The Experts below are selected from a list of 783 Experts worldwide ranked by ideXlab platform
Jorg Breitkreutz - One of the best experts on this subject based on the ideXlab platform.
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Real-Time Process Monitoring in a semi-continuous fluid-bed dryer – microwave resonance technology versus near-infrared spectroscopy
International Journal of Pharmaceutics, 2018Co-Authors: Johanna Peters, Claas Döscher, Andreas Teske, Reinhard Knöchel, Michael Höft, Wolfgang Taute, Jorg BreitkreutzAbstract:The trend towards continuous manufacturing in the pharmaceutical industry is associated with an increasing demand for advanced control strategies. It is a mandatory requirement to obtain reliable Real-Time information on critical quality attributes (CQA) during every Process step as the decision on diversion of material needs to be performed fast and automatically. Where possible, production equipment should provide redundant systems for in-Process control (IPC) measurements to ensure continuous Process Monitoring even if one of the systems is not available. In this paper, two methods for Real-Time Monitoring of granule moisture in a semi-continuous fluid-bed drying unit are compared. While near-infrared (NIR) spectroscopy has already proven to be a suitable Process analytical technology (PAT) tool for moisture measurements in fluid-bed applications, microwave resonance technology (MRT) showed difficulties to monitor moistures above 8% until recently. The results indicate, that the newly developed MRT sensor operating at four resonances is capable to compete with NIR spectroscopy. While NIR spectra were preProcessed by mean centering and first derivative before application of partial least squares (PLS) regression to build predictive models (RMSEP = 0.20%), microwave moisture values of two resonances sufficed to build a statistically close multiple linear regression (MLR) model (RMSEP = 0.07%) for moisture prediction. Thereby, it could be verified that moisture Monitoring by MRT sensor systems could be a valuable alternative to NIR spectroscopy or could be used as a redundant system providing great ease of application.
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Real-Time Process Monitoring in a semi-continuous fluid-bed dryer - microwave resonance technology versus near-infrared spectroscopy.
International Journal of Pharmaceutics, 2017Co-Authors: Johanna Peters, Claas Döscher, Andreas Teske, Reinhard Knöchel, Michael Höft, Wolfgang Taute, Jorg BreitkreutzAbstract:Abstract The trend towards continuous manufacturing in the pharmaceutical industry is associated with an increasing demand for advanced control strategies. It is a mandatory requirement to obtain reliable Real-Time information on critical quality attributes (CQA) during every Process step as the decision on diversion of material needs to be performed fast and automatically. Where possible, production equipment should provide redundant systems for in-Process control (IPC) measurements to ensure continuous Process Monitoring even if one of the systems is not available. In this paper, two methods for Real-Time Monitoring of granule moisture in a semi-continuous fluid-bed drying unit are compared. While near-infrared (NIR) spectroscopy has already proven to be a suitable Process analytical technology (PAT) tool for moisture measurements in fluid-bed applications, microwave resonance technology (MRT) showed difficulties to monitor moistures above 8% until recently. The results indicate, that the newly developed MRT sensor operating at four resonances is capable to compete with NIR spectroscopy. While NIR spectra were preProcessed by mean centering and first derivative before application of partial least squares (PLS) regression to build predictive models (RMSEP = 0.20%), microwave moisture values of two resonances sufficed to build a statistically close multiple linear regression (MLR) model (RMSEP = 0.07%) for moisture prediction. Thereby, it could be verified that moisture Monitoring by MRT sensor systems could be a valuable alternative to NIR spectroscopy or could be used as a redundant system providing great ease of application.
Johanna Peters - One of the best experts on this subject based on the ideXlab platform.
