The Experts below are selected from a list of 25119 Experts worldwide ranked by ideXlab platform

Helder C. Rodrigues - One of the best experts on this subject based on the ideXlab platform.

  • Surrogate-based visualization and sensitivity analysis of coronary stent performance: A study on the influence of geometric design: Visualization and sensitivity analysis of coronary stent performance
    International Journal for Numerical Methods in Biomedical Engineering, 2018
    Co-Authors: Nelson Ribeiro, João Folgado, Helder C. Rodrigues
    Abstract:

    The main goal of this numerical study is to assess the impact of geometric design perturbations on the performance of a representative coronary stent platform. In this context, first, a design parameterization model was defined for the stent under study. After, a set of metrics characterizing stent performance, namely, vessel injury, Radial recoil, bending resistance, longitudinal resistance, Radial Strength, the risk of fracture, prolapse index, and dogboning were evaluated within the context of a finite element analysis. Afterwards, accurate surrogate models were developed, using the efficient global optimization algorithm, as predictive tools in the execution of tasks that normally require a high number of model evaluations, such as global sensitivity analysis and visualization. In the end, the dependence of the output response surfaces on the geometric parameters was mechanically interpreted, which allowed us to understand the complex interplay that exists between the considered design variables and the defined performance metrics.

  • Surrogate-based visualization and sensitivity analysis of coronary stent performance: A study on the influence of geometric design.
    International journal for numerical methods in biomedical engineering, 2018
    Co-Authors: Nelson Ribeiro, João Folgado, Helder C. Rodrigues
    Abstract:

    The main goal of this numerical study is to assess the impact of geometric design perturbations on the performance of a representative coronary stent platform. In this context, first, a design parameterization model was defined for the stent under study. After, a set of metrics characterizing stent performance, namely, vessel injury, Radial recoil, bending resistance, longitudinal resistance, Radial Strength, the risk of fracture, prolapse index, and dogboning were evaluated within the context of a finite element analysis. Afterwards, accurate surrogate models were developed, using the efficient global optimization algorithm, as predictive tools in the execution of tasks that normally require a high number of model evaluations, such as global sensitivity analysis and visualization. In the end, the dependence of the output response surfaces on the geometric parameters was mechanically interpreted, which allowed us to understand the complex interplay that exists between the considered design variables and the defined performance metrics.

Robert Whitbourn - One of the best experts on this subject based on the ideXlab platform.

  • A FIRST-IN-HUMAN STUDY OF THE SECOND-GENERATION, THIN-STRUT, EVEROLIMUS-ELUTING BIORESORBABLE SCAFFOLD: 6-MONTH IVUS AND OCT RESULTS FROM THE FAST CLINICAL TRIAL
    Journal of the American College of Cardiology, 2019
    Co-Authors: Ryo Kameda, Kozo Okada, Masayasu Ikutomi, M. Brooke Hollak, Paul G. Yock, Jeffrey J. Popma, Sujith Seneviratne, Andrejs Erglis, Darren Walters, Robert Whitbourn
    Abstract:

    In second-generation bioresorbable scaffolds, thinner struts are often adopted to improve both deliverability and safety profiles, while theoretical concerns remain regarding Radial Strength and fracture resistance. This analysis aimed to evaluate acute and mid-term performance of the RENUVIA

  • TAXUS ® Element™ stent system
    Interventional Cardiology, 2011
    Co-Authors: Jithendra B. Somaratne, Robert Whitbourn
    Abstract:

    The TAXUS® Element™ stent system is the latest paclitaxel-eluting coronary stent by Boston Scientific. It uses a novel platinum–chromium alloy that enables low strut thickness, while maintaining high Radial Strength and radio-opacity. This new alloy has been coated with the established drug–polymer combination used in previous generations of TAXUS stents. This drug–polymer matrix has been extensively studied and has been shown to possess excellent efficacy compared with bare-metal stents. Subgroup analyses have demonstrated the TAXUS stent to be particularly efficacious in patients with diabetes. The new TAXUS Element stent has been further enhanced by a new low-profile stent delivery system, based on the Apex™ balloon catheter. This has been incorporated to improve deliverability, flexibility and pushability. The TAXUS Element has been carefully studied in a large randomized controlled trial that found it to be non-inferior to the previous generation TAXUS Express® stent in terms of both efficacy and safety.

Ari Heinonen - One of the best experts on this subject based on the ideXlab platform.

