The Experts below are selected from a list of 39 Experts worldwide ranked by ideXlab platform
Eman A. Z. Hanafi - One of the best experts on this subject based on the ideXlab platform.
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Reactions of pyrimidinonethione derivatives: Synthesis of 2-hydrazinopyrimidin-4-one, pyrimido[1,2-a]-1,2,4-triazine, triazolo-[1,2-a]pyrimidine, 2-(1-pyrazolo)pyrimidine and 2-arylhydrazonopyrimidine derivatives
Archives of Pharmacal Research, 1997Co-Authors: Fawzy A. Attaby, Sanaa M. Eldin, Eman A. Z. HanafiAbstract:6-Aryl-5-cyano-4-pyrimidinon-2-thione derivatives 1a-c reacted with ethyl iodide to give the corresponded 2-S-ethylpyrimidin-4-one derivatives 2a-c . Compounds 2a-c was, in turn, reacted with hydrazine hydrate to give the sulfur free reaction products, 3a-c . These reaction products were taken as the starting materials for the synthesis of several newly synthesized heterocyclic derivatives. Reactions with several halogenated ketones, esters, chloroacetic acid and chloroacetamide give Pyrimidotriazines 8, 12 and 15 while their reactions with formic acid, acetic acid and carbon disulfide gave the corresponded triazolopyrimidines 17 and 21 . The reaction with both acetyl acetone and ethylacetoacetate gave the corresponded 2-(3′, 5′-dimethyl-1′-pyrazoly) pyrimidine derivatives 20a-c and 24a-c respectively while the reaction with cinnamonitriles 25a-h afforded the corresponded aryl hydrazopyrimidines 27a-f . The structures of these reaction products were established based on both elemental analyses and spectral data studies.
Fawzy A. Attaby - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of Pyrimidine, Thiazolopyrimidine, Pyrimidotriazine and Triazolopyrimidine Derivatives and their Biological Evaluation
Zeitschrift für Naturforschung B, 1999Co-Authors: Fawzy A. Attaby, Sanaa M. EldinAbstract:Pyrimidin-4-one-2-thione (3) was synthesized via the reaction of thiourea (1) with ethyl benzoylacetate (2) and was taken as a starting material for the present study via its reactions with the halogen-containing reagents 6a-d and 10a-c to give the corresponding thiazolopyrimidines 8, 9 and 12a-c. The 2-hydrazino derivatives 5 were synthesized either via the reaction of 3 or 4 with hydrazine hydrate. Compound 5 reacted with 6a-c and 10a-c to give the corresponding Pyrimidotriazines 17a-c and 19 respectively. Also, compound 5 reacted with the active methylene-containing reagents 13 and 2a,b to give the corresponding 2-pyrazolopyrimidines 15 and 22a,b respectively. On the other hand, the triazolopyrimidines 21a,b and 30a,b were also obtained via the reaction of 5 with each of formic acid, acetic anhydride, ethyl chloroformate and carbon disulfide respectively. Some of the newly synthesized heterocyclic derivatives were tested for their biological activity.
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Reactions of pyrimidinonethione derivatives: Synthesis of 2-hydrazinopyrimidin-4-one, pyrimido[1,2-a]-1,2,4-triazine, triazolo-[1,2-a]pyrimidine, 2-(1-pyrazolo)pyrimidine and 2-arylhydrazonopyrimidine derivatives
Archives of Pharmacal Research, 1997Co-Authors: Fawzy A. Attaby, Sanaa M. Eldin, Eman A. Z. HanafiAbstract:6-Aryl-5-cyano-4-pyrimidinon-2-thione derivatives 1a-c reacted with ethyl iodide to give the corresponded 2-S-ethylpyrimidin-4-one derivatives 2a-c . Compounds 2a-c was, in turn, reacted with hydrazine hydrate to give the sulfur free reaction products, 3a-c . These reaction products were taken as the starting materials for the synthesis of several newly synthesized heterocyclic derivatives. Reactions with several halogenated ketones, esters, chloroacetic acid and chloroacetamide give Pyrimidotriazines 8, 12 and 15 while their reactions with formic acid, acetic acid and carbon disulfide gave the corresponded triazolopyrimidines 17 and 21 . The reaction with both acetyl acetone and ethylacetoacetate gave the corresponded 2-(3′, 5′-dimethyl-1′-pyrazoly) pyrimidine derivatives 20a-c and 24a-c respectively while the reaction with cinnamonitriles 25a-h afforded the corresponded aryl hydrazopyrimidines 27a-f . The structures of these reaction products were established based on both elemental analyses and spectral data studies.
