The Experts below are selected from a list of 31545 Experts worldwide ranked by ideXlab platform
Charles Feldman - One of the best experts on this subject based on the ideXlab platform.
-
Penicillin- and Cephalosporin-Resistant Streptococcus Pneumoniae
Drugs, 1999Co-Authors: Keith P. Klugman, Charles FeldmanAbstract:The global emergence of pneumococci resistant to antimicrobial therapy has led to dilemmas in the management of pneumococcal infections. The principles of pharmacodynamics predict that penicillin and cephalosporin therapy of pneumonia will be successful against pneumococci with minimum inhibitory concentrations of penicillin up to 4 μg/ml. These predictions are supported by the observations of a number of recent clinical studies. Otitis media therapy is influenced by penicillin-resistance and current recommendations are that amoxicillin is the drug of choice for this infection, given at a double dose of 80 to 90 mg/kg/day. For the therapy of meningitis, cefotaxime or ceftriaxone in maximal doses is recommended and vancomycin may be added if cephalosporin-resistant strains are encountered with Reasonable Frequency in the population. The new fluoroquinolones with excellent antipneumococcal activity may be considered for use in the setting of pneumonia caused by highly resistant pneumococci and are under evaluation for the management of meningitis.
-
Penicillin- and cephalosporin-resistant Streptococcus pneumoniae. Emerging treatment for an emerging problem.
Drugs, 1999Co-Authors: Keith P. Klugman, Charles FeldmanAbstract:The global emergence of pneumococci resistant to antimicrobial therapy has led to dilemmas in the management of pneumococcal infections. The principles of pharmacodynamics predict that penicillin and cephalosporin therapy of pneumonia will be successful against pneumococci with minimum inhibitory concentrations of penicillin up to 4 μg/ml. These predictions are supported by the observations of a number of recent clinical studies. Otitis media therapy is influenced by penicillin-resistance and current recommendations are that amoxicillin is the drug of choice for this infection, given at a double dose of 80 to 90 mg/kg/day. For the therapy of meningitis, cefotaxime or ceftriaxone in maximal doses is recommended and vancomycin may be added if cephalosporin-resistant strains are encountered with Reasonable Frequency in the population. The new fluoroquinolones with excellent antipneumococcal activity may be considered for use in the setting of pneumonia caused by highly resistant pneumococci and are under evaluation for the management of meningitis.
Keith P. Klugman - One of the best experts on this subject based on the ideXlab platform.
-
Penicillin- and Cephalosporin-Resistant Streptococcus Pneumoniae
Drugs, 1999Co-Authors: Keith P. Klugman, Charles FeldmanAbstract:The global emergence of pneumococci resistant to antimicrobial therapy has led to dilemmas in the management of pneumococcal infections. The principles of pharmacodynamics predict that penicillin and cephalosporin therapy of pneumonia will be successful against pneumococci with minimum inhibitory concentrations of penicillin up to 4 μg/ml. These predictions are supported by the observations of a number of recent clinical studies. Otitis media therapy is influenced by penicillin-resistance and current recommendations are that amoxicillin is the drug of choice for this infection, given at a double dose of 80 to 90 mg/kg/day. For the therapy of meningitis, cefotaxime or ceftriaxone in maximal doses is recommended and vancomycin may be added if cephalosporin-resistant strains are encountered with Reasonable Frequency in the population. The new fluoroquinolones with excellent antipneumococcal activity may be considered for use in the setting of pneumonia caused by highly resistant pneumococci and are under evaluation for the management of meningitis.
-
Penicillin- and cephalosporin-resistant Streptococcus pneumoniae. Emerging treatment for an emerging problem.
Drugs, 1999Co-Authors: Keith P. Klugman, Charles FeldmanAbstract:The global emergence of pneumococci resistant to antimicrobial therapy has led to dilemmas in the management of pneumococcal infections. The principles of pharmacodynamics predict that penicillin and cephalosporin therapy of pneumonia will be successful against pneumococci with minimum inhibitory concentrations of penicillin up to 4 μg/ml. These predictions are supported by the observations of a number of recent clinical studies. Otitis media therapy is influenced by penicillin-resistance and current recommendations are that amoxicillin is the drug of choice for this infection, given at a double dose of 80 to 90 mg/kg/day. For the therapy of meningitis, cefotaxime or ceftriaxone in maximal doses is recommended and vancomycin may be added if cephalosporin-resistant strains are encountered with Reasonable Frequency in the population. The new fluoroquinolones with excellent antipneumococcal activity may be considered for use in the setting of pneumonia caused by highly resistant pneumococci and are under evaluation for the management of meningitis.
