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Jerome Gros - One of the best experts on this subject based on the ideXlab platform.

  • the Quail genome insights into social behaviour seasonal biology and infectious disease response
    BMC Biology, 2020
    Co-Authors: Katrina M Morris, David Gourichon, Matthew Hindle, Simon Boitard, David W Burt, Angela Danner, Lel Eory, Heather L Forrest, Jerome Gros
    Abstract:

    The Japanese Quail (Coturnix japonica) is a popular domestic poultry species and an increasingly significant model species in avian developmental, behavioural and disease research. We have produced a high-quality Quail genome sequence, spanning 0.93 Gb assigned to 33 chromosomes. In terms of contiguity, assembly statistics, gene content and chromosomal organisation, the Quail genome shows high similarity to the chicken genome. We demonstrate the utility of this genome through three diverse applications. First, we identify selection signatures and candidate genes associated with social behaviour in the Quail genome, an important agricultural and domestication trait. Second, we investigate the effects and interaction of photoperiod and temperature on the transcriptome of the Quail medial basal hypothalamus, revealing key mechanisms of photoperiodism. Finally, we investigate the response of Quail to H5N1 influenza infection. In Quail lung, many critical immune genes and pathways were downregulated after H5N1 infection, and this may be key to the susceptibility of Quail to H5N1. We have produced a high-quality genome of the Quail which will facilitate further studies into diverse research questions using the Quail as a model avian species.

  • the Quail as an avian model system its genome provides insights into social behaviour seasonal biology and infectious disease response
    bioRxiv, 2019
    Co-Authors: Katrina M Morris, David Gourichon, Matthew Hindle, Simon Boitard, David W Burt, Angela Danner, Lel Eory, Heather L Forrest, Jerome Gros, L Gourichon
    Abstract:

    ABSTRACT The Japanese Quail (Coturnix japonica) is a popular domestic poultry species and an increasingly significant model species in avian developmental, behavioural and disease research. We have produced a high-quality Quail genome sequence, spanning 0.93 Gb assigned to 33 chromosomes. In terms of contiguity, assembly statistics, gene content and chromosomal organization, the Quail genome shows high similarity to the chicken genome. We demonstrate the utility of this genome through three diverse applications. First, we identify selection signatures and candidate genes associated with social behaviour in the Quail genome, an important agricultural and domestication trait. Second, we investigate the effects and interaction of photoperiod and temperature on the transcriptome of the Quail medial basal hypothalamus, revealing key mechanisms of photoperiodism. Finally, we investigate the response of Quail to H5N1 influenza infection. In Quail lung, many critical immune genes and pathways were downregulated, and this may be key to the susceptibility of Quail to H5N1. This genome will facilitate further research into diverse research questions using the Quail as a model avian species.

Jiři Hejnar - One of the best experts on this subject based on the ideXlab platform.

  • identification of new world Quails susceptible to infection with avian leukosis virus subgroup j
    Journal of Virology, 2017
    Co-Authors: Jiři Plachý, Dana Kucerova, Filip Senigl, Volodymyr Stepanets, Kateřina Trejbalova, Tomas Hron, Daniel Elleder, Markéta Reinišová, Jiři Hejnar
    Abstract:

    The J subgroup of avian leukosis virus (ALV-J) infects domestic chickens, jungle fowl, and turkeys. This virus enters the host cell through a receptor encoded by the tvj locus and identified as Na+/H+ exchanger 1. The resistance to avian leukosis virus subgroup J in a great majority of galliform species has been explained by deletions or substitutions of the critical tryptophan 38 in the first extracellular loop of Na+/H+ exchanger 1. Because there are concerns of transspecies virus transmission, we studied natural polymorphisms and susceptibility/resistance in wild galliforms and found the presence of tryptophan 38 in four species of New World Quails. The embryo fibroblasts of New World Quails are susceptible to infection with avian leukosis virus subgroup J, and the cloned Na+/H+ exchanger 1 confers susceptibility on the otherwise resistant host. New World Quails are also susceptible to new avian leukosis virus subgroup J variants but resistant to subgroups A and B and weakly susceptible to subgroups C and D of avian sarcoma/leukosis virus due to obvious defects of the respective receptors. Our results suggest that the avian leukosis virus subgroup J could be transmitted to New World Quails and establish a natural reservoir of circulating virus with a potential for further evolution. IMPORTANCE: Since its spread in broiler chickens in China and Southeast Asia in 2000, ALV-J remains a major enzootic challenge for the poultry industry. Although the virus diversifies rapidly in the poultry, its spillover and circulation in wild bird species has been prevented by the resistance of most species to ALV-J. It is, nevertheless, important to understand the evolution of the virus and its potential host range in wild birds. Because resistance to avian retroviruses is due particularly to receptor incompatibility, we studied Na+/H+ exchanger 1, the receptor for ALV-J. In New World Quails, we found a receptor compatible with virus entry, and we confirmed the susceptibilities of four New World Quail species in vitro We propose that a prospective molecular epidemiology study be conducted to identify species with the potential to become reservoirs for ALV-J.

