The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
Isao Kubo - One of the best experts on this subject based on the ideXlab platform.
-
2 3 dehydro 10 oxo α isosparteine in uresiphita reversalis larvae fed on cytisus monspessulanus leaves
Phytochemistry, 2002Co-Authors: Ken-ichi Nihei, Kozo Shibata, Isao KuboAbstract:Abstract Quinolizidine Alkaloids, found in the leaves of Cytisus monspessulanus L. (Leguminosae), were characterized in the cuticle of larvae of the pyralid moth Uresiphita reversalis (Lepidoptera: Pyralidae) when the latter were fed on this weed. By GC–MS analysis of the methanolic extracts of the cuticle, four Quinolizidine Alkaloids, N -methylcytisine, cytisine, aphylline and anagyrine, were identified as possible defense substances. In addition, the Quinolizidine Alkaloid, (+)-2,3-dehydro-10-oxo-α-isosparteine was characterized in both the insect and host plant.
-
(+)-2,3-Dehydro-10-oxo-α-isosparteine in Uresiphita reversalis larvae fed on Cytisus monspessulanus leaves
Phytochemistry, 2002Co-Authors: Ken-ichi Nihei, Kozo Shibata, Isao KuboAbstract:Abstract Quinolizidine Alkaloids, found in the leaves of Cytisus monspessulanus L. (Leguminosae), were characterized in the cuticle of larvae of the pyralid moth Uresiphita reversalis (Lepidoptera: Pyralidae) when the latter were fed on this weed. By GC–MS analysis of the methanolic extracts of the cuticle, four Quinolizidine Alkaloids, N -methylcytisine, cytisine, aphylline and anagyrine, were identified as possible defense substances. In addition, the Quinolizidine Alkaloid, (+)-2,3-dehydro-10-oxo-α-isosparteine was characterized in both the insect and host plant.
Edison Serrano - One of the best experts on this subject based on the ideXlab platform.
-
responses in rainbow trout oncorhynchus mykiss to increasing dietary doses of lupinine the main Quinolizidine Alkaloid found in yellow lupins lupinus luteus
Aquaculture, 2011Co-Authors: Edison Serrano, Trond Storebakken, Michael H Penn, Margareth Overland, Jon Ovrum Hansen, Liv Torunn MydlandAbstract:Abstract This experiment investigated the effect of increasing dietary doses of lupinine, the main Quinolizidine Alkaloid in Lupinus luteus , on feed intake, growth performance, tissue histology and nutritional composition of rainbow trout ( Oncorhynchus mykiss ). Duplicate groups of rainbow trout (initial body weight of 330 g) were fed extruded fish meal based diets containing 0, 50, 75, 100, 250, 500, 1000 and 5000 mg lupinine kg −1 for 60 days. Feed intake and growth were reduced in response to dietary lupinine, best fit by quadratic regression. Based on these results, the practical tolerance level of lupinine, with regard to growth and feed intake, was ≤ 100 mg kg −1 feed. Carcass composition did not vary among treatments. Despite a depletion of glycogen and lipid stores in the hepatocytes, lupinine did not induce any morphological changes in spleen, kidney, heart or intestinal tissues. These results indicate that the lupinine possesses a strong anti-palatability effect, but does not appear to pose short-term health risks for rainbow trout.
Ken-ichi Nihei - One of the best experts on this subject based on the ideXlab platform.
-
2 3 dehydro 10 oxo α isosparteine in uresiphita reversalis larvae fed on cytisus monspessulanus leaves
Phytochemistry, 2002Co-Authors: Ken-ichi Nihei, Kozo Shibata, Isao KuboAbstract:Abstract Quinolizidine Alkaloids, found in the leaves of Cytisus monspessulanus L. (Leguminosae), were characterized in the cuticle of larvae of the pyralid moth Uresiphita reversalis (Lepidoptera: Pyralidae) when the latter were fed on this weed. By GC–MS analysis of the methanolic extracts of the cuticle, four Quinolizidine Alkaloids, N -methylcytisine, cytisine, aphylline and anagyrine, were identified as possible defense substances. In addition, the Quinolizidine Alkaloid, (+)-2,3-dehydro-10-oxo-α-isosparteine was characterized in both the insect and host plant.
