The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform
Tadashi Matsuda - One of the best experts on this subject based on the ideXlab platform.
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preoperative Pyuria predicts for intravesical recurrence in patients with urothelial carcinoma of the upper urinary tract after radical nephroureterectomy without a history of bladder cancer
Clinical Genitourinary Cancer, 2020Co-Authors: Goro Sato, Takashi Yoshida, Hidefumi Kinoshita, Masaaki Yanishi, Ryoichi Saito, Takashi Murota, Gen Kawa, Tadashi MatsudaAbstract:Abstract Background We assessed preoperative Pyuria as a significant predictor of intravesical recurrence (IVR) in patients with upper urinary tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU). Patients and Methods We evaluated the data from 268 patients with UTUC without a history of bladder cancer who had undergone RNU from 2006 to 2016 at 4 academic institutions. The associations between the clinical variables and the presence of Pyuria were evaluated by univariate analysis. IVR was assessed using the Kaplan-Meier method and Cox regression analysis. Results The median postoperative follow-up of patients with IVR-free survival was 29.1 months (interquartile range, 15.4-55.3 months). The rate of IVR was significantly greater in the patients with than in those without Pyuria (P = .025). Multivariate analysis showed that preoperative Pyuria (hazard ratio [HR], 1.70; P = .007), a ureteral tumor site (HR, 1.64; P = .012), and positive surgical margins (HR, 2.70; P = .013) were associated with a significantly increased risk of IVR. A postoperative risk stratification model using these factors showed significant differences among the 3 subgroups of patients with low, intermediate, and high risk. The 5-year IVR-free survival rates for the patients with low, intermediate, and high risk were 69.1%, 51.8%, and 18.8%, respectively (P = .004). Conclusion Preoperative Pyuria, a ureteral tumor site, and positive surgical margins were associated with a significantly increased risk of IVR. Although external validation is required, the presence of preoperative Pyuria could be a significant predictor of IVR in patients with UTUC after RNU.
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preoperative Pyuria is a poor prognostic factor in patients with urothelial carcinoma of the upper urinary tract after surgery
Clinical Genitourinary Cancer, 2017Co-Authors: Takashi Yoshida, Hidefumi Kinoshita, Seiji Shimada, Motohiko Sugi, Tadashi MatsudaAbstract:Abstract Introduction The purpose of this study was to determine the prognostic significance of preoperative Pyuria in patients with upper urinary tract urothelial carcinoma after surgery. Patients and Methods We retrospectively evaluated data on 157 patients with nonmetastatic upper urinary tract urothelial carcinoma who had undergone surgery at our institution. The associations between clinical features and advanced pathological findings were evaluated using a logistic regression model. Recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) were assessed with the Kaplan–Meier method and Cox regression analysis. The influence of Pyuria on the predictive accuracy of the multivariate model was assessed using the concordance index. Results The median postoperative follow-up among patients who survived was 48.1 months. Preoperative Pyuria was significantly correlated with worse RFS, CSS, and OS ( P P = .003), high tumor Grade (G3; odds ratio, 2.25; P = .038), and lymphovascular invasion (odds ratio, 2.25; P = .008). Moreover, multivariate Cox regression analyses showed that Pyuria was an independent prognostic factor for RFS (hazard ratio, 3.02; P P = .043), and OS (hazard ratio, 2.10; P = .019). For CSS, the addition of Pyuria to the multivariate model increased its predictive accuracy from 0.87 to 0.90. Conclusion Preoperative Pyuria is significantly associated with CSS, OS, and increased risk of locally advanced disease and subsequent disease recurrence in patients with upper urinary tract urothelial carcinoma who undergo surgery.
Ulrich H Reichard - One of the best experts on this subject based on the ideXlab platform.
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Sterile Pyuria in a population of wild white-handed gibbons (Hylobates lar).
