Quinoline

14,000,000 Leading Edge Experts on the ideXlab platform

Scan Science and Technology

Contact Leading Edge Experts & Companies

Scan Science and Technology

Contact Leading Edge Experts & Companies

The Experts below are selected from a list of 22683 Experts worldwide ranked by ideXlab platform

Scott D Bohle - One of the best experts on this subject based on the ideXlab platform.

  • Unexpected 5,6,7,8,9,10-Hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-Tetrahydro-4,4-tetramethylene-1H-cyclopenta[c]Quinolines from Skraup–Doebner–Von Miller Quinoline Synthesis and Their Implications for the Mechanism of That Reaction
    2016
    Co-Authors: Jean Fotie, Hilaire Kemami V Wangun, Frank R Fronczek, Nancy Massawe, Jessica L Rhodus, Thomas A Singleton, Bijay T. Bhattarai, Scott D Bohle
    Abstract:

    The real mechanism of the Skraup–Doebner–Von Miller Quinoline synthesis remains controversial and not well understood despite several mechanistic studies reported on the matter. A series of unexpected and unusual 5,6,7,8,9,10-hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-tetrahydro-4,4-tetramethylene-1H-cyclopenta­[c]­Quinolines have been obtained through the Skraup–Doebner–Von Miller Quinoline synthesis. On the basis of these unexpected results and in agreement with some of the previously reported Quinoline syntheses, an alternative mechanistic pathway is proposed for this variant of the reaction. It involves the formation of a Schiff base through a reaction between the ketone and the aniline derivative in the first step, followed by a cycloalkenylation at the ortho-position to the amine functional group of the aniline derivative, and an annulation in the final step to close the Quinoline ring, leading to a dihydroQuinoline derivative. To the best of our knowledge, this is the first report of such a mechanistic pathway being proposed for any variant of the Skraup–Doebner–Von Miller Quinoline synthesis

  • unexpected 5 6 7 8 9 10 hexahydro 6 6 pentamethylenephenanthridines and 2 3 4 5 tetrahydro 4 4 tetramethylene 1h cyclopenta c Quinolines from skraup doebner von miller Quinoline synthesis and their implications for the mechanism of that reaction
    Journal of Organic Chemistry, 2012
    Co-Authors: Jean Fotie, Hilaire Kemami V Wangun, Frank R Fronczek, Nancy Massawe, Bijay Bhattarai, Jessica L Rhodus, Thomas A Singleton, Scott D Bohle
    Abstract:

    The real mechanism of the Skraup-Doebner-Von Miller Quinoline synthesis remains controversial and not well understood despite several mechanistic studies reported on the matter. A series of unexpected and unusual 5,6,7,8,9,10-hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-tetrahydro-4,4-tetramethylene-1H-cyclopenta[c]Quinolines have been obtained through the Skraup-Doebner-Von Miller Quinoline synthesis. On the basis of these unexpected results and in agreement with some of the previously reported Quinoline syntheses, an alternative mechanistic pathway is proposed for this variant of the reaction. It involves the formation of a Schiff base through a reaction between the ketone and the aniline derivative in the first step, followed by a cycloalkenylation at the ortho-position to the amine functional group of the aniline derivative, and an annulation in the final step to close the Quinoline ring, leading to a dihydroQuinoline derivative. To the best of our knowledge, this is the first report of such a mechanistic pathway being proposed for any variant of the Skraup-Doebner-Von Miller Quinoline synthesis.

Jean Fotie - One of the best experts on this subject based on the ideXlab platform.

