The Experts below are selected from a list of 27 Experts worldwide ranked by ideXlab platform
J M Weintraub - One of the best experts on this subject based on the ideXlab platform.
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receiver operating characteristic curve analysis of cutaneous skin test reactions to predict hay fever and asthma symptoms in the normative aging study
Allergy, 2001Co-Authors: J M Weintraub, D Sparrow, Scott T WeissAbstract:Background: We used receiver operating characteristic (ROC) curves to determine optimal cutoff values and to evaluate the ability of Ragweed, mixed grasses, mixed trees, and house-dust Antigens to predict symptoms of hay fever and asthma. Methods: Between 1984 and 1993, 1386 members of the Normative Aging Study cohort had at least one examination that included evaluation of cutaneous hypersensitivity to common aeroallergens by skin prick testing. Standard questionnaires based on the American Thoracic Society DLD-78 questionnaire obtained information on respiratory symptoms, illness, and smoking habits. Results: Ragweed was the best univariate predictor for both hay fever and asthma symptoms: the area under the ROC curve for hay fever was 0.71 (95% CI 0.67–0.74); for asthma, it was 0.65 (95% CI 0.55–0.75). For hay fever, dichotomizing the average reaction to four Antigens at 2 mm gave a sensitivity of 56% and a specificity of 83%; at 3 mm, the sensitivity was 38% and specificity 92%. For asthma, dichotomizing the skin test reaction at 2 mm gave a sensitivity ranging from 30% for reaction to mixed grasses to 56% for the Ragweed Antigen reaction. Conclusions: Although in this older population skin test reactivities did not predict current asthma symptoms with high sensitivity, our results support the use of cutoff values of 2 or 3 mm as commonly used in studies of hay fever symptoms.
Scott T Weiss - One of the best experts on this subject based on the ideXlab platform.
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receiver operating characteristic curve analysis of cutaneous skin test reactions to predict hay fever and asthma symptoms in the normative aging study
Allergy, 2001Co-Authors: J M Weintraub, D Sparrow, Scott T WeissAbstract:Background: We used receiver operating characteristic (ROC) curves to determine optimal cutoff values and to evaluate the ability of Ragweed, mixed grasses, mixed trees, and house-dust Antigens to predict symptoms of hay fever and asthma. Methods: Between 1984 and 1993, 1386 members of the Normative Aging Study cohort had at least one examination that included evaluation of cutaneous hypersensitivity to common aeroallergens by skin prick testing. Standard questionnaires based on the American Thoracic Society DLD-78 questionnaire obtained information on respiratory symptoms, illness, and smoking habits. Results: Ragweed was the best univariate predictor for both hay fever and asthma symptoms: the area under the ROC curve for hay fever was 0.71 (95% CI 0.67–0.74); for asthma, it was 0.65 (95% CI 0.55–0.75). For hay fever, dichotomizing the average reaction to four Antigens at 2 mm gave a sensitivity of 56% and a specificity of 83%; at 3 mm, the sensitivity was 38% and specificity 92%. For asthma, dichotomizing the skin test reaction at 2 mm gave a sensitivity ranging from 30% for reaction to mixed grasses to 56% for the Ragweed Antigen reaction. Conclusions: Although in this older population skin test reactivities did not predict current asthma symptoms with high sensitivity, our results support the use of cutoff values of 2 or 3 mm as commonly used in studies of hay fever symptoms.
Eugene R Bleecker - One of the best experts on this subject based on the ideXlab platform.
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anti inflammatory effects of zileuton in a subpopulation of allergic asthmatics
American Journal of Respiratory and Critical Care Medicine, 2000Co-Authors: Jeffrey D Hasday, Susan S Meltzer, Wendy C Moore, P Wisniewski, J R Hebel, C Lanni, L M Dube, Eugene R BleeckerAbstract:The objective of this study was to determine the effects of allergen exposure on leukotriene generation and inflammation within the airways of allergic asthmatics and evaluate the effects of the 5-lipoxygenase inhibitor zileuton on these responses. We measured leukotriene-B4 (LTB4) and LTC4/D4/E4, inflammatory cytokine mediators, and cellular responses in bronchoalveolar lavage fluid (BALF) before and 24 h after segmental Ragweed Antigen challenge in 18 asthmatic subjects at baseline. Before initiating therapy with the 5-lipoxygenase inhibitor or placebo, only nine of 18 asthmatic subjects had a significant increase (234 ± 102-fold, mean ± SE) in BALF LTC4/D4/E4 levels 24 h after segmental Antigen challenge, whereas leukotriene levels were essentially unchanged (1.14 ± 0.22-fold) in the other nine subjects. The high LT producers also had higher postAntigen BALF levels of LTB4, total protein, IL-5, IL-6, TNF- α , and recovery of more eosinophils than the low LT producers. Treatment with the 5-lipoxygenase ...
William W Busse - One of the best experts on this subject based on the ideXlab platform.
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the effect of t cell depletion on enhanced basophil histamine release after in vitro incubation with live influenza a virus
American Journal of Respiratory Cell and Molecular Biology, 1992Co-Authors: M A Huftel, Cheri A Swensen, W R Borcherding, Elliot C Dick, R Hong, H Kita, Gerald J Gleich, William W BusseAbstract:A number of mechanisms participate in virus-induced asthma. Previously, we described enhanced basophil histamine release (HR) during an experimentally induced rhinovirus infection and after in vitro incubation of peripheral blood mononuclear cells (PBMC) with influenza virus. This study extends our previous observations and examines the effect of influenza A virus on basophil leukotriene C4 (LTC4) release as well as the effect of T-cell depletion on virus-enhanced basophil HR. PBMC were isolated from Ragweed-allergic subjects and incubated with live influenza A virus or control medium (allantoic fluid). After incubation with influenza A, Ragweed Antigen (AgE) stimulated LTC4 and HR were enhanced (P < 0.05). To further define the role of T cells in virus-enhanced basophil secretion, PBMC were isolated and divided into two aliquots. In one aliquot, T cells were removed by magnetic bead separation of mouse monoclonal anti-CD3-coated lymphocytes. T-cell-depleted and nontreated PBMC suspensions were incubated ...
Jeffrey D Hasday - One of the best experts on this subject based on the ideXlab platform.
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anti inflammatory effects of zileuton in a subpopulation of allergic asthmatics
American Journal of Respiratory and Critical Care Medicine, 2000Co-Authors: Jeffrey D Hasday, Susan S Meltzer, Wendy C Moore, P Wisniewski, J R Hebel, C Lanni, L M Dube, Eugene R BleeckerAbstract:The objective of this study was to determine the effects of allergen exposure on leukotriene generation and inflammation within the airways of allergic asthmatics and evaluate the effects of the 5-lipoxygenase inhibitor zileuton on these responses. We measured leukotriene-B4 (LTB4) and LTC4/D4/E4, inflammatory cytokine mediators, and cellular responses in bronchoalveolar lavage fluid (BALF) before and 24 h after segmental Ragweed Antigen challenge in 18 asthmatic subjects at baseline. Before initiating therapy with the 5-lipoxygenase inhibitor or placebo, only nine of 18 asthmatic subjects had a significant increase (234 ± 102-fold, mean ± SE) in BALF LTC4/D4/E4 levels 24 h after segmental Antigen challenge, whereas leukotriene levels were essentially unchanged (1.14 ± 0.22-fold) in the other nine subjects. The high LT producers also had higher postAntigen BALF levels of LTB4, total protein, IL-5, IL-6, TNF- α , and recovery of more eosinophils than the low LT producers. Treatment with the 5-lipoxygenase ...