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Torben Bjerregaard Larsen - One of the best experts on this subject based on the ideXlab platform.
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maternal smoking obesity and risk of venous thromboembolism during pregnancy and the Puerperium a population based nested case control study
Thrombosis Research, 2007Co-Authors: Torben Bjerregaard Larsen, Henrik Toft Sorensen, Mette Gislum, Soren Paaske JohnsenAbstract:Abstract Background Smoking and obesity are associated with adverse pregnancy outcomes. The aim of the present study was to examine the association between smoking, obesity (BMI>30), and risk for venous thromboembolism (VTE) during pregnancy and the Puerperium. Materials and methods In a population-based case-control study nested within a Danish cohort of 71,729 women, we identified 129 cases with VTE in pregnancy or the Puerperium, and 258 pregnant non-VTE controls. We obtained data from medical records regarding current smoking status, BMI, and other covariates, and computed the odds ratios (OR) for VTE as a measure of relative risk. Results Smoking and obesity were associated with increased risk of VTE during pregnancy and the Puerperium (adjusted OR 2.7 (95% CI: 1.5, 4.9) and 5.3 (95% CI: 2.1, 13.5), respectively). Obesity appeared to be associated with a higher risk of pulmonary embolism (adjusted OR: 14.9 (95% CI: 3.0, 74.8) than of deep venous thrombosis (adjusted OR: 4.4, 95% CI: 1.6, 11.9). Conclusion Smoking and obesity are risk factors for VTE in pregnancy and the Puerperium.
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abo blood groups and risk of venous thromboembolism during pregnancy and the Puerperium a population based nested case control study
Journal of Thrombosis and Haemostasis, 2005Co-Authors: Torben Bjerregaard Larsen, Mette Gislum, Soren Paaske Johnsen, Charlotte Moller, Helle Larsen, Henrik Toft SorensenAbstract:Summary. Objectives: To examine possible associations of ABO blood types with the risk of venous thromboembolism (VTE) in pregnancy and the Puerperium. Patients and methods: We conducted a nested case–control study within a cohort of 71 729 women who gave birth to 126 783 children in the North Jutland County, Denmark, from 1980 to 2001. We identified 129 cases with VTE in pregnancy (n = 61) or the Puerperium (n = 68), and 258 controls with no VTE. We collected information on ABO blood groups and possible maternal confounding factors and estimated the relative risk [odds ratio (OR)]. Results: Women with an A or AB blood group had elevated risk estimates of VTE in pregnancy or the Puerperium compared with women with a O blood group [adjusted ORs 2.4, 95% confidence interval (CI) 1.3, 4.3, and 2.0, 95% CI 0.7, 5.8, respectively]. No increased risk estimate was found for group B (adjusted OR 1.2, 95% CI 0.5, 3.0). The increased risk estimates of VTE for blood groups A and AB appeared present in both pregnancy (adjusted ORs of 3.9, 95% CI 1.5, 9.7, and 2.2, 95% CI 0.4, 12.5) and in the Puerperium (adjusted ORs of 2.4, 95% CI 1.0, 4.9 and 2.7, 95% CI 0.8, 9.3). Furthermore, blood groups A and AB appeared to be associated with increased risk estimates for both DVT and pulmonary embolism. Conclusion: Keeping the modest statistical precision of our study in mind, blood groups A and AB may be associated with increased risk estimates for VTE in pregnancy and the Puerperium.
Henrik Toft Sorensen - One of the best experts on this subject based on the ideXlab platform.
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maternal smoking obesity and risk of venous thromboembolism during pregnancy and the Puerperium a population based nested case control study
Thrombosis Research, 2007Co-Authors: Torben Bjerregaard Larsen, Henrik Toft Sorensen, Mette Gislum, Soren Paaske JohnsenAbstract:Abstract Background Smoking and obesity are associated with adverse pregnancy outcomes. The aim of the present study was to examine the association between smoking, obesity (BMI>30), and risk for venous thromboembolism (VTE) during pregnancy and the Puerperium. Materials and methods In a population-based case-control study nested within a Danish cohort of 71,729 women, we identified 129 cases with VTE in pregnancy or the Puerperium, and 258 pregnant non-VTE controls. We obtained data from medical records regarding current smoking status, BMI, and other covariates, and computed the odds ratios (OR) for VTE as a measure of relative risk. Results Smoking and obesity were associated with increased risk of VTE during pregnancy and the Puerperium (adjusted OR 2.7 (95% CI: 1.5, 4.9) and 5.3 (95% CI: 2.1, 13.5), respectively). Obesity appeared to be associated with a higher risk of pulmonary embolism (adjusted OR: 14.9 (95% CI: 3.0, 74.8) than of deep venous thrombosis (adjusted OR: 4.4, 95% CI: 1.6, 11.9). Conclusion Smoking and obesity are risk factors for VTE in pregnancy and the Puerperium.
