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Philip Chowienczyk - One of the best experts on this subject based on the ideXlab platform.
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vasoactive drugs influence aortic augmentation index independently of Pulse Wave Velocity in healthy men
Hypertension, 2001Co-Authors: R P Kelly, Sandrine Millasseau, James M Ritter, Philip ChowienczykAbstract:Abstract —Aortic augmentation index, a measure of central systolic blood pressure augmentation arising mainly from pressure-Wave reflection, increases with vascular aging. The augmentation index is influenced by aortic Pulse-Wave Velocity (related to aortic stiffness) and by the site and extent of Wave reflection. To clarify the relative influence of Pulse-Wave Velocity and Wave reflection on the augmentation index, we studied the association between augmentation index, Pulse-Wave Velocity, and age and examined the effects of vasoactive drugs to determine whether altering vascular tone has differential effects on Pulse-Wave Velocity and the augmentation index. We made simultaneous measurements of the augmentation index and carotid-to-femoral Pulse-Wave Velocity in 50 asymptomatic men aged 19 to 74 years at baseline and, in a subset, during the administration of nitroglycerin, angiotensin II, and saline vehicle. The aortic augmentation index was obtained by radial tonometry (Sphygmocor device, PWV Medical) with the use of an inbuilt radial to aortic transfer function. In multiple regression analysis, the aortic augmentation index was independently correlated only with age ( R =0.58, P <0.0001). Nitroglycerin (3 to 300 μg/min IV) reduced the aortic augmentation index from 4.8±2.3% to −11.9±5.3% (n=10, P <0.002). Angiotensin II (75 to 300 ng/min IV) increased the aortic augmentation index from 9.3±2.4% to 18.3±2.9% (n=12, P <0.001). These drugs had small effects on aortic Pulse-Wave Velocity, producing mean changes from baseline of <1 m/s (each P <0.05). In healthy men, vasoactive drugs may change aortic augmentation index independently from aortic Pulse-Wave Velocity.
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Vasoactive Drugs Influence Aortic Augmentation Index Independently of Pulse-Wave Velocity in Healthy Men
Hypertension, 2001Co-Authors: R P Kelly, Sandrine Millasseau, James M Ritter, Philip ChowienczykAbstract:Abstract —Aortic augmentation index, a measure of central systolic blood pressure augmentation arising mainly from pressure-Wave reflection, increases with vascular aging. The augmentation index is influenced by aortic Pulse-Wave Velocity (related to aortic stiffness) and by the site and extent of Wave reflection. To clarify the relative influence of Pulse-Wave Velocity and Wave reflection on the augmentation index, we studied the association between augmentation index, Pulse-Wave Velocity, and age and examined the effects of vasoactive drugs to determine whether altering vascular tone has differential effects on Pulse-Wave Velocity and the augmentation index. We made simultaneous measurements of the augmentation index and carotid-to-femoral Pulse-Wave Velocity in 50 asymptomatic men aged 19 to 74 years at baseline and, in a subset, during the administration of nitroglycerin, angiotensin II, and saline vehicle. The aortic augmentation index was obtained by radial tonometry (Sphygmocor device, PWV Medical) with the use of an inbuilt radial to aortic transfer function. In multiple regression analysis, the aortic augmentation index was independently correlated only with age ( R =0.58, P
R P Kelly - One of the best experts on this subject based on the ideXlab platform.
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vasoactive drugs influence aortic augmentation index independently of Pulse Wave Velocity in healthy men
Hypertension, 2001Co-Authors: R P Kelly, Sandrine Millasseau, James M Ritter, Philip ChowienczykAbstract:Abstract —Aortic augmentation index, a measure of central systolic blood pressure augmentation arising mainly from pressure-Wave reflection, increases with vascular aging. The augmentation index is influenced by aortic Pulse-Wave Velocity (related to aortic stiffness) and by the site and extent of Wave reflection. To clarify the relative influence of Pulse-Wave Velocity and Wave reflection on the augmentation index, we studied the association between augmentation index, Pulse-Wave Velocity, and age and examined the effects of vasoactive drugs to determine whether altering vascular tone has differential effects on Pulse-Wave Velocity and the augmentation index. We made simultaneous measurements of the augmentation index and carotid-to-femoral Pulse-Wave Velocity in 50 asymptomatic men aged 19 to 74 years at baseline and, in a subset, during the administration of nitroglycerin, angiotensin II, and saline vehicle. The aortic augmentation index was obtained by radial tonometry (Sphygmocor device, PWV Medical) with the use of an inbuilt radial to aortic transfer function. In multiple regression analysis, the aortic augmentation index was independently correlated only with age ( R =0.58, P <0.0001). Nitroglycerin (3 to 300 μg/min IV) reduced the aortic augmentation index from 4.8±2.3% to −11.9±5.3% (n=10, P <0.002). Angiotensin II (75 to 300 ng/min IV) increased the aortic augmentation index from 9.3±2.4% to 18.3±2.9% (n=12, P <0.001). These drugs had small effects on aortic Pulse-Wave Velocity, producing mean changes from baseline of <1 m/s (each P <0.05). In healthy men, vasoactive drugs may change aortic augmentation index independently from aortic Pulse-Wave Velocity.
