The Experts below are selected from a list of 222 Experts worldwide ranked by ideXlab platform
Tetsuro Shinada - One of the best experts on this subject based on the ideXlab platform.
-
Short Total Synthesis of (−)-Kainic Acid
Organic letters, 2014Co-Authors: Yasufumi Ohfune, Tetsuro ShinadaAbstract:A short total synthesis of (−)-kainic acid has been developed involving a novel diastereofacial differentiating Cu-catalyzed Michael addition–cyclization reaction, which provided access to a chiral Pyrroline in a highly stereoselective manner. The chiral Pyrroline was converted to (−)-kainic acid via the stereoselective 1,4-reduction of the Pyrroline double bond in three steps.
-
short total synthesis of kainic acid
Organic Letters, 2014Co-Authors: Yasufumi Ohfune, Tetsuro ShinadaAbstract:A short total synthesis of (−)-kainic acid has been developed involving a novel diastereofacial differentiating Cu-catalyzed Michael addition–cyclization reaction, which provided access to a chiral Pyrroline in a highly stereoselective manner. The chiral Pyrroline was converted to (−)-kainic acid via the stereoselective 1,4-reduction of the Pyrroline double bond in three steps.
Yasufumi Ohfune - One of the best experts on this subject based on the ideXlab platform.
-
Short Total Synthesis of (−)-Kainic Acid
Organic letters, 2014Co-Authors: Yasufumi Ohfune, Tetsuro ShinadaAbstract:A short total synthesis of (−)-kainic acid has been developed involving a novel diastereofacial differentiating Cu-catalyzed Michael addition–cyclization reaction, which provided access to a chiral Pyrroline in a highly stereoselective manner. The chiral Pyrroline was converted to (−)-kainic acid via the stereoselective 1,4-reduction of the Pyrroline double bond in three steps.
-
short total synthesis of kainic acid
Organic Letters, 2014Co-Authors: Yasufumi Ohfune, Tetsuro ShinadaAbstract:A short total synthesis of (−)-kainic acid has been developed involving a novel diastereofacial differentiating Cu-catalyzed Michael addition–cyclization reaction, which provided access to a chiral Pyrroline in a highly stereoselective manner. The chiral Pyrroline was converted to (−)-kainic acid via the stereoselective 1,4-reduction of the Pyrroline double bond in three steps.
Teck-peng Loh - One of the best experts on this subject based on the ideXlab platform.
-
visible light promoted carboimination of unactivated alkenes for the synthesis of densely functionalized Pyrroline derivatives
ACS Catalysis, 2016Co-Authors: Sai-hu Cai, Jia-hao Xie, Shengjin Song, Chao Feng, Teck-peng LohAbstract:An efficient strategy which integrates visible-light-induced iminyl-radical formation with carboimination of unactivated alkenes has been developed for the easy access of densely functionalized Pyrroline derivatives. With fac-[Ir(ppy)3] as photoredox catalyst, the acyl oximes were converted into iminyl radical intermediates by one electron reduction, and evolve through a cascade of intramolecular cyclization and intermolecular carbon radical trapping to give the functionalized Pyrrolines. The utilization of silyl enol ethers as coupling partners not only allows the introduction of synthetically useful ketone functionalities but also renders catalyst regeneration without any external reductants. This protocol is characterized by its mild reaction conditions and the tolerance of a broad range of functionalities.
-
Visible-Light-Promoted Carboimination of Unactivated Alkenes for the Synthesis of Densely Functionalized Pyrroline Derivatives
2016Co-Authors: Sai-hu Cai, Jia-hao Xie, Shengjin Song, Chao Feng, Teck-peng LohAbstract:An efficient strategy which integrates visible-light-induced iminyl-radical formation with carboimination of unactivated alkenes has been developed for the easy access of densely functionalized Pyrroline derivatives. With fac-[Ir(ppy)3] as photoredox catalyst, the acyl oximes were converted into iminyl radical intermediates by one electron reduction, and evolve through a cascade of intramolecular cyclization and intermolecular carbon radical trapping to give the functionalized Pyrrolines. The utilization of silyl enol ethers as coupling partners not only allows the introduction of synthetically useful ketone functionalities but also renders catalyst regeneration without any external reductants. This protocol is characterized by its mild reaction conditions and the tolerance of a broad range of functionalities
Jetze J. Tepe - One of the best experts on this subject based on the ideXlab platform.
-
Stereoselective Synthesis of Highly Substituted Δ1-Pyrrolines: exo-Selective 1,3-Dipolar Cycloaddition Reactions with Azlactones
Journal of the American Chemical Society, 2004Co-Authors: Satyamaheshwar Peddibhotla, Jetze J. TepeAbstract:We report herein a silver(I)-catalyzed exo-selective synthesis of highly substituted Δ1-Pyrroline scaffolds from amino acid-derived munchnones. Silver acetate successfully catalyzed the cycloaddition reaction of azlactones with alkenes, generating Δ1-Pyrrolines in very good yields without isomerization to the Δ2-Pyrrolines or decarboxylation.
Bruce E. Maryanoff - One of the best experts on this subject based on the ideXlab platform.
-
Organic Syntheses - N‐Vinylpyrrolidin‐2‐One as a 3‐Aminopropyl Carbanion Equivalent in the Synthesis of Substituted 1‐Pyrrolines: 2‐Phenyl‐1‐Pyrroline
Organic Syntheses, 2003Co-Authors: Kirk L. Sorgi, Cynthia A. Maryanoff, David F. Mccomsey, Bruce E. MaryanoffAbstract:N-Vinylpyrrolidin-2-One as a 3-Aminopropyl Carbanion Equivalent in the Synthesis of Substituted 1-Pyrrolines: 2-Phenyl-1-Pyrroline Keywords: acylation; addition, to CO; annulation, heterocyclic-[5]; cyclization, condensation; enamine or imine formation; hydrolysis, amides; ring opening reactions