American journal of primatology, 2009Co-Authors: Barbara A. Beaman, Tommaso Savini, Wyatt J. Hesemeyer, Nathaniel J. Dominy, Ulrich H ReichardAbstract:Urinalysis is an emerging method for monitoring the health and energy balance of wild primates. Here, we report the first urinalysis of wild gibbons. We used multi-reagent test strips to monitor the health status of 52 individual white-handed gibbons (Hylobates lar) inhabiting Khao Yai National Park, Thailand. Most urinary reference values were within normal ranges; however, regardless of age- and sex-class or monthly fruit productivity, we found unexpectedly high rates of urinary leukocytes (50% and 90% of individuals in 2001–2003 and 2006, respectively). In contrast to previous studies of African apes, this finding is coupled with the near absence of urinary nitrites, demonstrating pervasive levels of sterile Pyuria. This result is the first reported case of sterile Pyuria in a population of wild primates. The etiology of human sterile Pyuria is diverse, but in all cases it is diagnostic of systemic inflammation. We discuss the potential causes of sterile Pyuria in the gibbons of Khao Yai. Am. J. Primatol. 71:880–883, 2009. © 2009 Wiley-Liss, Inc.
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RESEARCH ARTICLE Sterile Pyuria in a Population of Wild White-Handed Gibbons (Hylobates lar)
2009Co-Authors: Barbara A. Beaman, Tommaso Savini, Wyatt J. Hesemeyer, Nathaniel J. Dominy, Ulrich H ReichardAbstract:Urinalysis is an emerging method for monitoring the health and energy balance of wild primates. Here, we report the first urinalysis of wild gibbons. We used multi-reagent test strips to monitor the health status of 52 individual white-handed gibbons (Hylobates lar) inhabiting Khao Yai National Park, Thailand. Most urinary reference values were within normal ranges; however, regardless of age- and sex-class or monthly fruit productivity, we found unexpectedly high rates of urinary leukocytes (50% and 90% of individuals in 2001‐2003 and 2006, respectively). In contrast to previous studies of African apes, this finding is coupled with the near absence of urinary nitrites, demonstrating pervasive levels of sterile Pyuria. This result is the first reported case of sterile Pyuria in a population of wild primates. The etiology of human sterile Pyuria is diverse, but in all cases it is diagnostic of systemic inflammation. We discuss the potential causes of sterile Pyuria in the gibbons of Khao Yai. Am. J. Primatol. 71:880‐883, 2009. r 2009 Wiley-Liss, Inc.
Takashi Yoshida - One of the best experts on this subject based on the ideXlab platform.
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preoperative Pyuria predicts for intravesical recurrence in patients with urothelial carcinoma of the upper urinary tract after radical nephroureterectomy without a history of bladder cancer
Clinical Genitourinary Cancer, 2020Co-Authors: Goro Sato, Takashi Yoshida, Hidefumi Kinoshita, Masaaki Yanishi, Ryoichi Saito, Takashi Murota, Gen Kawa, Tadashi MatsudaAbstract:Abstract Background We assessed preoperative Pyuria as a significant predictor of intravesical recurrence (IVR) in patients with upper urinary tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU). Patients and Methods We evaluated the data from 268 patients with UTUC without a history of bladder cancer who had undergone RNU from 2006 to 2016 at 4 academic institutions. The associations between the clinical variables and the presence of Pyuria were evaluated by univariate analysis. IVR was assessed using the Kaplan-Meier method and Cox regression analysis. Results The median postoperative follow-up of patients with IVR-free survival was 29.1 months (interquartile range, 15.4-55.3 months). The rate of IVR was significantly greater in the patients with than in those without Pyuria (P = .025). Multivariate analysis showed that preoperative Pyuria (hazard ratio [HR], 1.70; P = .007), a ureteral tumor site (HR, 1.64; P = .012), and positive surgical margins (HR, 2.70; P = .013) were associated with a significantly increased risk of IVR. A postoperative risk stratification model using these factors showed significant differences among the 3 subgroups of patients with low, intermediate, and high risk. The 5-year IVR-free survival rates for the patients with low, intermediate, and high risk were 69.1%, 51.8%, and 18.8%, respectively (P = .004). Conclusion Preoperative Pyuria, a ureteral tumor site, and positive surgical margins were associated with a significantly increased risk of IVR. Although external validation is required, the presence of preoperative Pyuria could be a significant predictor of IVR in patients with UTUC after RNU.
