The Experts below are selected from a list of 6258 Experts worldwide ranked by ideXlab platform
Osamu Uchikawa - One of the best experts on this subject based on the ideXlab platform.
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synthesis of a novel tricyclic 1 6 7 8 tetrahydro 2h cyclopenta b furo 3 2 d Pyridine Derivative the 5 aza analog of ramelteon
Tetrahedron Letters, 2014Co-Authors: Yasutaka Hoashi, Tatsuki Koike, Takafumi Takai, Osamu UchikawaAbstract:Abstract The 5-aza analog of ramelteon 3, a novel tricyclic 1,6,7,8-tetrahydro-2H-cyclopenta[b]furo[3,2-d]Pyridine Derivative, was synthesized by hetero-Diels–Alder reaction and chemoselective Dieckmann condensation.
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synthesis of 4 aza analog of ramelteon a novel tricyclic 1 6 7 8 tetrahydro 2h cyclopenta d furo 2 3 b Pyridine Derivative as melatonin receptor ligand
Tetrahedron Letters, 2011Co-Authors: Tatsuki Koike, Yasutaka Hoashi, Takafumi Takai, Osamu UchikawaAbstract:Abstract The 4-aza analog of ramelteon (−)- 1 , a novel tricyclic 1,6,7,8-tetrahydro-2 H -cyclopenta[ d ]furo[2,3- b ]Pyridine Derivative, was synthesized via the intramolecular inverse electron demand Diels–Alder reaction followed by fluoride-induced desilylation–cyclization.
Yasutaka Hoashi - One of the best experts on this subject based on the ideXlab platform.
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synthesis of a novel tricyclic 1 6 7 8 tetrahydro 2h cyclopenta b furo 3 2 d Pyridine Derivative the 5 aza analog of ramelteon
Tetrahedron Letters, 2014Co-Authors: Yasutaka Hoashi, Tatsuki Koike, Takafumi Takai, Osamu UchikawaAbstract:Abstract The 5-aza analog of ramelteon 3, a novel tricyclic 1,6,7,8-tetrahydro-2H-cyclopenta[b]furo[3,2-d]Pyridine Derivative, was synthesized by hetero-Diels–Alder reaction and chemoselective Dieckmann condensation.
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synthesis of 4 aza analog of ramelteon a novel tricyclic 1 6 7 8 tetrahydro 2h cyclopenta d furo 2 3 b Pyridine Derivative as melatonin receptor ligand
Tetrahedron Letters, 2011Co-Authors: Tatsuki Koike, Yasutaka Hoashi, Takafumi Takai, Osamu UchikawaAbstract:Abstract The 4-aza analog of ramelteon (−)- 1 , a novel tricyclic 1,6,7,8-tetrahydro-2 H -cyclopenta[ d ]furo[2,3- b ]Pyridine Derivative, was synthesized via the intramolecular inverse electron demand Diels–Alder reaction followed by fluoride-induced desilylation–cyclization.
Tatsuki Koike - One of the best experts on this subject based on the ideXlab platform.
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synthesis of a novel tricyclic 1 6 7 8 tetrahydro 2h cyclopenta b furo 3 2 d Pyridine Derivative the 5 aza analog of ramelteon
Tetrahedron Letters, 2014Co-Authors: Yasutaka Hoashi, Tatsuki Koike, Takafumi Takai, Osamu UchikawaAbstract:Abstract The 5-aza analog of ramelteon 3, a novel tricyclic 1,6,7,8-tetrahydro-2H-cyclopenta[b]furo[3,2-d]Pyridine Derivative, was synthesized by hetero-Diels–Alder reaction and chemoselective Dieckmann condensation.
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synthesis of 4 aza analog of ramelteon a novel tricyclic 1 6 7 8 tetrahydro 2h cyclopenta d furo 2 3 b Pyridine Derivative as melatonin receptor ligand
Tetrahedron Letters, 2011Co-Authors: Tatsuki Koike, Yasutaka Hoashi, Takafumi Takai, Osamu UchikawaAbstract:Abstract The 4-aza analog of ramelteon (−)- 1 , a novel tricyclic 1,6,7,8-tetrahydro-2 H -cyclopenta[ d ]furo[2,3- b ]Pyridine Derivative, was synthesized via the intramolecular inverse electron demand Diels–Alder reaction followed by fluoride-induced desilylation–cyclization.
