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Ortega Baltazar Edgar - One of the best experts on this subject based on the ideXlab platform.

  • Factores genéticos y ambientales que afectan el comportamiento reproductivo de conejas Nueva Zelanda, California y Chinchilla.
    Colegio de Postgraduados (COLPOS), 2012
    Co-Authors: Ortega Baltazar Edgar
    Abstract:

    Es poco conocido el comportamiento reproductivo de las principales razas de conejo en México aunque se cuenta con información proveniente del Centro Nacional de Cunicultura. Se estudio el tamaño total de la camada al nacimiento (TTCN), tamaño de la camada viva al nacimiento (TCVN), intervalo interparto (II), tamaño de la camada al destete (TCD), peso de la camada al destete (PCD) y el peso medio del gazapo al destete (PMD) de hembras Nueva Zelanda (NZ), California (CL) y Chinchilla (CH) utilizando un modelo estadístico mixto que incluyo los efectos de raza, coneja y año-estación de parto. Se utilizaron 8,162 registros reproductivos. Se definieron 18 épocas año-estación de parto, agrupadas trimestralmente de Diciembre de 2005 a Julio de 2010. Los datos fueron analizados utilizando el procedimiento MIXED de SAS. Las conejas NZ tuvieron el mejor comportamiento reproductivo (p≤0.01) con medias de TTCN de 8.1±.05 gazapos, TCVN 7.9 ±.05, TCD 6.9±0.1 y PCD 6589 ± 63 g. El efecto de número de parto fue importante (p≤0.01) en la mayoría de las características estudiadas, con una tendencia positiva del primero al cuarto parto. El efecto de año-estación de parto en las características estudiadas fue diferencial para las conejas de las tres razas (p≤0.01). _______________ GENETIC AND ENVIRONMENTAL FACTORS THAT AFFECT THE REPRODUCTIVE BEHAVIOR OF NEW ZEALAND, CALIFORNIA, AND CHINCHILLA DAMS. ABSTRACT: Little is known about the reproductive behavior of the principal Rabbit Breeds in Mexico, although there is information from the National Cuniculture Center. The factors studied were: total litter size at birth (TLSB), live litter size at birth (LLSB), interpartum interval (II), litter size at weaning (LSW), litter weight at weaning (LWW), and mean kit weight at weaning (MWW) in New Zealand (NZ), California (CL), and Chinchilla (CH) Rabbits, using a mixed statistical model that included the effects of breed, dam, and year-season of birthing. A total 8,162 reproductive registries were used. Eighteen birthing year-season times were defined and grouped quarterly from December 2005 to July 2010. Data were analyzed using the MIXED procedure in SAS. The NZ dams had the best reproductive behavior (p≤0.01) with the following means: TLSB 8.1±.05 kits, LLSB 7.9±.05,LSW 6.9±0.1, and LWW 6589±63 g. The effect of the birthing number was important (p≤0.01) in most of the studied characteristics, with a positive trend from the first to the fourth birthing. The effect of the year-season of the birthing on the studied characteristics was differential for dams of all three Breeds (p≤0.01)

  • Factores genéticos y ambientales que afectan el comportamiento reproductivo de conejas Nueva Zelanda, California y Chinchilla.
    Colegio de Postgraduados (COLPOS), 2012
    Co-Authors: Ortega Baltazar Edgar
    Abstract:

