The Experts below are selected from a list of 11964 Experts worldwide ranked by ideXlab platform
Nathalie Picqué - One of the best experts on this subject based on the ideXlab platform.
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dual comb coherent raman spectroscopy with lasers of 1 ghz Pulse Repetition Frequency
Optics Letters, 2017Co-Authors: Kathrin J. Mohler, Bernhard J. Bohn, Ming Yan, Theodor W. Hänsch, Gwenaelle Melen, Nathalie PicquéAbstract:We extend the technique of multiplex coherent Raman spectroscopy with two femtosecond mode-locked lasers to oscillators of a Pulse Repetition Frequency of 1 GHz. We demonstrate a spectra of liquids, which span 1100 cm−1 of Raman shifts. At a resolution of 6 cm−1, their measurement time may be as short as 5 μs for a refresh rate of 2 kHz. The waiting period between acquisitions is improved 10-fold compared to previous experiments with two lasers of 100-MHz Repetition frequencies.
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Dual-Comb Coherent Raman Spectroscopy with Lasers of 1-GHz Pulse Repetition Frequency
Optics letters, 2017Co-Authors: Kathrin J. Mohler, Bernhard J. Bohn, Ming Yan, Theodor W. Hänsch, Nathalie PicquéAbstract:We extend the technique of multiplex coherent Raman spectroscopy with two femtosecond mode-locked lasers to oscillators of a Pulse Repetition Frequency of 1 GHz. We demonstrate spectra of liquids, which span 1100 cm$^{-1}$ of Raman shifts. At a resolution of 6 cm$^{-1}$, their measurement time may be as short as 5 microseconds for a refresh rate of 2 kHz. The waiting period between acquisitions is improved ten-fold compared to previous experiments with two lasers of 100-MHz Repetition frequencies.
Pete N Urns - One of the best experts on this subject based on the ideXlab platform.
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sonoporation by ultrasound activated microbubble contrast agents effect of acoustic exposure parameters on cell membrane permeability and cell viability
Ultrasound in Medicine and Biology, 2009Co-Authors: Raffi Karshafia, Ross Williams, Sanya Samac, Pete D Eva, Pete N UrnsAbstract:Abtract This work investigates the effect of ultrasound exposure parameters on the sonoporation of KHT-C cells in suspension by perflutren microbubbles. Variations in insonating acoustic pressure (0.05 to 3.5 MPa), Pulse Frequency (0.5 to 5.0 MHz), Pulse Repetition Frequency (10 to 3000 Hz), Pulse duration (4 to 32 μs) and insonation time (0.1 to 900 s) were studied. The number of cells permeabilised to a fluorescent tracer molecule (70 kDa FITC-dextran) and the number of viable cells were measured using flow cytometry. The effect of exposure on the microbubble population was measured using a Coulter counter. Cell viability and membrane permeability were found to depend strongly on the acoustic exposure conditions. Cell permeability increased and viability decreased with increasing peak negative pressure, Pulse Repetition Frequency, Pulse duration and insonation time and with decreasing Pulse centre Frequency. The highest therapeutic ratio (defined as the ratio of permeabilised to nonviable cells) achieved was 8.8 with 32 ± 4% permeabilisation and 96 ± 1% viability at 570 kPa peak negative pressure, 8 μs Pulse duration, 3 kHz Pulse Repetition Frequency, 500 kHz centre Frequency and 12 s insonation time with microbubbles at 3.3% volume concentration. These settings correspond to an acoustic energy density (E SPPA ) of 3.12 J/cm 2 . Cell permeability and viability did not correlate with bubble disruption. The results indicate that ultrasound exposure parameters can be optimized for therapeutic sonoporation and that bubble disruption is a necessary but insufficient indicator of ultrasound-induced permeabilisation. (E-mail: raffik@sri.utoronto.ca )
A A Lagatsky - One of the best experts on this subject based on the ideXlab platform.
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2 μm solid state laser mode locked by single layer graphene
Applied Physics Letters, 2013Co-Authors: A A Lagatsky, Zhipei Sun, Tero S Kulmala, R S Sundaram, S Milana, F Torrisi, O L Antipov, Youngze Lee, Jong Hyun Ahn, C T A BrownAbstract:We report a 2 μm ultrafast solid-state Tm:Lu2O3 laser, mode-locked by single-layer graphene, generating transform-limited ∼410 fs Pulses, with a spectral width ∼11.1 nm at 2067 nm. The maximum average output power is 270 mW, at a Pulse Repetition Frequency of 110 MHz. This is a convenient high-power transform-limited ultrafast laser at 2 μm for various applications, such as laser surgery and material processing.
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2 mu m solid state laser mode locked by single layer graphene
arXiv: Mesoscale and Nanoscale Physics, 2012Co-Authors: A A Lagatsky, Zhipei Sun, Tero S Kulmala, R S Sundaram, S Milana, F Torrisi, O L Antipov, Youngze Lee, Jong Hyun Ahn, C T A BrownAbstract:We report a 2\mu m ultrafast solid-state Tm:Lu2O3 laser, mode-locked by single-layer graphene, generating transform-limited~410fs Pulses, with a spectral width~11.1nm at 2067nm. The maximum average output power is 270mW, at a Pulse Repetition Frequency of 110MHz. This is a convenient high-power transform-limited laser at 2\mu m for various applications, such as laser surgery and material processing.