Takafumi Takai - One of the best experts on this subject based on the ideXlab platform.
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synthesis of a novel tricyclic 1 6 7 8 tetrahydro 2h cyclopenta b furo 3 2 d Pyridine Derivative the 5 aza analog of ramelteon
Tetrahedron Letters, 2014Co-Authors: Yasutaka Hoashi, Tatsuki Koike, Takafumi Takai, Osamu UchikawaAbstract:Abstract The 5-aza analog of ramelteon 3, a novel tricyclic 1,6,7,8-tetrahydro-2H-cyclopenta[b]furo[3,2-d]Pyridine Derivative, was synthesized by hetero-Diels–Alder reaction and chemoselective Dieckmann condensation.
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synthesis of 4 aza analog of ramelteon a novel tricyclic 1 6 7 8 tetrahydro 2h cyclopenta d furo 2 3 b Pyridine Derivative as melatonin receptor ligand
Tetrahedron Letters, 2011Co-Authors: Tatsuki Koike, Yasutaka Hoashi, Takafumi Takai, Osamu UchikawaAbstract:Abstract The 4-aza analog of ramelteon (−)- 1 , a novel tricyclic 1,6,7,8-tetrahydro-2 H -cyclopenta[ d ]furo[2,3- b ]Pyridine Derivative, was synthesized via the intramolecular inverse electron demand Diels–Alder reaction followed by fluoride-induced desilylation–cyclization.
Paola Gratteri - One of the best experts on this subject based on the ideXlab platform.
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Pyridine Derivative of the natural alkaloid berberine as human telomeric g4 dna binder a solution and solid state study
ACS Medicinal Chemistry Letters, 2020Co-Authors: Francesco Papi, Paolo Lombardi, Carla Bazzicalupi, M Ferraroni, Giulia Ciolli, Asma Yasmeen Khan, Gopinatha Suresh Kumar, Paola GratteriAbstract:Telomerase is an enzyme deputed to the maintenance of eukaryotic chromosomes; however, its overexpression is a recognized hallmark of many cancer forms. A viable route for the inhibition of telomerase in malignant cells is the stabilization of G-quadruplex structures (G4) at the 3′ overhang of telomeres. Berberine has shown in this regard valuable G4 binding properties together with a significant anticancer activity and telomerase inhibition effects. Here, we focused on a berberine Derivative featuring a Pyridine containing side group at the 13th position. Such modification actually improves the binding toward telomeric G-quadruplexes and establishes a degree of selectivity in the interaction with different sequences. Moreover, the X-ray crystal structure obtained for the complex formed by the ligand and a bimolecular human telomeric quadruplex affords a better understanding of the 13-berberine Derivatives behavior with telomeric G4 and allows to draw useful insights for the future design of Derivatives w...
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Pyridine Derivative of the natural alkaloid berberine as human telomeric g4 dna binder a solution and solid state study
ACS Medicinal Chemistry Letters, 2020Co-Authors: Francesco Papi, Paolo Lombardi, Carla Bazzicalupi, M Ferraroni, Giulia Ciolli, Asma Yasmeen Khan, Gopinatha Suresh Kumar, Paola GratteriAbstract:Telomerase is an enzyme deputed to the maintenance of eukaryotic chromosomes; however, its overexpression is a recognized hallmark of many cancer forms. A viable route for the inhibition of telomerase in malignant cells is the stabilization of G-quadruplex structures (G4) at the 3' overhang of telomeres. Berberine has shown in this regard valuable G4 binding properties together with a significant anticancer activity and telomerase inhibition effects. Here, we focused on a berberine Derivative featuring a Pyridine containing side group at the 13th position. Such modification actually improves the binding toward telomeric G-quadruplexes and establishes a degree of selectivity in the interaction with different sequences. Moreover, the X-ray crystal structure obtained for the complex formed by the ligand and a bimolecular human telomeric quadruplex affords a better understanding of the 13-berberine Derivatives behavior with telomeric G4 and allows to draw useful insights for the future design of Derivatives with remarkable anticancer properties.
