The Experts below are selected from a list of 53262 Experts worldwide ranked by ideXlab platform
Michael Douek - One of the best experts on this subject based on the ideXlab platform.
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novel techniques for sentinel lymph node biopsy in breast cancer a systematic review
Lancet Oncology, 2014Co-Authors: Arnie Purushotham, Muneer Ahmed, Michael DouekAbstract:Summary The existing standard for axillary lymph node staging in breast cancer patients with a clinically and radiologically normal axilla is sentinel lymph node biopsy with a Radioisotope and blue dye (dual technique). The dependence on Radioisotopes means that uptake of the procedure is limited to only about 60% of eligible patients in developed countries and is negligible elsewhere. We did a systematic review to assess three techniques for sentinel lymph node biopsy that are not Radioisotope dependent or that refine the existing method: indocyanine green fluorescence, contrast-enhanced ultrasound using microbubbles, and superparamagnetic iron oxide nanoparticles. Our systematic review suggested that these new methods for sentinel lymph node biopsy have clinical potential but give high levels of false-negative results. We could not identify any technique that challenged the existing standard procedure. Further assessment of these techniques against the standard dual technique in randomised trials is needed.
Muneer Ahmed - One of the best experts on this subject based on the ideXlab platform.
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novel techniques for sentinel lymph node biopsy in breast cancer a systematic review
Lancet Oncology, 2014Co-Authors: Arnie Purushotham, Muneer Ahmed, Michael DouekAbstract:Summary The existing standard for axillary lymph node staging in breast cancer patients with a clinically and radiologically normal axilla is sentinel lymph node biopsy with a Radioisotope and blue dye (dual technique). The dependence on Radioisotopes means that uptake of the procedure is limited to only about 60% of eligible patients in developed countries and is negligible elsewhere. We did a systematic review to assess three techniques for sentinel lymph node biopsy that are not Radioisotope dependent or that refine the existing method: indocyanine green fluorescence, contrast-enhanced ultrasound using microbubbles, and superparamagnetic iron oxide nanoparticles. Our systematic review suggested that these new methods for sentinel lymph node biopsy have clinical potential but give high levels of false-negative results. We could not identify any technique that challenged the existing standard procedure. Further assessment of these techniques against the standard dual technique in randomised trials is needed.
Arnie Purushotham - One of the best experts on this subject based on the ideXlab platform.
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novel techniques for sentinel lymph node biopsy in breast cancer a systematic review
Lancet Oncology, 2014Co-Authors: Arnie Purushotham, Muneer Ahmed, Michael DouekAbstract:Summary The existing standard for axillary lymph node staging in breast cancer patients with a clinically and radiologically normal axilla is sentinel lymph node biopsy with a Radioisotope and blue dye (dual technique). The dependence on Radioisotopes means that uptake of the procedure is limited to only about 60% of eligible patients in developed countries and is negligible elsewhere. We did a systematic review to assess three techniques for sentinel lymph node biopsy that are not Radioisotope dependent or that refine the existing method: indocyanine green fluorescence, contrast-enhanced ultrasound using microbubbles, and superparamagnetic iron oxide nanoparticles. Our systematic review suggested that these new methods for sentinel lymph node biopsy have clinical potential but give high levels of false-negative results. We could not identify any technique that challenged the existing standard procedure. Further assessment of these techniques against the standard dual technique in randomised trials is needed.
Gianpiero Manca - One of the best experts on this subject based on the ideXlab platform.
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Sentinel lymph node biopsy in small papillary thyroid cancer. A review on novel surgical techniques
Endocrine, 2018Co-Authors: Ludovico Maria Garau, Domenico Rubello, Alice Ferretti, Giuseppe Boni, Duccio Volterrani, Gianpiero MancaAbstract:Purpose Sentinel lymph node biopsy (SNB) in patients with papillary thyroid carcinoma (PTC) and negative for clinically neck lymph node metastatic involvement (N0) has emerged as a promising minimally invasive procedure to detect metastatic nodes. Methods The MEDLINE database was searched via the PubMed interface on 10 January 2018 for the MeSH headings “sentinel lymph node biopsy” and “thyroid carcinoma”. Results Vital blue dye, Radioisotope, and the combination of both techniques are used in PTC patients. These methods and the emerging role of SPECT/CT are discussed in this review. The sentinel lymph node (SLN) identification rates ranged from 0 to 100% for blue dye, 83 to 100% for Radioisotopes, and 66 to 100% for the combination of both techniques, respectively. Conclusions SNB based on Radioisotope technique with the use of intraoperative gamma-probe is an accurate and safe method that allows the highest SLN detection rate. There is sufficient evidence to propagate the increasing use of SNB procedure that has the potential to avoid prophylactic lymph node surgery in patients clinically N0.
