The Experts below are selected from a list of 54 Experts worldwide ranked by ideXlab platform
G Vallancien - One of the best experts on this subject based on the ideXlab platform.
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ablation of superficial bladder tumors with focused extracorporeal Pyrotherapy
Urology, 1996Co-Authors: G Vallancien, M Harouni, Bertrand Guillonneau, B Veillon, Joelle BougaranAbstract:OBJECTIVES: We report the first experimental studies of focused extracorporeal Pyrotherapy. METHODS: Focused extracorporeal Pyrotherapy has been used to treat superficial bladder tumors in a Phase II protocol in 25 patients. In 5 cases, for technical reasons, Pyrotherapy was not used. In 20 patients (10 under general anesthesia and 10 under spinal anesthesia), the mean treated volume was 3 cm3 with an average of 300 shots and a mean skin focused length of 90 mm. Treatment time was 44 minutes; hospital stay was 2 days. Postoperatively, two skin burns and one acute retention were observed. RESULTS: Of 20 patients, 15 (75%) had a normal urinary cytology bladder ultrasonography and cystoscopy at 1 month. In 67% of patients with primary tumor, there was no recurrence at 1 year; 33% had recurrent tumors. No infiltrative tumor or metastases have been observed during this follow-up (3 to 21 months). CONCLUSIONS: These encouraging results show that ablation of superficial bladder tumor is feasible. The technique must be improved to allow treatment of larger tumor volume in a shorter time.
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antitumoral local effect and metastatic risk of focused extracorporeal Pyrotherapy on dunning r 3327 tumors
European Urology, 1996Co-Authors: N Bataille, G Vallancien, D ChopinAbstract:We evaluated the effect of focused extracorporeal Pyrotherapy on local tumor growth and metastatic potential of the Dunning R-3327 tumor inoculated into male Copenhagen Fisher rats, using the highly metastatic MAT Ly Lu cell line in 64 rats and the slightly metastatic G cell line in 60 rats. Five million cells were inoculated subcutaneously into a lower limb and the tumor volume was determined every 48 h. The local effect, the presence of lung and/or lymph node metastases and the spontaneous survival were evaluated in the treated groups (n = 30 for MAT Ly Lu and n = 29 for G) and in the sham control groups (n = 19 for MAT Ly Lu and n = 13 for G) by autopsy of the animals at successive times after treatment. A local effect of treatment was obtained for the two cell lines with complete local cure in 53% of cases. The animals developing metastases were not more numerous in the treated groups than in the control groups. Long-term survivals were obtained in the animals inoculated with the two cell lines. These results suggest that Pyrotherapy exerts a local effect on the Dunning R-3327 tumor model without increasing its metastatic potential and allows long-term survivals. Controlled therapeutic trials in human cancers are envisaged.
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the effects of focused extracorporeal Pyrotherapy on a human bladder tumor cell line 647 v
The Journal of Urology, 1993Co-Authors: E Chartierkastler, D Chopin, G VallancienAbstract:Abstract Human transitional cell bladder carcinoma cell-line 647 V has been used to evaluate the effects on tumor cells in vitro of a new technique: focused extracorporeal Pyrotherapy (F.E.P.)· The device is made of multi-sources of piezoelectric ceramics focused at 320 mm. The focal area is 10 mm. high on 1.5 mm. width, and shots of 0.25 to 0.50 seconds were delivered on 4 groups of cell pellets placed in a polyurethane tube at the focus. Trypan blue MTT cell growth curve and Colony forming tests were used. There was a significant reduction (Student’s t test) of the cell variability rate on the Trypan Blue test, 5% (in the treated Group) against 95% (control Group). The growth curve was flattened whether 0.50 second shots were single or repeated. The colony formation test was also significantly altered: 5.7% (treated group) against 70% (control group). Conclusion focused extracorporeal Pyrotherapy is able to alter or kill tumor cells in vitro.
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focused extracorporeal Pyrotherapy
European Urology, 1993Co-Authors: G Vallancien, M Harouni, E Chartierkastler, N Bataille, D Chopin, Joelle BougaranAbstract:: A system generating focused elastic ultrashort waves has been developed with the aim to destroy tumors by an extracorporeal way. Experimental studies on different targets (plastic phantoms, organ samples and normal live tissues in pigs) have been done showing the good focusing of the device and the possibility of getting a focal tissular coagulative necrosis. Studies on cultured tumor cells and implanted tumors in rats have shown a local effect on cells or tumor growth with the absence of metastatic risks. First human trials are summarized. This technique we call focused extracorporeal Pyrotherapy could be useful for the treatment of cancers.
