The Experts below are selected from a list of 126 Experts worldwide ranked by ideXlab platform
Aziz Ogutlu - One of the best experts on this subject based on the ideXlab platform.
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tularemia Rabbit Fever
Journal of Microbiology and Infectious Diseases, 2014Co-Authors: Oguz Karabay, Aziz OgutluAbstract:Tularemi, aerop, hareketsiz, sporsuz, gram negatif bir basil olan Francisella tularensis’in neden oldugu zoonotik bir hastaliktir. Insanlara, enfekte bir hayvanin islenmesi, enfekte hayvanin vucut sivilariyla temas, kontamine su veya besinlerin yenmesi, icilmesi aerosollerin solunmasi ya da kene isirigi ile bulasir. Kultur islemi sirasinda kolayca bulasmasina ragmen, insandan insana bulasmaz
Oguz Karabay - One of the best experts on this subject based on the ideXlab platform.
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tularemia Rabbit Fever
Journal of Microbiology and Infectious Diseases, 2014Co-Authors: Oguz Karabay, Aziz OgutluAbstract:Tularemi, aerop, hareketsiz, sporsuz, gram negatif bir basil olan Francisella tularensis’in neden oldugu zoonotik bir hastaliktir. Insanlara, enfekte bir hayvanin islenmesi, enfekte hayvanin vucut sivilariyla temas, kontamine su veya besinlerin yenmesi, icilmesi aerosollerin solunmasi ya da kene isirigi ile bulasir. Kultur islemi sirasinda kolayca bulasmasina ragmen, insandan insana bulasmaz
Zygmunt F. Dembek - One of the best experts on this subject based on the ideXlab platform.
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Encyclopedia of Bioterrorism Defense - Tularemia (Francisella Tularensis)
Encyclopedia of Bioterrorism Defense, 2011Co-Authors: Zygmunt F. DembekAbstract:Tularemia is a zoonosis, a disease of animals transmissible to humans, and is caused by the facultative intracellular bacterium Francisella tularensis. F. tularensis is considered a potential agent of biological warfare and bioterrorism and as such has been rated among the top 6 category A agents (see also “Category Agents A-C”). Formerly, F. tularensis was included among agents developed and used by state-sponsored bioweapons programs. F. tularensis is one of the most infectious pathogenic bacteria known, requiring inoculation or inhalation of as few as 10 organisms to cause human infection. At present there are four recognized subspecies of F. tularensis: tularensis, holarctica, mediasiatica, and novicida, although only tularensis and holoarctica consistently cause disease in humans. Complete identification of all the natural reservoirs of F. tularensis has probably not yet occurred. Ongoing research continues to delineate the virulence mechanisms of F. tularensis. In a bioterrorism scenario, respiratory tularemia (acquired through inhalation) is judged to be the greatest threat. Natural outbreaks of human respiratory type A or type B tularemia have repeatedly been recorded in farmers and landscape workers illustrating the potential of effective F. tularensis transmission by dry aerosols. The clinical expression of tularemia largely depends on the route of entrance of the infectious agent and the prognosis in tularemia is highly dependent on the causative subspecies of F. tularensis. There is currently no licensed and widely available tularemia vaccine. Tularemia warrants antibiotic treatment and is not transmitted from person to person. Currently, there is renewed interest in tularemia and development of new diagnostics, prophylactics and therapies. Keywords: biological weapon; bioterrorism; category A agent; deerfly Fever; Francisella tularensis; hare Fever; holarctica; lemming Fever; mediasiatica; novicida; Ohara's disease; Rabbit Fever; tularemia; zoonotic
Anders Johansson - One of the best experts on this subject based on the ideXlab platform.
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Encyclopedia of Bioterrorism Defense - Tularemia (Francisella tularensis)
Encyclopedia of Bioterrorism Defense, 2005Co-Authors: Anders JohanssonAbstract:Tularemia is a zoonosis, a disease of animals transmissible to humans, and is caused by the facultative intracellular bacterium Francisella tularensis. F. tularensis is considered a potential agent of biological warfare and bioterrorism and as such has been rated among the top 6 category A agents. Formerly, F. tularensis was included among agents developed and used by state-sponsored bioweapons programs. In fact, F. tularensis is one of the most infectious pathogenic bacteria known, requiring inoculation or inhalation of as few as 10 organisms to cause human infection. At present there are four recognized subspecies of F. tularensis: tularensis, holarctica, mediasiatica, and novicida. The natural reservoirs of F. tularensis still await complete delineation. Little is known about the virulence mechanisms of F. tularensis. In a bioterrorism scenario, respiratory tularemia (acquired through inhalation) is judged to be the greatest threat. Natural outbreaks of human respiratory type A or type B tularemia have repeatedly been recorded in farmers and landscape workers illustrating the potential of effective F. tularensis transmission by dry aerosols. The clinical expression of tularemia largely depends on the route of entrance of the infectious agent and the prognosis in tularemia is highly dependent on the causative subspecies of F. tularensis. There is currently no licensed and widely available tularemia vaccine. Tularemia warrants antibiotic treatment and is not transmitted from person to person. Currently, there is a reawakened interest in tularemia and a rapid development of new diagnostics, prophylactics and therapies. Keywords: biological weapon; bioterrorism; category A agent; deerfly Fever; Francisella tularensis; hare Fever; holarctica; lemming Fever; mediasiatica; novicida; O'Hara's disease; Rabbit Fever; tularemia; zoonotic
Ciara K. O’sullivan - One of the best experts on this subject based on the ideXlab platform.
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Development of an immunosensor for the detection of Francisella tularensis antibodies
Analytical and Bioanalytical Chemistry, 2014Co-Authors: Samuel B. Dulay, Sandra Julich, Herbert Tomaso, Ciara K. O’sullivanAbstract:Tularemia, also known as Rabbit Fever, is a highly infectious zoonotic disease caused by a non-motile and non-spore-forming Gram-negative coccoid rod bacterium, Francisella tularensis . It occurs naturally in lagomorphs (Rabbits and hares), but many animals have been reported to be susceptible. Transmission to humans is mostly caused by inhalation of aerosolised bacteria, handling of infected animals, arthropod stings, and ingestion of contaminated foods and water. At present, pathogenic isolation, molecular detection, and serology are the most commonly used methods to confirm the diagnosis of tularemia. In this work, an electrochemical immunosensor for the detection of anti- F. tularensis antibodies was developed, consisting of gold-based self-assembled monolayers of a carboxylic-group-terminated bipodal alkanethiol that is covalently linked to a lipopolysaccharide (LPS) that can be found in the outer membrane of the bacteria F. tularensis . The presence of anti- F. tularensis antibodies was measured using horseradish peroxidase-labelled protein A (HRP-protein A) from Staphylococcus aureus , and the developed immunosensor gave a stable quantitative response to different anti- F. tularensis FB11 antibody concentrations after 30 min with a limit of detection of 15 ng/mL, RSD of 9 %, n = 3. The developed immunosensor was tested with serum from animals infected with tularemia and was compared to the results obtained using ELISA showing an excellent degree of correlation.