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abo blood groups and risk of venous thromboembolism during pregnancy and the Puerperium a population based nested case control study
Journal of Thrombosis and Haemostasis, 2005Co-Authors: Torben Bjerregaard Larsen, Mette Gislum, Soren Paaske Johnsen, Charlotte Moller, Helle Larsen, Henrik Toft SorensenAbstract:Summary. Objectives: To examine possible associations of ABO blood types with the risk of venous thromboembolism (VTE) in pregnancy and the Puerperium. Patients and methods: We conducted a nested case–control study within a cohort of 71 729 women who gave birth to 126 783 children in the North Jutland County, Denmark, from 1980 to 2001. We identified 129 cases with VTE in pregnancy (n = 61) or the Puerperium (n = 68), and 258 controls with no VTE. We collected information on ABO blood groups and possible maternal confounding factors and estimated the relative risk [odds ratio (OR)]. Results: Women with an A or AB blood group had elevated risk estimates of VTE in pregnancy or the Puerperium compared with women with a O blood group [adjusted ORs 2.4, 95% confidence interval (CI) 1.3, 4.3, and 2.0, 95% CI 0.7, 5.8, respectively]. No increased risk estimate was found for group B (adjusted OR 1.2, 95% CI 0.5, 3.0). The increased risk estimates of VTE for blood groups A and AB appeared present in both pregnancy (adjusted ORs of 3.9, 95% CI 1.5, 9.7, and 2.2, 95% CI 0.4, 12.5) and in the Puerperium (adjusted ORs of 2.4, 95% CI 1.0, 4.9 and 2.7, 95% CI 0.8, 9.3). Furthermore, blood groups A and AB appeared to be associated with increased risk estimates for both DVT and pulmonary embolism. Conclusion: Keeping the modest statistical precision of our study in mind, blood groups A and AB may be associated with increased risk estimates for VTE in pregnancy and the Puerperium.
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the cumulative incidence of venous thromboembolism during pregnancy and Puerperium
Acta Obstetricia et Gynecologica Scandinavica, 1998Co-Authors: Birthe S Andersen, Henrik Toft Sorensen, Flemming Hald Steffensen, Gunnar Lauge Nielsen, Jorn OlsenAbstract:OBJECTIVES: The aim of the study was to estimate the cumulative incidence of venous thromboembolism during pregnancy and the Puerperium. METHODS: All diagnoses concerning venous thromboembolism in the Hospital Discharge Registry from a Danish County in women less than 49 years of age from 1984 to 1994 were included. The number of deliveries in the County during this period was obtained from The Medical Registry of Birth. RESULTS: The cumulative incidence of venous thromboembolism during pregnancy and Puerperium was 0.85 (95% CI: 0.64-1.11) per 1000 deliveries. The cumulative incidence was 0.49 (95% CI: 0.28-04).80) in 1984-89 but increased to 1.23 (95% CI: 0.87-1.69) after the introduction of ultrasound. CONCLUSION: The risk of diagnosed venous thromboembolism is low but estimates of the incidence are probably procedure dependent.
Pier Mannuccio Mannucci - One of the best experts on this subject based on the ideXlab platform.
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the risk of first venous thromboembolism during pregnancy and Puerperium in double heterozygotes for factor v leiden and prothrombin g20210a
Journal of Thrombosis and Haemostasis, 2008Co-Authors: Ida Martinelli, Valerio De Stefano, Tullia Battaglioli, Daniela Tormene, L Valdre, Elvira Grandone, Alberto Tosetto, Pier Mannuccio MannucciAbstract:BACKGROUND: The risk of venous thromboembolism (VTE) during pregnancy in double heterozygous carriers of factor (F) V Leiden and prothrombin G20210A is not established. Hence, whether or not these women deserve antithrombotic prophylaxis when pregnant is unknown. PATIENTS AND METHODS: In the frame of a multicenter family study, 52 double heterozygous carriers of FV Leiden and prothrombin G20210A who had remained pregnant at least once before knowledge of thrombophilia, were retrospectively investigated with respect to the occurrence of first VTE during pregnancy and Puerperium. They were compared with 104 heterozygous carriers of FV Leiden, 104 of prothrombin G20210A and 104 women without thrombophilia. RESULTS: Double heterozygotes were similar to single heterozygous carriers and non-carriers for the age at first pregnancy, age at testing and rate of full-term pregnancies. No VTE during pregnancy was observed in the four groups of women, whereas in the Puerperium it occurred in two double carriers (1.8% of pregnancies, 95% CI: 0.5-6.3), three single FV Leiden carriers (1.5%, 0.5-4.3), two single prothrombin G20210A carriers (1%, 0.2-3.6) and one non-carrier (0.4%, 0-2.5). CONCLUSIONS: The risk of first VTE during pregnancy and Puerperium in double heterozygous carriers of FV Leiden and prothrombin G20210A is low and similar to that of single carriers. As for single heterozygotes, antithrombotic prophylaxis in asymptomatic double heterozygous carriers appears to be justified only in Puerperium.