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Real-Time Process Monitoring in a semi-continuous fluid-bed dryer – microwave resonance technology versus near-infrared spectroscopy
International Journal of Pharmaceutics, 2018Co-Authors: Johanna Peters, Claas Döscher, Andreas Teske, Reinhard Knöchel, Michael Höft, Wolfgang Taute, Jorg BreitkreutzAbstract:The trend towards continuous manufacturing in the pharmaceutical industry is associated with an increasing demand for advanced control strategies. It is a mandatory requirement to obtain reliable Real-Time information on critical quality attributes (CQA) during every Process step as the decision on diversion of material needs to be performed fast and automatically. Where possible, production equipment should provide redundant systems for in-Process control (IPC) measurements to ensure continuous Process Monitoring even if one of the systems is not available. In this paper, two methods for Real-Time Monitoring of granule moisture in a semi-continuous fluid-bed drying unit are compared. While near-infrared (NIR) spectroscopy has already proven to be a suitable Process analytical technology (PAT) tool for moisture measurements in fluid-bed applications, microwave resonance technology (MRT) showed difficulties to monitor moistures above 8% until recently. The results indicate, that the newly developed MRT sensor operating at four resonances is capable to compete with NIR spectroscopy. While NIR spectra were preProcessed by mean centering and first derivative before application of partial least squares (PLS) regression to build predictive models (RMSEP = 0.20%), microwave moisture values of two resonances sufficed to build a statistically close multiple linear regression (MLR) model (RMSEP = 0.07%) for moisture prediction. Thereby, it could be verified that moisture Monitoring by MRT sensor systems could be a valuable alternative to NIR spectroscopy or could be used as a redundant system providing great ease of application.
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Real-Time Process Monitoring in a semi-continuous fluid-bed dryer - microwave resonance technology versus near-infrared spectroscopy.
International Journal of Pharmaceutics, 2017Co-Authors: Johanna Peters, Claas Döscher, Andreas Teske, Reinhard Knöchel, Michael Höft, Wolfgang Taute, Jorg BreitkreutzAbstract:Abstract The trend towards continuous manufacturing in the pharmaceutical industry is associated with an increasing demand for advanced control strategies. It is a mandatory requirement to obtain reliable Real-Time information on critical quality attributes (CQA) during every Process step as the decision on diversion of material needs to be performed fast and automatically. Where possible, production equipment should provide redundant systems for in-Process control (IPC) measurements to ensure continuous Process Monitoring even if one of the systems is not available. In this paper, two methods for Real-Time Monitoring of granule moisture in a semi-continuous fluid-bed drying unit are compared. While near-infrared (NIR) spectroscopy has already proven to be a suitable Process analytical technology (PAT) tool for moisture measurements in fluid-bed applications, microwave resonance technology (MRT) showed difficulties to monitor moistures above 8% until recently. The results indicate, that the newly developed MRT sensor operating at four resonances is capable to compete with NIR spectroscopy. While NIR spectra were preProcessed by mean centering and first derivative before application of partial least squares (PLS) regression to build predictive models (RMSEP = 0.20%), microwave moisture values of two resonances sufficed to build a statistically close multiple linear regression (MLR) model (RMSEP = 0.07%) for moisture prediction. Thereby, it could be verified that moisture Monitoring by MRT sensor systems could be a valuable alternative to NIR spectroscopy or could be used as a redundant system providing great ease of application.
Claas Döscher - One of the best experts on this subject based on the ideXlab platform.
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Real-Time Process Monitoring in a semi-continuous fluid-bed dryer – microwave resonance technology versus near-infrared spectroscopy
International Journal of Pharmaceutics, 2018Co-Authors: Johanna Peters, Claas Döscher, Andreas Teske, Reinhard Knöchel, Michael Höft, Wolfgang Taute, Jorg BreitkreutzAbstract:The trend towards continuous manufacturing in the pharmaceutical industry is associated with an increasing demand for advanced control strategies. It is a mandatory requirement to obtain reliable Real-Time information on critical quality attributes (CQA) during every Process step as the decision on diversion of material needs to be performed fast and automatically. Where possible, production equipment should provide redundant systems for in-Process control (IPC) measurements to ensure continuous Process Monitoring even if one of the systems is not available. In this paper, two methods for Real-Time Monitoring of granule moisture in a semi-continuous fluid-bed drying unit are compared. While near-infrared (NIR) spectroscopy has already proven to be a suitable Process analytical technology (PAT) tool for moisture measurements in fluid-bed applications, microwave resonance technology (MRT) showed difficulties to monitor moistures above 8% until recently. The results indicate, that the newly developed MRT sensor operating at four resonances is capable to compete with NIR spectroscopy. While NIR spectra were preProcessed by mean centering and first derivative before application of partial least squares (PLS) regression to build predictive models (RMSEP = 0.20%), microwave moisture values of two resonances sufficed to build a statistically close multiple linear regression (MLR) model (RMSEP = 0.07%) for moisture prediction. Thereby, it could be verified that moisture Monitoring by MRT sensor systems could be a valuable alternative to NIR spectroscopy or could be used as a redundant system providing great ease of application.
