The Experts below are selected from a list of 11073 Experts worldwide ranked by ideXlab platform
Toshihide Nukada - One of the best experts on this subject based on the ideXlab platform.
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identification of R isomeR of efonidipine as a selective blockeR of t type ca2 channels
British Journal of Pharmacology, 2004Co-Authors: Taiji Furukawa, Reiko Miura, Natsuko Kamiya, Takaaki Isshiki, Yasuo Mori, Mitsuyoshi Honda, Satoshi Takeshita, Toshihide NukadaAbstract:Efonidipine, a deRivative of dihydRopyRidine Ca2+ antagonist, is known to block both L- and T-type Ca2+ channels. It Remains to be claRified, howeveR, whetheR efonidipine affects otheR voltage-dependent Ca2+ channel subtypes such as N-, P/Q- and R-types, and whetheR the optical isomeRs of efonidipine have diffeRent selectivities in blocking these Ca2+ channels, including L- and T-types. To addRess these issues, the effects of efonidipine and its R(−)- and S(+)-isomeRs on these Ca2+ channel subtypes weRe examined electRophysiologically in the expRession systems using Xenopus oocytes and baby hamsteR kidney cells (BHK tk-ts13). Efonidipine, a mixtuRe of R(−)- and S(+)-isomeRs, exeRted blocking actions on L- and T-types, but no effects on N-, P/Q- and R-type Ca2+ channels. The selective blocking actions on L- and T-type channels weRe RepRoduced by the S(+)-efonidipine isomeR. By contRast, the R(−)-efonidipine isomeR pRefeRentially blocked T-type channels. The blocking actions of efonidipine and its enantiomeRs weRe dependent on holding potentials. These findings indicate that the R(−)-isomeR of efonidipine is a specific blockeR of the T-type Ca2+ channel. BRitish JouRnal of PhaRmacology (2004) 143, 1050–1057. doi:10.1038/sj.bjp.0705944
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Identification of R(−)‐isomeR of efonidipine as a selective blockeR of T‐type Ca2+ channels
British Journal of Pharmacology, 2004Co-Authors: Taiji Furukawa, Reiko Miura, Natsuko Kamiya, Takaaki Isshiki, Yasuo Mori, Mitsuyoshi Honda, Satoshi Takeshita, Toshihide NukadaAbstract:Efonidipine, a deRivative of dihydRopyRidine Ca2+ antagonist, is known to block both L- and T-type Ca2+ channels. It Remains to be claRified, howeveR, whetheR efonidipine affects otheR voltage-dependent Ca2+ channel subtypes such as N-, P/Q- and R-types, and whetheR the optical isomeRs of efonidipine have diffeRent selectivities in blocking these Ca2+ channels, including L- and T-types. To addRess these issues, the effects of efonidipine and its R(−)- and S(+)-isomeRs on these Ca2+ channel subtypes weRe examined electRophysiologically in the expRession systems using Xenopus oocytes and baby hamsteR kidney cells (BHK tk-ts13). Efonidipine, a mixtuRe of R(−)- and S(+)-isomeRs, exeRted blocking actions on L- and T-types, but no effects on N-, P/Q- and R-type Ca2+ channels. The selective blocking actions on L- and T-type channels weRe RepRoduced by the S(+)-efonidipine isomeR. By contRast, the R(−)-efonidipine isomeR pRefeRentially blocked T-type channels. The blocking actions of efonidipine and its enantiomeRs weRe dependent on holding potentials. These findings indicate that the R(−)-isomeR of efonidipine is a specific blockeR of the T-type Ca2+ channel. BRitish JouRnal of PhaRmacology (2004) 143, 1050–1057. doi:10.1038/sj.bjp.0705944
Taiji Furukawa - One of the best experts on this subject based on the ideXlab platform.
