The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform
Martin S. Springer - One of the best experts on this subject based on the ideXlab platform.
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1,3,4-Trisubstituted Pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.
Bioorganic & medicinal chemistry letters, 2002Co-Authors: Christopher L. Lynch, Jeffrey J. Hale, Richard J. Budhu, Amy Gentry, Sander G. Mills, Kevin T. Chapman, Malcolm Maccoss, Lorraine Malkowitz, Martin S. Springer, Sandra L. GouldAbstract:A series of α-(pyrrolidin-1-yl)acetic acids is presented as selective and potent antivirals against HIV. Several of the Pyrrolidine zwitterions demonstrated reasonable in vitro properties, enhanced antiviral activities and improved pharmacokinetic profiles over Pyrrolidine 1.
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1,3,4-Trisubstituted Pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the Pyrrolidine scaffold and determination of its stereochemical requirements.
Bioorganic & medicinal chemistry letters, 2001Co-Authors: Jeffrey J. Hale, Richard J. Budhu, Sander G. Mills, Malcolm Maccoss, Lorraine Malkowitz, Sandra L. Gould, Salvatore J. Siciliano, Julie A. Demartino, Martin S. SpringerAbstract:Abstract A series of 1,3,4-trisubstituted Pyrrolidines was discovered to have the ability to displace [ 125 I]-MIP-1α from the CCR5 receptor expressed on Chinese hamster ovary (CHO) cell membranes. CCR5 activity was found to be dependent on the regiochemistry and the absolute stereochemistry of the Pyrrolidine.
Jeffrey J. Hale - One of the best experts on this subject based on the ideXlab platform.
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1,3,4-Trisubstituted Pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.
Bioorganic & medicinal chemistry letters, 2002Co-Authors: Christopher L. Lynch, Jeffrey J. Hale, Richard J. Budhu, Amy Gentry, Sander G. Mills, Kevin T. Chapman, Malcolm Maccoss, Lorraine Malkowitz, Martin S. Springer, Sandra L. GouldAbstract:A series of α-(pyrrolidin-1-yl)acetic acids is presented as selective and potent antivirals against HIV. Several of the Pyrrolidine zwitterions demonstrated reasonable in vitro properties, enhanced antiviral activities and improved pharmacokinetic profiles over Pyrrolidine 1.
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1,3,4-Trisubstituted Pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the Pyrrolidine scaffold and determination of its stereochemical requirements.
Bioorganic & medicinal chemistry letters, 2001Co-Authors: Jeffrey J. Hale, Richard J. Budhu, Sander G. Mills, Malcolm Maccoss, Lorraine Malkowitz, Sandra L. Gould, Salvatore J. Siciliano, Julie A. Demartino, Martin S. SpringerAbstract:Abstract A series of 1,3,4-trisubstituted Pyrrolidines was discovered to have the ability to displace [ 125 I]-MIP-1α from the CCR5 receptor expressed on Chinese hamster ovary (CHO) cell membranes. CCR5 activity was found to be dependent on the regiochemistry and the absolute stereochemistry of the Pyrrolidine.
Sandra L. Gould - One of the best experts on this subject based on the ideXlab platform.
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1,3,4-Trisubstituted Pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.
Bioorganic & medicinal chemistry letters, 2002Co-Authors: Christopher L. Lynch, Jeffrey J. Hale, Richard J. Budhu, Amy Gentry, Sander G. Mills, Kevin T. Chapman, Malcolm Maccoss, Lorraine Malkowitz, Martin S. Springer, Sandra L. GouldAbstract:A series of α-(pyrrolidin-1-yl)acetic acids is presented as selective and potent antivirals against HIV. Several of the Pyrrolidine zwitterions demonstrated reasonable in vitro properties, enhanced antiviral activities and improved pharmacokinetic profiles over Pyrrolidine 1.
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1,3,4-Trisubstituted Pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the Pyrrolidine scaffold and determination of its stereochemical requirements.
Bioorganic & medicinal chemistry letters, 2001Co-Authors: Jeffrey J. Hale, Richard J. Budhu, Sander G. Mills, Malcolm Maccoss, Lorraine Malkowitz, Sandra L. Gould, Salvatore J. Siciliano, Julie A. Demartino, Martin S. SpringerAbstract:Abstract A series of 1,3,4-trisubstituted Pyrrolidines was discovered to have the ability to displace [ 125 I]-MIP-1α from the CCR5 receptor expressed on Chinese hamster ovary (CHO) cell membranes. CCR5 activity was found to be dependent on the regiochemistry and the absolute stereochemistry of the Pyrrolidine.
Lorraine Malkowitz - One of the best experts on this subject based on the ideXlab platform.
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1,3,4-Trisubstituted Pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.
Bioorganic & medicinal chemistry letters, 2002Co-Authors: Christopher L. Lynch, Jeffrey J. Hale, Richard J. Budhu, Amy Gentry, Sander G. Mills, Kevin T. Chapman, Malcolm Maccoss, Lorraine Malkowitz, Martin S. Springer, Sandra L. GouldAbstract:A series of α-(pyrrolidin-1-yl)acetic acids is presented as selective and potent antivirals against HIV. Several of the Pyrrolidine zwitterions demonstrated reasonable in vitro properties, enhanced antiviral activities and improved pharmacokinetic profiles over Pyrrolidine 1.
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1,3,4-Trisubstituted Pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the Pyrrolidine scaffold and determination of its stereochemical requirements.
Bioorganic & medicinal chemistry letters, 2001Co-Authors: Jeffrey J. Hale, Richard J. Budhu, Sander G. Mills, Malcolm Maccoss, Lorraine Malkowitz, Sandra L. Gould, Salvatore J. Siciliano, Julie A. Demartino, Martin S. SpringerAbstract:Abstract A series of 1,3,4-trisubstituted Pyrrolidines was discovered to have the ability to displace [ 125 I]-MIP-1α from the CCR5 receptor expressed on Chinese hamster ovary (CHO) cell membranes. CCR5 activity was found to be dependent on the regiochemistry and the absolute stereochemistry of the Pyrrolidine.
Malcolm Maccoss - One of the best experts on this subject based on the ideXlab platform.
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1,3,4-Trisubstituted Pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.
Bioorganic & medicinal chemistry letters, 2002Co-Authors: Christopher L. Lynch, Jeffrey J. Hale, Richard J. Budhu, Amy Gentry, Sander G. Mills, Kevin T. Chapman, Malcolm Maccoss, Lorraine Malkowitz, Martin S. Springer, Sandra L. GouldAbstract:A series of α-(pyrrolidin-1-yl)acetic acids is presented as selective and potent antivirals against HIV. Several of the Pyrrolidine zwitterions demonstrated reasonable in vitro properties, enhanced antiviral activities and improved pharmacokinetic profiles over Pyrrolidine 1.
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1,3,4-Trisubstituted Pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the Pyrrolidine scaffold and determination of its stereochemical requirements.
Bioorganic & medicinal chemistry letters, 2001Co-Authors: Jeffrey J. Hale, Richard J. Budhu, Sander G. Mills, Malcolm Maccoss, Lorraine Malkowitz, Sandra L. Gould, Salvatore J. Siciliano, Julie A. Demartino, Martin S. SpringerAbstract:Abstract A series of 1,3,4-trisubstituted Pyrrolidines was discovered to have the ability to displace [ 125 I]-MIP-1α from the CCR5 receptor expressed on Chinese hamster ovary (CHO) cell membranes. CCR5 activity was found to be dependent on the regiochemistry and the absolute stereochemistry of the Pyrrolidine.