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focused extracorporeal Pyrotherapy feasibility study in man
Journal of Endourology, 1992Co-Authors: G Vallancien, M Harouni, B Veillon, Annick Mombet, Dominique Prapotnich, J M Brisset, Joelle BougaranAbstract:A feasibility study of focused extracorporeal Pyrotherapy was conducted in 50 patients. The instrument has a mobile Firing head, which is composed of multiple piezoelectric ceramics with a focal length of 320 mm. The energy focus was 10 mm high × 1.5 mm wide. A retractable and rotating central 3.5-MHz ultrasound transducer was used to localize the tissue target. A 7.5-MHz sectorial transrectal transducer was used for the prostate. The recording of the temperature curves by means of implanted thermocouples demonstrated that the apparatus was able to induce a peak temperature of 120°C in the focal zone. Heat diffusion was minimal because of the brief shot durations (0.015 to 1 second). Twenty-eight patients with benign prostatic hyperplasia were treated. There was virtually no heat diffusion to the rectum and urethra. The maximum temperature recorded in 12 patients who underwent Pyrotherapy for superficial bladder tumors was 65°C. Eight patients underwent the same treatment to the kidney, and two patients w...
D Chopin - One of the best experts on this subject based on the ideXlab platform.
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antitumoral local effect and metastatic risk of focused extracorporeal Pyrotherapy on dunning r 3327 tumors
European Urology, 1996Co-Authors: N Bataille, G Vallancien, D ChopinAbstract:We evaluated the effect of focused extracorporeal Pyrotherapy on local tumor growth and metastatic potential of the Dunning R-3327 tumor inoculated into male Copenhagen Fisher rats, using the highly metastatic MAT Ly Lu cell line in 64 rats and the slightly metastatic G cell line in 60 rats. Five million cells were inoculated subcutaneously into a lower limb and the tumor volume was determined every 48 h. The local effect, the presence of lung and/or lymph node metastases and the spontaneous survival were evaluated in the treated groups (n = 30 for MAT Ly Lu and n = 29 for G) and in the sham control groups (n = 19 for MAT Ly Lu and n = 13 for G) by autopsy of the animals at successive times after treatment. A local effect of treatment was obtained for the two cell lines with complete local cure in 53% of cases. The animals developing metastases were not more numerous in the treated groups than in the control groups. Long-term survivals were obtained in the animals inoculated with the two cell lines. These results suggest that Pyrotherapy exerts a local effect on the Dunning R-3327 tumor model without increasing its metastatic potential and allows long-term survivals. Controlled therapeutic trials in human cancers are envisaged.
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the effects of focused extracorporeal Pyrotherapy on a human bladder tumor cell line 647 v
The Journal of Urology, 1993Co-Authors: E Chartierkastler, D Chopin, G VallancienAbstract:Abstract Human transitional cell bladder carcinoma cell-line 647 V has been used to evaluate the effects on tumor cells in vitro of a new technique: focused extracorporeal Pyrotherapy (F.E.P.)· The device is made of multi-sources of piezoelectric ceramics focused at 320 mm. The focal area is 10 mm. high on 1.5 mm. width, and shots of 0.25 to 0.50 seconds were delivered on 4 groups of cell pellets placed in a polyurethane tube at the focus. Trypan blue MTT cell growth curve and Colony forming tests were used. There was a significant reduction (Student’s t test) of the cell variability rate on the Trypan Blue test, 5% (in the treated Group) against 95% (control Group). The growth curve was flattened whether 0.50 second shots were single or repeated. The colony formation test was also significantly altered: 5.7% (treated group) against 70% (control group). Conclusion focused extracorporeal Pyrotherapy is able to alter or kill tumor cells in vitro.
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focused extracorporeal Pyrotherapy
European Urology, 1993Co-Authors: G Vallancien, M Harouni, E Chartierkastler, N Bataille, D Chopin, Joelle BougaranAbstract:: A system generating focused elastic ultrashort waves has been developed with the aim to destroy tumors by an extracorporeal way. Experimental studies on different targets (plastic phantoms, organ samples and normal live tissues in pigs) have been done showing the good focusing of the device and the possibility of getting a focal tissular coagulative necrosis. Studies on cultured tumor cells and implanted tumors in rats have shown a local effect on cells or tumor growth with the absence of metastatic risks. First human trials are summarized. This technique we call focused extracorporeal Pyrotherapy could be useful for the treatment of cancers.