  • Unexpected 5,6,7,8,9,10-Hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-Tetrahydro-4,4-tetramethylene-1H-cyclopenta[c]Quinolines from Skraup–Doebner–Von Miller Quinoline Synthesis and Their Implications for the Mechanism of That Reaction
    2016
    Co-Authors: Jean Fotie, Hilaire Kemami V Wangun, Frank R Fronczek, Nancy Massawe, Jessica L Rhodus, Thomas A Singleton, Bijay T. Bhattarai, Scott D Bohle
    Abstract:

    The real mechanism of the Skraup–Doebner–Von Miller Quinoline synthesis remains controversial and not well understood despite several mechanistic studies reported on the matter. A series of unexpected and unusual 5,6,7,8,9,10-hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-tetrahydro-4,4-tetramethylene-1H-cyclopenta­[c]­Quinolines have been obtained through the Skraup–Doebner–Von Miller Quinoline synthesis. On the basis of these unexpected results and in agreement with some of the previously reported Quinoline syntheses, an alternative mechanistic pathway is proposed for this variant of the reaction. It involves the formation of a Schiff base through a reaction between the ketone and the aniline derivative in the first step, followed by a cycloalkenylation at the ortho-position to the amine functional group of the aniline derivative, and an annulation in the final step to close the Quinoline ring, leading to a dihydroQuinoline derivative. To the best of our knowledge, this is the first report of such a mechanistic pathway being proposed for any variant of the Skraup–Doebner–Von Miller Quinoline synthesis

  • unexpected 5 6 7 8 9 10 hexahydro 6 6 pentamethylenephenanthridines and 2 3 4 5 tetrahydro 4 4 tetramethylene 1h cyclopenta c Quinolines from skraup doebner von miller Quinoline synthesis and their implications for the mechanism of that reaction
    Journal of Organic Chemistry, 2012
    Co-Authors: Jean Fotie, Hilaire Kemami V Wangun, Frank R Fronczek, Nancy Massawe, Bijay Bhattarai, Jessica L Rhodus, Thomas A Singleton, Scott D Bohle
    Abstract:

    The real mechanism of the Skraup-Doebner-Von Miller Quinoline synthesis remains controversial and not well understood despite several mechanistic studies reported on the matter. A series of unexpected and unusual 5,6,7,8,9,10-hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-tetrahydro-4,4-tetramethylene-1H-cyclopenta[c]Quinolines have been obtained through the Skraup-Doebner-Von Miller Quinoline synthesis. On the basis of these unexpected results and in agreement with some of the previously reported Quinoline syntheses, an alternative mechanistic pathway is proposed for this variant of the reaction. It involves the formation of a Schiff base through a reaction between the ketone and the aniline derivative in the first step, followed by a cycloalkenylation at the ortho-position to the amine functional group of the aniline derivative, and an annulation in the final step to close the Quinoline ring, leading to a dihydroQuinoline derivative. To the best of our knowledge, this is the first report of such a mechanistic pathway being proposed for any variant of the Skraup-Doebner-Von Miller Quinoline synthesis.

Thomas A Singleton - One of the best experts on this subject based on the ideXlab platform.

  • Unexpected 5,6,7,8,9,10-Hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-Tetrahydro-4,4-tetramethylene-1H-cyclopenta[c]Quinolines from Skraup–Doebner–Von Miller Quinoline Synthesis and Their Implications for the Mechanism of That Reaction
    2016
    Co-Authors: Jean Fotie, Hilaire Kemami V Wangun, Frank R Fronczek, Nancy Massawe, Jessica L Rhodus, Thomas A Singleton, Bijay T. Bhattarai, Scott D Bohle
    Abstract:

    The real mechanism of the Skraup–Doebner–Von Miller Quinoline synthesis remains controversial and not well understood despite several mechanistic studies reported on the matter. A series of unexpected and unusual 5,6,7,8,9,10-hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-tetrahydro-4,4-tetramethylene-1H-cyclopenta­[c]­Quinolines have been obtained through the Skraup–Doebner–Von Miller Quinoline synthesis. On the basis of these unexpected results and in agreement with some of the previously reported Quinoline syntheses, an alternative mechanistic pathway is proposed for this variant of the reaction. It involves the formation of a Schiff base through a reaction between the ketone and the aniline derivative in the first step, followed by a cycloalkenylation at the ortho-position to the amine functional group of the aniline derivative, and an annulation in the final step to close the Quinoline ring, leading to a dihydroQuinoline derivative. To the best of our knowledge, this is the first report of such a mechanistic pathway being proposed for any variant of the Skraup–Doebner–Von Miller Quinoline synthesis