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Vasoactive Drugs Influence Aortic Augmentation Index Independently of Pulse-Wave Velocity in Healthy Men
Hypertension, 2001Co-Authors: R P Kelly, Sandrine Millasseau, James M Ritter, Philip ChowienczykAbstract:Abstract —Aortic augmentation index, a measure of central systolic blood pressure augmentation arising mainly from pressure-Wave reflection, increases with vascular aging. The augmentation index is influenced by aortic Pulse-Wave Velocity (related to aortic stiffness) and by the site and extent of Wave reflection. To clarify the relative influence of Pulse-Wave Velocity and Wave reflection on the augmentation index, we studied the association between augmentation index, Pulse-Wave Velocity, and age and examined the effects of vasoactive drugs to determine whether altering vascular tone has differential effects on Pulse-Wave Velocity and the augmentation index. We made simultaneous measurements of the augmentation index and carotid-to-femoral Pulse-Wave Velocity in 50 asymptomatic men aged 19 to 74 years at baseline and, in a subset, during the administration of nitroglycerin, angiotensin II, and saline vehicle. The aortic augmentation index was obtained by radial tonometry (Sphygmocor device, PWV Medical) with the use of an inbuilt radial to aortic transfer function. In multiple regression analysis, the aortic augmentation index was independently correlated only with age ( R =0.58, P
Paolo Salvi - One of the best experts on this subject based on the ideXlab platform.
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Left ventricular ejection time, not heart rate, is an independent correlate of aortic Pulse Wave Velocity
Journal of Applied Physiology, 2013Co-Authors: Paolo Salvi, Carlo Palombo, Giovanni Matteo Salvi, Carlos Labat, Gianfranco Parati, Athanase BenetosAbstract:Several studies showed a positive association between heart rate and Pulse Wave Velocity, a sensitive marker of arterial stiffness. However, no study involving a large population has specifically addressed the dependence of Pulse Wave Velocity on different components of the cardiac cycle. The aim of this study was to explore in subjects of different age the link between Pulse Wave Velocity with heart period (the reciprocal of heart rate) and the temporal components of the cardiac cycle such as left ventricular ejection time and diastolic time. Carotid-femoral Pulse Wave Velocity was assessed in 3,020 untreated subjects (1,107 men). Heart period, left ventricular ejection time, diastolic time, and early-systolic dP/dt were determined by carotid Pulse Wave analysis with high-fidelity applanation tonometry. An inverse association was found between Pulse Wave Velocity and left ventricular ejection time at all ages (
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Pulse Wave Velocity and Pulse Wave Analysis in Experimental Animals
Pulse Waves, 2012Co-Authors: Paolo SalviAbstract:Until a few years ago, Pulse Wave Velocity in experimental animals (mice, rats, rabbits, etc.) could only be measured by invasive methods. The carotid or femoral artery was surgically isolated and catheterized to assess intra-arterial pressure. The carotid and femoral signals were measured simultaneously, and the Pulse Wave transit time was then calculated. However, this operation would cause the death of the small laboratory animal, which was then dissected to measure the distance between the two catheters. Pulse Wave Velocity was calculated in this way.
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reference values of Pulse Wave Velocity in healthy children and teenagers
Hypertension, 2010Co-Authors: George S Reusz, Orsolya Cseprekal, Mohamed Temmar, Abdelghani Bachir Cherif, Abddelhalim Thaleb, Andrea Fekete, Attila J Szabo, Athanase Benetos, Paolo SalviAbstract:Carotid-femoral Pulse Wave Velocity is an established method for characterizing aortic stiffness, an individual predictor of cardiovascular mortality in adults. Normal Pulse Wave Velocity values for the pediatric population derived from a large data collection have yet to be available. The aim of this study was to create a reference database and to characterize the factors determining Pulse Wave Velocity in children and teenagers. Carotid-femoral Pulse Wave Velocity was measured by applanation tonometry. Reference tables from Pulse Wave velocities obtained in 1008 healthy subjects (aged between 6 and 20 years; 495 males) were generated using a maximum-likelihood curve-fitting technique for calculating SD scores in accordance with the skewed distribution of the raw data. Effects of sex, age, height, weight, blood pressure, and heart rate on Pulse Wave Velocity were assessed. Sex-specific reference tables and curves for age and height are presented. Pulse Wave Velocity correlated positively ( P 1000 children, is the first to provide reference values for Pulse Wave Velocity in children and teenagers, thereby constituting a suitable tool for longitudinal clinical studies assessing subgroups of children who are at long-term risk of cardiovascular disease.