-
(+)-2,3-Dehydro-10-oxo-α-isosparteine in Uresiphita reversalis larvae fed on Cytisus monspessulanus leaves
Phytochemistry, 2002Co-Authors: Ken-ichi Nihei, Kozo Shibata, Isao KuboAbstract:Abstract Quinolizidine Alkaloids, found in the leaves of Cytisus monspessulanus L. (Leguminosae), were characterized in the cuticle of larvae of the pyralid moth Uresiphita reversalis (Lepidoptera: Pyralidae) when the latter were fed on this weed. By GC–MS analysis of the methanolic extracts of the cuticle, four Quinolizidine Alkaloids, N -methylcytisine, cytisine, aphylline and anagyrine, were identified as possible defense substances. In addition, the Quinolizidine Alkaloid, (+)-2,3-dehydro-10-oxo-α-isosparteine was characterized in both the insect and host plant.
Sophia S Borisevich - One of the best experts on this subject based on the ideXlab platform.
-
Antiviral activity of amides and carboxamides of Quinolizidine Alkaloid (-)-cytisine against human influenza virus A (H1N1) and parainfluenza virus type 3.
Natural product research, 2019Co-Authors: Victoria A. Fedorova, Aleksander V Slita, Anna A Muryleva, P R Petrova, A. V. Koval’skaya, Alexander N. Lobov, Renata A. Kadyrova, Zulfiya R. Zileeva, Dmiry O. Tsypyshev, Sophia S BorisevichAbstract:AbstractNovel derivatives of Quinolizidine Alkaloid (−)-cytisine were synthesised. ADME properties, cytotoxicity against HEK293 cells and activity against viruses of influenza A/California/07/09(H1...
-
antiviral activity of amides and carboxamides of Quinolizidine Alkaloid cytisine against human influenza virus a h1n1 and parainfluenza virus type 3
Natural Product Research, 2019Co-Authors: Victoria Fedorova, Aleksander V Slita, Anna A Muryleva, A V Kovalskaya, P R Petrova, Renata A. Kadyrova, Zulfiya R. Zileeva, Dmiry O. Tsypyshev, A N Lobov, Sophia S BorisevichAbstract:AbstractNovel derivatives of Quinolizidine Alkaloid (−)-cytisine were synthesised. ADME properties, cytotoxicity against HEK293 cells and activity against viruses of influenza A/California/07/09(H1...
-
synthesis of camphecene and cytisine conjugates using click chemistry methodology and study of their antiviral activity
Chemistry & Biodiversity, 2019Co-Authors: O I Artyushin, Aleksandra A Moiseeva, Vladimir V Zarubaev, Aleksander V Slita, Anastasiya V Galochkina, Anna A Muryleva, Sophia S Borisevich, O I Yarovaya, N F SalakhutdinovAbstract:: A series of camphecene and Quinolizidine Alkaloid (-)-cytisine conjugates has been obtained for the first time using 'click' chemistry methodology. The cytotoxicity and virus-inhibiting activity of compounds were determined against MDCK cells and influenza virus A/Puerto Rico/8/34 (H1N1), correspondingly, in in vitro tests. Based on the results obtained, values of 50 % cytotoxic dose (CC50 ), 50 % inhibition dose (IC50 ) and selectivity index (SI) were determined for each compound. It has been shown that the antiviral activity is affected by the length and nature of linkers between cytisine and camphor units. Conjugate 13 ((1R,5S)-3-(6-{4-[(2-{(E)-[(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene]amino}ethoxy)methyl]-1H-1,2,3-triazol-1-yl}hexyl)-1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one), which contains cytisine fragment separated from triazole ring by -C6 H12 - aliphatic linker, showed the highest activity at relatively low toxicity (CC50 =168 μmol, IC50 =8 μmol, SI=20). Its selectivity index appeared higher than that of reference compound, rimantadine. According to theoretical calculations, the antiviral activity of the lead compound 13 can be explained by its influence on the functioning of neuraminidase.
