The Experts below are selected from a list of 174 Experts worldwide ranked by ideXlab platform
Krikor Bijian - One of the best experts on this subject based on the ideXlab platform.
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targeting focal adhesion turnover in invasive breast cancer cells by the Purine Derivative reversine
British Journal of Cancer, 2013Co-Authors: Krikor Bijian, C Lougheed, Jie Su, Bin Xu, Henry Yu, Jianhui Wu, K Riccio, Moulay A AlaouijamaliAbstract:Targeting focal adhesion turnover in invasive breast cancer cells by the Purine Derivative reversine
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Targeting focal adhesion turnover in invasive breast cancer cells by the Purine Derivative reversine
British Journal of Cancer, 2013Co-Authors: Krikor Bijian, C Lougheed, Jie Su, Bin Xu, Henry Yu, K Riccio, J H Wu, M A Alaoui-jamaliAbstract:Background: The dynamics of focal adhesion (FA) turnover is a key determinant for the regulation of cancer cell migration. Here we investigated FA turnover in a panel of breast cancer models with distinct invasive properties and evaluated the impact of reversine on this turnover in relation to cancer cell invasion in in vitro and in vivo conditions. Methods: Live imaging and immunofluorescence assays were used to investigate FA turnover in breast cancer cells. Biochemical studies were used to investigate the impact of reversine on FA signalling and turnover. In vivo activity was investigated using orthotopic breast cancer mouse models. Results: Accelerated FA disassembly from plasma membrane protrusions was observed in invasive compared with non-invasive breast cancer cells or non-immortalised mammary epithelial cells. Reversine significantly inhibited FA disassembly leading to stable FAs, which was associated with reduced cell motility and invasion. The inhibitory effect of reversine on FA turnover accounted for a large part on its capacity to interfere with FAK function on regulating its downstream targets. In orthotopic breast cancer mouse models, reversine revealed a potent inhibitory activity on tumour progression to metastasis. Conclusion: These results support the utility of targeting FA turnover as a therapeutic approach for invasive breast cancer.
Moulay A Alaouijamali - One of the best experts on this subject based on the ideXlab platform.
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targeting focal adhesion turnover in invasive breast cancer cells by the Purine Derivative reversine
British Journal of Cancer, 2013Co-Authors: Krikor Bijian, C Lougheed, Jie Su, Bin Xu, Henry Yu, Jianhui Wu, K Riccio, Moulay A AlaouijamaliAbstract:Targeting focal adhesion turnover in invasive breast cancer cells by the Purine Derivative reversine
Jie Su - One of the best experts on this subject based on the ideXlab platform.
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targeting focal adhesion turnover in invasive breast cancer cells by the Purine Derivative reversine
British Journal of Cancer, 2013Co-Authors: Krikor Bijian, C Lougheed, Jie Su, Bin Xu, Henry Yu, Jianhui Wu, K Riccio, Moulay A AlaouijamaliAbstract:Targeting focal adhesion turnover in invasive breast cancer cells by the Purine Derivative reversine
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Targeting focal adhesion turnover in invasive breast cancer cells by the Purine Derivative reversine
British Journal of Cancer, 2013Co-Authors: Krikor Bijian, C Lougheed, Jie Su, Bin Xu, Henry Yu, K Riccio, J H Wu, M A Alaoui-jamaliAbstract:Background: The dynamics of focal adhesion (FA) turnover is a key determinant for the regulation of cancer cell migration. Here we investigated FA turnover in a panel of breast cancer models with distinct invasive properties and evaluated the impact of reversine on this turnover in relation to cancer cell invasion in in vitro and in vivo conditions. Methods: Live imaging and immunofluorescence assays were used to investigate FA turnover in breast cancer cells. Biochemical studies were used to investigate the impact of reversine on FA signalling and turnover. In vivo activity was investigated using orthotopic breast cancer mouse models. Results: Accelerated FA disassembly from plasma membrane protrusions was observed in invasive compared with non-invasive breast cancer cells or non-immortalised mammary epithelial cells. Reversine significantly inhibited FA disassembly leading to stable FAs, which was associated with reduced cell motility and invasion. The inhibitory effect of reversine on FA turnover accounted for a large part on its capacity to interfere with FAK function on regulating its downstream targets. In orthotopic breast cancer mouse models, reversine revealed a potent inhibitory activity on tumour progression to metastasis. Conclusion: These results support the utility of targeting FA turnover as a therapeutic approach for invasive breast cancer.