Sanaa M. Eldin - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of Pyrimidine, Thiazolopyrimidine, Pyrimidotriazine and Triazolopyrimidine Derivatives and their Biological Evaluation
Zeitschrift für Naturforschung B, 1999Co-Authors: Fawzy A. Attaby, Sanaa M. EldinAbstract:Pyrimidin-4-one-2-thione (3) was synthesized via the reaction of thiourea (1) with ethyl benzoylacetate (2) and was taken as a starting material for the present study via its reactions with the halogen-containing reagents 6a-d and 10a-c to give the corresponding thiazolopyrimidines 8, 9 and 12a-c. The 2-hydrazino derivatives 5 were synthesized either via the reaction of 3 or 4 with hydrazine hydrate. Compound 5 reacted with 6a-c and 10a-c to give the corresponding Pyrimidotriazines 17a-c and 19 respectively. Also, compound 5 reacted with the active methylene-containing reagents 13 and 2a,b to give the corresponding 2-pyrazolopyrimidines 15 and 22a,b respectively. On the other hand, the triazolopyrimidines 21a,b and 30a,b were also obtained via the reaction of 5 with each of formic acid, acetic anhydride, ethyl chloroformate and carbon disulfide respectively. Some of the newly synthesized heterocyclic derivatives were tested for their biological activity.
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Reactions of pyrimidinonethione derivatives: Synthesis of 2-hydrazinopyrimidin-4-one, pyrimido[1,2-a]-1,2,4-triazine, triazolo-[1,2-a]pyrimidine, 2-(1-pyrazolo)pyrimidine and 2-arylhydrazonopyrimidine derivatives
Archives of Pharmacal Research, 1997Co-Authors: Fawzy A. Attaby, Sanaa M. Eldin, Eman A. Z. HanafiAbstract:6-Aryl-5-cyano-4-pyrimidinon-2-thione derivatives 1a-c reacted with ethyl iodide to give the corresponded 2-S-ethylpyrimidin-4-one derivatives 2a-c . Compounds 2a-c was, in turn, reacted with hydrazine hydrate to give the sulfur free reaction products, 3a-c . These reaction products were taken as the starting materials for the synthesis of several newly synthesized heterocyclic derivatives. Reactions with several halogenated ketones, esters, chloroacetic acid and chloroacetamide give Pyrimidotriazines 8, 12 and 15 while their reactions with formic acid, acetic acid and carbon disulfide gave the corresponded triazolopyrimidines 17 and 21 . The reaction with both acetyl acetone and ethylacetoacetate gave the corresponded 2-(3′, 5′-dimethyl-1′-pyrazoly) pyrimidine derivatives 20a-c and 24a-c respectively while the reaction with cinnamonitriles 25a-h afforded the corresponded aryl hydrazopyrimidines 27a-f . The structures of these reaction products were established based on both elemental analyses and spectral data studies.
Povilas Vainilavicius - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and Functionalization of 8-Methyl-2h-pyrimido [2,1-c][1,2,4]triazine-3,6(1h,4h)-dione
Journal of Heterocyclic Chemistry, 2012Co-Authors: Virginija Jakubkiene, Vytautas Cepla, Milda M. Burbuliene, Povilas VainilaviciusAbstract:6-Methyl-2-methylthio-4-oxopyrimidin-3(4H)-yl)acetohydrazide on heating in benzylamine undergo cyclization to 8-methyl-2H-pyrimido[2,1-c][1,2,4]triazine-3,6(1H, 4H)-dione, which under treatment with bromine in glacial acetic acid was converted to 7-bromo substituted derivative and at reflux with Lawesson's reagent yielded 3-thioxo compound. The latter reacted with primary and secondary amines to give 3-amino substituted Pyrimidotriazines and on alkylation—the corresponding S-alkyl derivatives.
Virginija Jakubkiene - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and Functionalization of 8-Methyl-2h-pyrimido [2,1-c][1,2,4]triazine-3,6(1h,4h)-dione
Journal of Heterocyclic Chemistry, 2012Co-Authors: Virginija Jakubkiene, Vytautas Cepla, Milda M. Burbuliene, Povilas VainilaviciusAbstract:6-Methyl-2-methylthio-4-oxopyrimidin-3(4H)-yl)acetohydrazide on heating in benzylamine undergo cyclization to 8-methyl-2H-pyrimido[2,1-c][1,2,4]triazine-3,6(1H, 4H)-dione, which under treatment with bromine in glacial acetic acid was converted to 7-bromo substituted derivative and at reflux with Lawesson's reagent yielded 3-thioxo compound. The latter reacted with primary and secondary amines to give 3-amino substituted Pyrimidotriazines and on alkylation—the corresponding S-alkyl derivatives.