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broadly tunable femtosecond tm lu2o3 ceramic laser operating around 2070 nm
Optics Express, 2012Co-Authors: A A Lagatsky, O L Antipov, W SibbettAbstract:Femtosecond mode locking of a Tm-doped Lu2O3 ceramic laser is reported. Transform-limited Pulses as short as 180 fs are generated at 2076 nm with an average output power of 400 mW and a Pulse Repetition Frequency of 121.2 MHz. An output power up to 750 mW can be reached at the somewhat longer Pulse duration of 382 fs. Femtosecond Pulse generation is realized in the 2030-2100 nm spectral range. Passive mode locking was achieved using an ion-implanted InGaAsSb quantum-well-based SESAM.
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femtosecond Pulse operation of a tm ho codoped crystalline laser near 2 μm
Optics Letters, 2010Co-Authors: A A Lagatsky, C T A Brown, F Fusari, S Calvez, S V Kurilchik, V E Kisel, N V Kuleshov, M D Dawson, W SibbettAbstract:We demonstrate, for the first time to our knowledge, femtosecond-regime mode locking of a Tm,Ho-codoped crystalline laser operating in the 2 microm spectral region. Transform-limited 570 fs Pulses were generated at 2055 nm by a Tm,Ho:KY(WO(4))(2) laser that produced an average output power of 130 mW at a Pulse Repetition Frequency of 118 MHz. Mode locking was achieved using an ion-implanted InGaAsSb quantum-well-based semiconductor saturable absorber mirror.
C T A Brown - One of the best experts on this subject based on the ideXlab platform.
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2 μm solid state laser mode locked by single layer graphene
Applied Physics Letters, 2013Co-Authors: A A Lagatsky, Zhipei Sun, Tero S Kulmala, R S Sundaram, S Milana, F Torrisi, O L Antipov, Youngze Lee, Jong Hyun Ahn, C T A BrownAbstract:We report a 2 μm ultrafast solid-state Tm:Lu2O3 laser, mode-locked by single-layer graphene, generating transform-limited ∼410 fs Pulses, with a spectral width ∼11.1 nm at 2067 nm. The maximum average output power is 270 mW, at a Pulse Repetition Frequency of 110 MHz. This is a convenient high-power transform-limited ultrafast laser at 2 μm for various applications, such as laser surgery and material processing.
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2 mu m solid state laser mode locked by single layer graphene
arXiv: Mesoscale and Nanoscale Physics, 2012Co-Authors: A A Lagatsky, Zhipei Sun, Tero S Kulmala, R S Sundaram, S Milana, F Torrisi, O L Antipov, Youngze Lee, Jong Hyun Ahn, C T A BrownAbstract:We report a 2\mu m ultrafast solid-state Tm:Lu2O3 laser, mode-locked by single-layer graphene, generating transform-limited~410fs Pulses, with a spectral width~11.1nm at 2067nm. The maximum average output power is 270mW, at a Pulse Repetition Frequency of 110MHz. This is a convenient high-power transform-limited laser at 2\mu m for various applications, such as laser surgery and material processing.
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femtosecond Pulse operation of a tm ho codoped crystalline laser near 2 μm
Optics Letters, 2010Co-Authors: A A Lagatsky, C T A Brown, F Fusari, S Calvez, S V Kurilchik, V E Kisel, N V Kuleshov, M D Dawson, W SibbettAbstract:We demonstrate, for the first time to our knowledge, femtosecond-regime mode locking of a Tm,Ho-codoped crystalline laser operating in the 2 microm spectral region. Transform-limited 570 fs Pulses were generated at 2055 nm by a Tm,Ho:KY(WO(4))(2) laser that produced an average output power of 130 mW at a Pulse Repetition Frequency of 118 MHz. Mode locking was achieved using an ion-implanted InGaAsSb quantum-well-based semiconductor saturable absorber mirror.
Kathrin J. Mohler - One of the best experts on this subject based on the ideXlab platform.
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dual comb coherent raman spectroscopy with lasers of 1 ghz Pulse Repetition Frequency
Optics Letters, 2017Co-Authors: Kathrin J. Mohler, Bernhard J. Bohn, Ming Yan, Theodor W. Hänsch, Gwenaelle Melen, Nathalie PicquéAbstract:We extend the technique of multiplex coherent Raman spectroscopy with two femtosecond mode-locked lasers to oscillators of a Pulse Repetition Frequency of 1 GHz. We demonstrate a spectra of liquids, which span 1100 cm−1 of Raman shifts. At a resolution of 6 cm−1, their measurement time may be as short as 5 μs for a refresh rate of 2 kHz. The waiting period between acquisitions is improved 10-fold compared to previous experiments with two lasers of 100-MHz Repetition frequencies.
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Dual-Comb Coherent Raman Spectroscopy with Lasers of 1-GHz Pulse Repetition Frequency
Optics letters, 2017Co-Authors: Kathrin J. Mohler, Bernhard J. Bohn, Ming Yan, Theodor W. Hänsch, Nathalie PicquéAbstract:We extend the technique of multiplex coherent Raman spectroscopy with two femtosecond mode-locked lasers to oscillators of a Pulse Repetition Frequency of 1 GHz. We demonstrate spectra of liquids, which span 1100 cm$^{-1}$ of Raman shifts. At a resolution of 6 cm$^{-1}$, their measurement time may be as short as 5 microseconds for a refresh rate of 2 kHz. The waiting period between acquisitions is improved ten-fold compared to previous experiments with two lasers of 100-MHz Repetition frequencies.
