The Experts below are selected from a list of 20379 Experts worldwide ranked by ideXlab platform
Yoshinori Hasegawa - One of the best experts on this subject based on the ideXlab platform.
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successful re treatment with gefitinib for carcinomatous meningitis as disease recurrence of non small cell lung cancer
Lung Cancer, 2006Co-Authors: Naozumi Hashimoto, Toyohiro Honda, Kazuyoshi Imaizumi, Tsutomu Kawabe, Tetsuro Nagasaka, Kaoru Shimokata, Yoshinori HasegawaAbstract:We report the case of a woman with gefitinib-sensitive lung adenocarcinoma, who was successfully re-treated with gefitinib for carcinomatous meningitis as the disease recurrence. The good response to gefitinib treatment was supported in part by the existence of epidermal growth factor receptor mutation in carcinoma cells in the specimen obtained from transbronchial lung biopsy, in which E709G in exon 18 and L858R in exon 21 were shown. Although carcinomatous meningitis had been well controlled by the treatment with gefitinib, serum carcinoembryonic antigen (CEA) level increased with re-growth of primary tumor and development of lymphangitic carcinomatosis. Immunohistochemical findings revealed de novo emergence of CEA-producing carcinoma cells in the biopsy specimen taken after recurrence of Pulmonary Lesion during re-treatment of gefitinib, but revealed little or no CEA expression in the specimen obtained at first presentation. These facts may suggest the possibility of oligo clonality of carcinoma cells in this case.
Jun Nakajima - One of the best experts on this subject based on the ideXlab platform.
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Resection of solitary Pulmonary Lesion is beneficial to patients with a history of malignancy.
The Annals of thoracic surgery, 2010Co-Authors: Miki Sakamoto, Tomohiro Murakawa, Kentaro Kitano, Tomonori Murayama, Takehiro Tsuchiya, Jun NakajimaAbstract:Background Solitary Pulmonary Lesion poses a diagnostic challenge, especially in patients with a history of malignancy. The purpose of this study was to evaluate the characteristics of solitary Pulmonary Lesions and the outcome of surgical resection. Methods We retrospectively analyzed 243 patients with a history of cancer who underwent surgery for new-found solitary Pulmonary Lesion between January 1998 and December 2007. Results The diagnosis was primary lung cancer in 92 patients, metastasis in 133, and benign Lesions in 18. The 5-year survival rate was 67.9% in all patients, 74.6% in those with primary lung cancer, 62.8% in those with metastasis, and 79.9% in those with benign Lesions ( p = 0.56). In metastasis patients, history of extraPulmonary recurrence and larger diameter Lesion were risk factors for recurrence by multivariate analysis. History of cancers other than colorectal and bone and soft tissue sarcoma and shorter disease-free interval were indicators of poor prognosis. Pathologic stage was the only indicator of prognosis for primary lung cancer, and none of the factors concerning antecedent cancer influenced prognosis. Conclusions Surgical resection of solitary Pulmonary Lesion is essential in patients with a history of cancer because substantial numbers of benign Lesions are included. In the case of malignancy, metastasectomy had a life-prolonging effect for selected patients, and prognosis of primary lung cancer was no worse than for the general population if treated appropriately. It is important not to hesitate to take a surgical approach for a diagnosis and to treat with standard therapy for primary lung cancer.
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resection of a Pulmonary Lesion after liver transplantation report of a case
Surgery Today, 2005Co-Authors: Nobuhisa Akamatsu, Jun Nakajima, Yasuhiko Sugawara, Yoji Kishi, Takashi Niiya, Junichi Kaneko, Masatoshi MakuuchiAbstract:A 44-year-old Chinese-Indonesian man who underwent living-donor liver transplantation with a right liver graft presented 4 months later with a cough and fever. Chest X-ray showed a nodular shadow in the apex of the left lung, which was diagnosed as Pulmonary tuberculosis. After 1 week of antituberculous chemotherapy, we performed a left upper lobectomy. Postoperative antituberculous chemotherapy, consisting of isoniazid (300 mg/day) and rifampin (450 mg/day), was continued for 4 months, and there has been no sign of recurrence for 1 year since the thoracotomy. This case supports the feasibility of surgery for localized Pulmonary tuberculosis soon after transplantation.
Xuan Xie - One of the best experts on this subject based on the ideXlab platform.
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solitary Pulmonary Lesion in patients with history of malignancy primary lung cancer or metastatic cancer
Annals of Surgical Oncology, 2018Co-Authors: Ke Jin, Kexi Wang, Huizhong Zhang, Yuejiang Pan, Dexiong Cao, Minghui Wang, Ju Chen, Boshen Chen, Xuan XieAbstract:Defining the status of solitary Pulmonary Lesion (SPL) in patients with history of malignancy is important because primary lung cancer (PLC) or intraPulmonary metastasis might indicate different surgical strategies. The aim of this study is to identify factors related to the status of these Lesions and construct a clinical model to estimate the pretest probability of PLC. From January 2005 to January 2016, 104 patients with previous malignancy and suitable for surgery were retrospectively studied. Univariate and multivariate analyses were performed to identify possible factors related to SPLs. A nomogram was constructed to differentiate PLC from intraPulmonary metastasis. Ninety-seven (93.3%) patients were diagnosed as malignant postoperatively, including 61 patients with intraPulmonary metastasis and 36 patients with PLC. Multivariate analysis showed that site of primary tumor [head and neck squamous cell cancer: odds ratio (OR) = 28.509, P = 0.006; genitourinary cancer: OR = 23.928, P = 0.012], negative lymph node status of primary tumor (OR = 3.154, P = 0.038), spiculation of SPL (OR = 3.972, P = 0.022), and central location of SPL (OR = 4.679, P = 0.026) were four independent factors differentiating PLC from intraPulmonary metastasis. All of these were included in the nomogram. The C-index of the nomogram for predicting probability was 0.82. Incidence of malignant SPLs was fairly high in patients with history of malignancy. A nomogram including site and lymph node status of primary tumor, and spiculation and location of SPL might be a good tool for differentiating PLC from intraPulmonary metastasis preoperatively and guiding treatment.
Sammy Saab - One of the best experts on this subject based on the ideXlab platform.
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apparent remission of a solitary metastatic Pulmonary Lesion in a liver transplant recipient treated with sorafenib
American Journal of Transplantation, 2009Co-Authors: M Yeganeh, R S Finn, Sammy SaabAbstract:Hepatocellular carcinoma (HCC) remains a significant disease worldwide and its incidence is expected to increase. In selected patients, liver transplantation offers a 5-year patient survival between 48% and 75%. However, HCC recurrence occurs in approximately 20% of transplant recipients. No therapy has proven efficacious in decreasing the risk of recurrence after transplantation. Sorafenib, a multitargeted tyrosine kinase inhibitor, has been shown to improve survival in patients with advanced HCC that have no history of liver transplantation. We report complete remission of HCC in a 54-year-old man who developed biopsy-proven lung metastasis after liver transplantation treated with sorafenib.
Vinay Duddalwar - One of the best experts on this subject based on the ideXlab platform.
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radiomics in Pulmonary Lesion imaging
American Journal of Roentgenology, 2019Co-Authors: Cameron Hassani, Bino Varghese, Jorge Nieva, Vinay DuddalwarAbstract:OBJECTIVE. Diagnostic imaging has traditionally relied on a limited set of qualitative imaging characteristics for the diagnosis and management of lung cancer. Radiomics—the extraction and analysis...