  • Identification of New World Quails Susceptible to Infection with Avian Leukosis Virus Subgroup J
    Journal of Virology, 2017
    Co-Authors: Jiři Plachý, Dana Kucerova, Filip Senigl, Volodymyr Stepanets, Kateřina Trejbalova, Tomas Hron, Daniel Elleder, Markéta Reinišová, Jiři Hejnar
    Abstract:

    The J subgroup of avian leukosis virus (ALV-J) infects domestic chickens, jungle fowl, and turkeys. This virus enters the host cell through a receptor encoded by the tvj locus and identified as Na+/H+ exchanger 1. The resistance to avian leukosis virus subgroup J in a great majority of galliform species has been explained by deletions or substitutions of the critical tryptophan 38 in the first extracellular loop of Na+/H+ exchanger 1. Because there are concerns of transspecies virus transmission, we studied natural polymorphisms and susceptibility/resistance in wild galliforms and found the presence of tryptophan 38 in four species of New World Quails. The embryo fibroblasts of New World Quails are susceptible to infection with avian leukosis virus subgroup J, and the cloned Na+/H+ exchanger 1 confers susceptibility on the otherwise resistant host. New World Quails are also susceptible to new avian leukosis virus subgroup J variants but resistant to subgroups A and B and weakly susceptible to subgroups C and D of avian sarcoma/leukosis virus due to obvious defects of the respective receptors. Our results suggest that the avian leukosis virus subgroup J could be transmitted to New World Quails and establish a natural reservoir of circulating virus with a potential for further evolution. Since its spread in broiler chickens in China and Southeast Asia in 2000, ALV-J remains a major enzootic challenge for the poultry industry. Although the virus diversifies rapidly in the poultry, its spillover and circulation in wild bird species has been prevented by the resistance of most species to ALV-J. It is, nevertheless, important to understand the evolution of the virus and its potential host range in wild birds. Because resistance to avian retroviruses is due particularly to receptor incompatibility, we studied Na+/H+ exchanger 1, the receptor for ALV-J. In New World Quails, we found a receptor compatible with virus entry, and we confirmed the susceptibilities of four New World Quail species in vitro We propose that a prospective molecular epidemiology study be conducted to identify species with the potential to become reservoirs for ALV-J. Copyright © 2017 American Society for Microbiology.

Yoshihiro Kawaoka - One of the best experts on this subject based on the ideXlab platform.

  • the Quail and chicken intestine have sialyl galactose sugar chains responsible for the binding of influenza a viruses to human type receptors
    Glycobiology, 2007
    Co-Authors: Noriko Takahashi, Hirokazu Yagi, Koichi Kato, Tadanobu Takahashi, Shuangqin Yi, Yong Chen, Koichi Otsuki, Hiroshi Kida, Yoshihiro Kawaoka
    Abstract:

    The receptor specificity of influenza viruses is one factor that allows avian influenza viruses to cross the species barrier. The recent transmissions of avian H5N1 and H9N2 influenza viruses from chickens and/or Quails to humans indicate that avian influenza viruses can directly infect humans without an intermediate host, such as pigs. In this study, we used two strains of influenza A virus (A/PR/8/34, which preferentially binds to an avian-type receptor, and A/Memphis/1/71, which preferentially binds to a human-type receptor) to probe the receptor specificities in host cells. Epithelial cells of both Quail and chicken intestines (colons) could bind both avian- and human-type viruses. Infected cultured Quail colon cells expressed viral protein and allowed replication of the virus strain A/PR/8/34 or A/Memphis/1/71. To understand the molecular basis of these phenomena, we further investigated the abundance of sialic acid (Sia) linked to galactose (Gal) by the α2-3 linkage (Siaα2-3Gal) and Siaα2-6Gal in host cells. In glycoprotein and glycolipid fractions from Quail and chicken colon epithelial cells, there were some bound components of Sia-Gal linkage-specific lectins, Maackia amurensis agglutinin (specific for Siaα2-3 Gal) and Sambucus nigra agglutinin (specific for Siaα2-6Gal), indicating that both Siaα2-3Gal and Siaα2-6Gal exist in Quail and chicken colon cells. Furthermore, we demonstrated by fluorescence high-performance liquid chromatography (HPLC) analysis that 5-N-acetylneuraminic acid was the main molecular species of Sia, and we demonstrated by multi-dimensional HPLC mapping and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis that bi-antennary complex-type glycans α2-6 sialylated at the terminal Gal residue(s) are major (more than 79%) sialyl N-glycans expressed by intestinal epithelial tissues in both the chicken and Quail. Taken together, these results indicate that Quails and chickens have molecular characterization as potential intermediate hosts for avian influenza virus transmission to humans and could generate new influenza viruses with pandemic potential.

