The Experts below are selected from a list of 144 Experts worldwide ranked by ideXlab platform
Patricia E. Molina - One of the best experts on this subject based on the ideXlab platform.
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A Lateral Fluid Percussion Injury Model for Studying Traumatic Brain Injury in Rats.
Methods in molecular biology (Clifton N.J.), 2018Co-Authors: Paige S. Katz, Patricia E. MolinaAbstract:Traumatic brain injury (TBI) diagnoses have increased in frequency during the past decade, becoming a silent epidemic. The pathophysiology of TBI involves pathophysiological processes affecting the brain, induced by traumatic biomechanical forces resulting in temporary impairment of neurological function. Preclinical models have been generated to recapitulate the mechanical, neuroinflammatory, and behavioral outcomes observed in the clinical setting. The lateral fluid percussion (LFP) model is the most extensively used and well-characterized model of nonpenetrating and nonischemic TBI. The model is reproducible and can be adjusted to produce a mild to moderate and severe injury, as reflected by mortality and return of reflexes, by adjusting the amount of force applied. The histopathological changes achieved with this model reproduce that seen in human TBI including focal contusion in the cortex, with accompanying intraparenchymal Punctate Hemorrhage, followed by inflammation and neuronal degeneration. This chapter describes the LFP model, which produces a mixed model of focal and diffuse brain injury that progresses over time affecting predominantly the cortical parenchyma.
Paige S. Katz - One of the best experts on this subject based on the ideXlab platform.
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A Lateral Fluid Percussion Injury Model for Studying Traumatic Brain Injury in Rats.
Methods in molecular biology (Clifton N.J.), 2018Co-Authors: Paige S. Katz, Patricia E. MolinaAbstract:Traumatic brain injury (TBI) diagnoses have increased in frequency during the past decade, becoming a silent epidemic. The pathophysiology of TBI involves pathophysiological processes affecting the brain, induced by traumatic biomechanical forces resulting in temporary impairment of neurological function. Preclinical models have been generated to recapitulate the mechanical, neuroinflammatory, and behavioral outcomes observed in the clinical setting. The lateral fluid percussion (LFP) model is the most extensively used and well-characterized model of nonpenetrating and nonischemic TBI. The model is reproducible and can be adjusted to produce a mild to moderate and severe injury, as reflected by mortality and return of reflexes, by adjusting the amount of force applied. The histopathological changes achieved with this model reproduce that seen in human TBI including focal contusion in the cortex, with accompanying intraparenchymal Punctate Hemorrhage, followed by inflammation and neuronal degeneration. This chapter describes the LFP model, which produces a mixed model of focal and diffuse brain injury that progresses over time affecting predominantly the cortical parenchyma.
Francis W. Wessbecher - One of the best experts on this subject based on the ideXlab platform.
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Thrombolysis for Superior Sagittal Sinus Thrombosis
Journal of vascular and interventional radiology : JVIR, 1991Co-Authors: Joseph M. Eskridge, Francis W. WessbecherAbstract:A 29-year old woman who began taking oral contraceptives (OCs) after the birth of her 7-month old complained of bifrontal headaches and had a grand mal seizure on the 4th day. She had no history of previous thromboembolic or ischemic disease and other than the seizure was very healthy. After arrival at a health facility she was conscious not confused and neurologically fine. The computed tomographic (CT) scans appeared normal. Other than an elevated opening pressure of 55 cm of water the lumbar puncture was normal. Health workers transferred her to the University of Washington Medical Center in Seattle. Physicians thought her to look healthy at admission. A repeat CT scan and a cerebral angiogram indicated thrombosis of the superior sagittal sinus straight sinus and the transverse sinuses. Over the next 24 hours she worsened neurologically and then went into a coma. Her intracranial pressure was 60 mm Hg. They began fibrinolysis (urokinase infusion 4000U/min per minute and 5000 U of iv heparin for 2 hours and then a decreased infusion rate) after 1st attempting to advance the catheter beyond the sigmoid sinus and the superior sagittal sinus. Angiography revealed that the clot at the right transverse sinus had broken up by the next morning. 12 hours later the thrombosis at the sagittal sinus and the bilateral cortical veins had begun to lyse. After 36 hours of infusion a 2 mm Punctate Hemorrhage occurred in the front left thalamus so the physicians stopped fibrinolytic therapy. It completely abated during the next 48 hours. Even though neurologically she remained the same her intracranial pressure dropped to 20 mm Hg. Within 24 hours she responded to commands. 1 week after therapy began her neurological status was normal. Physicians prescribed oral anticoagulants at discharge. Since hematologic tests did not uncover coagulopathy the physicians believed OCs caused the sinus thrombosis.
Jan Show Chu - One of the best experts on this subject based on the ideXlab platform.
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Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts
Journal of the Formosan Medical Association = Taiwan yi zhi, 2010Co-Authors: Hui Chin Peng, Ming Te Huang, Da Jeng Chen, Ting Kai Leung, Jan Show ChuAbstract:Pleomorphic hyalinizing angiectatic tumor (PHAT) of soft parts is a rare, nonmetastasizing tumor of uncertain lineage which was first reported in 1996. Here, we report a case of PHAT and review the literature. A 49-year-old man presented with a soft and progressively enlarging mass over the right buttock for several years. On suspicion that the mass was a right gluteal lipoma, he underwent surgical excision. The excised lesion measured 14 × 6 × 3.5 cm. It had a variegated appearance with a white-tan to yellowish color on the cut surface. Some Punctate Hemorrhage and vessel thrombosis were seen. Microscopically, the tumor was a PHAT characterized by clusters of ectatic, fibrin-lined, thin-walled vessels, which were surrounded by a mitotically inert, spindled, pleomorphic, neoplastic stroma that contained a variable inflammatory component. Immunohistochemical study showed that the tumor cells were positive for CD34, and negative for S-100, HMB45 and actin. The patient experienced local recurrence 6 months later. The recurrent tumor was widely excised. No evidence of metastasis was found during the 18 months after the second operation. The recurrent lesion had a microscopic appearance that was similar to the initial lesion.
Xue-yan Zhang - One of the best experts on this subject based on the ideXlab platform.
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SWI obtained in a 64-year-old woman after heat stroke with a score of 3 in Glasgow Coma Scale.
2014Co-Authors: Xue-yan ZhangAbstract:On the 5th day after admission, amplitude (A) and minIP (B) images show Punctate Hemorrhage detected in brain stem.
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SWI obtained in a 90-year-old man after heat stroke with a score of 6 in Glasgow Coma Scale.
2014Co-Authors: Xue-yan ZhangAbstract:On the 4th day after admission, amplitude (A) and minIP (B) images show Punctate Hemorrhage detected in right frontal lobe.
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SWI obtained in a 43-year-old man after heat stroke with a score of 3 in Glasgow Coma Scale.
2014Co-Authors: Xue-yan ZhangAbstract:On the 4th day after admission, amplitude (A) and minIP (B) images show Punctate Hemorrhage detected in right corona radiata.
