The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Akhila K Sahoo - One of the best experts on this subject based on the ideXlab platform.
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dimethyl sulfoxide and n iodosuccinimide promoted 5 exo dig oxidative cyclization of yne tethered ynamide access to Pyrrolidones and spiro Pyrrolidones
Organic Letters, 2016Co-Authors: B Prabagar, Sanatan Nayak, Rangu Prasad, Akhila K SahooAbstract:An unprecedented metal-free dimethyl sulfoxide (DMSO) and N-iodosuccinimide mediated regioselective 5-exo-dig oxidative cyclization of an in situ generated enol equivalent of amides from ynamides bearing internal alkynes is demonstrated. The reaction allows easy access to functionalized pyrrolidone skeletons. Pyrrolidones having 3-o-biaryl motifs successfully undergo intramolecular electrophilic cyclization with the α,β-unsaturated olefin, furnishing spiro-pyrrolidone motifs. A one-pot sequential 5-exo-dig cyclization of the yne-tethered ynamides, followed by electrophilic cyclization of the pyrrolidone, is presented. The role of DMSO in the transformation is clarified, and a tentative reaction pathway is proposed.
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Dimethyl Sulfoxide and N‑Iodosuccinimide Promoted 5-exo-dig Oxidative Cyclization of Yne-Tethered Ynamide: Access to Pyrrolidones and Spiro-Pyrrolidones
2016Co-Authors: B Prabagar, Sanatan Nayak, Rangu Prasad, Akhila K SahooAbstract:An unprecedented metal-free dimethyl sulfoxide (DMSO) and N-iodosuccinimide mediated regioselective 5-exo-dig oxidative cyclization of an in situ generated enol equivalent of amides from ynamides bearing internal alkynes is demonstrated. The reaction allows easy access to functionalized pyrrolidone skeletons. Pyrrolidones having 3-o-biaryl motifs successfully undergo intramolecular electrophilic cyclization with the α,β-unsaturated olefin, furnishing spiro-pyrrolidone motifs. A one-pot sequential 5-exo-dig cyclization of the yne-tethered ynamides, followed by electrophilic cyclization of the pyrrolidone, is presented. The role of DMSO in the transformation is clarified, and a tentative reaction pathway is proposed
B Prabagar - One of the best experts on this subject based on the ideXlab platform.
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dimethyl sulfoxide and n iodosuccinimide promoted 5 exo dig oxidative cyclization of yne tethered ynamide access to Pyrrolidones and spiro Pyrrolidones
Organic Letters, 2016Co-Authors: B Prabagar, Sanatan Nayak, Rangu Prasad, Akhila K SahooAbstract:An unprecedented metal-free dimethyl sulfoxide (DMSO) and N-iodosuccinimide mediated regioselective 5-exo-dig oxidative cyclization of an in situ generated enol equivalent of amides from ynamides bearing internal alkynes is demonstrated. The reaction allows easy access to functionalized pyrrolidone skeletons. Pyrrolidones having 3-o-biaryl motifs successfully undergo intramolecular electrophilic cyclization with the α,β-unsaturated olefin, furnishing spiro-pyrrolidone motifs. A one-pot sequential 5-exo-dig cyclization of the yne-tethered ynamides, followed by electrophilic cyclization of the pyrrolidone, is presented. The role of DMSO in the transformation is clarified, and a tentative reaction pathway is proposed.
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Dimethyl Sulfoxide and N‑Iodosuccinimide Promoted 5-exo-dig Oxidative Cyclization of Yne-Tethered Ynamide: Access to Pyrrolidones and Spiro-Pyrrolidones
2016Co-Authors: B Prabagar, Sanatan Nayak, Rangu Prasad, Akhila K SahooAbstract:An unprecedented metal-free dimethyl sulfoxide (DMSO) and N-iodosuccinimide mediated regioselective 5-exo-dig oxidative cyclization of an in situ generated enol equivalent of amides from ynamides bearing internal alkynes is demonstrated. The reaction allows easy access to functionalized pyrrolidone skeletons. Pyrrolidones having 3-o-biaryl motifs successfully undergo intramolecular electrophilic cyclization with the α,β-unsaturated olefin, furnishing spiro-pyrrolidone motifs. A one-pot sequential 5-exo-dig cyclization of the yne-tethered ynamides, followed by electrophilic cyclization of the pyrrolidone, is presented. The role of DMSO in the transformation is clarified, and a tentative reaction pathway is proposed
Malcolm A Kelland - One of the best experts on this subject based on the ideXlab platform.
