The Experts below are selected from a list of 402 Experts worldwide ranked by ideXlab platform

Florence, Alastair J. - One of the best experts on this subject based on the ideXlab platform.

  • Peptide isolation via spray drying : particle formation, Process design and implementation for the production of spray dried glucagon
    'Springer Science and Business Media LLC', 2020
    Co-Authors: Doerr, Frederik J. S., Burns, Lee J., Lee Becky, Hinds Jeremy, Davis-harrison, Rebecca L., Frank, Scott A., Florence, Alastair J.
    Abstract:

    Purpose Spray drying plays an important role in the pharmaceutical industry for product development of sensitive bio-pharmaceutical formulations. Process design, implementation and optimisation require in-depth knowledge of Process-product interactions. Here, an integrated approach for the rapid, early-stage spray drying Process development of trehalose and glucagon on lab-scale is presented. Methods Single droplet drying experiments were used to investigate the particle formation Process. Process implementation was supported using in-line Process analytical technology within a data acquisition framework recording temperature, humidity, pressure and feed rate. During Process implementation, off-line product characterisation provided additional information on key product properties related to residual moisture, solid state structure, particle size/morphology and peptide fibrillation/degradation. Results A Psychrometric Process model allowed the identification of feasible operating conditions for spray drying trehalose, achieving high yields of up to 84.67%, and significantly reduced levels of residual moisture and particle agglomeration compared to product obtained during non-optimal drying. The Process was further translated to produce powders of glucagon and glucagon-trehalose formulations with yields of >83.24%. Extensive peptide aggregation or degradation was not observed. Conclusions The presented data-driven Process development concept can be applied to address future isolation problems on lab-scale and facilitate a systematic implementation of spray drying for the manufacturing of sensitive bio-pharmaceutical formulations

Yıldırım, Ruhsar Gözde - One of the best experts on this subject based on the ideXlab platform.

  • Exergy analysis of Psychrometric Process of HVAC&R systems
    'Marmara Universitesi Ilahiyat Fakultesi Dergisi', 2009
    Co-Authors: Yıldırım, Ruhsar Gözde
    Abstract:

    HVAC&R SİSTEMLERİ İÇİN PSİKROMETRİK PROSESLERİN EKSERJİ ANALİZİ Bu tez kapsamında çeşitli iklimlendirme sistemlerinin termodinamiğin ikinci kanunu esas alınarak ekserji analizi yapılmıştır. Kütle, enerji, entropi, ekserji korunumu ve ekserji verimi eşitlikleri geliştirilerek önce ısıtma ve soğutma, nemlendirerek ısıtma, nem alarak soğutma, buharlaştırarak soğutma ve hava akımlarının ısı transferi olmaksızın karıştırılması şeklindeki iklimlendirme sistemlerinin ana proseslerinin analizleri yapılmıştır. Daha sonra bir yaz kliması sisteminin temel uygulaması, baypas yöntemi kullanılan uygulaması ve tekrar ısıtma yöntemi kullanılan uygulamasının analizleri yapılarak ekserji verimleri karşılaştırılmıştır. Daha kompleks iklimlendirme sistem analizlerini yapmak adına çift bölmeli yaz kliması sistemlerinde tekrar ısıtmalı, değişken hava miktarlı ve çift borulu yöntemlerin analizleri ayrı ayrı yapılarak ekserji verim sonuçları karşılaştırılmıştır. Bu sistemlerin ekserji analizleri yapılırken genel termodinamik prensipler kullanılmıştır. Ekserji analizine farklı bir yaklaşımla yaz ve kış klima sistemleri, nem alarak soğutma prosesinin ekserji verimleri hesaplanmış, durgun hal seçimine göre sonuçların nasıl etkilendiği gösterilmiş ve Chengqin et. al.’ ın ‘Principles of exergy analysis in HVAC and evaluation of evaporative cooling schemes’ isimli çalışmasıyla karşılaştırılmıştır. Ekserji ısıl, mekanik ve kimyasal ekserji olarak üç şekilde incelenerek nemli havanın ekserjisi bulunmuş, grafiklendirilmiştir. Buna bağlı olarak buharlaştırarak soğutma yöntemleri incelenip grafikleri oluşturulmuş ve bu sonuçlar da Chengqin et. al.’ ın çalışmasındaki sonuçlarla karşılaştırılmıştır. ABSTRACT EXERGY ANALYSIS OF Psychrometric ProcessES OF HVAC&R SYSTEMS This thesis presents a theoretical analysis on second law of thermodynamics (exergy analysis) to estimate exergetic efficiency for various air conditioning systems. Mass, energy, entropy, exergy balances and exergy efficiency relations are developed for common air conditioning Processes that include simple heating and cooling, heating with humidification, cooling wih dehumidification, evaporative cooling and adiabatic mixing of air streams. Various single zone summer air conditioning systems that include elementary summer air conditioning system, summer air conditioning with bypass system and summer air conditioning with reheat system are analyzed and comparisons of exergy efficiencies for the systems are visualized. Various multiple zones summer air conditioning systems that include reheat, variable air volume and dual duct systems are analyzed and comparison of exergy efficiencies for the systems are visualized for analyzing more complex HVAC&R systems . General principles of exergy analysis are used to calculate exergy efficiencies of these sytems. Besides, exergy analysis is developed in HVAC systems that include summer and winter air conditioning systems and coolling and dehumidification Process. According to this analysis, the effect of dead state is demonstrated. Results of this analysis are compared with ‘Principles of exergy analysis in HVAC and evaluation of evaporative cooling schemes’ by Chengqin et. al. The exergy of moist air is analyzed and broken down into three components: thermal, mechanical and chemical, each of them are represented with a specially devised diagram applicable to various conditions and ambient states for the evaluation of evaporative schemes. Results and graphics of this analysis is compared with Chengqin et. al study

Doerr, Frederik J. S. - One of the best experts on this subject based on the ideXlab platform.