    Es poco conocido el comportamiento reproductivo de las principales razas de conejo en México aunque se cuenta con información proveniente del Centro Nacional de Cunicultura. Se estudio el tamaño total de la camada al nacimiento (TTCN), tamaño de la camada viva al nacimiento (TCVN), intervalo interparto (II), tamaño de la camada al destete (TCD), peso de la camada al destete (PCD) y el peso medio del gazapo al destete (PMD) de hembras Nueva Zelanda (NZ), California (CL) y Chinchilla (CH) utilizando un modelo estadístico mixto que incluyo los efectos de raza, coneja y año-estación de parto. Se utilizaron 8,162 registros reproductivos. Se definieron 18 épocas año-estación de parto, agrupadas trimestralmente de Diciembre de 2005 a Julio de 2010. Los datos fueron analizados utilizando el procedimiento MIXED de SAS. Las conejas NZ tuvieron el mejor comportamiento reproductivo (p≤0.01) con medias de TTCN de 8.1±.05 gazapos, TCVN 7.9 ±.05, TCD 6.9±0.1 y PCD 6589 ± 63 g. El efecto de número de parto fue importante (p≤0.01) en la mayoría de las características estudiadas, con una tendencia positiva del primero al cuarto parto. El efecto de año-estación de parto en las características estudiadas fue diferencial para las conejas de las tres razas (p≤0.01). _______________ GENETIC AND ENVIRONMENTAL FACTORS THAT AFFECT THE REPRODUCTIVE BEHAVIOR OF NEW ZEALAND, CALIFORNIA, AND CHINCHILLA DAMS. ABSTRACT: Little is known about the reproductive behavior of the principal Rabbit Breeds in Mexico, although there is information from the National Cuniculture Center. The factors studied were: total litter size at birth (TLSB), live litter size at birth (LLSB), interpartum interval (II), litter size at weaning (LSW), litter weight at weaning (LWW), and mean kit weight at weaning (MWW) in New Zealand (NZ), California (CL), and Chinchilla (CH) Rabbits, using a mixed statistical model that included the effects of breed, dam, and year-season of birthing. A total 8,162 reproductive registries were used. Eighteen birthing year-season times were defined and grouped quarterly from December 2005 to July 2010. Data were analyzed using the MIXED procedure in SAS. The NZ dams had the best reproductive behavior (p≤0.01) with the following means: TLSB 8.1±.05 kits, LLSB 7.9±.05,LSW 6.9±0.1, and LWW 6589±63 g. The effect of the birthing number was important (p≤0.01) in most of the studied characteristics, with a positive trend from the first to the fourth birthing. The effect of the year-season of the birthing on the studied characteristics was differential for dams of all three Breeds (p≤0.01).Tesis (Maestría en Ciencias, especialista en Ganadería).- Colegio de Postgraduados, 2012.Consejo Nacional de Ciencia y Tecnología (CONACYT)

Pałka Sylwia - One of the best experts on this subject based on the ideXlab platform.

  • Polymorphisms in coding and non-coding regions of Rabbit (Oryctolagus cuniculus) myogenin (MyoG) gene
    'Universitat Politecnica de Valencia', 2021
    Co-Authors: Migdał Łukasz, Pałka Sylwia
    Abstract:

    [EN] In animal breeding, selection based on growth is very often used, as this trait affects the profitability of animal production. Identification of  polymorphisms within the genes affecting the growth process seems to be very important. Therefore, we decided to analyse Rabbit myogenin (MyoG gene) for potential polymorphic sites and their association with growth and carcass traits in Termond White (TER), Belgian Giant Grey (BGG) and crossbred New Zealand White×Belgian Giant Grey (NZW×BGG) Rabbits. We found three single nucleotide polymorphisms (SNPs) – in 5’ upstream sequence g.68679476 C>T, in exon 1 – silent mutation g.68680096 T>C and g.68680097 G>A resulting in change of GTG triplet (valine) into ATG triplet (methionine). Association analysis showed that GG genotype weaning weight was statistically higher compared to GA in TER population (P=0.005), and that the hind parts for GG genotypes were heavier compared to those of GA (P=0.024), but association analysis of dissectible parts showed this was caused by higher bone weight (P=0.015). For g.68679476 C>T in NZW×BGG population, the CC genotypes for fore (678±35) and hind part (615±29) weights were heavier compared to CT (588±16 and 549±13, respectively); moreover, association analysis of dissectible parts showed that weight of dissectible meat in hind part. Unfortunately, we did not find similar associations for other analysed Breeds. For g.68679476 C>T in NZWxBGG musculus longissimus lumborum pH leg after 24 h chilling (pH24L) were statistically lower for CC genotypes compared to CT (P=0.027). For g.68680097 G>A in Termond White population L* value on the hind leg after 24 h chilling (L*24H) was higher for GA genotypes compared to GG (P=0.03), while for g.68679476 C>T for musculus longissimus lumborum L* value after 24 h (L*24L) CC genotypes had higher value compared to CT (P=0.016) in BGG population. Moreover, in BGG population CT genotypes had higher weaning weight compared to CC (P=0.018). Our results show that SNPs within the MyoG gene may influence growth traits in some Rabbit Breeds, but the evolutionary conserved sequence may not be favourable for changes within coding sequences. For a better understanding thereof, additional analysis is required.This research was financed by the National Centre for Research and Development (Poland) decision number LIDER/27/0104/L-9/17/NCBR/2018.Migdał, Ł.; Pałka, S. (2021). Polymorphisms in coding and non-coding regions of Rabbit (Oryctolagus cuniculus) myogenin (MyoG) gene. World Rabbit Science. 29(2):69-79. https://doi.org/10.4995/wrs.2021.11830OJS697929