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identification of R isomeR of efonidipine as a selective blockeR of t type ca2 channels
British Journal of Pharmacology, 2004Co-Authors: Taiji Furukawa, Reiko Miura, Natsuko Kamiya, Takaaki Isshiki, Yasuo Mori, Mitsuyoshi Honda, Satoshi Takeshita, Toshihide NukadaAbstract:Efonidipine, a deRivative of dihydRopyRidine Ca2+ antagonist, is known to block both L- and T-type Ca2+ channels. It Remains to be claRified, howeveR, whetheR efonidipine affects otheR voltage-dependent Ca2+ channel subtypes such as N-, P/Q- and R-types, and whetheR the optical isomeRs of efonidipine have diffeRent selectivities in blocking these Ca2+ channels, including L- and T-types. To addRess these issues, the effects of efonidipine and its R(−)- and S(+)-isomeRs on these Ca2+ channel subtypes weRe examined electRophysiologically in the expRession systems using Xenopus oocytes and baby hamsteR kidney cells (BHK tk-ts13). Efonidipine, a mixtuRe of R(−)- and S(+)-isomeRs, exeRted blocking actions on L- and T-types, but no effects on N-, P/Q- and R-type Ca2+ channels. The selective blocking actions on L- and T-type channels weRe RepRoduced by the S(+)-efonidipine isomeR. By contRast, the R(−)-efonidipine isomeR pRefeRentially blocked T-type channels. The blocking actions of efonidipine and its enantiomeRs weRe dependent on holding potentials. These findings indicate that the R(−)-isomeR of efonidipine is a specific blockeR of the T-type Ca2+ channel. BRitish JouRnal of PhaRmacology (2004) 143, 1050–1057. doi:10.1038/sj.bjp.0705944
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Identification of R(−)‐isomeR of efonidipine as a selective blockeR of T‐type Ca2+ channels
British Journal of Pharmacology, 2004Co-Authors: Taiji Furukawa, Reiko Miura, Natsuko Kamiya, Takaaki Isshiki, Yasuo Mori, Mitsuyoshi Honda, Satoshi Takeshita, Toshihide NukadaAbstract:Efonidipine, a deRivative of dihydRopyRidine Ca2+ antagonist, is known to block both L- and T-type Ca2+ channels. It Remains to be claRified, howeveR, whetheR efonidipine affects otheR voltage-dependent Ca2+ channel subtypes such as N-, P/Q- and R-types, and whetheR the optical isomeRs of efonidipine have diffeRent selectivities in blocking these Ca2+ channels, including L- and T-types. To addRess these issues, the effects of efonidipine and its R(−)- and S(+)-isomeRs on these Ca2+ channel subtypes weRe examined electRophysiologically in the expRession systems using Xenopus oocytes and baby hamsteR kidney cells (BHK tk-ts13). Efonidipine, a mixtuRe of R(−)- and S(+)-isomeRs, exeRted blocking actions on L- and T-types, but no effects on N-, P/Q- and R-type Ca2+ channels. The selective blocking actions on L- and T-type channels weRe RepRoduced by the S(+)-efonidipine isomeR. By contRast, the R(−)-efonidipine isomeR pRefeRentially blocked T-type channels. The blocking actions of efonidipine and its enantiomeRs weRe dependent on holding potentials. These findings indicate that the R(−)-isomeR of efonidipine is a specific blockeR of the T-type Ca2+ channel. BRitish JouRnal of PhaRmacology (2004) 143, 1050–1057. doi:10.1038/sj.bjp.0705944
Takaaki Isshiki - One of the best experts on this subject based on the ideXlab platform.
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identification of R isomeR of efonidipine as a selective blockeR of t type ca2 channels
British Journal of Pharmacology, 2004Co-Authors: Taiji Furukawa, Reiko Miura, Natsuko Kamiya, Takaaki Isshiki, Yasuo Mori, Mitsuyoshi Honda, Satoshi Takeshita, Toshihide NukadaAbstract:Efonidipine, a deRivative of dihydRopyRidine Ca2+ antagonist, is known to block both L- and T-type Ca2+ channels. It Remains to be claRified, howeveR, whetheR efonidipine affects otheR voltage-dependent Ca2+ channel subtypes such as N-, P/Q- and R-types, and whetheR the optical isomeRs of efonidipine have diffeRent selectivities in blocking these Ca2+ channels, including L- and T-types. To addRess these issues, the effects of efonidipine and its R(−)- and S(+)-isomeRs on these Ca2+ channel subtypes weRe examined electRophysiologically in the expRession systems using Xenopus oocytes and baby hamsteR kidney cells (BHK tk-ts13). Efonidipine, a mixtuRe of R(−)- and S(+)-isomeRs, exeRted blocking actions on L- and T-types, but no effects on N-, P/Q- and R-type Ca2+ channels. The selective blocking actions on L- and T-type channels weRe RepRoduced by the S(+)-efonidipine isomeR. By contRast, the R(−)-efonidipine isomeR pRefeRentially blocked T-type channels. The blocking actions of efonidipine and its enantiomeRs weRe dependent on holding potentials. These findings indicate that the R(−)-isomeR of efonidipine is a specific blockeR of the T-type Ca2+ channel. BRitish JouRnal of PhaRmacology (2004) 143, 1050–1057. doi:10.1038/sj.bjp.0705944
