The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
Kajal Chakraborty - One of the best experts on this subject based on the ideXlab platform.
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first report of two new antioxidative meroterpeno 2h Pyranoids from short necked yellow foot clam paphia malabarica family veneridae with bioactivity against pro inflammatory cyclooxygenases and lipoxygenase
Natural Product Research, 2017Co-Authors: Minju Joy, Kajal ChakrabortyAbstract:AbstractTwo new meroterpeno 2H-Pyranoids were isolated from the EtOAc:MeOH extract of yellow-foot clam Paphia malabarica. The structures of these newly reported compounds were elucidated based on spectroscopic interpretations. This is the first report of biogenic 2H-Pyrans bearing decadienyl and allyloxy-(isopentanyl)-cyclohexene skeletons from marine biota. The extended C18 sesquiterpenoid with prenylated irregular farnesene framework was characterised as 2-((E)-deca-1,8-dien-10-yl)-11,12-dihydro-13-propyl-2H-Pyran (1). The compound 2, 1′-((10E)-10-(10-(pentan-4-yl)-cyclohex-4-enyl)-allyloxy)-tetrahydro-2′,2′-dimethyl-2H-Pyran represents the first example of naturally occurring C21 prenylated bisabolene-type meroterpenoid, whereas tetrahydro-2′,2′-dimethyl-2H-Pyran remains attached at C-2′ position of rearranged bisabolene framework formed by allyloxy linkage. The antioxidant activities (DPPH/ABTS+) of 1 and 2 were comparable (IC50 < 1.0 mg/mL) with α-tocopherol. In addition, these compounds exhibited gr...
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First report of two new antioxidative meroterpeno 2H-Pyranoids from short-necked yellow-foot clam Paphia malabarica (family: Veneridae) with bioactivity against pro-inflammatory cyclooxygenases and lipoxygenase
2016Co-Authors: Minju Joy, Kajal ChakrabortyAbstract:Two new meroterpeno 2H-Pyranoids were isolated from the EtOAc:MeOH extract of yellow-foot clam Paphia malabarica. The structures of these newly reported compounds were elucidated based on spectroscopic interpretations. This is the first report of biogenic 2H-Pyrans bearing decadienyl and allyloxy-(isopentanyl)-cyclohexene skeletons from marine biota. The extended C18 sesquiterpenoid with prenylated irregular farnesene framework was characterised as 2-((E)-deca-1,8-dien-10-yl)-11,12-dihydro-13-propyl-2H-Pyran (1). The compound 2, 1′-((10E)-10-(10-(pentan-4-yl)-cyclohex-4-enyl)-allyloxy)-tetrahydro-2′,2′-dimethyl-2H-Pyran represents the first example of naturally occurring C21 prenylated bisabolene-type meroterpenoid, whereas tetrahydro-2′,2′-dimethyl-2H-Pyran remains attached at C-2′ position of rearranged bisabolene framework formed by allyloxy linkage. The antioxidant activities (DPPH/ABTS+) of 1 and 2 were comparable (IC50
Minju Joy - One of the best experts on this subject based on the ideXlab platform.
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first report of two new antioxidative meroterpeno 2h Pyranoids from short necked yellow foot clam paphia malabarica family veneridae with bioactivity against pro inflammatory cyclooxygenases and lipoxygenase
Natural Product Research, 2017Co-Authors: Minju Joy, Kajal ChakrabortyAbstract:AbstractTwo new meroterpeno 2H-Pyranoids were isolated from the EtOAc:MeOH extract of yellow-foot clam Paphia malabarica. The structures of these newly reported compounds were elucidated based on spectroscopic interpretations. This is the first report of biogenic 2H-Pyrans bearing decadienyl and allyloxy-(isopentanyl)-cyclohexene skeletons from marine biota. The extended C18 sesquiterpenoid with prenylated irregular farnesene framework was characterised as 2-((E)-deca-1,8-dien-10-yl)-11,12-dihydro-13-propyl-2H-Pyran (1). The compound 2, 1′-((10E)-10-(10-(pentan-4-yl)-cyclohex-4-enyl)-allyloxy)-tetrahydro-2′,2′-dimethyl-2H-Pyran represents the first example of naturally occurring C21 prenylated bisabolene-type meroterpenoid, whereas tetrahydro-2′,2′-dimethyl-2H-Pyran remains attached at C-2′ position of rearranged bisabolene framework formed by allyloxy linkage. The antioxidant activities (DPPH/ABTS+) of 1 and 2 were comparable (IC50 < 1.0 mg/mL) with α-tocopherol. In addition, these compounds exhibited gr...
