with psychogenic aetiology. Although still mainly treated by behavioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic anti depressants (SSRIs) in delaying ejaculation. We describe here the europhysiology and the peripheral neuroanatomy of ejaculation and provide a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections. A hypothesis of the role of 5-HT1A and 5-HT2C receptors in premature ejaculation is postulated.

  • Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system
    Behavioural brain research, 1998
    Co-Authors: Marcel D. Waldinger, Hemmie H.g. Berendsen, Bertil F.m. Blok, Berend Olivier, Gert Holstege
    Abstract:

    Premature ejaculation has generally been considered a Psychosexual Disorder with psychogenic aetiology. Although still mainly treated by behavioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic antidepressants (SSRIs) in delaying ejaculation. We describe here the neurophysiology and the peripheral neuroanatomy of ejaculation and provide a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections. A hypothesis of the role of 5-HT1A and 5-HT2C receptors in premature ejaculation is postulated.

Bertil F.m. Blok - One of the best experts on this subject based on the ideXlab platform.

  • Premature Ejaculation, Selective Serotonin Reuptake Inhibitor (ssri) Induced Delayed Ejaculation In The Framework Of The Emotional Motor System
    1998
    Co-Authors: Marcel D. Waldinger, Hemmie H.g. Berendsen, Bertil F.m. Blok, Berend Olivier, Gert Holstege
    Abstract:

    Premature ejaculation has generally been considered a Psychosexual Disorder with psychogenic aetiology. Although still mainly treated by behavioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic anti depressants (SSRIs) in delaying ejaculation. We describe here the europhysiology and the peripheral neuroanatomy of ejaculation and provide a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections. A hypothesis of the role of 5-HT1A and 5-HT2C receptors in premature ejaculation is postulated.

  • Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system
    Behavioural brain research, 1998
    Co-Authors: Marcel D. Waldinger, Hemmie H.g. Berendsen, Bertil F.m. Blok, Berend Olivier, Gert Holstege
    Abstract:

    Premature ejaculation has generally been considered a Psychosexual Disorder with psychogenic aetiology. Although still mainly treated by behavioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic antidepressants (SSRIs) in delaying ejaculation. We describe here the neurophysiology and the peripheral neuroanatomy of ejaculation and provide a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections. A hypothesis of the role of 5-HT1A and 5-HT2C receptors in premature ejaculation is postulated.