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focused extracorporeal Pyrotherapy initial experimental results
Progres En Urologie, 1991Co-Authors: G Vallancien, B Veillon, D Chopin, J M Brisset, C Davila, B Guiillonneau, E Perreira, J AndrebougaranAbstract:: The objective of this study was to develop an apparatus allowing the generation of a high temperature (exceeding 80 degrees C) in a precise focus (20 mm x 2 mm) by means of extracorporeal elastic waves. The treatment time at high temperatures is brief and administered in sequences of 4 to 7 seconds. In vitro studies on blocks of polyurethane demonstrated melting of the plastic at the focal point. Studies on plastic spheres introduced into the bladder of the pig demonstrated melting of the sphere without any alteration in the tissues in the wave path. Studies of cellular viability of bladder carcinoma cultures demonstrated a significant difference after 48 hours between the non-treated control group and the group of cells submitted to high temperatures. This technique, called Pyrotherapy, should be promising if the preliminary results are confirmed.
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focussed extracorporeal Pyrotherapy experimental results
European Urology, 1991Co-Authors: G Vallancien, B Veillon, E Chartierkastler, D Chopin, J M Brisset, J AndrebougaranAbstract:: A new device made of piezoelectric ceramic placed in a semispherical dish and focussed at 320 mm was developed in order to generate heat and cavitation responsible for coagulative necrosis of deep tissues. The target to be treated is located with a central ultrasound probe of 3.5 MHz. In vitro studies with polyurethane phantoms showed that the ultrasound melted a surface of 2 x 12 mm within 1 s. The temperature recorded at the focus was 270 degrees C. In tissue samples (prostate cancer and benign prostate hyperplasia), the temperature rose to 85 degrees C in vitro and a hyperechoic zone appeared at the focus during shots. In vivo 8-mm plastic spheres, introduced surgically into the bladder of pigs, were melted by repeat shots without burning of crossed tissues. These studies were performed in the kidney and the liver. Autopsy performed on day 0 showed congestion, autopsy performed between day 6 and day 11 showed necrosis, whereas at 3 months the focussed area was fibrosed. This technique, which we called 'focussed extracorporeal Pyrotherapy', combines phenomena of cavitation and high heat at the focus. Prostate tumors, bladder tumors, kidney tumors and liver metastases are potential indications for Pyrotherapy.
Joelle Bougaran - One of the best experts on this subject based on the ideXlab platform.
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ablation of superficial bladder tumors with focused extracorporeal Pyrotherapy
Urology, 1996Co-Authors: G Vallancien, M Harouni, Bertrand Guillonneau, B Veillon, Joelle BougaranAbstract:OBJECTIVES: We report the first experimental studies of focused extracorporeal Pyrotherapy. METHODS: Focused extracorporeal Pyrotherapy has been used to treat superficial bladder tumors in a Phase II protocol in 25 patients. In 5 cases, for technical reasons, Pyrotherapy was not used. In 20 patients (10 under general anesthesia and 10 under spinal anesthesia), the mean treated volume was 3 cm3 with an average of 300 shots and a mean skin focused length of 90 mm. Treatment time was 44 minutes; hospital stay was 2 days. Postoperatively, two skin burns and one acute retention were observed. RESULTS: Of 20 patients, 15 (75%) had a normal urinary cytology bladder ultrasonography and cystoscopy at 1 month. In 67% of patients with primary tumor, there was no recurrence at 1 year; 33% had recurrent tumors. No infiltrative tumor or metastases have been observed during this follow-up (3 to 21 months). CONCLUSIONS: These encouraging results show that ablation of superficial bladder tumor is feasible. The technique must be improved to allow treatment of larger tumor volume in a shorter time.
-
focused extracorporeal Pyrotherapy
European Urology, 1993Co-Authors: G Vallancien, M Harouni, E Chartierkastler, N Bataille, D Chopin, Joelle BougaranAbstract:: A system generating focused elastic ultrashort waves has been developed with the aim to destroy tumors by an extracorporeal way. Experimental studies on different targets (plastic phantoms, organ samples and normal live tissues in pigs) have been done showing the good focusing of the device and the possibility of getting a focal tissular coagulative necrosis. Studies on cultured tumor cells and implanted tumors in rats have shown a local effect on cells or tumor growth with the absence of metastatic risks. First human trials are summarized. This technique we call focused extracorporeal Pyrotherapy could be useful for the treatment of cancers.