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reference values of aortic Pulse Wave Velocity in the elderly
Journal of Hypertension, 2008Co-Authors: C Alecu, Paolo Salvi, Carlos Labat, A Kearneyschwartz, Laure Joly, Patrick Lacolley, Herve Vespignani, Athanase BenetosAbstract:BackgroundIncreased aortic Pulse Wave Velocity (AoPWV) is an independent predictor of cardiovascular morbidity and mortality. There are, however, no generally accepted limits for defining the normal or reference values. The aim of the present study was to define reference values for AoPWV.Patients a
Athanase Benetos - One of the best experts on this subject based on the ideXlab platform.
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Left ventricular ejection time, not heart rate, is an independent correlate of aortic Pulse Wave Velocity
Journal of Applied Physiology, 2013Co-Authors: Paolo Salvi, Carlo Palombo, Giovanni Matteo Salvi, Carlos Labat, Gianfranco Parati, Athanase BenetosAbstract:Several studies showed a positive association between heart rate and Pulse Wave Velocity, a sensitive marker of arterial stiffness. However, no study involving a large population has specifically addressed the dependence of Pulse Wave Velocity on different components of the cardiac cycle. The aim of this study was to explore in subjects of different age the link between Pulse Wave Velocity with heart period (the reciprocal of heart rate) and the temporal components of the cardiac cycle such as left ventricular ejection time and diastolic time. Carotid-femoral Pulse Wave Velocity was assessed in 3,020 untreated subjects (1,107 men). Heart period, left ventricular ejection time, diastolic time, and early-systolic dP/dt were determined by carotid Pulse Wave analysis with high-fidelity applanation tonometry. An inverse association was found between Pulse Wave Velocity and left ventricular ejection time at all ages (
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reference values of Pulse Wave Velocity in healthy children and teenagers
Hypertension, 2010Co-Authors: George S Reusz, Orsolya Cseprekal, Mohamed Temmar, Abdelghani Bachir Cherif, Abddelhalim Thaleb, Andrea Fekete, Attila J Szabo, Athanase Benetos, Paolo SalviAbstract:Carotid-femoral Pulse Wave Velocity is an established method for characterizing aortic stiffness, an individual predictor of cardiovascular mortality in adults. Normal Pulse Wave Velocity values for the pediatric population derived from a large data collection have yet to be available. The aim of this study was to create a reference database and to characterize the factors determining Pulse Wave Velocity in children and teenagers. Carotid-femoral Pulse Wave Velocity was measured by applanation tonometry. Reference tables from Pulse Wave velocities obtained in 1008 healthy subjects (aged between 6 and 20 years; 495 males) were generated using a maximum-likelihood curve-fitting technique for calculating SD scores in accordance with the skewed distribution of the raw data. Effects of sex, age, height, weight, blood pressure, and heart rate on Pulse Wave Velocity were assessed. Sex-specific reference tables and curves for age and height are presented. Pulse Wave Velocity correlated positively ( P 1000 children, is the first to provide reference values for Pulse Wave Velocity in children and teenagers, thereby constituting a suitable tool for longitudinal clinical studies assessing subgroups of children who are at long-term risk of cardiovascular disease.
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reference values of aortic Pulse Wave Velocity in the elderly
Journal of Hypertension, 2008Co-Authors: C Alecu, Paolo Salvi, Carlos Labat, A Kearneyschwartz, Laure Joly, Patrick Lacolley, Herve Vespignani, Athanase BenetosAbstract:BackgroundIncreased aortic Pulse Wave Velocity (AoPWV) is an independent predictor of cardiovascular morbidity and mortality. There are, however, no generally accepted limits for defining the normal or reference values. The aim of the present study was to define reference values for AoPWV.Patients a
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Pulse Wave Velocity as endpoint in large scale intervention trial the complior study
Journal of Hypertension, 2001Co-Authors: Roland Asmar, Bruno Pannier, Athanase Benetos, Jirar Topouchian, Michel E SafarAbstract:ObjectiveTo evaluate the ability of an antihypertensive therapy to improve arterial stiffness as assessed by aortic Pulse Wave Velocity (PWV) in a large population of hypertensive patients.SettingSixty-nine healthcare centres, private and institutional (19 countries).PatientsSubjects aged 18–79 year
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assessment of arterial distensibility by automatic Pulse Wave Velocity measurement validation and clinical application studies