Yoichi Matsuda - One of the best experts on this subject based on the ideXlab platform.

  • Embryonic development and inviability phenotype of chicken-Japanese Quail F_1 hybrids
    Scientific Reports, 2016
    Co-Authors: Satoshi Ishishita, Keiji Kinoshita, Mikiharu Nakano, Yoichi Matsuda
    Abstract:

    Interspecific hybrid incompatibility, including inviability and sterility, is important in speciation; however, its genetic basis remains largely unknown in vertebrates. Crosses between male chickens and female Japanese Quails using artificial insemination can generate intergeneric hybrids; however, the hatching rate is low and hatched hybrids are only sterile males. Hybrid development is arrested frequently during the early embryonic stages and the sex ratio of living embryos is male-biased. However, the development and sex ratio of hybrid embryos have not been comprehensively analyzed. In the present study, we observed delayed embryonic development of chicken-Quail hybrids during the early stage, compared with that of chickens and Quails. The survival rate of hybrids decreased markedly during the blastoderm-to-pre-circulation stage and then decreased gradually through the subsequent stages. Hybrid females were observed at more than 10 d of incubation; however, the sex ratio of hybrids became male-biased from 10 d of incubation. Severely malformed embryos were observed frequently in hybrids. These results suggest that developmental arrest occurs at various stages in hybrid embryos, including a sexually non-biased arrest during the early stage and a female-biased arrest during the late stage. We discuss the genetic basis for hybrid inviability and its sex bias.

  • Chromosome size-correlated and chromosome size-uncorrelated homogenization of centromeric repetitive sequences in New World Quails
    Chromosome Research, 2014
    Co-Authors: Satoshi Ishishita, Yuri Tsuruta, Chizuko Nishida, Masaoki Tsudzuki, Darren K Griffin, Atsushi Nakamura, Yoichi Matsuda
    Abstract:

    Many families of centromeric repetitive DNA sequences isolated from Struthioniformes, Galliformes, Falconiformes, and Passeriformes are localized primarily to microchromosomes. However, it is unclear whether chromosome size-correlated homogenization is a common characteristic of centromeric repetitive sequences in Aves. New World and Old World Quails have the typical avian karyotype comprising chromosomes of two distinct sizes, and C-positive heterochromatin is distributed in centromeric regions of most autosomes and the whole W chromosome. We isolated six types of centromeric repetitive sequences from three New World Quail species ( Colinus virginianus , CVI; Callipepla californica , CCA; and Callipepla squamata , CSQ; Odontophoridae) and one Old World Quail species ( Alectoris chukar , ACH; Phasianidae), and characterized the sequences by nucleotide sequencing, chromosome in situ hybridization, and filter hybridization. The 385-bp CVI- Msp I, 591-bp CCA- BamH I, 582-bp CSQ- BamH I, and 366-bp ACH- Sau 3AI fragments exhibited tandem arrays of the monomer unit, and the 224-bp CVI- Hae III and 135-bp CCA- Hae III fragments were composed of minisatellite-like and microsatellite-like repeats, respectively. ACH- Sau 3AI was a homolog of the chicken nuclear membrane repeat sequence, whose homologs are common in Phasianidae. CVI- Msp I, CCA- BamH I, and CSQ- BamH I showed high homology and were specific to the Odontophoridae. CVI- Msp I was localized to microchromosomes, whereas CVI- Hae III, CCA- BamH I, and CSQ- BamH I were mapped to almost all chromosomes. CCA- Hae III was localized to five pairs of macrochromosomes and most microchromosomes. ACH- Sau 3AI was distributed in three pairs of macrochromosomes and all microchromosomes. Centromeric repetitive sequences may be homogenized in chromosome size-correlated and -uncorrelated manners in New World Quails, although there may be a mechanism that causes homogenization of centromeric repetitive sequences primarily between microchromosomes, which is commonly observed in phasianid birds.