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preoperative Pyuria is a poor prognostic factor in patients with urothelial carcinoma of the upper urinary tract after surgery
Clinical Genitourinary Cancer, 2017Co-Authors: Takashi Yoshida, Hidefumi Kinoshita, Seiji Shimada, Motohiko Sugi, Tadashi MatsudaAbstract:Abstract Introduction The purpose of this study was to determine the prognostic significance of preoperative Pyuria in patients with upper urinary tract urothelial carcinoma after surgery. Patients and Methods We retrospectively evaluated data on 157 patients with nonmetastatic upper urinary tract urothelial carcinoma who had undergone surgery at our institution. The associations between clinical features and advanced pathological findings were evaluated using a logistic regression model. Recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) were assessed with the Kaplan–Meier method and Cox regression analysis. The influence of Pyuria on the predictive accuracy of the multivariate model was assessed using the concordance index. Results The median postoperative follow-up among patients who survived was 48.1 months. Preoperative Pyuria was significantly correlated with worse RFS, CSS, and OS ( P P = .003), high tumor Grade (G3; odds ratio, 2.25; P = .038), and lymphovascular invasion (odds ratio, 2.25; P = .008). Moreover, multivariate Cox regression analyses showed that Pyuria was an independent prognostic factor for RFS (hazard ratio, 3.02; P P = .043), and OS (hazard ratio, 2.10; P = .019). For CSS, the addition of Pyuria to the multivariate model increased its predictive accuracy from 0.87 to 0.90. Conclusion Preoperative Pyuria is significantly associated with CSS, OS, and increased risk of locally advanced disease and subsequent disease recurrence in patients with upper urinary tract urothelial carcinoma who undergo surgery.
Hidefumi Kinoshita - One of the best experts on this subject based on the ideXlab platform.
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preoperative Pyuria predicts for intravesical recurrence in patients with urothelial carcinoma of the upper urinary tract after radical nephroureterectomy without a history of bladder cancer
Clinical Genitourinary Cancer, 2020Co-Authors: Goro Sato, Takashi Yoshida, Hidefumi Kinoshita, Masaaki Yanishi, Ryoichi Saito, Takashi Murota, Gen Kawa, Tadashi MatsudaAbstract:Abstract Background We assessed preoperative Pyuria as a significant predictor of intravesical recurrence (IVR) in patients with upper urinary tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU). Patients and Methods We evaluated the data from 268 patients with UTUC without a history of bladder cancer who had undergone RNU from 2006 to 2016 at 4 academic institutions. The associations between the clinical variables and the presence of Pyuria were evaluated by univariate analysis. IVR was assessed using the Kaplan-Meier method and Cox regression analysis. Results The median postoperative follow-up of patients with IVR-free survival was 29.1 months (interquartile range, 15.4-55.3 months). The rate of IVR was significantly greater in the patients with than in those without Pyuria (P = .025). Multivariate analysis showed that preoperative Pyuria (hazard ratio [HR], 1.70; P = .007), a ureteral tumor site (HR, 1.64; P = .012), and positive surgical margins (HR, 2.70; P = .013) were associated with a significantly increased risk of IVR. A postoperative risk stratification model using these factors showed significant differences among the 3 subgroups of patients with low, intermediate, and high risk. The 5-year IVR-free survival rates for the patients with low, intermediate, and high risk were 69.1%, 51.8%, and 18.8%, respectively (P = .004). Conclusion Preoperative Pyuria, a ureteral tumor site, and positive surgical margins were associated with a significantly increased risk of IVR. Although external validation is required, the presence of preoperative Pyuria could be a significant predictor of IVR in patients with UTUC after RNU.