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the risk of recurrent venous thromboembolism in pregnancy and Puerperium without antithrombotic prophylaxis
British Journal of Haematology, 2006Co-Authors: Valerio De Stefano, Ida Martinelli, Elena Rossi, Tullia Battaglioli, Tommaso Za, Pier Mannuccio Mannucci, Giuseppe LeoneAbstract:Summary Whether or not pregnant women with a previous episode of venous thromboembolism (VTE) should receive antithrombotic prophylaxis is a matter of debate. In order to estimate the rate of recurrent deep venous thrombosis (DVT) or pulmonary embolism (PE) during pregnancy and Puerperium we retrospectively investigated a cohort of 1104 women with previous VTE; after a single DVT or isolated PE, 88 of them became pregnant at least once without receiving antithrombotic prophylaxis. Overall, 155 pregnancies and 120 Puerperium periods without prophylaxis were recorded. There were nine recurrences during pregnancy and 10 during Puerperium, with a rate of 5AE8% [95% confidence interval (CI) 3AE0–10AE6] and 8AE3% (95%CI 4AE5–14AE6) respectively. In pregnancy, the rate of recurrence was 7AE5% (95%CI 4AE0–13AE7) if the first VTE was unprovoked, related to pregnancy or to oral contraceptive use, whereas no recurrence occurred if the first VTE was related to other transient risk factors. In Puerperium, the rate of recurrence was 15AE5% (95%CI 7AE7–28AE7) in women with a pregnancy-related first VTE, with a risk 3AE9-times higher than in the remaining women. Inherited thrombophilia was not associated with a statistically significant increase in risk of recurrence in pregnancy or in Puerperium, yet the rate of recurrence in Puerperium was 14AE2% (95%CI 5AE7–31AE4) in overall carriers of factor V Leiden and 30% (95%CI 10AE7–60AE3) in carriers with a pregnancy-related first VTE, with a risk 6AE8 times higher than in women without thrombophilia and with a non pregnancy-related first VTE.
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inherited thrombophilia and first venous thromboembolism during pregnancy and Puerperium
Thrombosis and Haemostasis, 2002Co-Authors: Ida Martinelli, Valerio De Stefano, Elena Rossi, Emanuela Taioli, Katia Paciaroni, Pier Mannuccio MannucciAbstract:Venous thromboembolism is a rare but threatening complication of pregnancy. Little conclusive information is available on the actual risk of venous thromboembolism during pregnancy or Puerperium in women with inherited thrombophilia, particularly in carriers of factor V Leiden and of the G20210A prothrombin gene mutation. To determine the pregnancy-related and Puerperium-related risk of venous thrombo-embolism in women with inherited thrombophilia, we performed a case-control study on 119 women who had a first episode of deep vein thrombosis and/or pulmonary embolism during pregnancy or Puerperium and 232 healthy women who had at least one pregnancy without throm-bosis. Inherited thrombophilia was diagnosed in 47 patients (39.5%) and 15 controls (6.5%). The relative risk of venous thromboembolism was 10.6 (95% CI, 5.6-20.4) for heterozygous carriers of factor V Leiden, 2.9 (95% CI, 1.0-8.6) for heterozygous carriers of the prothrombin mutati-on and 13.1 (95% CI, 5.0-34.2) for those with antithrombin, protein C or protein S deficiency taken together. Sixty-eight of the 119 women (57%) had thrombosis after delivery, confirming the Puerperium as a particularly high-risk period. When women were divided into two groups of those with antenatal or postnatal thrombosis, the relative risks associated with each type of inherited thrombophilia were of similar magnitude. In conclusion, women with inherited thrombophilia have an increased risk of venous thromboembolism during pregnancy. Among thrombophilic abnormalities, the prothrombin mutation was the weak-est risk factor. Thrombosis occurred more frequently in Puerperium than in pregnancy, whether or not thrombophilia was diagnosed.