K Riccio - One of the best experts on this subject based on the ideXlab platform.
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targeting focal adhesion turnover in invasive breast cancer cells by the Purine Derivative reversine
British Journal of Cancer, 2013Co-Authors: Krikor Bijian, C Lougheed, Jie Su, Bin Xu, Henry Yu, Jianhui Wu, K Riccio, Moulay A AlaouijamaliAbstract:Targeting focal adhesion turnover in invasive breast cancer cells by the Purine Derivative reversine
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Targeting focal adhesion turnover in invasive breast cancer cells by the Purine Derivative reversine
British Journal of Cancer, 2013Co-Authors: Krikor Bijian, C Lougheed, Jie Su, Bin Xu, Henry Yu, K Riccio, J H Wu, M A Alaoui-jamaliAbstract:Background: The dynamics of focal adhesion (FA) turnover is a key determinant for the regulation of cancer cell migration. Here we investigated FA turnover in a panel of breast cancer models with distinct invasive properties and evaluated the impact of reversine on this turnover in relation to cancer cell invasion in in vitro and in vivo conditions. Methods: Live imaging and immunofluorescence assays were used to investigate FA turnover in breast cancer cells. Biochemical studies were used to investigate the impact of reversine on FA signalling and turnover. In vivo activity was investigated using orthotopic breast cancer mouse models. Results: Accelerated FA disassembly from plasma membrane protrusions was observed in invasive compared with non-invasive breast cancer cells or non-immortalised mammary epithelial cells. Reversine significantly inhibited FA disassembly leading to stable FAs, which was associated with reduced cell motility and invasion. The inhibitory effect of reversine on FA turnover accounted for a large part on its capacity to interfere with FAK function on regulating its downstream targets. In orthotopic breast cancer mouse models, reversine revealed a potent inhibitory activity on tumour progression to metastasis. Conclusion: These results support the utility of targeting FA turnover as a therapeutic approach for invasive breast cancer.
Henry Yu - One of the best experts on this subject based on the ideXlab platform.
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targeting focal adhesion turnover in invasive breast cancer cells by the Purine Derivative reversine
British Journal of Cancer, 2013Co-Authors: Krikor Bijian, C Lougheed, Jie Su, Bin Xu, Henry Yu, Jianhui Wu, K Riccio, Moulay A AlaouijamaliAbstract:Targeting focal adhesion turnover in invasive breast cancer cells by the Purine Derivative reversine
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Targeting focal adhesion turnover in invasive breast cancer cells by the Purine Derivative reversine
British Journal of Cancer, 2013Co-Authors: Krikor Bijian, C Lougheed, Jie Su, Bin Xu, Henry Yu, K Riccio, J H Wu, M A Alaoui-jamaliAbstract:Background: The dynamics of focal adhesion (FA) turnover is a key determinant for the regulation of cancer cell migration. Here we investigated FA turnover in a panel of breast cancer models with distinct invasive properties and evaluated the impact of reversine on this turnover in relation to cancer cell invasion in in vitro and in vivo conditions. Methods: Live imaging and immunofluorescence assays were used to investigate FA turnover in breast cancer cells. Biochemical studies were used to investigate the impact of reversine on FA signalling and turnover. In vivo activity was investigated using orthotopic breast cancer mouse models. Results: Accelerated FA disassembly from plasma membrane protrusions was observed in invasive compared with non-invasive breast cancer cells or non-immortalised mammary epithelial cells. Reversine significantly inhibited FA disassembly leading to stable FAs, which was associated with reduced cell motility and invasion. The inhibitory effect of reversine on FA turnover accounted for a large part on its capacity to interfere with FAK function on regulating its downstream targets. In orthotopic breast cancer mouse models, reversine revealed a potent inhibitory activity on tumour progression to metastasis. Conclusion: These results support the utility of targeting FA turnover as a therapeutic approach for invasive breast cancer.