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Real-Time Process Monitoring in a semi-continuous fluid-bed dryer - microwave resonance technology versus near-infrared spectroscopy.
International Journal of Pharmaceutics, 2017Co-Authors: Johanna Peters, Claas Döscher, Andreas Teske, Reinhard Knöchel, Michael Höft, Wolfgang Taute, Jorg BreitkreutzAbstract:Abstract The trend towards continuous manufacturing in the pharmaceutical industry is associated with an increasing demand for advanced control strategies. It is a mandatory requirement to obtain reliable Real-Time information on critical quality attributes (CQA) during every Process step as the decision on diversion of material needs to be performed fast and automatically. Where possible, production equipment should provide redundant systems for in-Process control (IPC) measurements to ensure continuous Process Monitoring even if one of the systems is not available. In this paper, two methods for Real-Time Monitoring of granule moisture in a semi-continuous fluid-bed drying unit are compared. While near-infrared (NIR) spectroscopy has already proven to be a suitable Process analytical technology (PAT) tool for moisture measurements in fluid-bed applications, microwave resonance technology (MRT) showed difficulties to monitor moistures above 8% until recently. The results indicate, that the newly developed MRT sensor operating at four resonances is capable to compete with NIR spectroscopy. While NIR spectra were preProcessed by mean centering and first derivative before application of partial least squares (PLS) regression to build predictive models (RMSEP = 0.20%), microwave moisture values of two resonances sufficed to build a statistically close multiple linear regression (MLR) model (RMSEP = 0.07%) for moisture prediction. Thereby, it could be verified that moisture Monitoring by MRT sensor systems could be a valuable alternative to NIR spectroscopy or could be used as a redundant system providing great ease of application.
Wolfgang Taute - One of the best experts on this subject based on the ideXlab platform.
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Real-Time Process Monitoring in a semi-continuous fluid-bed dryer – microwave resonance technology versus near-infrared spectroscopy
International Journal of Pharmaceutics, 2018Co-Authors: Johanna Peters, Claas Döscher, Andreas Teske, Reinhard Knöchel, Michael Höft, Wolfgang Taute, Jorg BreitkreutzAbstract:The trend towards continuous manufacturing in the pharmaceutical industry is associated with an increasing demand for advanced control strategies. It is a mandatory requirement to obtain reliable Real-Time information on critical quality attributes (CQA) during every Process step as the decision on diversion of material needs to be performed fast and automatically. Where possible, production equipment should provide redundant systems for in-Process control (IPC) measurements to ensure continuous Process Monitoring even if one of the systems is not available. In this paper, two methods for Real-Time Monitoring of granule moisture in a semi-continuous fluid-bed drying unit are compared. While near-infrared (NIR) spectroscopy has already proven to be a suitable Process analytical technology (PAT) tool for moisture measurements in fluid-bed applications, microwave resonance technology (MRT) showed difficulties to monitor moistures above 8% until recently. The results indicate, that the newly developed MRT sensor operating at four resonances is capable to compete with NIR spectroscopy. While NIR spectra were preProcessed by mean centering and first derivative before application of partial least squares (PLS) regression to build predictive models (RMSEP = 0.20%), microwave moisture values of two resonances sufficed to build a statistically close multiple linear regression (MLR) model (RMSEP = 0.07%) for moisture prediction. Thereby, it could be verified that moisture Monitoring by MRT sensor systems could be a valuable alternative to NIR spectroscopy or could be used as a redundant system providing great ease of application.
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Real-Time Process Monitoring in a semi-continuous fluid-bed dryer - microwave resonance technology versus near-infrared spectroscopy.