Hypertension, 1995Co-Authors: Roland Asmar, Bruno Pannier, Athanase Benetos, Jirar Topouchian, Pierre Laurent, Annemarie Brisac, Ralph Target, Bernard I LevyAbstract:Abstract Pulse Wave Velocity is widely used as an index of arterial distensibility. The aim of this study was to evaluate the accuracy of a new automatic device to measure it and then to analyze the major determinants of Pulse Wave Velocity by application of this device in a large population. We evaluated the accuracy of on-line and computerized measurement of Pulse Wave Velocity using an algorithm based on the time-shifted and repeated linear correlation calculation between the initial rise in pressure Waveforms compared with the reference method (manual calculation) in 56 subjects. The results, analyzed according to the recommendations of Bland and Altman, showed a mean difference of −0.20±0.45 m/s for the mean carotid-femoral Pulse Wave Velocity values (reference method, 11.05±2.58 m/s; automatic device, 10.85±2.44 m/s). The inter-reproducibility and intrareproducibility of measurements by each method were analyzed with the use of the repeatability coefficient according to the British Standards Institution. The interobserver repeatability coefficient was 0.947 for the manual method and 0.890 for the automatic, and intraobserver repeatability coefficients were 0.938 and 0.935, respectively. We evaluated the major determinants of the carotid-femoral Pulse Wave Velocity measured by the automatic method in a separate study performed in 418 subjects of both sexes without any cardiovascular treatment or complication (18 to 77 years of age; 98 to 222 mm Hg systolic and 62 to 130 mm Hg diastolic pressure). Multiple regression analysis between Pulse Wave Velocity and clinical parameters (age, sex, weight, height, smoking, arterial blood pressure, heart rate) and biological plasma parameters (total cholesterol, high-density lipoprotein cholesterol, glycemia) showed that Pulse Wave Velocity correlated positively and independently with age and systolic pressure ( r 2 =.47; P
James M Ritter - One of the best experts on this subject based on the ideXlab platform.
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vasoactive drugs influence aortic augmentation index independently of Pulse Wave Velocity in healthy men
Hypertension, 2001Co-Authors: R P Kelly, Sandrine Millasseau, James M Ritter, Philip ChowienczykAbstract:Abstract —Aortic augmentation index, a measure of central systolic blood pressure augmentation arising mainly from pressure-Wave reflection, increases with vascular aging. The augmentation index is influenced by aortic Pulse-Wave Velocity (related to aortic stiffness) and by the site and extent of Wave reflection. To clarify the relative influence of Pulse-Wave Velocity and Wave reflection on the augmentation index, we studied the association between augmentation index, Pulse-Wave Velocity, and age and examined the effects of vasoactive drugs to determine whether altering vascular tone has differential effects on Pulse-Wave Velocity and the augmentation index. We made simultaneous measurements of the augmentation index and carotid-to-femoral Pulse-Wave Velocity in 50 asymptomatic men aged 19 to 74 years at baseline and, in a subset, during the administration of nitroglycerin, angiotensin II, and saline vehicle. The aortic augmentation index was obtained by radial tonometry (Sphygmocor device, PWV Medical) with the use of an inbuilt radial to aortic transfer function. In multiple regression analysis, the aortic augmentation index was independently correlated only with age ( R =0.58, P <0.0001). Nitroglycerin (3 to 300 μg/min IV) reduced the aortic augmentation index from 4.8±2.3% to −11.9±5.3% (n=10, P <0.002). Angiotensin II (75 to 300 ng/min IV) increased the aortic augmentation index from 9.3±2.4% to 18.3±2.9% (n=12, P <0.001). These drugs had small effects on aortic Pulse-Wave Velocity, producing mean changes from baseline of <1 m/s (each P <0.05). In healthy men, vasoactive drugs may change aortic augmentation index independently from aortic Pulse-Wave Velocity.
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Vasoactive Drugs Influence Aortic Augmentation Index Independently of Pulse-Wave Velocity in Healthy Men
Hypertension, 2001Co-Authors: R P Kelly, Sandrine Millasseau, James M Ritter, Philip ChowienczykAbstract:Abstract —Aortic augmentation index, a measure of central systolic blood pressure augmentation arising mainly from pressure-Wave reflection, increases with vascular aging. The augmentation index is influenced by aortic Pulse-Wave Velocity (related to aortic stiffness) and by the site and extent of Wave reflection. To clarify the relative influence of Pulse-Wave Velocity and Wave reflection on the augmentation index, we studied the association between augmentation index, Pulse-Wave Velocity, and age and examined the effects of vasoactive drugs to determine whether altering vascular tone has differential effects on Pulse-Wave Velocity and the augmentation index. We made simultaneous measurements of the augmentation index and carotid-to-femoral Pulse-Wave Velocity in 50 asymptomatic men aged 19 to 74 years at baseline and, in a subset, during the administration of nitroglycerin, angiotensin II, and saline vehicle. The aortic augmentation index was obtained by radial tonometry (Sphygmocor device, PWV Medical) with the use of an inbuilt radial to aortic transfer function. In multiple regression analysis, the aortic augmentation index was independently correlated only with age ( R =0.58, P