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Identification of R(−)‐isomeR of efonidipine as a selective blockeR of T‐type Ca2+ channels
British Journal of Pharmacology, 2004Co-Authors: Taiji Furukawa, Reiko Miura, Natsuko Kamiya, Takaaki Isshiki, Yasuo Mori, Mitsuyoshi Honda, Satoshi Takeshita, Toshihide NukadaAbstract:Efonidipine, a deRivative of dihydRopyRidine Ca2+ antagonist, is known to block both L- and T-type Ca2+ channels. It Remains to be claRified, howeveR, whetheR efonidipine affects otheR voltage-dependent Ca2+ channel subtypes such as N-, P/Q- and R-types, and whetheR the optical isomeRs of efonidipine have diffeRent selectivities in blocking these Ca2+ channels, including L- and T-types. To addRess these issues, the effects of efonidipine and its R(−)- and S(+)-isomeRs on these Ca2+ channel subtypes weRe examined electRophysiologically in the expRession systems using Xenopus oocytes and baby hamsteR kidney cells (BHK tk-ts13). Efonidipine, a mixtuRe of R(−)- and S(+)-isomeRs, exeRted blocking actions on L- and T-types, but no effects on N-, P/Q- and R-type Ca2+ channels. The selective blocking actions on L- and T-type channels weRe RepRoduced by the S(+)-efonidipine isomeR. By contRast, the R(−)-efonidipine isomeR pRefeRentially blocked T-type channels. The blocking actions of efonidipine and its enantiomeRs weRe dependent on holding potentials. These findings indicate that the R(−)-isomeR of efonidipine is a specific blockeR of the T-type Ca2+ channel. BRitish JouRnal of PhaRmacology (2004) 143, 1050–1057. doi:10.1038/sj.bjp.0705944
Mitsuyoshi Honda - One of the best experts on this subject based on the ideXlab platform.
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identification of R isomeR of efonidipine as a selective blockeR of t type ca2 channels
British Journal of Pharmacology, 2004Co-Authors: Taiji Furukawa, Reiko Miura, Natsuko Kamiya, Takaaki Isshiki, Yasuo Mori, Mitsuyoshi Honda, Satoshi Takeshita, Toshihide NukadaAbstract:Efonidipine, a deRivative of dihydRopyRidine Ca2+ antagonist, is known to block both L- and T-type Ca2+ channels. It Remains to be claRified, howeveR, whetheR efonidipine affects otheR voltage-dependent Ca2+ channel subtypes such as N-, P/Q- and R-types, and whetheR the optical isomeRs of efonidipine have diffeRent selectivities in blocking these Ca2+ channels, including L- and T-types. To addRess these issues, the effects of efonidipine and its R(−)- and S(+)-isomeRs on these Ca2+ channel subtypes weRe examined electRophysiologically in the expRession systems using Xenopus oocytes and baby hamsteR kidney cells (BHK tk-ts13). Efonidipine, a mixtuRe of R(−)- and S(+)-isomeRs, exeRted blocking actions on L- and T-types, but no effects on N-, P/Q- and R-type Ca2+ channels. The selective blocking actions on L- and T-type channels weRe RepRoduced by the S(+)-efonidipine isomeR. By contRast, the R(−)-efonidipine isomeR pRefeRentially blocked T-type channels. The blocking actions of efonidipine and its enantiomeRs weRe dependent on holding potentials. These findings indicate that the R(−)-isomeR of efonidipine is a specific blockeR of the T-type Ca2+ channel. BRitish JouRnal of PhaRmacology (2004) 143, 1050–1057. doi:10.1038/sj.bjp.0705944
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Identification of R(−)‐isomeR of efonidipine as a selective blockeR of T‐type Ca2+ channels
British Journal of Pharmacology, 2004Co-Authors: Taiji Furukawa, Reiko Miura, Natsuko Kamiya, Takaaki Isshiki, Yasuo Mori, Mitsuyoshi Honda, Satoshi Takeshita, Toshihide NukadaAbstract:Efonidipine, a deRivative of dihydRopyRidine Ca2+ antagonist, is known to block both L- and T-type Ca2+ channels. It Remains to be claRified, howeveR, whetheR efonidipine affects otheR voltage-dependent Ca2+ channel subtypes such as N-, P/Q- and R-types, and whetheR the optical isomeRs of efonidipine have diffeRent selectivities in blocking these Ca2+ channels, including L- and T-types. To addRess these issues, the effects of efonidipine and its R(−)- and S(+)-isomeRs on these Ca2+ channel subtypes weRe examined electRophysiologically in the expRession systems using Xenopus oocytes and baby hamsteR kidney cells (BHK tk-ts13). Efonidipine, a mixtuRe of R(−)- and S(+)-isomeRs, exeRted blocking actions on L- and T-types, but no effects on N-, P/Q- and R-type Ca2+ channels. The selective blocking actions on L- and T-type channels weRe RepRoduced by the S(+)-efonidipine isomeR. By contRast, the R(−)-efonidipine isomeR pRefeRentially blocked T-type channels. The blocking actions of efonidipine and its enantiomeRs weRe dependent on holding potentials. These findings indicate that the R(−)-isomeR of efonidipine is a specific blockeR of the T-type Ca2+ channel. BRitish JouRnal of PhaRmacology (2004) 143, 1050–1057. doi:10.1038/sj.bjp.0705944
Yasuo Mori - One of the best experts on this subject based on the ideXlab platform.
