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Jun Kagawa - One of the best experts on this subject based on the ideXlab platform.
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acute biological effects of intRatracheally instilled titanium dioxide whiskers compared with nonfibrous titanium dioxide and amosite in Rats
Inhalation Toxicology, 1999Co-Authors: Yoko Ishihara, Hiroko Kyono, Norihiko Kohyama, Noriko Otaki, Fumio Serita, Tadao Toya, Jun KagawaAbstract:The dimensions of man-made mineral fiber whiskers are similar to those of some kinds of asbestos. Thus these mineral fibers raise the concern for potential health hazard for workers exposed in the occupational environments. This study was designed to define acute biological effects of intRatracheally administered titanium dioxide whiskers (TO1) compared with nonfibrous titanium dioxide (TOP) and UICC amosite (Ams), and their relations to acute lung inflammation in Rats. The observed geometric mean length (mum) and width (mum) and geometric standard deviation are: TO1(2.1[2.0], 0.14[1.53]); Ams (4.3[3.3], 0.31[1.9]); and TOP (50 nm, 1-2 mum aggregates). Ten-week-old Wistar-Jcl male Rats received a single tracheal injection of test materials at doses between 0.05 and 1.0 mg/Rat. Control animals were injected with the same volume of saline. Lung tissue and bronchoalveolar lavage (BAL) fluid were collected from Rats on days 1, 3, and 7 after administRation. In the group injected with TO1, total protein, cytok...
Yoko Ishihara - One of the best experts on this subject based on the ideXlab platform.
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acute biological effects of intRatracheally instilled titanium dioxide whiskers compared with nonfibrous titanium dioxide and amosite in Rats
Inhalation Toxicology, 1999Co-Authors: Yoko Ishihara, Hiroko Kyono, Norihiko Kohyama, Noriko Otaki, Fumio Serita, Tadao Toya, Jun KagawaAbstract:The dimensions of man-made mineral fiber whiskers are similar to those of some kinds of asbestos. Thus these mineral fibers raise the concern for potential health hazard for workers exposed in the occupational environments. This study was designed to define acute biological effects of intRatracheally administered titanium dioxide whiskers (TO1) compared with nonfibrous titanium dioxide (TOP) and UICC amosite (Ams), and their relations to acute lung inflammation in Rats. The observed geometric mean length (mum) and width (mum) and geometric standard deviation are: TO1(2.1[2.0], 0.14[1.53]); Ams (4.3[3.3], 0.31[1.9]); and TOP (50 nm, 1-2 mum aggregates). Ten-week-old Wistar-Jcl male Rats received a single tracheal injection of test materials at doses between 0.05 and 1.0 mg/Rat. Control animals were injected with the same volume of saline. Lung tissue and bronchoalveolar lavage (BAL) fluid were collected from Rats on days 1, 3, and 7 after administRation. In the group injected with TO1, total protein, cytok...
Norihiko Kohyama - One of the best experts on this subject based on the ideXlab platform.
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acute biological effects of intRatracheally instilled titanium dioxide whiskers compared with nonfibrous titanium dioxide and amosite in Rats
Inhalation Toxicology, 1999Co-Authors: Yoko Ishihara, Hiroko Kyono, Norihiko Kohyama, Noriko Otaki, Fumio Serita, Tadao Toya, Jun KagawaAbstract:The dimensions of man-made mineral fiber whiskers are similar to those of some kinds of asbestos. Thus these mineral fibers raise the concern for potential health hazard for workers exposed in the occupational environments. This study was designed to define acute biological effects of intRatracheally administered titanium dioxide whiskers (TO1) compared with nonfibrous titanium dioxide (TOP) and UICC amosite (Ams), and their relations to acute lung inflammation in Rats. The observed geometric mean length (mum) and width (mum) and geometric standard deviation are: TO1(2.1[2.0], 0.14[1.53]); Ams (4.3[3.3], 0.31[1.9]); and TOP (50 nm, 1-2 mum aggregates). Ten-week-old Wistar-Jcl male Rats received a single tracheal injection of test materials at doses between 0.05 and 1.0 mg/Rat. Control animals were injected with the same volume of saline. Lung tissue and bronchoalveolar lavage (BAL) fluid were collected from Rats on days 1, 3, and 7 after administRation. In the group injected with TO1, total protein, cytok...
Noriko Otaki - One of the best experts on this subject based on the ideXlab platform.
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acute biological effects of intRatracheally instilled titanium dioxide whiskers compared with nonfibrous titanium dioxide and amosite in Rats
Inhalation Toxicology, 1999Co-Authors: Yoko Ishihara, Hiroko Kyono, Norihiko Kohyama, Noriko Otaki, Fumio Serita, Tadao Toya, Jun KagawaAbstract:The dimensions of man-made mineral fiber whiskers are similar to those of some kinds of asbestos. Thus these mineral fibers raise the concern for potential health hazard for workers exposed in the occupational environments. This study was designed to define acute biological effects of intRatracheally administered titanium dioxide whiskers (TO1) compared with nonfibrous titanium dioxide (TOP) and UICC amosite (Ams), and their relations to acute lung inflammation in Rats. The observed geometric mean length (mum) and width (mum) and geometric standard deviation are: TO1(2.1[2.0], 0.14[1.53]); Ams (4.3[3.3], 0.31[1.9]); and TOP (50 nm, 1-2 mum aggregates). Ten-week-old Wistar-Jcl male Rats received a single tracheal injection of test materials at doses between 0.05 and 1.0 mg/Rat. Control animals were injected with the same volume of saline. Lung tissue and bronchoalveolar lavage (BAL) fluid were collected from Rats on days 1, 3, and 7 after administRation. In the group injected with TO1, total protein, cytok...
Hiroko Kyono - One of the best experts on this subject based on the ideXlab platform.
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acute biological effects of intRatracheally instilled titanium dioxide whiskers compared with nonfibrous titanium dioxide and amosite in Rats
Inhalation Toxicology, 1999Co-Authors: Yoko Ishihara, Hiroko Kyono, Norihiko Kohyama, Noriko Otaki, Fumio Serita, Tadao Toya, Jun KagawaAbstract:The dimensions of man-made mineral fiber whiskers are similar to those of some kinds of asbestos. Thus these mineral fibers raise the concern for potential health hazard for workers exposed in the occupational environments. This study was designed to define acute biological effects of intRatracheally administered titanium dioxide whiskers (TO1) compared with nonfibrous titanium dioxide (TOP) and UICC amosite (Ams), and their relations to acute lung inflammation in Rats. The observed geometric mean length (mum) and width (mum) and geometric standard deviation are: TO1(2.1[2.0], 0.14[1.53]); Ams (4.3[3.3], 0.31[1.9]); and TOP (50 nm, 1-2 mum aggregates). Ten-week-old Wistar-Jcl male Rats received a single tracheal injection of test materials at doses between 0.05 and 1.0 mg/Rat. Control animals were injected with the same volume of saline. Lung tissue and bronchoalveolar lavage (BAL) fluid were collected from Rats on days 1, 3, and 7 after administRation. In the group injected with TO1, total protein, cytok...