  • Peptide isolation via spray drying : particle formation, Process design and implementation for the production of spray dried glucagon
    'Springer Science and Business Media LLC', 2020
    Co-Authors: Doerr, Frederik J. S., Burns, Lee J., Lee Becky, Hinds Jeremy, Davis-harrison, Rebecca L., Frank, Scott A., Florence, Alastair J.
    Abstract:

    Purpose Spray drying plays an important role in the pharmaceutical industry for product development of sensitive bio-pharmaceutical formulations. Process design, implementation and optimisation require in-depth knowledge of Process-product interactions. Here, an integrated approach for the rapid, early-stage spray drying Process development of trehalose and glucagon on lab-scale is presented. Methods Single droplet drying experiments were used to investigate the particle formation Process. Process implementation was supported using in-line Process analytical technology within a data acquisition framework recording temperature, humidity, pressure and feed rate. During Process implementation, off-line product characterisation provided additional information on key product properties related to residual moisture, solid state structure, particle size/morphology and peptide fibrillation/degradation. Results A Psychrometric Process model allowed the identification of feasible operating conditions for spray drying trehalose, achieving high yields of up to 84.67%, and significantly reduced levels of residual moisture and particle agglomeration compared to product obtained during non-optimal drying. The Process was further translated to produce powders of glucagon and glucagon-trehalose formulations with yields of >83.24%. Extensive peptide aggregation or degradation was not observed. Conclusions The presented data-driven Process development concept can be applied to address future isolation problems on lab-scale and facilitate a systematic implementation of spray drying for the manufacturing of sensitive bio-pharmaceutical formulations

Burns, Lee J. - One of the best experts on this subject based on the ideXlab platform.

  • Peptide isolation via spray drying : particle formation, Process design and implementation for the production of spray dried glucagon
    'Springer Science and Business Media LLC', 2020
    Co-Authors: Doerr, Frederik J. S., Burns, Lee J., Lee Becky, Hinds Jeremy, Davis-harrison, Rebecca L., Frank, Scott A., Florence, Alastair J.
    Abstract:

    Purpose Spray drying plays an important role in the pharmaceutical industry for product development of sensitive bio-pharmaceutical formulations. Process design, implementation and optimisation require in-depth knowledge of Process-product interactions. Here, an integrated approach for the rapid, early-stage spray drying Process development of trehalose and glucagon on lab-scale is presented. Methods Single droplet drying experiments were used to investigate the particle formation Process. Process implementation was supported using in-line Process analytical technology within a data acquisition framework recording temperature, humidity, pressure and feed rate. During Process implementation, off-line product characterisation provided additional information on key product properties related to residual moisture, solid state structure, particle size/morphology and peptide fibrillation/degradation. Results A Psychrometric Process model allowed the identification of feasible operating conditions for spray drying trehalose, achieving high yields of up to 84.67%, and significantly reduced levels of residual moisture and particle agglomeration compared to product obtained during non-optimal drying. The Process was further translated to produce powders of glucagon and glucagon-trehalose formulations with yields of >83.24%. Extensive peptide aggregation or degradation was not observed. Conclusions The presented data-driven Process development concept can be applied to address future isolation problems on lab-scale and facilitate a systematic implementation of spray drying for the manufacturing of sensitive bio-pharmaceutical formulations

Lee Becky - One of the best experts on this subject based on the ideXlab platform.

  • Peptide isolation via spray drying : particle formation, Process design and implementation for the production of spray dried glucagon
    'Springer Science and Business Media LLC', 2020
    Co-Authors: Doerr, Frederik J. S., Burns, Lee J., Lee Becky, Hinds Jeremy, Davis-harrison, Rebecca L., Frank, Scott A., Florence, Alastair J.
    Abstract:

    Purpose Spray drying plays an important role in the pharmaceutical industry for product development of sensitive bio-pharmaceutical formulations. Process design, implementation and optimisation require in-depth knowledge of Process-product interactions. Here, an integrated approach for the rapid, early-stage spray drying Process development of trehalose and glucagon on lab-scale is presented. Methods Single droplet drying experiments were used to investigate the particle formation Process. Process implementation was supported using in-line Process analytical technology within a data acquisition framework recording temperature, humidity, pressure and feed rate. During Process implementation, off-line product characterisation provided additional information on key product properties related to residual moisture, solid state structure, particle size/morphology and peptide fibrillation/degradation. Results A Psychrometric Process model allowed the identification of feasible operating conditions for spray drying trehalose, achieving high yields of up to 84.67%, and significantly reduced levels of residual moisture and particle agglomeration compared to product obtained during non-optimal drying. The Process was further translated to produce powders of glucagon and glucagon-trehalose formulations with yields of >83.24%. Extensive peptide aggregation or degradation was not observed. Conclusions The presented data-driven Process development concept can be applied to address future isolation problems on lab-scale and facilitate a systematic implementation of spray drying for the manufacturing of sensitive bio-pharmaceutical formulations