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first investigation of the kinetic hydrate inhibitor performance of polymers of alkylated n vinyl Pyrrolidones
Energy & Fuels, 2013Co-Authors: Fernando T Reyes, Malcolm A KellandAbstract:A series of water-soluble homopolymers and copolymers of 1-alkyl-vinyl Pyrrolidones (1-alkyl-VPs) with alkyl groups, including methyl, ethyl, isopropyl, and n-propyl, has been synthesized. Homopolymers with larger alkyl groups had cloud points in water lower than 0 °C. The comonomers used in the copolymers were N-vinyl pyrrolidone (VP) and N-methyl-N-vinyl acetamide (VIMA). The performance of the water-soluble 1-alkyl-VP polymers as kinetic hydrate inhibitors was investigated for the first time. Tests were conducted in high-pressure rocking cells using a structure II hydrate-forming natural gas mixture and compared to poly(N-vinyl lactam)s of similar molecular weight. The best copolymer of this series was the 1:1 nPr-VP/VIMA copolymer. 1-dimethyl-VP and 1-ethyl-VP homopolymers and the 1:1 n-propyl-VP/VP copolymer also showed better performance than poly(N-vinyl caprolactam) and poly(N-vinyl azocyclooctanone) of similar molecular weights. The structure–performance analysis in this study suggests that a mor...
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first investigation of the kinetic hydrate inhibitor performance of polymers of alkylated n vinyl Pyrrolidones
Energy & Fuels, 2013Co-Authors: Fernando T Reyes, Malcolm A KellandAbstract:A series of water-soluble homopolymers and copolymers of 1-alkyl-vinyl Pyrrolidones (1-alkyl-VPs) with alkyl groups, including methyl, ethyl, isopropyl, and n-propyl, has been synthesized. Homopoly...
Yajun Wang - One of the best experts on this subject based on the ideXlab platform.
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copper catalyzed aerobic oxidative dehydrogenative formal 2 3 cyclization of glycine esters with α angelicalactone approach to construct polysubstituted Pyrrolidones
Organic Letters, 2015Co-Authors: Congde Huo, Yong Yuan, Fengjuan Chen, Jing Tang, Yajun WangAbstract:A novel and efficient copper-catalyzed aerobic oxidative dehydrogenative formal [2 + 3] cyclization of glycine derivatives with α-angelicalactone is described. A series of complex Pyrrolidones were produced under mild and simple reaction conditions.
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Copper-Catalyzed Aerobic Oxidative Dehydrogenative Formal [2 + 3] Cyclization of Glycine Esters with α‑Angelicalactone: Approach To Construct Polysubstituted Pyrrolidones
2015Co-Authors: Congde Huo, Yong Yuan, Fengjuan Chen, Jing Tang, Yajun WangAbstract:A novel and efficient copper-catalyzed aerobic oxidative dehydrogenative formal [2 + 3] cyclization of glycine derivatives with α-angelicalactone is described. A series of complex Pyrrolidones were produced under mild and simple reaction conditions
Yingsheng Zhao - One of the best experts on this subject based on the ideXlab platform.
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oxalyl amide assisted palladium catalyzed synthesis of Pyrrolidones via carbonylation of γ c sp3 h bonds of aliphatic amine substrates
ChemInform, 2015Co-Authors: Chao Wang, Changpeng Chen, Jian Han, Li Zhang, Yingming Yao, Yingsheng ZhaoAbstract:The first Pd-catalyzed regioselective γ-carbonylation of oxalyl amide protected aliphatic amines with carbon monoxide results in the formation of Pyrrolidones.
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oxalyl amide assisted palladium catalyzed synthesis of Pyrrolidones via carbonylation of γ c sp3 h bonds of aliphatic amine substrates
Chemical Science, 2015Co-Authors: Chao Wang, Changpeng Chen, Jian Han, Li Zhang, Yingming Yao, Yingsheng ZhaoAbstract:The first Pd-catalyzed regioselective γ-carbonylation of oxalyl amide protected aliphatic amines with carbon monoxide leading to synthesis of Pyrrolidones has been developed. Both γ-methyl and cyclopropyl methylene C–H bonds are well activated to obtain the corresponding Pyrrolidones in moderate to excellent yields. The role of 3-(trifluoromethyl)benzoic acid as an additive is critical as it helps in stabilizing the palladium intermediate formed during the catalytic cycle. The reaction scope is extended to benzylamine and allyl amine derivatives, thereby affording the corresponding products in good to excellent yields.