David Gourichon - One of the best experts on this subject based on the ideXlab platform.

  • the Quail genome insights into social behaviour seasonal biology and infectious disease response
    BMC Biology, 2020
    Co-Authors: Katrina M Morris, David Gourichon, Matthew Hindle, Simon Boitard, David W Burt, Angela Danner, Lel Eory, Heather L Forrest, Jerome Gros
    Abstract:

    The Japanese Quail (Coturnix japonica) is a popular domestic poultry species and an increasingly significant model species in avian developmental, behavioural and disease research. We have produced a high-quality Quail genome sequence, spanning 0.93 Gb assigned to 33 chromosomes. In terms of contiguity, assembly statistics, gene content and chromosomal organisation, the Quail genome shows high similarity to the chicken genome. We demonstrate the utility of this genome through three diverse applications. First, we identify selection signatures and candidate genes associated with social behaviour in the Quail genome, an important agricultural and domestication trait. Second, we investigate the effects and interaction of photoperiod and temperature on the transcriptome of the Quail medial basal hypothalamus, revealing key mechanisms of photoperiodism. Finally, we investigate the response of Quail to H5N1 influenza infection. In Quail lung, many critical immune genes and pathways were downregulated after H5N1 infection, and this may be key to the susceptibility of Quail to H5N1. We have produced a high-quality genome of the Quail which will facilitate further studies into diverse research questions using the Quail as a model avian species.

  • the Quail as an avian model system its genome provides insights into social behaviour seasonal biology and infectious disease response
    bioRxiv, 2019
    Co-Authors: Katrina M Morris, David Gourichon, Matthew Hindle, Simon Boitard, David W Burt, Angela Danner, Lel Eory, Heather L Forrest, Jerome Gros, L Gourichon
    Abstract:

    ABSTRACT The Japanese Quail (Coturnix japonica) is a popular domestic poultry species and an increasingly significant model species in avian developmental, behavioural and disease research. We have produced a high-quality Quail genome sequence, spanning 0.93 Gb assigned to 33 chromosomes. In terms of contiguity, assembly statistics, gene content and chromosomal organization, the Quail genome shows high similarity to the chicken genome. We demonstrate the utility of this genome through three diverse applications. First, we identify selection signatures and candidate genes associated with social behaviour in the Quail genome, an important agricultural and domestication trait. Second, we investigate the effects and interaction of photoperiod and temperature on the transcriptome of the Quail medial basal hypothalamus, revealing key mechanisms of photoperiodism. Finally, we investigate the response of Quail to H5N1 influenza infection. In Quail lung, many critical immune genes and pathways were downregulated, and this may be key to the susceptibility of Quail to H5N1. This genome will facilitate further research into diverse research questions using the Quail as a model avian species.

  • characterization of japanese Quail yellow as a genomic deletion upstream of the avian homolog of the mammalian asip agouti gene
    Genetics, 2008
    Co-Authors: Nicola J Nadeau, F Minvielle, Miho Inouemurayama, David Gourichon, Sarah A Follett, Terry Burke, Nicholas I Mundy
    Abstract:

    ASIP is an important pigmentation gene responsible for dorsoventral and hair-cycle-specific melanin-based color patterning in mammals. We report some of the first evidence that the avian ASIP gene has a role in pigmentation. We have characterized the genetic basis of the homozygous lethal Japanese Quail yellow mutation as a >90-kb deletion upstream of ASIP. This deletion encompasses almost the entire coding sequence of two upstream loci, RALY and EIF2B, and places ASIP expression under control of the RALY promoter, leading to the presence of a novel transcript. ASIP mRNA expression was upregulated in many tissues in yellow compared to wild type but was not universal, and consistent differences were not observed among skins of yellow and wild-type Quail. In a microarray analysis on developing feather buds, the locus with the largest downregulation in yellow Quail was SLC24A5, implying that it is regulated by ASIP. Finally, we document the presence of ventral skin-specific isoforms of ASIP mRNA in both wild-type Quails and chickens. Overall, there are remarkable similarities between yellow in Quail and lethal yellow in mouse, which involve a deletion in a similar genomic position. The presence of ventral-specific ASIP expression in birds shows that this feature is conserved across vertebrates.