The Experts below are selected from a list of 714 Experts worldwide ranked by ideXlab platform
Martínez Galofré, María José - One of the best experts on this subject based on the ideXlab platform.
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Manifestaciones purpúricas atípicas por parvovirus B19 en dos miembros de una familia: Caso clínico
Revista médica de Chile, 2008Co-Authors: Martínez Galofré, María José, Elgueta N,andreaAbstract:Two atypical cases of parvovirus B19 infection occurred consecutively within a family. A 14 year-old patient presented an extended papular-Purpuric "gloves and socks" syndrome and two weeks later his mother developed a predominantly unilateral Purpuric Rash in the limbs with severe malaise. Specific IgM antibodies in the boy and polymerase chain reaction (PCR) and serology in the mother, confirmed parvovirus B19 infection. We emphasize the variable presentation of B19 infection within a family. The importance ofetiologic studies in the presence of atypical exanthemas and the utility of PCR in the diagnosis ofB19 are undesrscore
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A family outbreak of parvovirus B19 atypical exanthemas. Report of two cases Manifestaciones purpúricas atípicas por parvovirus B19 en dos miembros de una familia. Caso clínico
2008Co-Authors: Martínez Galofré, María José, Elgueta N AndreaAbstract:Two atypical cases of parvovirus B19 infection occurred consecutively within a family. A 14 year-old patient presented an extended papular-Purpuric "gloves and socks" syndrome and two weeks later his mother developed a predominantly unilateral Purpuric Rash in the limbs with severe malaise. Specific IgM antibodies in the boy and polymerase chain reaction (PCR) and serology in the mother, confirmed parvovirus B19 infection. We emphasize the variable presentation of B19 infection within a family. The importance of etiologic studies in the presence of atypical exanthemas and the utility of PCR in the diagnosis of B19 are undesrscored
Olivier Gilliaux - One of the best experts on this subject based on the ideXlab platform.
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indications and efficiency of dapsone in iga vasculitis henoch schonlein purpura case series and a review of the literature
European Journal of Pediatrics, 2019Co-Authors: Celine Roman, Bogdan Dima, Laurence Muyshont, Thierry Schurmans, Olivier GilliauxAbstract:Immunoglobulin A (IgA) vasculitis (Henoch-Schonlein purpura (HSP)) is the most common vasculitis in children. It is characterized by Purpuric Rash, arthritis, gastrointestinal, and/or renal involvement. Spontaneous resolution is the typical outcome. In chronic cutaneous manifestations of IgA vasculitis, dapsone seems to show a good effectiveness. Multiple case reports and case series about dapsone in chronic IgA vasculitis are available. However, no clear evaluation of its indications, its effectiveness, or its usage guidelines (optimal dosage or duration of treatment) is available. We reviewed the published cases of IgA vasculitis treated by dapsone and compared them with 2 similar cases that we encountered. Seventeen patients (ranging from 22 months old to 16 years old) with severe or persistent clinical signs of IgA vasculitis were included. Dapsone showed good results on the resolution of cutaneous lesions but not on renal manifestations. Complications (methemoglobinemia) were observed on 1 patient. Half of the patients relapsed after treatment discontinuation. The difference between the time lapse before initiation and the duration of the treatment was not significant. Conclusion: We suggest that dapsone can have a positive effect in chronic IgA vasculitis when cutaneous manifestations last more than 6 weeks at the dosage of 1–2 mg/kg once per day during 1 week.
Dan Luo - One of the best experts on this subject based on the ideXlab platform.
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transient hypofibrinogenemia due to allopurinol
Drug Design Development and Therapy, 2014Co-Authors: Zhiqiang Yin, Jiping Xia, Dan LuoAbstract:This study reports a case of an 80-year-old male who suffered from drug eruption due to oral allopurinol for the treatment of gout. This patient complained of widespread erythema and maculopapule with itch, and small quantities of purplish-red Rash with diffused distribution on four limbs were noted. After he was hospitalized, the area with Purpuric Rash increased in size, and hypofibrinogenemia was found. After treatment with intravenous infusion of fibrinogen and cryoprecipitate, and continued treatment with high-dose methylprednisolone, the skin Rash gradually went away. This is the first report of purpura and hypofibrinogenemia induced by allopurinol and the pathophysiology underlying this reaction remained unknown.