Soren Paaske Johnsen - One of the best experts on this subject based on the ideXlab platform.
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maternal smoking obesity and risk of venous thromboembolism during pregnancy and the Puerperium a population based nested case control study
Thrombosis Research, 2007Co-Authors: Torben Bjerregaard Larsen, Henrik Toft Sorensen, Mette Gislum, Soren Paaske JohnsenAbstract:Abstract Background Smoking and obesity are associated with adverse pregnancy outcomes. The aim of the present study was to examine the association between smoking, obesity (BMI>30), and risk for venous thromboembolism (VTE) during pregnancy and the Puerperium. Materials and methods In a population-based case-control study nested within a Danish cohort of 71,729 women, we identified 129 cases with VTE in pregnancy or the Puerperium, and 258 pregnant non-VTE controls. We obtained data from medical records regarding current smoking status, BMI, and other covariates, and computed the odds ratios (OR) for VTE as a measure of relative risk. Results Smoking and obesity were associated with increased risk of VTE during pregnancy and the Puerperium (adjusted OR 2.7 (95% CI: 1.5, 4.9) and 5.3 (95% CI: 2.1, 13.5), respectively). Obesity appeared to be associated with a higher risk of pulmonary embolism (adjusted OR: 14.9 (95% CI: 3.0, 74.8) than of deep venous thrombosis (adjusted OR: 4.4, 95% CI: 1.6, 11.9). Conclusion Smoking and obesity are risk factors for VTE in pregnancy and the Puerperium.
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abo blood groups and risk of venous thromboembolism during pregnancy and the Puerperium a population based nested case control study
Journal of Thrombosis and Haemostasis, 2005Co-Authors: Torben Bjerregaard Larsen, Mette Gislum, Soren Paaske Johnsen, Charlotte Moller, Helle Larsen, Henrik Toft SorensenAbstract:Summary. Objectives: To examine possible associations of ABO blood types with the risk of venous thromboembolism (VTE) in pregnancy and the Puerperium. Patients and methods: We conducted a nested case–control study within a cohort of 71 729 women who gave birth to 126 783 children in the North Jutland County, Denmark, from 1980 to 2001. We identified 129 cases with VTE in pregnancy (n = 61) or the Puerperium (n = 68), and 258 controls with no VTE. We collected information on ABO blood groups and possible maternal confounding factors and estimated the relative risk [odds ratio (OR)]. Results: Women with an A or AB blood group had elevated risk estimates of VTE in pregnancy or the Puerperium compared with women with a O blood group [adjusted ORs 2.4, 95% confidence interval (CI) 1.3, 4.3, and 2.0, 95% CI 0.7, 5.8, respectively]. No increased risk estimate was found for group B (adjusted OR 1.2, 95% CI 0.5, 3.0). The increased risk estimates of VTE for blood groups A and AB appeared present in both pregnancy (adjusted ORs of 3.9, 95% CI 1.5, 9.7, and 2.2, 95% CI 0.4, 12.5) and in the Puerperium (adjusted ORs of 2.4, 95% CI 1.0, 4.9 and 2.7, 95% CI 0.8, 9.3). Furthermore, blood groups A and AB appeared to be associated with increased risk estimates for both DVT and pulmonary embolism. Conclusion: Keeping the modest statistical precision of our study in mind, blood groups A and AB may be associated with increased risk estimates for VTE in pregnancy and the Puerperium.
Ida Martinelli - One of the best experts on this subject based on the ideXlab platform.
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the risk of first venous thromboembolism during pregnancy and Puerperium in double heterozygotes for factor v leiden and prothrombin g20210a
Journal of Thrombosis and Haemostasis, 2008Co-Authors: Ida Martinelli, Valerio De Stefano, Tullia Battaglioli, Daniela Tormene, L Valdre, Elvira Grandone, Alberto Tosetto, Pier Mannuccio MannucciAbstract:BACKGROUND: The risk of venous thromboembolism (VTE) during pregnancy in double heterozygous carriers of factor (F) V Leiden and prothrombin G20210A is not established. Hence, whether or not these women deserve antithrombotic prophylaxis when pregnant is unknown. PATIENTS AND METHODS: In the frame of a multicenter family study, 52 double heterozygous carriers of FV Leiden and prothrombin G20210A who had remained pregnant at least once before knowledge of thrombophilia, were retrospectively investigated with respect to the occurrence of first VTE during pregnancy and Puerperium. They were compared with 104 heterozygous carriers of FV Leiden, 104 of prothrombin G20210A and 104 women without thrombophilia. RESULTS: Double heterozygotes were similar to single heterozygous carriers and non-carriers for the age at first pregnancy, age at testing and rate of full-term pregnancies. No VTE during pregnancy was observed in the four groups of women, whereas in the Puerperium it occurred in two double carriers (1.8% of pregnancies, 95% CI: 0.5-6.3), three single FV Leiden carriers (1.5%, 0.5-4.3), two single prothrombin G20210A carriers (1%, 0.2-3.6) and one non-carrier (0.4%, 0-2.5). CONCLUSIONS: The risk of first VTE during pregnancy and Puerperium in double heterozygous carriers of FV Leiden and prothrombin G20210A is low and similar to that of single carriers. As for single heterozygotes, antithrombotic prophylaxis in asymptomatic double heterozygous carriers appears to be justified only in Puerperium.