-
nootropic activity of a novel cytisine derivative 3ar 4s 8s 12r 12as 12br 10 methyl 2 phenyloctahydro 1h 4 12a etheno 8 12 methanopyrrolo 3 4 3 4 pyrido 1 2 a 1 5 diazocine 1 3 5 4h trione
Bulletin of Experimental Biology and Medicine, 2018Co-Authors: N S Makara, Sophia S Borisevich, T A Sapozhnikova, Yu R Khisamutdinova, I P Tsypysheva, A V Kovalskaya, P R Petrova, C L Khursan, F S ZarudiiAbstract:: We performed screening of nootropic properties of 10 new derivatives of Quinolizidine Alkaloid (-)-cytisine. Compounds with β-endo stereochemistry were more active than α-endo-isomers. Under stress conditions (3aR,4S,8S,12R,12aS,12bR)-10-methyl-2-phenyloctahydro-1H-4,12a-etheno-8,12-methanopyrrolo[3',4':3,4]pyrido[1,2-a] [1,5]diazocine-1,3,5(4H)-trione enhanced memory and had a positive effect on cognitive functions of rats. According to molecular docking data, the nootropic activity of the compound can be associated with its affinity for the glutamate-binding subunits GluK1 and GluR2 of the kainate and AMPA receptor, respectively.
-
aza michael reaction of 12 n carboxamide of cytisine under high pressure conditions
Natural Product Research, 2015Co-Authors: I P Tsypysheva, Sophia S Borisevich, A V Kovalskaya, A N Lobov, Polina R Petrova, S P Ivanov, Shamil A Rameev, R L Safiullin, M S YunusovAbstract:The first example of aza-Michael reaction of 12-N-carboxamide of Quinolizidine Alkaloid (–)-cytisine with α,β-unsaturated ketones, dimethyl acetylenedicarboxylate and β-nitrostyrene under high pressure condition has been described. It has been shown that the [4+2]-cycloaddition takes place in the case with N-phenylmaleimide.
Liv Torunn Mydland - One of the best experts on this subject based on the ideXlab platform.
-
responses in rainbow trout oncorhynchus mykiss to increasing dietary doses of lupinine the main Quinolizidine Alkaloid found in yellow lupins lupinus luteus
Aquaculture, 2011Co-Authors: Edison Serrano, Trond Storebakken, Michael H Penn, Margareth Overland, Jon Ovrum Hansen, Liv Torunn MydlandAbstract:Abstract This experiment investigated the effect of increasing dietary doses of lupinine, the main Quinolizidine Alkaloid in Lupinus luteus , on feed intake, growth performance, tissue histology and nutritional composition of rainbow trout ( Oncorhynchus mykiss ). Duplicate groups of rainbow trout (initial body weight of 330 g) were fed extruded fish meal based diets containing 0, 50, 75, 100, 250, 500, 1000 and 5000 mg lupinine kg −1 for 60 days. Feed intake and growth were reduced in response to dietary lupinine, best fit by quadratic regression. Based on these results, the practical tolerance level of lupinine, with regard to growth and feed intake, was ≤ 100 mg kg −1 feed. Carcass composition did not vary among treatments. Despite a depletion of glycogen and lipid stores in the hepatocytes, lupinine did not induce any morphological changes in spleen, kidney, heart or intestinal tissues. These results indicate that the lupinine possesses a strong anti-palatability effect, but does not appear to pose short-term health risks for rainbow trout.