  • Polymorphisms in coding and non-coding regions of Rabbit (Oryctolagus cuniculus) myogenin (MyoG) gene
    'Universitat Politecnica de Valencia', 2021
    Co-Authors: Migdał Łukasz, Pałka Sylwia
    Abstract:

    [EN] In animal breeding, selection based on growth is very often used, as this trait affects the profitability of animal production. Identification of  polymorphisms within the genes affecting the growth process seems to be very important. Therefore, we decided to analyse Rabbit myogenin (MyoG gene) for potential polymorphic sites and their association with growth and carcass traits in Termond White (TER), Belgian Giant Grey (BGG) and crossbred New Zealand White×Belgian Giant Grey (NZW×BGG) Rabbits. We found three single nucleotide polymorphisms (SNPs) – in 5’ upstream sequence g.68679476 C>T, in exon 1 – silent mutation g.68680096 T>C and g.68680097 G>A resulting in change of GTG triplet (valine) into ATG triplet (methionine). Association analysis showed that GG genotype weaning weight was statistically higher compared to GA in TER population (P=0.005), and that the hind parts for GG genotypes were heavier compared to those of GA (P=0.024), but association analysis of dissectible parts showed this was caused by higher bone weight (P=0.015). For g.68679476 C>T in NZW×BGG population, the CC genotypes for fore (678±35) and hind part (615±29) weights were heavier compared to CT (588±16 and 549±13, respectively); moreover, association analysis of dissectible parts showed that weight of dissectible meat in hind part. Unfortunately, we did not find similar associations for other analysed Breeds. For g.68679476 C>T in NZWxBGG musculus longissimus lumborum pH leg after 24 h chilling (pH24L) were statistically lower for CC genotypes compared to CT (P=0.027). For g.68680097 G>A in Termond White population L* value on the hind leg after 24 h chilling (L*24H) was higher for GA genotypes compared to GG (P=0.03), while for g.68679476 C>T for musculus longissimus lumborum L* value after 24 h (L*24L) CC genotypes had higher value compared to CT (P=0.016) in BGG population. Moreover, in BGG population CT genotypes had higher weaning weight compared to CC (P=0.018). Our results show that SNPs within the MyoG gene may influence growth traits in some Rabbit Breeds, but the evolutionary conserved sequence may not be favourable for changes within coding sequences. For a better understanding thereof, additional analysis is required.This research was financed by the National Centre for Research and Development (Poland) decision number LIDER/27/0104/L-9/17/NCBR/2018.Migdał, Ł.; Pałka, S. (2021). Polymorphisms in coding and non-coding regions of Rabbit (Oryctolagus cuniculus) myogenin (MyoG) gene. World Rabbit Science. 29(2):69-79. https://doi.org/10.4995/wrs.2021.11830OJS6979292Abu El-Magd M., Abo-Al-Ela G.H., El-Nahas A., Mansour A.A. 2015. SNPs of the MyoD and MyoG genes and their association with growth traits in Egyptian water buffalo (Bubalus bubalis). Indian J. Appl. Res., 3: 34-40. https://doi.org/10.15373/2249555X/DEC2013/178Anton I., Fésüs L., Zsolnai A. 2002. Simultaneous identification of two MspI polymorphisms of the porcine myogenin gene in Hungarian Breeds. J. Anim. Breed. Genet., 119: 280-283. https://doi.org/10.1046/j.1439-0388.2002.00343.xAnton I., Zsolnai