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the risk of recurrent venous thromboembolism in pregnancy and Puerperium without antithrombotic prophylaxis
British Journal of Haematology, 2006Co-Authors: Valerio De Stefano, Ida Martinelli, Elena Rossi, Tullia Battaglioli, Tommaso Za, Pier Mannuccio Mannucci, Giuseppe LeoneAbstract:Summary Whether or not pregnant women with a previous episode of venous thromboembolism (VTE) should receive antithrombotic prophylaxis is a matter of debate. In order to estimate the rate of recurrent deep venous thrombosis (DVT) or pulmonary embolism (PE) during pregnancy and Puerperium we retrospectively investigated a cohort of 1104 women with previous VTE; after a single DVT or isolated PE, 88 of them became pregnant at least once without receiving antithrombotic prophylaxis. Overall, 155 pregnancies and 120 Puerperium periods without prophylaxis were recorded. There were nine recurrences during pregnancy and 10 during Puerperium, with a rate of 5AE8% [95% confidence interval (CI) 3AE0–10AE6] and 8AE3% (95%CI 4AE5–14AE6) respectively. In pregnancy, the rate of recurrence was 7AE5% (95%CI 4AE0–13AE7) if the first VTE was unprovoked, related to pregnancy or to oral contraceptive use, whereas no recurrence occurred if the first VTE was related to other transient risk factors. In Puerperium, the rate of recurrence was 15AE5% (95%CI 7AE7–28AE7) in women with a pregnancy-related first VTE, with a risk 3AE9-times higher than in the remaining women. Inherited thrombophilia was not associated with a statistically significant increase in risk of recurrence in pregnancy or in Puerperium, yet the rate of recurrence in Puerperium was 14AE2% (95%CI 5AE7–31AE4) in overall carriers of factor V Leiden and 30% (95%CI 10AE7–60AE3) in carriers with a pregnancy-related first VTE, with a risk 6AE8 times higher than in women without thrombophilia and with a non pregnancy-related first VTE.
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inherited thrombophilia and first venous thromboembolism during pregnancy and Puerperium
Thrombosis and Haemostasis, 2002Co-Authors: Ida Martinelli, Valerio De Stefano, Elena Rossi, Emanuela Taioli, Katia Paciaroni, Pier Mannuccio MannucciAbstract:Venous thromboembolism is a rare but threatening complication of pregnancy. Little conclusive information is available on the actual risk of venous thromboembolism during pregnancy or Puerperium in women with inherited thrombophilia, particularly in carriers of factor V Leiden and of the G20210A prothrombin gene mutation. To determine the pregnancy-related and Puerperium-related risk of venous thrombo-embolism in women with inherited thrombophilia, we performed a case-control study on 119 women who had a first episode of deep vein thrombosis and/or pulmonary embolism during pregnancy or Puerperium and 232 healthy women who had at least one pregnancy without throm-bosis. Inherited thrombophilia was diagnosed in 47 patients (39.5%) and 15 controls (6.5%). The relative risk of venous thromboembolism was 10.6 (95% CI, 5.6-20.4) for heterozygous carriers of factor V Leiden, 2.9 (95% CI, 1.0-8.6) for heterozygous carriers of the prothrombin mutati-on and 13.1 (95% CI, 5.0-34.2) for those with antithrombin, protein C or protein S deficiency taken together. Sixty-eight of the 119 women (57%) had thrombosis after delivery, confirming the Puerperium as a particularly high-risk period. When women were divided into two groups of those with antenatal or postnatal thrombosis, the relative risks associated with each type of inherited thrombophilia were of similar magnitude. In conclusion, women with inherited thrombophilia have an increased risk of venous thromboembolism during pregnancy. Among thrombophilic abnormalities, the prothrombin mutation was the weak-est risk factor. Thrombosis occurred more frequently in Puerperium than in pregnancy, whether or not thrombophilia was diagnosed.
