The Experts below are selected from a list of 195 Experts worldwide ranked by ideXlab platform
Jean-bernard Behr - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and Fucosidase Inhibitory Study of Unnatural Pyrrolidine Alkaloid 4-epi-(+)-Codonopsinine
The Journal of organic chemistry, 2011Co-Authors: Alexis Kotland, Fabien Accadbled, Koen Robeyns, Jean-bernard BehrAbstract:The total synthesis of enantiopure 4-epi-(+)-codonopsinine was achieved in 10 steps starting from D-ribose as a chiral building block. The key step involved a highly stereoselective nucleophilic addition of a Grignard reagent to a protected ribosylamine. Synthesis of the N-desmethyl derivative and its p-tolyl analogue was also accomplished, and the compounds were assayed against α-fucosidase.
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synthesis and fucosidase inhibitory study of unnatural Pyrrolidine Alkaloid 4 epi codonopsinine
Journal of Organic Chemistry, 2011Co-Authors: Alexis Kotland, Fabien Accadbled, Koen Robeyns, Jean-bernard BehrAbstract:The total synthesis of enantiopure 4-epi-(+)-codonopsinine was achieved in 10 steps starting from D-ribose as a chiral building block. The key step involved a highly stereoselective nucleophilic addition of a Grignard reagent to a protected ribosylamine. Synthesis of the N-desmethyl derivative and its p-tolyl analogue was also accomplished, and the compounds were assayed against α-fucosidase.
Batchu Venkateswara Rao - One of the best experts on this subject based on the ideXlab platform.
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A Short, Efficient, and Stereoselective Total Synthesis of a Pyrrolidine Alkaloid: (−)-Codonopsinine†
The Journal of organic chemistry, 2007Co-Authors: Jangari Santhosh Reddy, Batchu Venkateswara RaoAbstract:An efficient total synthesis of antibiotic (−)-codonopsinine 1 with an overall yield of 44% was achieved from d-alanine as a chiral template. The key steps in our strategy are modified Sharpless asymmetric dihydroxylation reaction and the highly stereoselective intramolecular acid-catalyzed amidocyclization.
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a short efficient and stereoselective total synthesis of a Pyrrolidine Alkaloid codonopsinine
Journal of Organic Chemistry, 2007Co-Authors: Jangari Santhosh Reddy, Batchu Venkateswara RaoAbstract:An efficient total synthesis of antibiotic (−)-codonopsinine 1 with an overall yield of 44% was achieved from d-alanine as a chiral template. The key steps in our strategy are modified Sharpless asymmetric dihydroxylation reaction and the highly stereoselective intramolecular acid-catalyzed amidocyclization.
Bing-xin Zhao - One of the best experts on this subject based on the ideXlab platform.
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Acanthophoraine A, a new Pyrrolidine Alkaloid from the red alga Acanthophora spicifera.
Natural product research, 2019Co-Authors: Jia-li Lin, Yong-qian Liang, Xiao-jian Liao, Jian-ting Yang, Yu-ling Huang, Zhi-hui Jiang, Bing-xin ZhaoAbstract:A new Pyrrolidine Alkaloid, acanthophoraine A (1), along with six known Alkaloids (2-7), had been isolated from the red alga Acanthophora spicifera. The structures of these compounds were identified by spectroscopic analyses. The absolute configuration of 1 was established by ECD calculation. Compound 1 represents the first example of N-isobutyl pyrrolidone with an urea arm. The antimicrobial activity of 1 was also evaluated.[Figure: see text].
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Acanthophoraine A, a new Pyrrolidine Alkaloid from the red alga Acanthophora spicifera
2019Co-Authors: Jia-li Lin, Yong-qian Liang, Xiao-jian Liao, Jian-ting Yang, Yu-ling Huang, Zhi-hui Jiang, Bing-xin ZhaoAbstract:A new Pyrrolidine Alkaloid, acanthophoraine A (1), along with six known Alkaloids (2–7), had been isolated from the red alga Acanthophora spicifera. The structures of these compounds were identified by spectroscopic analyses. The absolute configuration of 1 was established by ECD calculation. Compound 1 represents the first example of N-isobutyl pyrrolidone with an urea arm. The antimicrobial activity of 1 was also evaluated.
Alexis Kotland - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and Fucosidase Inhibitory Study of Unnatural Pyrrolidine Alkaloid 4-epi-(+)-Codonopsinine
The Journal of organic chemistry, 2011Co-Authors: Alexis Kotland, Fabien Accadbled, Koen Robeyns, Jean-bernard BehrAbstract:The total synthesis of enantiopure 4-epi-(+)-codonopsinine was achieved in 10 steps starting from D-ribose as a chiral building block. The key step involved a highly stereoselective nucleophilic addition of a Grignard reagent to a protected ribosylamine. Synthesis of the N-desmethyl derivative and its p-tolyl analogue was also accomplished, and the compounds were assayed against α-fucosidase.
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synthesis and fucosidase inhibitory study of unnatural Pyrrolidine Alkaloid 4 epi codonopsinine
Journal of Organic Chemistry, 2011Co-Authors: Alexis Kotland, Fabien Accadbled, Koen Robeyns, Jean-bernard BehrAbstract:The total synthesis of enantiopure 4-epi-(+)-codonopsinine was achieved in 10 steps starting from D-ribose as a chiral building block. The key step involved a highly stereoselective nucleophilic addition of a Grignard reagent to a protected ribosylamine. Synthesis of the N-desmethyl derivative and its p-tolyl analogue was also accomplished, and the compounds were assayed against α-fucosidase.
Jangari Santhosh Reddy - One of the best experts on this subject based on the ideXlab platform.
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A Short, Efficient, and Stereoselective Total Synthesis of a Pyrrolidine Alkaloid: (−)-Codonopsinine†
The Journal of organic chemistry, 2007Co-Authors: Jangari Santhosh Reddy, Batchu Venkateswara RaoAbstract:An efficient total synthesis of antibiotic (−)-codonopsinine 1 with an overall yield of 44% was achieved from d-alanine as a chiral template. The key steps in our strategy are modified Sharpless asymmetric dihydroxylation reaction and the highly stereoselective intramolecular acid-catalyzed amidocyclization.
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a short efficient and stereoselective total synthesis of a Pyrrolidine Alkaloid codonopsinine
Journal of Organic Chemistry, 2007Co-Authors: Jangari Santhosh Reddy, Batchu Venkateswara RaoAbstract:An efficient total synthesis of antibiotic (−)-codonopsinine 1 with an overall yield of 44% was achieved from d-alanine as a chiral template. The key steps in our strategy are modified Sharpless asymmetric dihydroxylation reaction and the highly stereoselective intramolecular acid-catalyzed amidocyclization.