International Journal of Pharmaceutics, 2017Co-Authors: Johanna Peters, Claas Döscher, Andreas Teske, Reinhard Knöchel, Michael Höft, Wolfgang Taute, Jorg BreitkreutzAbstract:Abstract The trend towards continuous manufacturing in the pharmaceutical industry is associated with an increasing demand for advanced control strategies. It is a mandatory requirement to obtain reliable Real-Time information on critical quality attributes (CQA) during every Process step as the decision on diversion of material needs to be performed fast and automatically. Where possible, production equipment should provide redundant systems for in-Process control (IPC) measurements to ensure continuous Process Monitoring even if one of the systems is not available. In this paper, two methods for Real-Time Monitoring of granule moisture in a semi-continuous fluid-bed drying unit are compared. While near-infrared (NIR) spectroscopy has already proven to be a suitable Process analytical technology (PAT) tool for moisture measurements in fluid-bed applications, microwave resonance technology (MRT) showed difficulties to monitor moistures above 8% until recently. The results indicate, that the newly developed MRT sensor operating at four resonances is capable to compete with NIR spectroscopy. While NIR spectra were preProcessed by mean centering and first derivative before application of partial least squares (PLS) regression to build predictive models (RMSEP = 0.20%), microwave moisture values of two resonances sufficed to build a statistically close multiple linear regression (MLR) model (RMSEP = 0.07%) for moisture prediction. Thereby, it could be verified that moisture Monitoring by MRT sensor systems could be a valuable alternative to NIR spectroscopy or could be used as a redundant system providing great ease of application.
Reinhard Knöchel - One of the best experts on this subject based on the ideXlab platform.
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Real-Time Process Monitoring in a semi-continuous fluid-bed dryer – microwave resonance technology versus near-infrared spectroscopy
International Journal of Pharmaceutics, 2018Co-Authors: Johanna Peters, Claas Döscher, Andreas Teske, Reinhard Knöchel, Michael Höft, Wolfgang Taute, Jorg BreitkreutzAbstract:The trend towards continuous manufacturing in the pharmaceutical industry is associated with an increasing demand for advanced control strategies. It is a mandatory requirement to obtain reliable Real-Time information on critical quality attributes (CQA) during every Process step as the decision on diversion of material needs to be performed fast and automatically. Where possible, production equipment should provide redundant systems for in-Process control (IPC) measurements to ensure continuous Process Monitoring even if one of the systems is not available. In this paper, two methods for Real-Time Monitoring of granule moisture in a semi-continuous fluid-bed drying unit are compared. While near-infrared (NIR) spectroscopy has already proven to be a suitable Process analytical technology (PAT) tool for moisture measurements in fluid-bed applications, microwave resonance technology (MRT) showed difficulties to monitor moistures above 8% until recently. The results indicate, that the newly developed MRT sensor operating at four resonances is capable to compete with NIR spectroscopy. While NIR spectra were preProcessed by mean centering and first derivative before application of partial least squares (PLS) regression to build predictive models (RMSEP = 0.20%), microwave moisture values of two resonances sufficed to build a statistically close multiple linear regression (MLR) model (RMSEP = 0.07%) for moisture prediction. Thereby, it could be verified that moisture Monitoring by MRT sensor systems could be a valuable alternative to NIR spectroscopy or could be used as a redundant system providing great ease of application.
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Real-Time Process Monitoring in a semi-continuous fluid-bed dryer - microwave resonance technology versus near-infrared spectroscopy.
International Journal of Pharmaceutics, 2017Co-Authors: Johanna Peters, Claas Döscher, Andreas Teske, Reinhard Knöchel, Michael Höft, Wolfgang Taute, Jorg BreitkreutzAbstract:Abstract The trend towards continuous manufacturing in the pharmaceutical industry is associated with an increasing demand for advanced control strategies. It is a mandatory requirement to obtain reliable Real-Time information on critical quality attributes (CQA) during every Process step as the decision on diversion of material needs to be performed fast and automatically. Where possible, production equipment should provide redundant systems for in-Process control (IPC) measurements to ensure continuous Process Monitoring even if one of the systems is not available. In this paper, two methods for Real-Time Monitoring of granule moisture in a semi-continuous fluid-bed drying unit are compared. While near-infrared (NIR) spectroscopy has already proven to be a suitable Process analytical technology (PAT) tool for moisture measurements in fluid-bed applications, microwave resonance technology (MRT) showed difficulties to monitor moistures above 8% until recently. The results indicate, that the newly developed MRT sensor operating at four resonances is capable to compete with NIR spectroscopy. While NIR spectra were preProcessed by mean centering and first derivative before application of partial least squares (PLS) regression to build predictive models (RMSEP = 0.20%), microwave moisture values of two resonances sufficed to build a statistically close multiple linear regression (MLR) model (RMSEP = 0.07%) for moisture prediction. Thereby, it could be verified that moisture Monitoring by MRT sensor systems could be a valuable alternative to NIR spectroscopy or could be used as a redundant system providing great ease of application.
