The Experts below are selected from a list of 7992 Experts worldwide ranked by ideXlab platform
Howard N. Hodis - One of the best experts on this subject based on the ideXlab platform.
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Serial Quantitative Coronary Angiography and Coronary events.
American heart journal, 2000Co-Authors: Wendy J. Mack, Min Xiang, Robert H. Selzer, Howard N. HodisAbstract:Abstract Background Although assessment of progression of atherosclerosis by Quantitative Coronary Angiography (QCA) is used as a surrogate for Coronary events, no validation study has compared the several QCA measures used. Methods and Results The Cholesterol Lowering Atherosclerosis Study was a clinical trial testing the efficacy of colestipol-niacin on the progression of Coronary atherosclerosis. Baseline/2-year Coronary angiograms were obtained on 156 men with prior Coronary artery bypass graft surgery. Changes in percent diameter stenosis and minimum lumen diameter (both measured in Coronary lesions and segments) and Coronary segment measures of average diameter, percent involvement, and vessel edge roughness were measured by QCA. Coronary events ascertained over 12 years of follow-up included myocardial infarction (MI), Coronary death, and Coronary artery revascularizations. Proportional hazards models evaluated the relation between QCA change measures and Coronary events. Changes in percent diameter stenosis and minimum lumen diameter of Coronary artery lesions were significantly related to the risk of MI/Coronary death. All QCA measures were significantly related to the risk of any Coronary event. Relative risks for each QCA measure were of similar magnitude when estimated separately within each treatment group. Change in minimum lumen diameter of lesions was the only measure independently associated with the risk of Coronary events. Conclusions All QCA measures of progression of Coronary artery disease were related to all Coronary events (including revascularizations). Only QCA measures of lesion progression were related to MI/Coronary death. QCA measures of lesion change may be better surrogate end points for "hard" Coronary events than measures of change in Coronary segments. (Am Heart J 2000;139:993-9.)
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triglyceride and cholesterol rich lipoproteins have a differential effect on mild moderate and severe lesion progression as assessed by Quantitative Coronary Angiography in a controlled trial of lovastatin
Circulation, 1994Co-Authors: Howard N. Hodis, Wendy J. Mack, Stanley P. Azen, Petar Alaupovic, Janice M. Pogoda, Laurie Labree, Linda C. Hemphill, Dieter M. Kramsch, David H. BlankenhornAbstract:BACKGROUNDThe Monitored Atherosclerosis Regression Study, a randomized, double-blind, placebo-controlled, 2-year trial of lovastatin monotherapy, found that Coronary lesions or = 50% S at baseline had different responses to therapy. We now report on clinical, lipid, and nonlipid risk factors of treatment response in these lesion subsets.METHODS AND RESULTSTwo hundred seventy subjects, 37 to 67 years old, with plasma total cholesterol (TC) 190 to 295 mg/dL (4.91 to 7.63 mmol/L) and total triglyceride or = 50% S) lesions in 220 angiogram pairs analyzed by computer Quantitative Coronary Angiography. In the placebo group, risk factors (P < .05) for the progression of mild/moderate lesions were trig...
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Triglyceride- and cholesterol-rich lipoproteins have a differential effect on mild/moderate and severe lesion progression as assessed by Quantitative Coronary Angiography in a controlled trial of lovastatin.
Circulation, 1994Co-Authors: Howard N. Hodis, Wendy J. Mack, Stanley P. Azen, Petar Alaupovic, Janice M. Pogoda, Laurie Labree, Linda C. Hemphill, Dieter M. Kramsch, David H. BlankenhornAbstract:BACKGROUNDThe Monitored Atherosclerosis Regression Study, a randomized, double-blind, placebo-controlled, 2-year trial of lovastatin monotherapy, found that Coronary lesions or = 50% S at baseline had different responses to therapy. We now report on clinical, lipid, and nonlipid risk factors of treatment response in these lesion subsets.METHODS AND RESULTSTwo hundred seventy subjects, 37 to 67 years old, with plasma total cholesterol (TC) 190 to 295 mg/dL (4.91 to 7.63 mmol/L) and total triglyceride or = 50% S) lesions in 220 angiogram pairs analyzed by computer Quantitative Coronary Angiography. In the placebo group, risk factors (P < .05) for the progression of mild/moderate lesions were trig...
John P A Ioannidis - One of the best experts on this subject based on the ideXlab platform.