Christiane Spitzmueller - One of the best experts on this subject based on the ideXlab platform.
-
what makes a salary seem Reasonable Frequency context effects on starting salary expectations
Journal of Occupational and Organizational Psychology, 2003Co-Authors: Scott Highhouse, Lilly F. Lin, Margaret E Brookslaber, Christiane SpitzmuellerAbstract:Although considerable research attention has been directed at understanding perceptions of salary fairness, very little attention has been given to how salary expectations are formed or how trivial elements of the job search context may influence these expectations. Two experiments demonstrated how the simple manipulation of response options for a multiple-choice item may influence subsequent salary expectations and salary satisfaction. Results are discussed in light of Parducci's (1995) contextual theory.
-
What makes a salary seem Reasonable? Frequency context effects on starting‐salary expectations
Journal of Occupational and Organizational Psychology, 2003Co-Authors: Scott Highhouse, Margaret E. Brooks‐laber, Lilly F. Lin, Christiane SpitzmuellerAbstract:Although considerable research attention has been directed at understanding perceptions of salary fairness, very little attention has been given to how salary expectations are formed or how trivial elements of the job search context may influence these expectations. Two experiments demonstrated how the simple manipulation of response options for a multiple-choice item may influence subsequent salary expectations and salary satisfaction. Results are discussed in light of Parducci's (1995) contextual theory.
Peter Ferenci - One of the best experts on this subject based on the ideXlab platform.
-
wilson s disease
Clinical Gastroenterology and Hepatology, 2005Co-Authors: Peter FerenciAbstract:Wilson's disease (WD) is an autosomal recessive inherited disorder leading to impaired intrahepatic trafficking and biliary excretion of copper, resulting in the accumulation of copper in various organs including the liver, cornea, and brain. The WD gene (OMIM 277900) codes for a copper transporting P-type ATPase (ATP7B). Although the finding of the gene resulted in a major breakthrough for understanding the pathophysiology of WD, the role of genetic testing in the clinical management of WD patients is not yet established. There is no gold standard for diagnosis of WD. Diagnosis requires a combination of clinical and biochemical tests. None of these parameters alone allows a certain diagnosis of WD. To facilitate diagnosis, a scoring system was developed at the 8th International Meeting on Wilson Disease in Leipzig, Germany in 2001. For clinical purposes, the use of mutation analysis is limited by the occurrence of many mutations (more than 200) causing WD. In contrast to direct DNA sequencing, direct mutation detection by using allele-specific probes is rapid and clinically very helpful, if a mutation occurs with a Reasonable Frequency in the population (ie, H1069Q in European WD patients or R778L in WD patients from the Far East). To date, mutation analysis is the only reliable tool for screening the family of an index case with known causative mutation. Alternatively, haplotype analysis can be used to address diagnostic dilemmas in differentiating heterozygote gene carriers and affected asymptomatic siblings.
Scott Highhouse - One of the best experts on this subject based on the ideXlab platform.
-
what makes a salary seem Reasonable Frequency context effects on starting salary expectations
Journal of Occupational and Organizational Psychology, 2003Co-Authors: Scott Highhouse, Lilly F. Lin, Margaret E Brookslaber, Christiane SpitzmuellerAbstract:Although considerable research attention has been directed at understanding perceptions of salary fairness, very little attention has been given to how salary expectations are formed or how trivial elements of the job search context may influence these expectations. Two experiments demonstrated how the simple manipulation of response options for a multiple-choice item may influence subsequent salary expectations and salary satisfaction. Results are discussed in light of Parducci's (1995) contextual theory.
-
What makes a salary seem Reasonable? Frequency context effects on starting‐salary expectations
Journal of Occupational and Organizational Psychology, 2003Co-Authors: Scott Highhouse, Margaret E. Brooks‐laber, Lilly F. Lin, Christiane SpitzmuellerAbstract:Although considerable research attention has been directed at understanding perceptions of salary fairness, very little attention has been given to how salary expectations are formed or how trivial elements of the job search context may influence these expectations. Two experiments demonstrated how the simple manipulation of response options for a multiple-choice item may influence subsequent salary expectations and salary satisfaction. Results are discussed in light of Parducci's (1995) contextual theory.