  • unexpected 5 6 7 8 9 10 hexahydro 6 6 pentamethylenephenanthridines and 2 3 4 5 tetrahydro 4 4 tetramethylene 1h cyclopenta c Quinolines from skraup doebner von miller Quinoline synthesis and their implications for the mechanism of that reaction
    Journal of Organic Chemistry, 2012
    Co-Authors: Jean Fotie, Hilaire Kemami V Wangun, Frank R Fronczek, Nancy Massawe, Bijay Bhattarai, Jessica L Rhodus, Thomas A Singleton, Scott D Bohle
    Abstract:

    The real mechanism of the Skraup-Doebner-Von Miller Quinoline synthesis remains controversial and not well understood despite several mechanistic studies reported on the matter. A series of unexpected and unusual 5,6,7,8,9,10-hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-tetrahydro-4,4-tetramethylene-1H-cyclopenta[c]Quinolines have been obtained through the Skraup-Doebner-Von Miller Quinoline synthesis. On the basis of these unexpected results and in agreement with some of the previously reported Quinoline syntheses, an alternative mechanistic pathway is proposed for this variant of the reaction. It involves the formation of a Schiff base through a reaction between the ketone and the aniline derivative in the first step, followed by a cycloalkenylation at the ortho-position to the amine functional group of the aniline derivative, and an annulation in the final step to close the Quinoline ring, leading to a dihydroQuinoline derivative. To the best of our knowledge, this is the first report of such a mechanistic pathway being proposed for any variant of the Skraup-Doebner-Von Miller Quinoline synthesis.

Jessica L Rhodus - One of the best experts on this subject based on the ideXlab platform.

  • Unexpected 5,6,7,8,9,10-Hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-Tetrahydro-4,4-tetramethylene-1H-cyclopenta[c]Quinolines from Skraup–Doebner–Von Miller Quinoline Synthesis and Their Implications for the Mechanism of That Reaction
    2016
    Co-Authors: Jean Fotie, Hilaire Kemami V Wangun, Frank R Fronczek, Nancy Massawe, Jessica L Rhodus, Thomas A Singleton, Bijay T. Bhattarai, Scott D Bohle
    Abstract:

    The real mechanism of the Skraup–Doebner–Von Miller Quinoline synthesis remains controversial and not well understood despite several mechanistic studies reported on the matter. A series of unexpected and unusual 5,6,7,8,9,10-hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-tetrahydro-4,4-tetramethylene-1H-cyclopenta­[c]­Quinolines have been obtained through the Skraup–Doebner–Von Miller Quinoline synthesis. On the basis of these unexpected results and in agreement with some of the previously reported Quinoline syntheses, an alternative mechanistic pathway is proposed for this variant of the reaction. It involves the formation of a Schiff base through a reaction between the ketone and the aniline derivative in the first step, followed by a cycloalkenylation at the ortho-position to the amine functional group of the aniline derivative, and an annulation in the final step to close the Quinoline ring, leading to a dihydroQuinoline derivative. To the best of our knowledge, this is the first report of such a mechanistic pathway being proposed for any variant of the Skraup–Doebner–Von Miller Quinoline synthesis

  • unexpected 5 6 7 8 9 10 hexahydro 6 6 pentamethylenephenanthridines and 2 3 4 5 tetrahydro 4 4 tetramethylene 1h cyclopenta c Quinolines from skraup doebner von miller Quinoline synthesis and their implications for the mechanism of that reaction
    Journal of Organic Chemistry, 2012
    Co-Authors: Jean Fotie, Hilaire Kemami V Wangun, Frank R Fronczek, Nancy Massawe, Bijay Bhattarai, Jessica L Rhodus, Thomas A Singleton, Scott D Bohle
    Abstract:

    The real mechanism of the Skraup-Doebner-Von Miller Quinoline synthesis remains controversial and not well understood despite several mechanistic studies reported on the matter. A series of unexpected and unusual 5,6,7,8,9,10-hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-tetrahydro-4,4-tetramethylene-1H-cyclopenta[c]Quinolines have been obtained through the Skraup-Doebner-Von Miller Quinoline synthesis. On the basis of these unexpected results and in agreement with some of the previously reported Quinoline syntheses, an alternative mechanistic pathway is proposed for this variant of the reaction. It involves the formation of a Schiff base through a reaction between the ketone and the aniline derivative in the first step, followed by a cycloalkenylation at the ortho-position to the amine functional group of the aniline derivative, and an annulation in the final step to close the Quinoline ring, leading to a dihydroQuinoline derivative. To the best of our knowledge, this is the first report of such a mechanistic pathway being proposed for any variant of the Skraup-Doebner-Von Miller Quinoline synthesis.

Nancy Massawe - One of the best experts on this subject based on the ideXlab platform.

  • Unexpected 5,6,7,8,9,10-Hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-Tetrahydro-4,4-tetramethylene-1H-cyclopenta[c]Quinolines from Skraup–Doebner–Von Miller Quinoline Synthesis and Their Implications for the Mechanism of That Reaction
    2016
    Co-Authors: Jean Fotie, Hilaire Kemami V Wangun, Frank R Fronczek, Nancy Massawe, Jessica L Rhodus, Thomas A Singleton, Bijay T. Bhattarai, Scott D Bohle
    Abstract:

    The real mechanism of the Skraup–Doebner–Von Miller Quinoline synthesis remains controversial and not well understood despite several mechanistic studies reported on the matter. A series of unexpected and unusual 5,6,7,8,9,10-hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-tetrahydro-4,4-tetramethylene-1H-cyclopenta­[c]­Quinolines have been obtained through the Skraup–Doebner–Von Miller Quinoline synthesis. On the basis of these unexpected results and in agreement with some of the previously reported Quinoline syntheses, an alternative mechanistic pathway is proposed for this variant of the reaction. It involves the formation of a Schiff base through a reaction between the ketone and the aniline derivative in the first step, followed by a cycloalkenylation at the ortho-position to the amine functional group of the aniline derivative, and an annulation in the final step to close the Quinoline ring, leading to a dihydroQuinoline derivative. To the best of our knowledge, this is the first report of such a mechanistic pathway being proposed for any variant of the Skraup–Doebner–Von Miller Quinoline synthesis

  • unexpected 5 6 7 8 9 10 hexahydro 6 6 pentamethylenephenanthridines and 2 3 4 5 tetrahydro 4 4 tetramethylene 1h cyclopenta c Quinolines from skraup doebner von miller Quinoline synthesis and their implications for the mechanism of that reaction
    Journal of Organic Chemistry, 2012
    Co-Authors: Jean Fotie, Hilaire Kemami V Wangun, Frank R Fronczek, Nancy Massawe, Bijay Bhattarai, Jessica L Rhodus, Thomas A Singleton, Scott D Bohle
    Abstract:

    The real mechanism of the Skraup-Doebner-Von Miller Quinoline synthesis remains controversial and not well understood despite several mechanistic studies reported on the matter. A series of unexpected and unusual 5,6,7,8,9,10-hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-tetrahydro-4,4-tetramethylene-1H-cyclopenta[c]Quinolines have been obtained through the Skraup-Doebner-Von Miller Quinoline synthesis. On the basis of these unexpected results and in agreement with some of the previously reported Quinoline syntheses, an alternative mechanistic pathway is proposed for this variant of the reaction. It involves the formation of a Schiff base through a reaction between the ketone and the aniline derivative in the first step, followed by a cycloalkenylation at the ortho-position to the amine functional group of the aniline derivative, and an annulation in the final step to close the Quinoline ring, leading to a dihydroQuinoline derivative. To the best of our knowledge, this is the first report of such a mechanistic pathway being proposed for any variant of the Skraup-Doebner-Von Miller Quinoline synthesis.