The Experts below are selected from a list of 53031 Experts worldwide ranked by ideXlab platform
Joseph M Guileyardo - One of the best experts on this subject based on the ideXlab platform.
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clinical and morphologic features of acute subacute and chronic cor pulmonale Pulmonary Heart Disease
American Journal of Cardiology, 2015Co-Authors: William C Roberts, Alexis E Shafii, Paul A Grayburn, Matthew R Weissenborn, Randall L Rosenblatt, Joseph M GuileyardoAbstract:Described are certain clinical and morphologic features of one patient with acute , another with subacute , and one with chronic cor pulmonale. All 3 had evidence of severe Pulmonary hypertension. The patient with acute cor pulmonale 4 days after coronary bypass for unstable angina pectoris suddenly developed severe breathlessness with cyanosis and had fatal cardiac arrest and necropsy disclosed massive Pulmonary embolism. The patient with subacute cor pulmonale had severe right-sided Heart failure for 5 weeks and necropsy disclosed microscopic-sized neoplastic Pulmonary emboli from a gastric carcinoma without parenchymal Pulmonary metastases. The patient with chronic cor pulmonale had evidence of right-sided Heart failure for years, the result of primary or idiopathic Pulmonary hypertension almost certainly present from birth because the pattern of elastic fibers in the Pulmonary trunk was that seen in newborns where the pressure in the Pulmonary trunk and ascending aorta are similar. The patient with chronic cor pulmonale had plexiform Pulmonary lesions indicative of irreversible Pulmonary hypertension. Neither the acute nor the subacute patient had chronic Pulmonary vascular changes. All 3 patients had dilated right ventricular cavities and non-dilated left ventricular cavities and only the patient with chronic cor pulmonale had right ventricular hypertrophy.
Derek G Waller - One of the best experts on this subject based on the ideXlab platform.
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xamoterol improves right ventricular systolic and diastolic function in Pulmonary Heart Disease
European Journal of Clinical Pharmacology, 1996Co-Authors: Richard M Oliver, J S Fleming, Derek G WallerAbstract:Objective: Abnormal right ventricular function in patients with Pulmonary Heart Disease (PHD) may contribute to their reduced exercise capacity. We have evaluated the effect of subacute dosing with xamoterol, a beta-1 adrenoreceptor partial agonist with inotropic properties, on right ventricular function in patients with PHD.
Bojan Zaric - One of the best experts on this subject based on the ideXlab platform.
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n terminal prohormone of brain natriuretic peptide nt probnp as a diagnostic biomarker of left ventricular systolic dysfunction in patients with acute exacerbation of chronic obstructive Pulmonary Disease aecopd
Lung, 2018Co-Authors: Ilija Andrijevic, Senka Milutinov, Zagorka Lozanov Crvenkovic, Jovan Matijasevic, Ana Andrijevic, Tomi Kovacevic, Darijo Bokan, Bojan ZaricAbstract:Left ventricular systolic dysfunction (LVSD) and cardiac decompensation often accompany AECOPD. Differentiation between the two is difficult and mainly relies on clinical and echocardiographic diagnostic procedures. The value of biomarkers, such as NT-proBNP, as diagnostic tools is still insufficiently investigated. The main goals of this trial were to investigate the value of NT-proBNP as a diagnostic tool for LVSD in AECOPD patients and determine its cut-off value which could reliably diagnose LVSD during AECOPD. This trial prospectively enrolled 209 patients with AECOPD. The patients were divided into four groups—AECOPD plus chronic Pulmonary Heart Disease (CPHD) with or without left ventricular compromise (LVSD), and AECOPD patients without CPHD with or without LVSD. NT-proBNP was measured within first 48 h of hospitalization. Majority of patients were male (61%) active smokers (41.6%), average age of 68 years. High quality of echocardiography was obtained in 63.3 and 22.5% of the patients had LVSD. Average value of NT-proBNP in patients with LVSD was 3303.2 vs. 1092.5 pg/mL in patients without LVSD. Significant differences in NT-proBNP value (p = 0.0001) were determined between observed patient groups. At the cut-off value of 1505 pg/mL, sensitivity, specificity, and positive and negative predictive values are 76.6, 83.3, 57.1, and 92.47%, respectively. At the cut-off value of 1505 pg/mL NT-proBNP could be used as a diagnostic marker for LVSD in acute exacerbation of COPD.
William C Roberts - One of the best experts on this subject based on the ideXlab platform.
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clinical and morphologic features of acute subacute and chronic cor pulmonale Pulmonary Heart Disease
American Journal of Cardiology, 2015Co-Authors: William C Roberts, Alexis E Shafii, Paul A Grayburn, Matthew R Weissenborn, Randall L Rosenblatt, Joseph M GuileyardoAbstract:Described are certain clinical and morphologic features of one patient with acute , another with subacute , and one with chronic cor pulmonale. All 3 had evidence of severe Pulmonary hypertension. The patient with acute cor pulmonale 4 days after coronary bypass for unstable angina pectoris suddenly developed severe breathlessness with cyanosis and had fatal cardiac arrest and necropsy disclosed massive Pulmonary embolism. The patient with subacute cor pulmonale had severe right-sided Heart failure for 5 weeks and necropsy disclosed microscopic-sized neoplastic Pulmonary emboli from a gastric carcinoma without parenchymal Pulmonary metastases. The patient with chronic cor pulmonale had evidence of right-sided Heart failure for years, the result of primary or idiopathic Pulmonary hypertension almost certainly present from birth because the pattern of elastic fibers in the Pulmonary trunk was that seen in newborns where the pressure in the Pulmonary trunk and ascending aorta are similar. The patient with chronic cor pulmonale had plexiform Pulmonary lesions indicative of irreversible Pulmonary hypertension. Neither the acute nor the subacute patient had chronic Pulmonary vascular changes. All 3 patients had dilated right ventricular cavities and non-dilated left ventricular cavities and only the patient with chronic cor pulmonale had right ventricular hypertrophy.
Richard M Oliver - One of the best experts on this subject based on the ideXlab platform.
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xamoterol improves right ventricular systolic and diastolic function in Pulmonary Heart Disease
European Journal of Clinical Pharmacology, 1996Co-Authors: Richard M Oliver, J S Fleming, Derek G WallerAbstract:Objective: Abnormal right ventricular function in patients with Pulmonary Heart Disease (PHD) may contribute to their reduced exercise capacity. We have evaluated the effect of subacute dosing with xamoterol, a beta-1 adrenoreceptor partial agonist with inotropic properties, on right ventricular function in patients with PHD.