P. Paris - One of the best experts on this subject based on the ideXlab platform.
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su ff i 59 acceptance and commissioning of a novel ionizing radiation emitting isotope hospital detection and notification system suitable for use in radiation counter terrorism
Medical Physics, 2009Co-Authors: Josef Novotny, R Palatine, Greg Bednarz, M O'reilly, P. ParisAbstract:Introduction and Purpose: Radioactive patient contamination (from dirty bomb explosions, etc.) could force shut down of hospital services for an extended time. The University of Pittsburgh Medical Center (UMPC) established testing of Thermo Fisher Scientific's Emergency Department Notification System (EDNS) at its Presbyterian Hospital. The EDNS discriminates non‐medical radioactive isotopes from medical isotopes. The EDNS at UPMC consists of large volume Sodium Iodide Detector Enclosures, System Control Unit, and networked Thermo Scientific ViewPoint™ Monitoring Software. The purpose of this study was to perform initial acceptance and commissioning of the EDNS. Methods and Materials: The following tests were performed for the initial acceptance of the EDNS: 1) evaluation of minimum detectable activity, 2) detector response distance to various source activities, 3) detector response to different speeds of a moving Radioisotope and 4) ability to detect different Radioisotopes passing under the detector at the same time. The Radioisotopes used in the experiments were: Cs‐137, Co‐60, Ba‐133, Th‐228, Am‐241, I 125 and Sr‐90. Results: The minimum detectable activity for the system was 4.38 μCi. The minimum detector response distance for a Cs‐137 source of activity 7.28 μCi moving at an approximate speed of 1.2 m/s was found to be 2.3 m from the detector's centerline. The system easily detected a Cs‐137 source of activity 7.28 μCi moving under the detector enclosure at speeds ranging from 0 to 2.5 m/s. The system detected and identified combinations of Radioisotopes when these were moved under the detector probe at an approx. speed of 1.2 m/s. Conclusions: All performed tests were within preset specifications. This novel EDNS system can effectively track movement of non‐medical/suspicious Radioisotopes in a hospital environment, identify potentially dangerous Radioisotopes, and report their location. Further testing and evaluation of the EDNS system is in progress.
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SU‐FF‐I‐59: Acceptance and Commissioning of a Novel Ionizing Radiation Emitting Isotope Hospital Detection and Notification System Suitable for Use in Radiation Counter‐Terrorism
Medical Physics, 2009Co-Authors: Josef Novotny, R Palatine, Greg Bednarz, M O'reilly, P. Paris, Joel S. GreenbergerAbstract:Introduction and Purpose: Radioactive patient contamination (from dirty bomb explosions, etc.) could force shut down of hospital services for an extended time. The University of Pittsburgh Medical Center (UMPC) established testing of Thermo Fisher Scientific's Emergency Department Notification System (EDNS) at its Presbyterian Hospital. The EDNS discriminates non‐medical radioactive isotopes from medical isotopes. The EDNS at UPMC consists of large volume Sodium Iodide Detector Enclosures, System Control Unit, and networked Thermo Scientific ViewPoint™ Monitoring Software. The purpose of this study was to perform initial acceptance and commissioning of the EDNS. Methods and Materials: The following tests were performed for the initial acceptance of the EDNS: 1) evaluation of minimum detectable activity, 2) detector response distance to various source activities, 3) detector response to different speeds of a moving Radioisotope and 4) ability to detect different Radioisotopes passing under the detector at the same time. The Radioisotopes used in the experiments were: Cs‐137, Co‐60, Ba‐133, Th‐228, Am‐241, I 125 and Sr‐90. Results: The minimum detectable activity for the system was 4.38 μCi. The minimum detector response distance for a Cs‐137 source of activity 7.28 μCi moving at an approximate speed of 1.2 m/s was found to be 2.3 m from the detector's centerline. The system easily detected a Cs‐137 source of activity 7.28 μCi moving under the detector enclosure at speeds ranging from 0 to 2.5 m/s. The system detected and identified combinations of Radioisotopes when these were moved under the detector probe at an approx. speed of 1.2 m/s. Conclusions: All performed tests were within preset specifications. This novel EDNS system can effectively track movement of non‐medical/suspicious Radioisotopes in a hospital environment, identify potentially dangerous Radioisotopes, and report their location. Further testing and evaluation of the EDNS system is in progress.