-
focused extracorporeal Pyrotherapy feasibility study in man
Journal of Endourology, 1992Co-Authors: G Vallancien, M Harouni, B Veillon, Annick Mombet, Dominique Prapotnich, J M Brisset, Joelle BougaranAbstract:A feasibility study of focused extracorporeal Pyrotherapy was conducted in 50 patients. The instrument has a mobile Firing head, which is composed of multiple piezoelectric ceramics with a focal length of 320 mm. The energy focus was 10 mm high × 1.5 mm wide. A retractable and rotating central 3.5-MHz ultrasound transducer was used to localize the tissue target. A 7.5-MHz sectorial transrectal transducer was used for the prostate. The recording of the temperature curves by means of implanted thermocouples demonstrated that the apparatus was able to induce a peak temperature of 120°C in the focal zone. Heat diffusion was minimal because of the brief shot durations (0.015 to 1 second). Twenty-eight patients with benign prostatic hyperplasia were treated. There was virtually no heat diffusion to the rectum and urethra. The maximum temperature recorded in 12 patients who underwent Pyrotherapy for superficial bladder tumors was 65°C. Eight patients underwent the same treatment to the kidney, and two patients w...
E Chartierkastler - One of the best experts on this subject based on the ideXlab platform.
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the effects of focused extracorporeal Pyrotherapy on a human bladder tumor cell line 647 v
The Journal of Urology, 1993Co-Authors: E Chartierkastler, D Chopin, G VallancienAbstract:Abstract Human transitional cell bladder carcinoma cell-line 647 V has been used to evaluate the effects on tumor cells in vitro of a new technique: focused extracorporeal Pyrotherapy (F.E.P.)· The device is made of multi-sources of piezoelectric ceramics focused at 320 mm. The focal area is 10 mm. high on 1.5 mm. width, and shots of 0.25 to 0.50 seconds were delivered on 4 groups of cell pellets placed in a polyurethane tube at the focus. Trypan blue MTT cell growth curve and Colony forming tests were used. There was a significant reduction (Student’s t test) of the cell variability rate on the Trypan Blue test, 5% (in the treated Group) against 95% (control Group). The growth curve was flattened whether 0.50 second shots were single or repeated. The colony formation test was also significantly altered: 5.7% (treated group) against 70% (control group). Conclusion focused extracorporeal Pyrotherapy is able to alter or kill tumor cells in vitro.
-
focused extracorporeal Pyrotherapy
European Urology, 1993Co-Authors: G Vallancien, M Harouni, E Chartierkastler, N Bataille, D Chopin, Joelle BougaranAbstract:: A system generating focused elastic ultrashort waves has been developed with the aim to destroy tumors by an extracorporeal way. Experimental studies on different targets (plastic phantoms, organ samples and normal live tissues in pigs) have been done showing the good focusing of the device and the possibility of getting a focal tissular coagulative necrosis. Studies on cultured tumor cells and implanted tumors in rats have shown a local effect on cells or tumor growth with the absence of metastatic risks. First human trials are summarized. This technique we call focused extracorporeal Pyrotherapy could be useful for the treatment of cancers.
-
focussed extracorporeal Pyrotherapy experimental results
European Urology, 1991Co-Authors: G Vallancien, B Veillon, E Chartierkastler, D Chopin, J M Brisset, J AndrebougaranAbstract:: A new device made of piezoelectric ceramic placed in a semispherical dish and focussed at 320 mm was developed in order to generate heat and cavitation responsible for coagulative necrosis of deep tissues. The target to be treated is located with a central ultrasound probe of 3.5 MHz. In vitro studies with polyurethane phantoms showed that the ultrasound melted a surface of 2 x 12 mm within 1 s. The temperature recorded at the focus was 270 degrees C. In tissue samples (prostate cancer and benign prostate hyperplasia), the temperature rose to 85 degrees C in vitro and a hyperechoic zone appeared at the focus during shots. In vivo 8-mm plastic spheres, introduced surgically into the bladder of pigs, were melted by repeat shots without burning of crossed tissues. These studies were performed in the kidney and the liver. Autopsy performed on day 0 showed congestion, autopsy performed between day 6 and day 11 showed necrosis, whereas at 3 months the focussed area was fibrosed. This technique, which we called 'focussed extracorporeal Pyrotherapy', combines phenomena of cavitation and high heat at the focus. Prostate tumors, bladder tumors, kidney tumors and liver metastases are potential indications for Pyrotherapy.
B Veillon - One of the best experts on this subject based on the ideXlab platform.
