PUVA Therapy

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Duk Kyu Chun - One of the best experts on this subject based on the ideXlab platform.

Warwick L. Morison - One of the best experts on this subject based on the ideXlab platform.

  • Consensus Workshop on the Toxic Effects of Long-term PUVA Therapy
    Archives of dermatology, 1998
    Co-Authors: Warwick L. Morison, Richard D. Baughman, Robert M. Day, P. Donald Forbes, Herbert Hoenigsmann, Gerald G. Krueger, Mark Lebwohl, Robert A. Lew, Luigi Naldi, John A. Parrish
    Abstract:

    The possibility that there is an increased risk of melanoma in patients with psoriasis treated with psoralen–UV-A (PUVA) Therapy has raised concern on the part of physicians and patients about the long-term safety of this treatment. In response to this concern, the National Psoriasis Foundation sponsored a workshop at which invited participants with expertise in PUVA Therapy, psoriasis treatment, melanoma and nonmelanoma skin cancer, and epidemiological and clinical trials were asked to develop a consensus on the following 3 issues: the risk of long-term adverse effects of PUVA Therapy with emphasis on nonmelanoma and melanoma skin cancer; the guidelines for physicians and patients for selection and use of PUVA Therapy with consideration of the risk-benefit ratio of this treatment compared with the risk-benefit ratios of alternative treatments; and the directions for further evaluation of the long-term effects of PUVA Therapy.

  • PUVA Therapy is preferable to uvb photoTherapy in the management of hiv associted dermatoses
    Photochemistry and Photobiology, 1996
    Co-Authors: Warwick L. Morison
    Abstract:

    Both methoxsalen plus UVA (PUVA) Therapy and UVB photoTherapy are commonly used in the management of human immunodeficiency virus-associated dermatoses but UVB photoTherapy appears to be the preferred treatment. There are several considerations, in particular therapeutic efficacy and therapeutic profile, which suggest that PUVA Therapy might be more effective, This needs to be established in clinical trials.

  • PUVA Therapy is Preferable to UVB PhotoTherapy in the Management of HIV‐Associted Dermatoses
    Photochemistry and photobiology, 1996
    Co-Authors: Warwick L. Morison
    Abstract:

    Both methoxsalen plus UVA (PUVA) Therapy and UVB photoTherapy are commonly used in the management of human immunodeficiency virus-associated dermatoses but UVB photoTherapy appears to be the preferred treatment. There are several considerations, in particular therapeutic efficacy and therapeutic profile, which suggest that PUVA Therapy might be more effective, This needs to be established in clinical trials.

  • PUVA Therapy for Chronic Cutaneous Graft-vs-Host Disease
    Archives of dermatology, 1991
    Co-Authors: Rise M. Jampel, Evan R. Farmer, Georgia B. Vogelsang, John R. Wingard, George W. Santos, Warwick L. Morison
    Abstract:

    • Chronic graft-vs-host disease (GVHD) is an immunologic disorder frequently occurring as a late sequelae of allogeneic bone marrow transplantation and characterized in the skin with lichenoid or sclerodermoid lesions. Systemic immunosuppressive agents such as corticosteroids or cyclosporine are usually required to control the disease. Therapy with psoralen and UVA (PUVA) has recently been shown to be effective for skin and oral mucosa in a few cases of GVHD. We present our experience with PUVA in six patients, five with lichenoid and one with sclerodermoid GVHD. None of these patients had significant systemic involvement. All five patients with lichenoid GVHD showed clinical improvement after PUVA Therapy. Three of these patients had complete clearance of skin lesions. Clinical clearance of the disease was accompanied by microscopic clearance. The patient with sclerodermoid GVHD did not respond to Therapy. No significant complications or exacerbation of systemic disease occurred. We confirm that PUVA is an effective and safe Therapy for the cutaneous manifestations of lichenoid chronic GVHD. We postulate that PUVA Therapy clears chronic lichenoid GVHD by selective cytotoxicity for the activated lymphoid cells in the inflammatory infiltrate. (Arch Dermatol.1991;127:1673-1678)

H S Park - One of the best experts on this subject based on the ideXlab platform.

Y S Lee - One of the best experts on this subject based on the ideXlab platform.

C M Hager - One of the best experts on this subject based on the ideXlab platform.

  • bath PUVA Therapy in three patients with scleredema adultorum
    Journal of The American Academy of Dermatology, 1998
    Co-Authors: C M Hager, H A Sobhi, N Hunzelmann, C Wickenhauser, R Scharenberg, T Krieg, Karin Scharffetterkochanek
    Abstract:

    Abstract Background: Scleredema adultorum (SA) is a rare connective tissue disorder for which no treatment has proven to be effective. Objective: Our purpose was to determine the effect of bath-PUVA Therapy on SA. Methods: Three patients were treated. Clinical evaluation of skin induration and thickness as well as ultrasonography were performed at baseline and after treatment. Results: All three patients showed substantial clinical improvement with bath-PUVA Therapy (median of 59 treatments and a cumulative UVA dose of 245.7 J/cm 2 ). Ultrasonography showed significant reduction in both skin thickness and density. Conclusion: Bath-PUVA Therapy appears to be effective in the treatment of SA.(J Am Acad Dermatol 1998;38:240-2.)

  • Bath-PUVA Therapy in three patients with scleredema adultorum.
    Journal of the American Academy of Dermatology, 1998
    Co-Authors: C M Hager, H A Sobhi, N Hunzelmann, C Wickenhauser, R Scharenberg, T Krieg, K Scharffetter-kochanek
    Abstract:

    Scleredema adultorum (SA) is a rare connective tissue disorder for which no treatment has proven to be effective. Our purpose was to determine the effect of bath-PUVA Therapy on SA. Three patients were treated. Clinical evaluation of skin induration and thickness as well as ultrasonography were performed at baseline and after treatment. All three patients showed substantial clinical improvement with bath-PUVA Therapy (median of 59 treatments and a cumulative UVA dose of 245.7 J/cm2). Ultrasonography showed significant reduction in both skin thickness and density. Bath-PUVA Therapy appears to be effective in the treatment of SA.

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