A., Komlósi I., Király A., Fésüs L. 2006. Effect of MYOG genotypes on growth rate and production traits in Hungarian large white pigs. Acta Vet. Hung., 54: 393-397. https://doi.org/10.1556/AVet.54.2006.3.9Bhuiyan M.S.A., Kim N.K., Cho Y.M., Yoon D., Kim K.S., Jeon J.T., Lee J.H. 2009. Identification of SNPs in MYOD gene family and their associations with carcass traits in cattle. Livest. Prod. Sci., 126: 292-297. https://doi.org/10.1016/j.livsci.2009.05.019Blasco A., Nagy I., Hernández P. 2018. Genetics of growth, carcass and meat quality in Rabbits. Meat Sci., 148: 178-185. https://doi.org/10.1016/j.meatsci.2018.06.030Bolet G., Brun J.M., Monnerot M., Abeni F., Arnal C., Arnold J., Bell D., Bergoglio G., Besenfelder U., Bosze S., Boucher S., Chanteloup N., Ducourouble M.C., Durand-Tardif M., Esteves P.J., Ferrand N., Gautier A., Haas C., Hewitt G., Jehl N., Joly T., Koehl P.F., Laube T., Lechevestrier S., Lopez M., Masoero G., Menigoz J.J., Piccinin R., Queney G., Saleil G., Surridge A., van der Loo W., Vicente J.S., Viudes de Castro M.P., ViragJ.S., Zimmermann J.M. 2000. Evaluation and conservation of European Rabbit (Oryctolagus cuniculus) genetic resources. First results and inferences (Main paper). In Proc: 7th World Rabbit Congress, 4-7 July, 2000. Valencia, Spain. Vol A: 281-315.Carneiro M., Rubin C.J., Di Palma F., Albert F.W., Alföldi J., Martinez Barrio A., Pielberg G., Rafati N., Sayyab S., Turner-Maier J., Younis S., Afonso S., Aken B., Alves J.M., Barrell D., Bolet G., Boucher S., Burbano H.A., Campos R., Chang J.L., Duranthon V., Fontanesi L., Garreau H., Heiman D., Johnson J., Mage R.G., Peng Z., Queney G., Rogel-Gaillard C., Ruffier M., Searle S., Villafuerte R., Xiong, A., Young S., Forsberg-Nilsson K., Good J.M., Lander E.S., Ferrand, N., Lindblad-Toh K., Andersson L. 2014. Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication. Sci. J., 345: 1074-1079. https://doi.org/10.1126/science.1253714Dalle Zotte A., Cullere M., Rémignon H., Alberghini L., Paci G. 2016. Meat physical quality and muscle fibre properties of Rabbit meat as affected by the sire breed, season, parity order and gender in an organic production system. World Rabbit Sci., 24: 145-154. https://doi.org/10.4995/wrs.2016.4300Hasty P., Bradley A., Morris J.H., Edmondson D.G., Venuti J.M., Olson E.N., Klein W.H. 1993. Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature, 364: 501-506. https://doi.org/10.1038/364501a0Kuang L., Xie X., Zhang X., Lei M., Li C., Ren Y., Zheng J., Guo Z., Zhang C., Yang C., Zheng Y. 2014. Expression profiles of myostatin, myogenin, and myosin heavy chain in skeletal muscles of two Rabbit Breeds differingin growth rate. Anim. Biotechnol., 25: 223-233. https://doi.org/10.1080/10495398.2013.865639Kapelanski W., Grajewska S., Kuryl J., Boclan M., Wyszynska-Koko J., Urbanski P. 2005. Polymorphism in coding and non coding regions of the MYOD gene family and meat quality in pigs. Fol. Biol., 53: 45-49. https://doi.org/10.3409/173491605775789506Kim J.M., Choi B.D., Kim B.C., ParkS.S., Hong K.C. 2009. Associations of the variation in the porcine myogenin gene with muscle fibre characteristics, lean meat production and meat quality traits. J. Anim. Breed. Genet., 126: 134-141. https://doi.org/10.1111/j.1439-0388.2008.00724.xKozioł K., Maj D., Bieniek J. 2015. Changes