  • genetic and environmental influence on structural Strength of weight bearing and non weight bearing bone a twin study
    Journal of Bone and Mineral Research, 2007
    Co-Authors: Tuija M Mikkola, Sarianna Sipila, Taina Rantanen, Harri Sievanen, Harri Suominen, Jaakko Kaprio, Markku Koskenvuo, Markku Kauppinen, Ari Heinonen
    Abstract:

    A bivariate genetic analysis among 217 older female twin pairs showed that, although the structural Strength of tibia and radius are mainly regulated by same genetic and environmental factors, the tibia is more affected by environment. Introduction: The habitual loading environment of the bone may modulate the relative contribution of genetic and environmental factors to bone structure. The purpose of this study was to estimate the contribution of the common and site-specific genetic and environmental factors to interindividual variation in compressive structural Strength of the weight-bearing tibia and non–weight-bearing radius. Materials and Methods: pQCT scans were obtained from both members of 103 monozygotic (MZ) and 114 dizygotic (DZ) 63- to 76-yr-old female twin pairs to estimate the compressive Strength of the distal tibia and distal radius. Quantitative genetic models were used to decompose the phenotypic variance into additive genetic, shared environmental, and individual environmental effects at each bone site and to study whether these bone sites share genetic or environmental effects. Results: The MZ and DZ twins did not differ in mean age, height, weight, or bone structural Strength. The age-adjusted Cholesky model showed that additive genetic factors accounted for 83% (95% CI, 77–88%) of the variance in Radial Strength and 61% (95% CI, 52–69%) of the variance in tibial Strength, and these were fully correlated. A shared environmental factor accounted for 15% (95% CI, 10–20%) of tibial Strength. An individual environmental factor accounted for 17% (95% CI, 12–23%) of the variance in Radial Strength and 10% (95% CI, 5–17%) of the variance in tibial Strength. The relative contribution of an individual environmental factor specific to tibial Strength was 14% (95% CI, 11–18%). Conclusions: The results suggest that, in older women, the majority of the individual differences in the compressive structural Strength of the forearm and leg are regulated by genetic and environmental factors that are common to both bone sites. However, the relative importance of environmental factors was greater for the weight-bearing tibia than for the non–weight-bearing radius. Thus, the heritability of bone Strength seems to vary between skeletal sites according to differences in the typical loading environment.

Nelson Ribeiro - One of the best experts on this subject based on the ideXlab platform.

  • Surrogate-based visualization and sensitivity analysis of coronary stent performance: A study on the influence of geometric design: Visualization and sensitivity analysis of coronary stent performance
    International Journal for Numerical Methods in Biomedical Engineering, 2018
    Co-Authors: Nelson Ribeiro, João Folgado, Helder C. Rodrigues
    Abstract:

    The main goal of this numerical study is to assess the impact of geometric design perturbations on the performance of a representative coronary stent platform. In this context, first, a design parameterization model was defined for the stent under study. After, a set of metrics characterizing stent performance, namely, vessel injury, Radial recoil, bending resistance, longitudinal resistance, Radial Strength, the risk of fracture, prolapse index, and dogboning were evaluated within the context of a finite element analysis. Afterwards, accurate surrogate models were developed, using the efficient global optimization algorithm, as predictive tools in the execution of tasks that normally require a high number of model evaluations, such as global sensitivity analysis and visualization. In the end, the dependence of the output response surfaces on the geometric parameters was mechanically interpreted, which allowed us to understand the complex interplay that exists between the considered design variables and the defined performance metrics.

  • Surrogate-based visualization and sensitivity analysis of coronary stent performance: A study on the influence of geometric design.
    International journal for numerical methods in biomedical engineering, 2018
    Co-Authors: Nelson Ribeiro, João Folgado, Helder C. Rodrigues
    Abstract:

    The main goal of this numerical study is to assess the impact of geometric design perturbations on the performance of a representative coronary stent platform. In this context, first, a design parameterization model was defined for the stent under study. After, a set of metrics characterizing stent performance, namely, vessel injury, Radial recoil, bending resistance, longitudinal resistance, Radial Strength, the risk of fracture, prolapse index, and dogboning were evaluated within the context of a finite element analysis. Afterwards, accurate surrogate models were developed, using the efficient global optimization algorithm, as predictive tools in the execution of tasks that normally require a high number of model evaluations, such as global sensitivity analysis and visualization. In the end, the dependence of the output response surfaces on the geometric parameters was mechanically interpreted, which allowed us to understand the complex interplay that exists between the considered design variables and the defined performance metrics.

Takashi Sasou - One of the best experts on this subject based on the ideXlab platform.