Radiation Pneumonia

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I Pandolfo - One of the best experts on this subject based on the ideXlab platform.

  • chronic infiltrative lung diseases value of gadolinium enhanced mri in the evaluation of disease activity early report
    Chest, 2000
    Co-Authors: Michele Gaeta, Alfredo Blandino, E Scribano, Fabio Minutoli, Mario Barone, Filippo Ando, I Pandolfo
    Abstract:

    Study objective To determine the value of gadolinium-enhanced MRI in the assessment of disease activity in chronic infiltrative lung diseases (CILDs). Design Retrospective study. Setting University hospital. Materials and Methods Twenty-five consecutive patients with CILD were studied. The following diseases were diagnosed: sarcoidosis (n = 10), bronchiolitis obliterans organizing Pneumonia (n = 3), usual interstitial Pneumonia (n = 4), Radiation Pneumonia (n = 2), desquamative interstitial Pneumonia (n = 1), rheumatoid lung (n = 1), vasculitis (n = 1), alveolar proteinosis (n = 1), bronchioloalveolar carcinoma (n = 1), and chronic eosinophilic Pneumonia (n = 1). In each patient, the disease activity was assessed by one or more of the following studies: BAL (n = 18), gallium-radioisotope lung scanning (n = 6), serum angiotensin-converting enzyme assay (n = 10), and open lung biopsy (n = 4). T1-weighted breath-hold MRI studies were obtained before and after IV injection of gadolinium. The MRI examinations were analyzed to assess the presence or absence of lesional enhancement. Results The presence of enhanced pulmonary lesions was seen in 14 patients. All of these patients had active disease. Of the 17 patients with active disease, 14 had enhanced lesions, and 3 had unenhanced lesions. Pulmonary lesions were not enhanced in any patients with inactive disease. The difference was statistically significant (Fisher Exact Test, p Conclusion Gadolinium-enhanced MRI may prove to be a useful tool in assessing disease activity in CILDs.

Song Qin - One of the best experts on this subject based on the ideXlab platform.

  • effects of phycocyanin on pulmonary and gut microbiota in a Radiation induced pulmonary fibrosis model
    Biomedicine & Pharmacotherapy, 2020
    Co-Authors: Bin Liu, Song Qin
    Abstract:

    Abstract Objective Radiation Pneumonia and fibrosis are major clinical complications of radiotherapy for thoracic tumor patients, and may significantly reduce survival and quality of life. At present, no safe and effective Radiation protection measures have been approved for clinical use. Phycocyanin, a protein responsible for photosynthesis from Spirulina, has been shown to have a variety of biological activities and to be beneficial for a variety of diseases, including pulmonary fibrosis. However, the preventive and protective effects of phycocyanin on Radiation-induced pulmonary fibrosis have not been studied. Design X-ray single dose irRadiation was used on the chest of mice to prepare a mouse model of pulmonary fibrosis, from which the effect of phycocyanin on pulmonary histopathologic change, pulmonary fibrosis, the microbiota in lung and gut, LPS, TNF-α, and IL-6 at different time after irRadiation were evaluated. Results Phycocyanin alleviated the Radiation-induced lung injury and reduced the level of inflammatory factors. Thorax irRadiation led to the disorder in microbiota of the lung and gut. The variation trend of the diversity of the two tissues was opposite, but that of the microbiota composition was similar. The phycocyanin intervention regulated the composition of the lung and gut microbiota, transformed them into normal state, and reduced the level of LPS, which significantly reduced the abundance of inflammation-related bacteria, and increased the abundance of probiotics that produce short-chain fatty acids. Conclusion Phycocyanin could regulate the Radiation-induced disorder in lung and gut microbiota of mice, and reduce the Radiation-induced lung inflammation and fibrosis.

Kunio Hiwada - One of the best experts on this subject based on the ideXlab platform.