in the colour and pH of Rabbit meatin the aging process. Med. Weter., 71: 104-108.Mattioli S., Martino M., Ruggeri S., Roscini V., Moscati L., Dal Bosco A., Castellini C. 2016. Fattening Rabbits in mobile arks: effect of housing system on in vivo oxidative status and meat quality. World Rabbit Sci., 24: 303-311. https://doi.org/10.4995/wrs.2016.4108Olson E.N. 1993. Regulation of muscle transcription by the MyoD family. The heart of the matter. Circ Res., 72: 1-6. https://doi.org/10.1161/01.RES.72.1.1Olson E.N., Klein W.H. 1994. HLH factors in muscle development: Dead lines and commitments, what to leave in and what to leave out. Genes Dev., 8: 1-8. https://doi.org/10.1101/gad.8.1.1Pałka S., Siudak Z., Kmiecik M., Kozioł K., Migdał Ł., Bieniek J. 2018. Królik belgijski olbrzym - charakterystyka rasy. Przegląd Hodowlany, 2: 31-33 [In Polish].Przybylski W., Hopkins D. 2016. Meat Quality Genetics and Environmental Factors. CRC Press, Taylor & Francis Group. https://doi.org/10.1201/b19250Tamura K., Stecher G., Peterson D., Filipski A., Kumar S. 2013. MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0. Mol. Biol. Evol., 30: 2725-2729. https://doi.org/10.1093/molbev/mst197te Pas M.F., Verburg F.J., Gerritsen C.L., de Greef K.H. 2000. Messenger ribonucleic acid expression of the MyoD gene family in muscle tissue at slaughter in relation to selection for porcine growth rate. J. Anim. Sci. 78: 69-77. https://doi.org/10.2527/2000.78169xRamírez J.A., Oliver M.A., Pla M., Guerrero L., Arino B., Blasco A., Pascual M., Gil M. 2004. Effects of selection for growth rate on biochemical quality and texture characteristics of meat from Rabbits. Meat Sci., 67: 617-624. https://doi.org/10.1016/j.meatsci.2003.12.012Soumillion A., Erkens J.H., Lenstra J.A., Rettenberger G., te Pas M.F. 1997. Genetic variation in the porcine myogenin gene locus. Mamm. Genome, 8: 564-568. https://doi.org/10.1007/s003359900504SAS (2014). SAS/STAT 13.2 User's Guide. SAS Institute Inc. Cary, NC.Sun Y., Han Y. 2017. Genetic polymorphisms of myogenin gene and their associations with growth traits in the Chinese Tibetan Sheep. Kafkas Univ. Vet. Fak. Derg., 23: 253-258. https://doi.org/10.9775/kvfd.2016.16371Tang H., Thomas P.D. 2016. PANTHER-PSEP: predicting disease-causing genetic variants using position-specific evolutionary preservation. Bioinformatics, 32: 2230-2232. https://doi.org/10.1093/bioinformatics/btw222Tseng B.S., Cavin S.T., Hoffman E.P., Iannaccone S.T., Mancias P., Booth F.W., Butler I.J. 1999. Human bHLH Transcription Factor GeneMyogenin (MYOG): Genomic Sequence and Negative Mutation Analysisin Patients with Severe Congenital Myopathies. Genomics, 57: 419-423. https://doi.org/10.1006/geno.1998.5719Wei Y., Zhang G.X., Zhang T., Wang J.Y., Fan Q.C., Tang Y., Ding F.X., Zhang L. 2016. Myf5 and MyoG gene SNPs associated with Bian chicken growth trait. Genet. Mol. Res., 15: 15037043. https://doi.org/10.4238/gmr.15037043Xue M., Zan L.S., Gao L., Wang H.B. 2011. A novel polymorphism of the myogenin gene is associated with body measurement traits in native Chinese Breeds. Genet. Mol. Res., 10: 2721-2728. https://doi.org/10.4238/2011.November.4.6Vaser R., Adusumalli S., Leng S., Sikic M., Ng P.C. 2016. SIFT missense predictions for genomes. Nat. Protoc., 11: 1-9. https://doi.org/10.1038/nprot.2015.12