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preoperative Pyuria is a poor prognostic factor in patients with urothelial carcinoma of the upper urinary tract after surgery
Clinical Genitourinary Cancer, 2017Co-Authors: Takashi Yoshida, Hidefumi Kinoshita, Seiji Shimada, Motohiko Sugi, Tadashi MatsudaAbstract:Abstract Introduction The purpose of this study was to determine the prognostic significance of preoperative Pyuria in patients with upper urinary tract urothelial carcinoma after surgery. Patients and Methods We retrospectively evaluated data on 157 patients with nonmetastatic upper urinary tract urothelial carcinoma who had undergone surgery at our institution. The associations between clinical features and advanced pathological findings were evaluated using a logistic regression model. Recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) were assessed with the Kaplan–Meier method and Cox regression analysis. The influence of Pyuria on the predictive accuracy of the multivariate model was assessed using the concordance index. Results The median postoperative follow-up among patients who survived was 48.1 months. Preoperative Pyuria was significantly correlated with worse RFS, CSS, and OS ( P P = .003), high tumor Grade (G3; odds ratio, 2.25; P = .038), and lymphovascular invasion (odds ratio, 2.25; P = .008). Moreover, multivariate Cox regression analyses showed that Pyuria was an independent prognostic factor for RFS (hazard ratio, 3.02; P P = .043), and OS (hazard ratio, 2.10; P = .019). For CSS, the addition of Pyuria to the multivariate model increased its predictive accuracy from 0.87 to 0.90. Conclusion Preoperative Pyuria is significantly associated with CSS, OS, and increased risk of locally advanced disease and subsequent disease recurrence in patients with upper urinary tract urothelial carcinoma who undergo surgery.
Barbara A. Beaman - One of the best experts on this subject based on the ideXlab platform.
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Sterile Pyuria in a population of wild white-handed gibbons (Hylobates lar).
American journal of primatology, 2009Co-Authors: Barbara A. Beaman, Tommaso Savini, Wyatt J. Hesemeyer, Nathaniel J. Dominy, Ulrich H ReichardAbstract:Urinalysis is an emerging method for monitoring the health and energy balance of wild primates. Here, we report the first urinalysis of wild gibbons. We used multi-reagent test strips to monitor the health status of 52 individual white-handed gibbons (Hylobates lar) inhabiting Khao Yai National Park, Thailand. Most urinary reference values were within normal ranges; however, regardless of age- and sex-class or monthly fruit productivity, we found unexpectedly high rates of urinary leukocytes (50% and 90% of individuals in 2001–2003 and 2006, respectively). In contrast to previous studies of African apes, this finding is coupled with the near absence of urinary nitrites, demonstrating pervasive levels of sterile Pyuria. This result is the first reported case of sterile Pyuria in a population of wild primates. The etiology of human sterile Pyuria is diverse, but in all cases it is diagnostic of systemic inflammation. We discuss the potential causes of sterile Pyuria in the gibbons of Khao Yai. Am. J. Primatol. 71:880–883, 2009. © 2009 Wiley-Liss, Inc.
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RESEARCH ARTICLE Sterile Pyuria in a Population of Wild White-Handed Gibbons (Hylobates lar)
2009Co-Authors: Barbara A. Beaman, Tommaso Savini, Wyatt J. Hesemeyer, Nathaniel J. Dominy, Ulrich H ReichardAbstract:Urinalysis is an emerging method for monitoring the health and energy balance of wild primates. Here, we report the first urinalysis of wild gibbons. We used multi-reagent test strips to monitor the health status of 52 individual white-handed gibbons (Hylobates lar) inhabiting Khao Yai National Park, Thailand. Most urinary reference values were within normal ranges; however, regardless of age- and sex-class or monthly fruit productivity, we found unexpectedly high rates of urinary leukocytes (50% and 90% of individuals in 2001‐2003 and 2006, respectively). In contrast to previous studies of African apes, this finding is coupled with the near absence of urinary nitrites, demonstrating pervasive levels of sterile Pyuria. This result is the first reported case of sterile Pyuria in a population of wild primates. The etiology of human sterile Pyuria is diverse, but in all cases it is diagnostic of systemic inflammation. We discuss the potential causes of sterile Pyuria in the gibbons of Khao Yai. Am. J. Primatol. 71:880‐883, 2009. r 2009 Wiley-Liss, Inc.