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identification of R isomeR of efonidipine as a selective blockeR of t type ca2 channels
British Journal of Pharmacology, 2004Co-Authors: Taiji Furukawa, Reiko Miura, Natsuko Kamiya, Takaaki Isshiki, Yasuo Mori, Mitsuyoshi Honda, Satoshi Takeshita, Toshihide NukadaAbstract:Efonidipine, a deRivative of dihydRopyRidine Ca2+ antagonist, is known to block both L- and T-type Ca2+ channels. It Remains to be claRified, howeveR, whetheR efonidipine affects otheR voltage-dependent Ca2+ channel subtypes such as N-, P/Q- and R-types, and whetheR the optical isomeRs of efonidipine have diffeRent selectivities in blocking these Ca2+ channels, including L- and T-types. To addRess these issues, the effects of efonidipine and its R(−)- and S(+)-isomeRs on these Ca2+ channel subtypes weRe examined electRophysiologically in the expRession systems using Xenopus oocytes and baby hamsteR kidney cells (BHK tk-ts13). Efonidipine, a mixtuRe of R(−)- and S(+)-isomeRs, exeRted blocking actions on L- and T-types, but no effects on N-, P/Q- and R-type Ca2+ channels. The selective blocking actions on L- and T-type channels weRe RepRoduced by the S(+)-efonidipine isomeR. By contRast, the R(−)-efonidipine isomeR pRefeRentially blocked T-type channels. The blocking actions of efonidipine and its enantiomeRs weRe dependent on holding potentials. These findings indicate that the R(−)-isomeR of efonidipine is a specific blockeR of the T-type Ca2+ channel. BRitish JouRnal of PhaRmacology (2004) 143, 1050–1057. doi:10.1038/sj.bjp.0705944
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Identification of R(−)‐isomeR of efonidipine as a selective blockeR of T‐type Ca2+ channels
British Journal of Pharmacology, 2004Co-Authors: Taiji Furukawa, Reiko Miura, Natsuko Kamiya, Takaaki Isshiki, Yasuo Mori, Mitsuyoshi Honda, Satoshi Takeshita, Toshihide NukadaAbstract:Efonidipine, a deRivative of dihydRopyRidine Ca2+ antagonist, is known to block both L- and T-type Ca2+ channels. It Remains to be claRified, howeveR, whetheR efonidipine affects otheR voltage-dependent Ca2+ channel subtypes such as N-, P/Q- and R-types, and whetheR the optical isomeRs of efonidipine have diffeRent selectivities in blocking these Ca2+ channels, including L- and T-types. To addRess these issues, the effects of efonidipine and its R(−)- and S(+)-isomeRs on these Ca2+ channel subtypes weRe examined electRophysiologically in the expRession systems using Xenopus oocytes and baby hamsteR kidney cells (BHK tk-ts13). Efonidipine, a mixtuRe of R(−)- and S(+)-isomeRs, exeRted blocking actions on L- and T-types, but no effects on N-, P/Q- and R-type Ca2+ channels. The selective blocking actions on L- and T-type channels weRe RepRoduced by the S(+)-efonidipine isomeR. By contRast, the R(−)-efonidipine isomeR pRefeRentially blocked T-type channels. The blocking actions of efonidipine and its enantiomeRs weRe dependent on holding potentials. These findings indicate that the R(−)-isomeR of efonidipine is a specific blockeR of the T-type Ca2+ channel. BRitish JouRnal of PhaRmacology (2004) 143, 1050–1057. doi:10.1038/sj.bjp.0705944