Nuno Ferrand - One of the best experts on this subject based on the ideXlab platform.

  • Dwarfism and Altered Craniofacial Development in Rabbits Is Caused by a 12.1 kb Deletion at the HMGA2 locus
    Genetics, 2017
    Co-Authors: Miguel Carneiro, John Archer, Chungang Feng, Sandra Afonso, Congying Chen, José A. Blanco-aguiar, Herve Garreau, Samuel Boucher, Paula G. Ferreira, Nuno Ferrand
    Abstract:

    The dwarf phenotype characterizes the smallest of Rabbit Breeds and is governed largely by the effects of a single dwarfing allele with an incompletely dominant effect on growth. Dwarf Rabbits typically weigh under 1 kg and have altered craniofacial morphology. The dwarf allele is recessive lethal and dwarf homozygotes die within a few days of birth. The dwarf phenotype is expressed in heterozygous individuals and Rabbits from dwarf Breeds homozygous for the wild-type allele are normal, although smaller when compared to other Breeds. Here, we show that the dwarf allele constitutes a similar to 12.1 kb deletion overlapping the promoter region and first three exons of the HMGA2 gene leading to inactivation of this gene. HMGA2 has been frequently associated with variation in body size across species. Homozygotes for null alleles are viable in mice but not in Rabbits and probably not in humans. RNA-sequencing analysis of Rabbit embryos showed that very few genes (4-29 genes) were differentially expressed among the three HMGA2/dwarf genotypes, suggesting that dwarfism and inviability in Rabbits are caused by modest changes in gene expression. Our results show that HMGA2 is critical for normal expression of IGF2BP2, which encodes an RNA-binding protein. Finally, we report a catalog of regions of elevated genetic differentiation between dwarf and normal-size Rabbits, including LCORL-NCAPG, STC2, HOXD cluster, and IGF2BP2. Levels and patterns of genetic diversity at the LCORL-NCAPG locus further suggest that small size in dwarf Breeds was enhanced by crosses with wild Rabbits. Overall, our results imply that small size in dwarf Rabbits results from a large effect, loss-of-function (LOF) mutation in HMGA2 combined with polygenic selection.

Migdał Łukasz - One of the best experts on this subject based on the ideXlab platform.

  • Polymorphisms in coding and non-coding regions of Rabbit (Oryctolagus cuniculus) myogenin (MyoG) gene
    'Universitat Politecnica de Valencia', 2021
    Co-Authors: Migdał Łukasz, Pałka Sylwia
    Abstract:

    [EN] In animal breeding, selection based on growth is very often used, as this trait affects the profitability of animal production. Identification of  polymorphisms within the genes affecting the growth process seems to be very important. Therefore, we decided to analyse Rabbit myogenin (MyoG gene) for potential polymorphic sites and their association with growth and carcass traits in Termond White (TER), Belgian Giant Grey (BGG) and crossbred New Zealand White×Belgian Giant Grey (NZW×BGG) Rabbits. We found three single nucleotide polymorphisms (SNPs) – in 5’ upstream sequence g.68679476 C>T, in exon 1 – silent mutation g.68680096 T>C and g.68680097 G>A resulting in change of GTG triplet (valine) into ATG triplet (methionine). Association analysis showed that GG genotype weaning weight was statistically higher compared to GA in TER population (P=0.005), and that the hind parts for GG genotypes were heavier compared to those of GA (P=0.024), but association analysis of dissectible parts showed this was caused by higher bone weight (P=0.015). For g.68679476 C>T in NZW×BGG population, the CC genotypes for fore (678±35) and hind part (615±29) weights were heavier compared to CT (588±16 and 549±13, respectively); moreover, association analysis of dissectible parts showed that weight of dissectible meat in hind part. Unfortunately, we did not find similar associations for other analysed Breeds. For g.68679476 C>T in NZWxBGG musculus longissimus lumborum pH leg after 24 h chilling (pH24L) were statistically lower for CC genotypes compared to CT (P=0.027). For g.68680097 G>A in Termond White population L* value on the hind leg after 24 h chilling (L*24H) was higher for GA genotypes compared to GG (P=0.03), while for g.68679476 C>T for musculus longissimus lumborum L* value after 24 h (L*24L) CC genotypes had higher value compared to CT (P=0.016) in BGG population. Moreover, in BGG population CT genotypes had higher weaning weight compared to CC (P=0.018). Our results show that SNPs within the MyoG gene may influence growth traits in some Rabbit Breeds, but the evolutionary conserved sequence may not be favourable for changes within coding sequences. For a better understanding thereof, additional analysis is required.This research was financed by the National Centre for Research and Development (Poland) decision number LIDER/27/0104/L-9/17/NCBR/2018.Migdał, Ł.; Pałka, S. (2021). Polymorphisms in coding and non-coding regions of Rabbit (Oryctolagus cuniculus) myogenin (MyoG) gene. World Rabbit Science. 29(2):69-79. https://doi.org/10.4995/wrs.2021.11830OJS697929