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meta analysis of fractional flow reserve versus Quantitative Coronary Angiography and noninvasive imaging for evaluation of myocardial ischemia
American Journal of Cardiology, 2007Co-Authors: Marios A. Christou, George C.m. Siontis, Demosthenes G Katritsis, John P A IoannidisAbstract:We performed a meta-analysis of 31 studies comparing the results of fractional flow reserve (FFR) against Quantitative Coronary Angiography (QCA) and/or noninvasive imaging of the same lesions. Studies were retrieved from PubMed (last search February 2006). Across 18 studies (1,522 lesions), QCA had a random effects sensitivity of 78% (95% confidence interval [CI] 67 to 86) and specificity of 51% (95% CI 40 to 61) against FFR (0.75 cutoff). Overall concordances were 61% for lesions with diameter stenosis 30% to 70%, 67% for stenoses >70%, and 95% for stenoses <30%. Compared with noninvasive imaging (21 studies, 1,249 lesions), FFR had a sensitivity of 76% (95% CI 69 to 82) and specificity of 76% (95% CI 71 to 81) by random effects. Summary receiver-operator characteristic estimates were similar. Most data addressed comparisons with perfusion scintigraphy (976 lesions, sensitivity 75%, specificity 77%), and some data were also available for dobutamine stress echocardiography (273 lesions, sensitivity 82%, specificity 74%). In conclusion, QCA does not predict the functional significance of Coronary lesions. FFR shows modest concordance with noninvasive imaging tests. The prognostic implications of discordant FFR and imaging results need further study.
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Meta-Analysis of Fractional Flow Reserve Versus Quantitative Coronary Angiography and Noninvasive Imaging for Evaluation of Myocardial Ischemia
The American journal of cardiology, 2006Co-Authors: Marios A. Christou, George C.m. Siontis, Demosthenes G Katritsis, John P A IoannidisAbstract:We performed a meta-analysis of 31 studies comparing the results of fractional flow reserve (FFR) against Quantitative Coronary Angiography (QCA) and/or noninvasive imaging of the same lesions. Studies were retrieved from PubMed (last search February 2006). Across 18 studies (1,522 lesions), QCA had a random effects sensitivity of 78% (95% confidence interval [CI] 67 to 86) and specificity of 51% (95% CI 40 to 61) against FFR (0.75 cutoff). Overall concordances were 61% for lesions with diameter stenosis 30% to 70%, 67% for stenoses >70%, and 95% for stenoses
Steven E Nissen - One of the best experts on this subject based on the ideXlab platform.
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effect of rosuvastatin therapy on Coronary artery stenoses assessed by Quantitative Coronary Angiography a study to evaluate the effect of rosuvastatin on intravascular ultrasound derived Coronary atheroma burden
Circulation, 2008Co-Authors: Christie M Ballantyne, Sorin J. Brener, Joel S Raichlen, Stephen J Nicholls, Raimund Erbel, Jeanclaude Tardif, Valerie A Cain, Steven E NissenAbstract:Background— Previous studies using Quantitative Coronary Angiography have demonstrated that statin therapy slows the progression of Coronary stenoses in proportion to average low-density lipoprotein cholesterol levels during therapy. However, no major statin monotherapy study has demonstrated either halted progression or regression of angiographic disease. A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden (ASTEROID) assessed whether rosuvastatin could regress Coronary atherosclerosis by intravascular ultrasound and Quantitative Coronary Angiography. Intravascular ultrasound showed atheroma volume regression in a single Coronary artery with <50% angiographic luminal narrowing. Methods and Results— ASTEROID treated 507 Coronary disease patients with rosuvastatin 40 mg/d for 24 months. Blinded Quantitative Coronary Angiography analyses of percent diameter stenosis and minimum lumen diameter were performed for up to 10 segments of Coronary arteries and...
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Effect of Rosuvastatin Therapy on Coronary Artery Stenoses Assessed by Quantitative Coronary Angiography A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden
Circulation, 2008Co-Authors: Christie M Ballantyne, Sorin J. Brener, Joel S Raichlen, Stephen J Nicholls, Raimund Erbel, Jeanclaude Tardif, Valerie A Cain, Steven E NissenAbstract:Background— Previous studies using Quantitative Coronary Angiography have demonstrated that statin therapy slows the progression of Coronary stenoses in proportion to average low-density lipoprotein cholesterol levels during therapy. However, no major statin monotherapy study has demonstrated either halted progression or regression of angiographic disease. A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden (ASTEROID) assessed whether rosuvastatin could regress Coronary atherosclerosis by intravascular ultrasound and Quantitative Coronary Angiography. Intravascular ultrasound showed atheroma volume regression in a single Coronary artery with
Wendy J. Mack - One of the best experts on this subject based on the ideXlab platform.
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Serial Quantitative Coronary Angiography and Coronary events.
American heart journal, 2000Co-Authors: Wendy J. Mack, Min Xiang, Robert H. Selzer, Howard N. HodisAbstract:Abstract Background Although assessment of progression of atherosclerosis by Quantitative Coronary Angiography (QCA) is used as a surrogate for Coronary events, no validation study has compared the several QCA measures used. Methods and Results The Cholesterol Lowering Atherosclerosis Study was a clinical trial testing the efficacy of colestipol-niacin on the progression of Coronary atherosclerosis. Baseline/2-year Coronary angiograms were obtained on 156 men with prior Coronary artery bypass graft surgery. Changes in percent diameter stenosis and minimum lumen diameter (both measured in Coronary lesions and segments) and Coronary segment measures of average diameter, percent involvement, and vessel edge roughness were measured by QCA. Coronary events ascertained over 12 years of follow-up included myocardial infarction (MI), Coronary death, and Coronary artery revascularizations. Proportional hazards models evaluated the relation between QCA change measures and Coronary events. Changes in percent diameter stenosis and minimum lumen diameter of Coronary artery lesions were significantly related to the risk of MI/Coronary death. All QCA measures were significantly related to the risk of any Coronary event. Relative risks for each QCA measure were of similar magnitude when estimated separately within each treatment group. Change in minimum lumen diameter of lesions was the only measure independently associated with the risk of Coronary events. Conclusions All QCA measures of progression of Coronary artery disease were related to all Coronary events (including revascularizations). Only QCA measures of lesion progression were related to MI/Coronary death. QCA measures of lesion change may be better surrogate end points for "hard" Coronary events than measures of change in Coronary segments. (Am Heart J 2000;139:993-9.)