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First report of two new antioxidative meroterpeno 2H-Pyranoids from short-necked yellow-foot clam Paphia malabarica (family: Veneridae) with bioactivity against pro-inflammatory cyclooxygenases and lipoxygenase
2016Co-Authors: Minju Joy, Kajal ChakrabortyAbstract:Two new meroterpeno 2H-Pyranoids were isolated from the EtOAc:MeOH extract of yellow-foot clam Paphia malabarica. The structures of these newly reported compounds were elucidated based on spectroscopic interpretations. This is the first report of biogenic 2H-Pyrans bearing decadienyl and allyloxy-(isopentanyl)-cyclohexene skeletons from marine biota. The extended C18 sesquiterpenoid with prenylated irregular farnesene framework was characterised as 2-((E)-deca-1,8-dien-10-yl)-11,12-dihydro-13-propyl-2H-Pyran (1). The compound 2, 1′-((10E)-10-(10-(pentan-4-yl)-cyclohex-4-enyl)-allyloxy)-tetrahydro-2′,2′-dimethyl-2H-Pyran represents the first example of naturally occurring C21 prenylated bisabolene-type meroterpenoid, whereas tetrahydro-2′,2′-dimethyl-2H-Pyran remains attached at C-2′ position of rearranged bisabolene framework formed by allyloxy linkage. The antioxidant activities (DPPH/ABTS+) of 1 and 2 were comparable (IC50
Bubun Banerjee - One of the best experts on this subject based on the ideXlab platform.
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facile and one pot access to diverse and densely functionalized 2 amino 3 cyano 4h Pyrans and Pyran annulated heterocyclic scaffolds via an eco friendly multicomponent reaction at room temperature using urea as a novel organo catalyst
ACS Sustainable Chemistry & Engineering, 2014Co-Authors: Goutam Brahmachari, Bubun BanerjeeAbstract:A simple, straightforward, and highly efficient multicomponent one-pot synthesis of a pharmaceutically interesting diverse kind of functionalized 2-amino-3-cyano-4H-Pyrans and Pyran-annulated heterocycles has been developed based on a low-cost and environmentally benign commercially available urea as a novel organo-catalyst. The reaction occurs via tandem Knoevenagel–cyclocondensation of aldehydes, malononitrile, and C–H-activated acidic compounds in aqueous ethanol at room temperature. Following this protocol, it was possible to synthesize 2-amino-3-cyano-Pyrano[3,2-c]chromen-5(4H)-ones (4aa–4al), 2-amino-3-cyano-Pyrano[4,3-b]Pyran-5(4H)-ones (4ba–4be), 2-amino-3-cyano-7,8-dihydro-4H-chromen-5(6H)-one (4ca–4cr), 1H-Pyrano[2,3-d]pyrimidine-2,4(3H,5H)-diones (4da–4dd), 2-amino-3-cyano-5,10-dioxo-5,10-dihydro-4H-benzo[g]chromenes (4ea–4ec), 2-amino-3-cyano-4H-Pyrans (4fa–4fh), and 1,4-dihydroPyrano[2,3-c]pyrazoles (4ga–4gb). The salient features of the present protocol are mild reaction conditions, excellen...
Rita Menicagli - One of the best experts on this subject based on the ideXlab platform.
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Regioselective Ni(II)-assisted alkylation of 2-methoxy-5,6-dihydro-2H-Pyran: a new route to 2-n-alkyl-5,6-dihydro-2H-Pyrans
Tetrahedron Letters, 1998Co-Authors: V. Guagnano, Corrado Malanga, Luciano Lardicci, Rita MenicagliAbstract:Abstract In the presence of a catalytic amount of NidppeCl 2 , 2-methoxy-5,6-dihydro-2H-Pyran reacts with primary Grignard reagents to give the corresponding 2- n .alkyl-5,6-dihydro-2H-Pyrans in satisfactory yields.
J L Marco - One of the best experts on this subject based on the ideXlab platform.
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friedlander reaction on 2 amino 3 cyano 4h Pyrans synthesis of derivatives of 4h Pyran 2 3 b quinoline new tacrine analogues
Bioorganic & Medicinal Chemistry Letters, 1997Co-Authors: Angeles Martinezgrau, J L MarcoAbstract:Abstract The unprecedented Friedlander reaction of densely functionalized 2-amino-3-cyano-4H-Pyrans (1) with cyclohexanone has afforded in one step and good yield 5-amino-4-aryl-3-ethoxycarbonyl-2-methyl-6,7,8,9-tetrahydro-4H-Pyran[2,3-b]quinolines (2), novel amino-substituted fused Pyran derivatives. These compounds are new tacrine analogues.