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ablation of superficial bladder tumors with focused extracorporeal Pyrotherapy
Urology, 1996Co-Authors: G Vallancien, M Harouni, Bertrand Guillonneau, B Veillon, Joelle BougaranAbstract:OBJECTIVES: We report the first experimental studies of focused extracorporeal Pyrotherapy. METHODS: Focused extracorporeal Pyrotherapy has been used to treat superficial bladder tumors in a Phase II protocol in 25 patients. In 5 cases, for technical reasons, Pyrotherapy was not used. In 20 patients (10 under general anesthesia and 10 under spinal anesthesia), the mean treated volume was 3 cm3 with an average of 300 shots and a mean skin focused length of 90 mm. Treatment time was 44 minutes; hospital stay was 2 days. Postoperatively, two skin burns and one acute retention were observed. RESULTS: Of 20 patients, 15 (75%) had a normal urinary cytology bladder ultrasonography and cystoscopy at 1 month. In 67% of patients with primary tumor, there was no recurrence at 1 year; 33% had recurrent tumors. No infiltrative tumor or metastases have been observed during this follow-up (3 to 21 months). CONCLUSIONS: These encouraging results show that ablation of superficial bladder tumor is feasible. The technique must be improved to allow treatment of larger tumor volume in a shorter time.
-
focused extracorporeal Pyrotherapy feasibility study in man
Journal of Endourology, 1992Co-Authors: G Vallancien, M Harouni, B Veillon, Annick Mombet, Dominique Prapotnich, J M Brisset, Joelle BougaranAbstract:A feasibility study of focused extracorporeal Pyrotherapy was conducted in 50 patients. The instrument has a mobile Firing head, which is composed of multiple piezoelectric ceramics with a focal length of 320 mm. The energy focus was 10 mm high × 1.5 mm wide. A retractable and rotating central 3.5-MHz ultrasound transducer was used to localize the tissue target. A 7.5-MHz sectorial transrectal transducer was used for the prostate. The recording of the temperature curves by means of implanted thermocouples demonstrated that the apparatus was able to induce a peak temperature of 120°C in the focal zone. Heat diffusion was minimal because of the brief shot durations (0.015 to 1 second). Twenty-eight patients with benign prostatic hyperplasia were treated. There was virtually no heat diffusion to the rectum and urethra. The maximum temperature recorded in 12 patients who underwent Pyrotherapy for superficial bladder tumors was 65°C. Eight patients underwent the same treatment to the kidney, and two patients w...
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focused extracorporeal Pyrotherapy initial experimental results
Progres En Urologie, 1991Co-Authors: G Vallancien, B Veillon, D Chopin, J M Brisset, C Davila, B Guiillonneau, E Perreira, J AndrebougaranAbstract:: The objective of this study was to develop an apparatus allowing the generation of a high temperature (exceeding 80 degrees C) in a precise focus (20 mm x 2 mm) by means of extracorporeal elastic waves. The treatment time at high temperatures is brief and administered in sequences of 4 to 7 seconds. In vitro studies on blocks of polyurethane demonstrated melting of the plastic at the focal point. Studies on plastic spheres introduced into the bladder of the pig demonstrated melting of the sphere without any alteration in the tissues in the wave path. Studies of cellular viability of bladder carcinoma cultures demonstrated a significant difference after 48 hours between the non-treated control group and the group of cells submitted to high temperatures. This technique, called Pyrotherapy, should be promising if the preliminary results are confirmed.
-
focussed extracorporeal Pyrotherapy experimental results
European Urology, 1991Co-Authors: G Vallancien, B Veillon, E Chartierkastler, D Chopin, J M Brisset, J AndrebougaranAbstract:: A new device made of piezoelectric ceramic placed in a semispherical dish and focussed at 320 mm was developed in order to generate heat and cavitation responsible for coagulative necrosis of deep tissues. The target to be treated is located with a central ultrasound probe of 3.5 MHz. In vitro studies with polyurethane phantoms showed that the ultrasound melted a surface of 2 x 12 mm within 1 s. The temperature recorded at the focus was 270 degrees C. In tissue samples (prostate cancer and benign prostate hyperplasia), the temperature rose to 85 degrees C in vitro and a hyperechoic zone appeared at the focus during shots. In vivo 8-mm plastic spheres, introduced surgically into the bladder of pigs, were melted by repeat shots without burning of crossed tissues. These studies were performed in the kidney and the liver. Autopsy performed on day 0 showed congestion, autopsy performed between day 6 and day 11 showed necrosis, whereas at 3 months the focussed area was fibrosed. This technique, which we called 'focussed extracorporeal Pyrotherapy', combines phenomena of cavitation and high heat at the focus. Prostate tumors, bladder tumors, kidney tumors and liver metastases are potential indications for Pyrotherapy.