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triglyceride and cholesterol rich lipoproteins have a differential effect on mild moderate and severe lesion progression as assessed by Quantitative Coronary Angiography in a controlled trial of lovastatin
Circulation, 1994Co-Authors: Howard N. Hodis, Wendy J. Mack, Stanley P. Azen, Petar Alaupovic, Janice M. Pogoda, Laurie Labree, Linda C. Hemphill, Dieter M. Kramsch, David H. BlankenhornAbstract:BACKGROUNDThe Monitored Atherosclerosis Regression Study, a randomized, double-blind, placebo-controlled, 2-year trial of lovastatin monotherapy, found that Coronary lesions or = 50% S at baseline had different responses to therapy. We now report on clinical, lipid, and nonlipid risk factors of treatment response in these lesion subsets.METHODS AND RESULTSTwo hundred seventy subjects, 37 to 67 years old, with plasma total cholesterol (TC) 190 to 295 mg/dL (4.91 to 7.63 mmol/L) and total triglyceride or = 50% S) lesions in 220 angiogram pairs analyzed by computer Quantitative Coronary Angiography. In the placebo group, risk factors (P < .05) for the progression of mild/moderate lesions were trig...
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Triglyceride- and cholesterol-rich lipoproteins have a differential effect on mild/moderate and severe lesion progression as assessed by Quantitative Coronary Angiography in a controlled trial of lovastatin.
Circulation, 1994Co-Authors: Howard N. Hodis, Wendy J. Mack, Stanley P. Azen, Petar Alaupovic, Janice M. Pogoda, Laurie Labree, Linda C. Hemphill, Dieter M. Kramsch, David H. BlankenhornAbstract:BACKGROUNDThe Monitored Atherosclerosis Regression Study, a randomized, double-blind, placebo-controlled, 2-year trial of lovastatin monotherapy, found that Coronary lesions or = 50% S at baseline had different responses to therapy. We now report on clinical, lipid, and nonlipid risk factors of treatment response in these lesion subsets.METHODS AND RESULTSTwo hundred seventy subjects, 37 to 67 years old, with plasma total cholesterol (TC) 190 to 295 mg/dL (4.91 to 7.63 mmol/L) and total triglyceride or = 50% S) lesions in 220 angiogram pairs analyzed by computer Quantitative Coronary Angiography. In the placebo group, risk factors (P < .05) for the progression of mild/moderate lesions were trig...
Peter Probst - One of the best experts on this subject based on the ideXlab platform.
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Assessing Coronary stenosis. Quantitative Coronary Angiography versus visual estimation from cine-film or pharmacological stress perfusion images
European heart journal, 1996Co-Authors: Michael Gottsauner-wolf, Heinz Sochor, Deddo Moertl, Marianne Gwechenberger, F Stockenhuber, Peter ProbstAbstract:UNLABELLED Visual judgment of stenosis severity from cine-film or single-photon emission computed tomographic dipyridamole perfusion images was compared to assessment of stenosis severity as measured with digital Quantitative Coronary Angiography. Thirty patients with angiographically verified single-vessel disease underwent dipyridamole thallium stress testing within 90 days of Angiography. RESULTS A percent diameter stenosis of > or = 50%, a percent area stenosis of > or = 75%, and a stenotic flow reserve of < 3.75 measured by Quantitative Coronary Angiography (CMS, version 1.1, Medis Inc.) corresponded to haemodynamically significant stenosis as evaluated by visual estimates from cine-film or perfusion images. Quantitative Coronary Angiography percent diameter stenosis (51.2% +/- 12.6%) correlated closely (r = 0.74) but underestimated significantly visual assessment of stenosis severity from cine-film (69.3% +/- 21.2%; P = 0.0001). However, Quantitative Coronary Angiography percent area stenosis (74.7% +/- 11.7%) more closely reflected visual estimates from cine-film (P = 0.19). Quantitative Coronary Angiography stenotic flow reserve showed the highest positive and negative predictive value regarding visual estimates from cine-film (88%, 86%) or perfusion images (88%, 64%) followed by percent diameter stenosis (86%, 75% 86%, 56%) and percent area stenosis (87%, 80%, 87%, 60%), respectively. CONCLUSION Evaluation of Coronary lesions by Quantitative Coronary Angiography corresponds closely with visual estimates from cine-film and haemodynamic significance as evaluated by dipyridamole perfusion images.
