The Experts below are selected from a list of 1998 Experts worldwide ranked by ideXlab platform
Robert Pennisi - One of the best experts on this subject based on the ideXlab platform.
-
acute generalised exanthematous Pustulosis induced by the herbal remedy ginkgo biloba
The Medical Journal of Australia, 2006Co-Authors: Robert PennisiAbstract:Acute generalised exanthematous Pustulosis (AGEP) is a clinical reaction pattern that is induced, in over 90% of cases, by systemic drugs (most frequently antibacterial drugs). This is the first reported case of AGEP caused by the herbal remedy Ginkgo biloba.
Mario G Bianchetti - One of the best experts on this subject based on the ideXlab platform.
-
synovitis acne Pustulosis hyperostosis osteitis sapho syndrome in childhood a report of ten cases and review of the literature
European Journal of Pediatrics, 2000Co-Authors: Benedetta C Berettapiccoli, M J Sauvain, Imre Gal, Andreas Schibler, Traudel Saurenmann, Helene Kressebuch, Mario G BianchettiAbstract:Chronic recurrent multifocal osteomyelitis is a rare chronic inflammatory musculoskeletal process observed in children and young adults. Recently, the acronym SAPHO syndrome (for synovitis, acne, Pustulosis, hyperostosis, osteitis) was coined to emphasise the association between osteo-articular inflammations and different skin abnormalities which are aseptic and filled with neutrophils. In adults, chronic recurrent multifocal osteomyelitis is now a classical manifestation of SAPHO syndrome. Chronic skin disorders were seen in eight of ten children on follow-up at the University Children's Hospitals in Bern and Zurich and in 61 of 260 paediatric cases reported in the literature. The different skin lesions were palmoplantar Pustulosis (n=40), non-palmoplantar Pustulosis (n=6), psoriasis vulgaris (n=16) or severe acne (n=4). More rarely Sweet syndrome (n=2) or pyoderma gangrenosum (n=1) were reported.
-
synovitis acne Pustulosis hyperostosis osteitis sapho syndrome in childhood a report of ten cases and review of the literature
European Journal of Pediatrics, 2000Co-Authors: Benedetta C Berettapiccoli, M J Sauvain, Imre Gal, Andreas Schibler, Traudel Saurenmann, Helene Kressebuch, Mario G BianchettiAbstract:Chronic recurrent multifocal osteomyelitis is a rare chronic inflammatory musculoskeletal process observed in children and young adults. Recently, the acronym SAPHO syndrome (for synovitis, acne, Pustulosis, hyperostosis, osteitis) was coined to emphasise the association between osteo-articular inflammations and different skin abnormalities which are aseptic and filled with neutrophils. In adults, chronic recurrent multifocal osteomyelitis is now a classical manifestation of SAPHO syndrome. Chronic skin disorders were seen in eight of ten children on follow-up at the University Children's Hospitals in Bern and Zurich and in 61 of 260 paediatric cases reported in the literature. The different skin lesions were palmoplantar Pustulosis (n=40), non-palmoplantar Pustulosis (n=6), psoriasis vulgaris (n=16) or severe acne (n=4). More rarely Sweet syndrome (n=2) or pyoderma gangrenosum (n=1) were reported. Conclusion The synovitis, acne, Pustulosis, hyperostosis, osteitis syndrome is pertinent even in paediatrics since skin involvement is frequent.
Wen Zhang - One of the best experts on this subject based on the ideXlab platform.
-
serum levels of proinflammatory anti inflammatory cytokines and rankl opg in synovitis acne Pustulosis hyperostosis and osteitis sapho syndrome
Modern Rheumatology, 2019Co-Authors: Shuo Zhang, Siya Zhang, Weihong Zhang, Zhenhua Dong, Wen ZhangAbstract:Objective: To measure the expression of proinflammatory, anti-inflammatory cytokines, and receptor activator NK-κB ligand (RANKL)/osteoprotegerin (OPG) in synovitis, acne, Pustulosis, hyperostosis,...
-
clinical heterogeneity of sapho syndrome challenge of diagnosis
Modern Rheumatology, 2018Co-Authors: Yihan Cao, Wen ZhangAbstract:Synovitis, acne, Pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is spectrum of highly heterogeneous diseases firstly proposed by Chamot et al. [1]. Characterized by the coexisting of derma...
Sima Halevy - One of the best experts on this subject based on the ideXlab platform.
-
acute generalized exanthematous Pustulosis
Current Opinion in Allergy and Clinical Immunology, 2009Co-Authors: Sima HalevyAbstract:Acute generalized exanthematous Pustulosis (AGEP) is a rare, severe, pustular reaction pattern, attributed mainly to drugs. Other triggers such as infections, spider bite, and contact sensitivity have been implicated. AGEP is characterized by typical morphology, unique histology, and a rapid clinical course. The AGEP validation score (EuroSCAR group criteria) is a useful tool for establishing the diagnosis. The immune pathogenesis involves drug-specific T-cells, neutrophils, and the release of cytokines/chemokines (i.e., IL-8/CXCL8). In view of the remarkable clinical and histological similarity between AGEP and pustular psoriasis, the genetic basis of AGEP should be further evaluated.
Muhammad Asim Khan - One of the best experts on this subject based on the ideXlab platform.
-
new insights into synovitis acne Pustulosis hyperostosis and osteitis sapho syndrome
Current Rheumatology Reports, 2009Co-Authors: Marina Magrey, Muhammad Asim KhanAbstract:In 1987, synovitis, acne, Pustulosis, hyperostosis and osteitis (SAPHO) syndrome was proposed as an umbrella term for a group of diseases with similar musculoskeletal manifestations, in particular hyperostosis of anterior chest wall, synovitis, and multifocal aseptic osteomyelitis, observed in association with dermatologic conditions such as palmoplantar Pustulosis, severe acne, and hidradenitis suppurativa. Despite recent advances in our understanding of the epidemiologic, pathophysiologic, and immunogenetic mechanisms involved in SAPHO syndrome, etiopathogenesis remains poorly understood. Propionibacterium acnes, the microorganism associated with acne, has been recovered on bone biopsy in some patients, but the possible pathogenetic role of an infectious agent in a genetically predisposed individual, resulting in exaggerated inflammatory response as “reactive osteitis,“ is a largely unproven hypothesis. The newly available whole-body MRI will assist early diagnosis by detecting multifocal osteitis lesions, some of them asymptomatic, in axial (anterior chest wall, spine, and jaws) and nonaxial sites. Moreover, outcomes are vastly improved by treatment with bisphosphonates and tumor necrosis factor-α antagonists.
-
the sapho syndrome
Baillière's clinical rheumatology, 1994Co-Authors: M F Kahn, Muhammad Asim KhanAbstract:The occurrence of musculoskeletal manifestations (including synovitis, chest wall arthro-osteitis and multifocal aseptic osteomyelitis) in association with severe acne, palmoplantar Pustulosis and perhaps with some presentations of psoriasis, have been described by many authors in the past 30 years. These different multifaceted descriptions have been designated by a variety of terms. More recently, a possible link between these conditions and spondarthritides has also been underlined by a slightly increased prevalence of HLA-B27 and occasional occurrences of sacroiliitis, chronic inflammatory bowel disease and possibly psoriasis. An acronym, the SAPHO syndrome (which stands for Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) is proposed for this group of diseases because of the similarity of musculoskeletal manifestations in patients with severe acne and Pustulosis. The clinical, epidemiological, pathophysiological, immunogenetic and diagnostic aspects, as well as the management of this syndrome, are reviewed.