  • Polymorphisms in coding and non-coding regions of Rabbit (Oryctolagus cuniculus) myogenin (MyoG) gene
    'Universitat Politecnica de Valencia', 2021
    Co-Authors: Migdał Łukasz, Pałka Sylwia
    Abstract:

    [EN] In animal breeding, selection based on growth is very often used, as this trait affects the profitability of animal production. Identification of  polymorphisms within the genes affecting the growth process seems to be very important. Therefore, we decided to analyse Rabbit myogenin (MyoG gene) for potential polymorphic sites and their association with growth and carcass traits in Termond White (TER), Belgian Giant Grey (BGG) and crossbred New Zealand White×Belgian Giant Grey (NZW×BGG) Rabbits. We found three single nucleotide polymorphisms (SNPs) – in 5’ upstream sequence g.68679476 C>T, in exon 1 – silent mutation g.68680096 T>C and g.68680097 G>A resulting in change of GTG triplet (valine) into ATG triplet (methionine). Association analysis showed that GG genotype weaning weight was statistically higher compared to GA in TER population (P=0.005), and that the hind parts for GG genotypes were heavier compared to those of GA (P=0.024), but association analysis of dissectible parts showed this was caused by higher bone weight (P=0.015). For g.68679476 C>T in NZW×BGG population, the CC genotypes for fore (678±35) and hind part (615±29) weights were heavier compared to CT (588±16 and 549±13, respectively); moreover, association analysis of dissectible parts showed that weight of dissectible meat in hind part. Unfortunately, we did not find similar associations for other analysed Breeds. For g.68679476 C>T in NZWxBGG musculus longissimus lumborum pH leg after 24 h chilling (pH24L) were statistically lower for CC genotypes compared to CT (P=0.027). For g.68680097 G>A in Termond White population L* value on the hind leg after 24 h chilling (L*24H) was higher for GA genotypes compared to GG (P=0.03), while for g.68679476 C>T for musculus longissimus lumborum L* value after 24 h (L*24L) CC genotypes had higher value compared to CT (P=0.016) in BGG population. Moreover, in BGG population CT genotypes had higher weaning weight compared to CC (P=0.018). Our results show that SNPs within the MyoG gene may influence growth traits in some Rabbit Breeds, but the evolutionary conserved sequence may not be favourable for changes within coding sequences. For a better understanding thereof, additional analysis is required.This research was financed by the National Centre for Research and Development (Poland) decision number LIDER/27/0104/L-9/17/NCBR/2018.Migdał, Ł.; Pałka, S. (2021). Polymorphisms in coding and non-coding regions of Rabbit (Oryctolagus cuniculus) myogenin (MyoG) gene. 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Associations of the variation in the porcine myogenin gene with muscle fibre characteristics, lean meat production and meat quality traits. J. Anim. Breed. Genet., 126: 134-141. https://doi.org/10.1111/j.1439-0388.2008.00724.xKozioł K., Maj D., Bieniek J. 2015. Changes in the colour and pH of Rabbit meatin the aging process. Med. Weter., 71: 104-108.Mattioli S., Martino M., Ruggeri S., Roscini V., Moscati L., Dal Bosco A., Castellini C. 2016. Fattening Rabbits in mobile arks: effect of housing system on in vivo oxidative status and meat quality. World Rabbit Sci., 24: 303-311. https://doi.org/10.4995/wrs.2016.4108Olson E.N. 1993. Regulation of muscle transcription by the MyoD family. The heart of the matter. Circ Res., 72: 1-6. https://doi.org/10.1161/01.RES.72.1.1Olson E.N., Klein W.H. 1994. HLH factors in muscle development: Dead lines and commitments, what to leave in and what to leave out. 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  • Genetic diversity and population structure of four Chinese Rabbit Breeds.
    'Public Library of Science (PLoS)', 2019
    Co-Authors: Anyong Ren, Shiyi Chen, Xianbo Jia, Rui Yang, Jie Wang, Songjia Lai
    Abstract:

    There are a few well-known indigenous Breeds of Chinese Rabbits in Sichuan and Fujian provinces, for which the genetic diversity and population structure have been poorly investigated. In the present study, we successfully employed the restriction-site-associated DNA sequencing (RAD-seq) approach to comprehensively discover genome-wide SNPs of 104 Rabbits from four Chinese indigenous Breeds: 30 Sichuan White, 34 Tianfu Black, 32 Fujian Yellow and eight Fujian Black. A total of 7,055,440 SNPs were initially obtained, from which 113,973 high-confidence SNPs (read depth ≥ 3, calling rate = 100% and biallelic SNPs) were selected to study the genetic diversity and population structure. The mean polymorphism information content (PIC) and nucleotide diversity (π) of each breed slightly varied with ranging from 0.2000 to 0.2281 and from 0.2678 to 0.2902, respectively. On the whole, Fujian Yellow Rabbits showed the highest genetic diversity, which was followed by Tianfu Black and Sichuan White Rabbits. The principal component analysis (PCA) revealed that the four Breeds were clearly distinguishable. Our results first reveal the genetic differences among these four Rabbit Breeds in the Sichuan and Fujian provinces and also provide a high-confidence set of genome-wide SNPs for Chinese indigenous Rabbits that could be employed for gene linkage and association analyses in the future

  • Myopalladin gene polymorphism is associated with Rabbit meat quality traits
    'Informa UK Limited', 2017
    Co-Authors: Jie Wang, Shiyi Chen, Xianbo Jia, Yu Shi, Mauricio A. Elzo, Songjia Lai
    Abstract:

    The objective of this study was to investigate the effect of the polymorphism in the Myopalladin (MYPN) gene on meat quality traits in the Hyla, Champagne, Tianfu Black Rabbit Breeds using PCR and DNA sequencing. A novel SNP (g.18497416 G > A) was found at 229 bp in exon 13 of chromosome 18. The three Rabbit populations had intermediate levels of genetic diversity according to their polymorphism information content values. The statistical analysis indicated that Rabbits with the GG genotype had a significantly greater a*24h and b*24h than Rabbits with the AA genotype (p 

  • A synonymous mutation of uncoupling protein 2 (UCP2) gene is associated with growth performance, carcass characteristics and meat quality in Rabbits
    Guhmok Publishing Co., 2016
    Co-Authors: Wen-chao Liu, Songjia Lai
    Abstract:

    Abstract Background Uncoupling proteins 2 (UCP2) plays an important role in energy regulation, previous studies suggested that UCP2 is an excellent candidate gene for human obesity and growth-related traits in cattle and chicks. The current study was designed to detect the genetic variation of UCP2 gene, and to explore the association between polymorphism of UCP2 gene and growth, carcass and meat quality traits in Rabbits. Results A synonymous mutation in exon 1 and four variants in the first intron of the UCP2 gene were identified by using PCR-sequencing. The synonymous mutation c.72G>A was subsequently genotyped by MassArray system (Sequenom iPLEXassay) in 248 samples from three meat Rabbit Breeds (94 Ira Rabbits, 83 Champagne Rabbits, and 71 Tianfu black Rabbits). Association analysis suggested that the individuals with AA and AG genotypes showed greater 70 d body weight (P 

  • correlation analysis between single nucleotide polymorphism of fgf5 gene and wool yield in Rabbits
    Hereditas, 2008
    Co-Authors: Meishan Jiang, Shiyi Chen, Songjia Lai
    Abstract:

    Single nucleotide polymorphism (SNP) in exon 1 and 3 of fibroblast growth factor (FGF5) gene was studied by DNA sequencing in Yingjing angora Rabbit, Tianfu black Rabbit and California Rabbit. A frameshift mutation (TCT insert) at base position 217 (site A) of exon 1 and a T/C missense mutation at base position 59 (site B) of exon 3 were found in Yingjing angora Rabbit with a high frequency; a T/C same-sense mutation at base position 3 (site C) of exon 3 was found with similar frequency in three Rabbit Breeds. Least square analysis showed that different genotypes had no significant association with wool yield in site A, and had high significant association with wool yield in site B (P<0.01) and significant association with wool yield in site C (P<0.05). It was concluded from the results that FGF5 gene could be the potential major gene affecting wool yield or link with the major gene, and polymorphic loci B and C may be used as molecular markers for im-proving wool yield in angora Rabbits.