Nam Hee Won - One of the best experts on this subject based on the ideXlab platform.
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a case of late onset acute tubulointerstitial nephritis with infliximab and mesalazine treatment in a patient with crohn s disease
The Korean Journal of Gastroenterology, 2014Co-Authors: Yang Ae J Yoo, Sang Oon Y Chung, Heui Jung Pyo, Young Joo Kwon, Young Tae Bak, Nam Hee WonAbstract:Infliximab is a chimeric anti-tumor necrosis factor-alpha monoclonal antibody. Infusion related reactions and infection are well known side effects of infliximab; however, renal complications have not been well recognized. We report on a patient with late onset-acute tubulointerstitial nephritis (ATIN) after treatment with infliximab and mesalazine for Crohn's disease. A 25-year-old woman was admitted with a Purpuric Rash on both lower extremities and arthralgia. She had been diagnosed with Crohn's disease 5.6 years previously and had been treated with mesalazine and infliximab. Serum creatinine level, last measured one year ago, was elevated from 0.6 mg/dL to 1.9 mg/dL. Results of urinalysis, ultrasound, and serologic examinations were normal. With a tentative diagnosis of Henoch-Schonlein purpura, oral prednisolone was given, and serum creatinine decreased to 1.46 mg/dL, but was elevated to 2.6 mg/dL again at two months after discontinuation of prednisolone. Renal biopsy indicated that ATIN was probably induced by drug, considering significant infiltration of eosinophils. Concomitant use of infliximab with mesalazine was supposed to trigger ATIN. Oral prednisolone was administered, and serum creatinine level showed partial recovery. Thus, ATIN should be suspected as a cause of renal impairment in Crohn's disease even after a long period of maintenance treatment with infliximab and mesalazine.
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A Case of Late Onset-Acute Tubulointerstitial Nephritis with Infliximab and Mesalazine Treatment in a Patient with Crohn’s Disease
2013Co-Authors: Yang Jae Yoo, Heui Jung Pyo, Young Joo Kwon, Young Tae Bak, Sang Yoon Chung, Nam Hee WonAbstract:Infliximab is a chimeric anti-tumor necrosis factor-alpha monoclonal antibody. Infusion related reactions and infection are well known side effects of infliximab; however, renal complications have not been well recognized. We report on a patient with late onset-acute tubulointerstitial nephritis (ATIN) after treatment with infliximab and mesalazine for Crohn’s disease. A 25-year-old woman was admitted with a Purpuric Rash on both lower extremities and arthralgia. She had been diagnosed with Crohn’s disease 5.6 years previously and had been treated with mesalazine and infliximab. Serum creatinine level, last measured one year ago, was elevated from 0.6 mg/dL to 1.9 mg/dL. Results of urinalysis, ultrasound, and serologic examinations were normal. With a tentative diagnosis of Henoch-Schönlein purpura, oral prednisolone was given, and serum creatinine decreased to 1.46 mg/dL, but was elevated to 2.6 mg/dL again at two months after discontinuation of prednisolone. Renal biopsy indicated that ATIN was probably induced by drug, considering significant infiltration of eosinophils. Concomitant use of infliximab with mesalazine was supposed to trigger ATIN. Oral prednisolone was administered, and serum creatinine level showed partial recovery. Thus, ATIN should be suspected as a cause of renal impairment in Crohn’s disease even after a long period of maintenance treatment with infliximab and mesalazine. (Korean J Gastroenterol 2014;63:308-312
Elgueta N,andrea - One of the best experts on this subject based on the ideXlab platform.
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Manifestaciones purpúricas atípicas por parvovirus B19 en dos miembros de una familia: Caso clínico
Revista médica de Chile, 2008Co-Authors: Martínez Galofré, María José, Elgueta N,andreaAbstract:Two atypical cases of parvovirus B19 infection occurred consecutively within a family. A 14 year-old patient presented an extended papular-Purpuric "gloves and socks" syndrome and two weeks later his mother developed a predominantly unilateral Purpuric Rash in the limbs with severe malaise. Specific IgM antibodies in the boy and polymerase chain reaction (PCR) and serology in the mother, confirmed parvovirus B19 infection. We emphasize the variable presentation of B19 infection within a family. The importance ofetiologic studies in the presence of atypical exanthemas and the utility of PCR in the diagnosis ofB19 are undesrscore