  • monitoring of serum kl 6 antigen in a patient with Radiation Pneumonia
    Chest, 1992
    Co-Authors: Hironobu Hamada, Nobuoki Kohno, Mitoshi Akiyama, Kunio Hiwada
    Abstract:

    Serum marker KL-6 antigen has been reported to be a valuable indicator of the disease activity of interstitial Pneumonia. 1 It is not clear how sensitive the serum KL-6 antigen level is in reflecting histologic changes in lung tissues. We report here the results of serial measurements of serum KL-6 antigen in a 76-year-old male patient with Radiation Pneumonia. Serum KL-6 antigen levels were more sensitive than lactate dehydrogenase and procollagen type III N-terminal pep tide. The level of serum KL-6 antigen appears to reflect the histologic changes of the lung more sensitively than does C-reactive protein.

Michele Gaeta - One of the best experts on this subject based on the ideXlab platform.

  • chronic infiltrative lung diseases value of gadolinium enhanced mri in the evaluation of disease activity early report
    Chest, 2000
    Co-Authors: Michele Gaeta, Alfredo Blandino, E Scribano, Fabio Minutoli, Mario Barone, Filippo Ando, I Pandolfo
    Abstract:

    Study objective To determine the value of gadolinium-enhanced MRI in the assessment of disease activity in chronic infiltrative lung diseases (CILDs). Design Retrospective study. Setting University hospital. Materials and Methods Twenty-five consecutive patients with CILD were studied. The following diseases were diagnosed: sarcoidosis (n = 10), bronchiolitis obliterans organizing Pneumonia (n = 3), usual interstitial Pneumonia (n = 4), Radiation Pneumonia (n = 2), desquamative interstitial Pneumonia (n = 1), rheumatoid lung (n = 1), vasculitis (n = 1), alveolar proteinosis (n = 1), bronchioloalveolar carcinoma (n = 1), and chronic eosinophilic Pneumonia (n = 1). In each patient, the disease activity was assessed by one or more of the following studies: BAL (n = 18), gallium-radioisotope lung scanning (n = 6), serum angiotensin-converting enzyme assay (n = 10), and open lung biopsy (n = 4). T1-weighted breath-hold MRI studies were obtained before and after IV injection of gadolinium. The MRI examinations were analyzed to assess the presence or absence of lesional enhancement. Results The presence of enhanced pulmonary lesions was seen in 14 patients. All of these patients had active disease. Of the 17 patients with active disease, 14 had enhanced lesions, and 3 had unenhanced lesions. Pulmonary lesions were not enhanced in any patients with inactive disease. The difference was statistically significant (Fisher Exact Test, p Conclusion Gadolinium-enhanced MRI may prove to be a useful tool in assessing disease activity in CILDs.

Bin Liu - One of the best experts on this subject based on the ideXlab platform.

  • effects of phycocyanin on pulmonary and gut microbiota in a Radiation induced pulmonary fibrosis model
    Biomedicine & Pharmacotherapy, 2020
    Co-Authors: Bin Liu, Song Qin
    Abstract:

    Abstract Objective Radiation Pneumonia and fibrosis are major clinical complications of radiotherapy for thoracic tumor patients, and may significantly reduce survival and quality of life. At present, no safe and effective Radiation protection measures have been approved for clinical use. Phycocyanin, a protein responsible for photosynthesis from Spirulina, has been shown to have a variety of biological activities and to be beneficial for a variety of diseases, including pulmonary fibrosis. However, the preventive and protective effects of phycocyanin on Radiation-induced pulmonary fibrosis have not been studied. Design X-ray single dose irRadiation was used on the chest of mice to prepare a mouse model of pulmonary fibrosis, from which the effect of phycocyanin on pulmonary histopathologic change, pulmonary fibrosis, the microbiota in lung and gut, LPS, TNF-α, and IL-6 at different time after irRadiation were evaluated. Results Phycocyanin alleviated the Radiation-induced lung injury and reduced the level of inflammatory factors. Thorax irRadiation led to the disorder in microbiota of the lung and gut. The variation trend of the diversity of the two tissues was opposite, but that of the microbiota composition was similar. The phycocyanin intervention regulated the composition of the lung and gut microbiota, transformed them into normal state, and reduced the level of LPS, which significantly reduced the abundance of inflammation-related bacteria, and increased the abundance of probiotics that produce short-chain fatty acids. Conclusion Phycocyanin could regulate the Radiation-induced disorder in lung and gut microbiota of mice, and reduce the Radiation-induced lung inflammation and fibrosis.